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Aiming at the existing heavy-haul railway, bridges hardly meet the transportation requirements. Based on the spatial vibration calculation model of the freight train–track–bridge (FTTB) system, the FTTB spatial vibration model under the condition of auxiliary steel beam reinforcement is established. Besides, according to the random analysis method of train derailment energy, coming up with an evaluation method of auxiliary steel beam reinforcement is based on safety and dynamic response, which is used to discuss the train safety and the change law of FTTB system vibration response. The results show that the derailment resistance of the FTTB system is increased by 22.6% after the auxiliary steel beam is reinforced. Compared with the previous speed (115.56 km/h), the speed is 132.73 km/h after the auxiliary steel beam reinforcement; at the same time, the allowable limit speed increases from 92.49 km/h to 106.18 km/h. In addition, the reinforcement of the auxiliary steel beam can not only effectively reduce the lateral vibration response of the FTTB system under the action of empty wagon but also effectively decline the vertical vibration response of the FTTB system under the action of the loaded wagon, which can meet the stability requirement for running at the speed of 90 km/h. In summary, the reinforcement of auxiliary steel beams can improve the running safety of trains, reduce the vibration response of the FTTB system, and meet the requirements of operation stability.

Background This study aimed to investigate the clinical outcome of adjuvant S-1 with 2-week administration followed by a 1-week rest for locally advanced gastric cancer (GC) patients. Methods The current study was a single retrospective cohort study that focused on the efficacy and toxicity of adjuvant S-1 with a 3-week schedule. A total of 60 patients who underwent total or subtotal gastrectomy plus D2 lymph node dissection and adjuvant S-1 treatment were identified. S-1 treatment began within 4 weeks after the operation; it was administered orally for 2 weeks, followed by a 1-week rest. The dose of S-1 was adjusted depending on adverse events (AEs), with at least 80 mg administered daily. The completion of 1-year S-1 was defined as S-1 continuation for 1 year with over 70% of the planned dose. Patients were followed up with for 5 years postoperatively and underwent hematologic tests and assessments of clinical symptoms every 3-6 weeks for 1 year after surgery. Computed tomography of the abdomen and panendoscopy were performed every 6 months during the first 2 years and at 1-year intervals thereafter until year 5 after surgery. Results The completion rate of 1-year adjuvant S-1 was 71.7%, and the 3-year disease-free survival and overall survival rates were 70.2% and 79.5%, respectively. Seventeen patients did not complete S-1 for 1 year, including 11 patients with tumor recurrence and 6 patients who developed intolerance. Most AEs of S-1 were grade 1-2, and the most frequent AEs (>20%) included anemia, fatigue, pigmentation, nausea, and diarrhea. The most common grade 3-4 AE was fatigue, which was observed in 6.7% of patients. Most patients tolerated the side effects. Conclusions The results of our study confirm that the efficacy and safety of schedule modification of adjuvant S-1 treatment in patients with GC who underwent gastrectomy with D2 lymph node dissection are equal to those in a previous phase 3 study.

In order to research train derailment law under ship impact, the spatial vibration calculation model of a freight train-track-bridge (FTTB) system is used to establish the vibration model of the FTTB system under ship impact. Meanwhile, the calculation method of a train derailment process under ship impact is proposed based on the random analysis method of train derailment energy. Further, the train derailment process on a bridge under ship impact is calculated, and the variation law of the FTTB system spatial vibration response under different impact loads and speeds is analyzed. The results show that the ship impact load has a great influence on wheel lift value. When the impact load is greater than 15 MN, the wheel derails more easily. With the increase of impact load, the derailment coefficient, wheel load reduction rate, and lateral relative displacement of bogie and rail, the lateral displacement of the bridge increases significantly, but the limits of them make it difficult to determine whether the wheel has derailed. The lateral relative displacement of the bogie and rail considering the safety factor is calculated at the moment of derailment, which is taken as the early warning threshold of train derailment. The above conclusions can provide a reference for controlling train safety under ship impact.

Large Array Device (LAD)’s electrical performance is very sensitive to its layout. Signal control switching (SCS) can add LAD’s performances, but the layout impacting is not depicted in the prior. In this study, the layout with different poly finger amount in one guard ring is discussed for device improvement.

Background: For lymphedema patients who received a vascularized lymph node flap transfer (VLNT) as their primary treatment, what are the treatment options when they seek further improvement? With recent publications supporting the use of lymphaticovenous anastomosis (LVA) for treating severe lymphedema, we examined whether LVA could benefit post-VLNT patients seeking further improvement. Methods: This retrospective cohort study enrolled eight lymphedema patients with nine lymphedematous limbs (one patient suffered from bilateral lower limb lymphedema) who had received VLNT as their primary surgery. Patients with previous LVA, liposuction, excisional therapy, or incomplete data were excluded. LVA was performed on nine lower lymphedematous limbs. Demographic data and intraoperative findings were recorded. Preoperative and postoperative limb volumes were measured with magnetic resonance volumetry. The primary outcome was the limb volume measured 6 months post-LVA. Results: The median duration of lymphedema before LVA was 10.5 (4.9–15.3) years. The median waiting time between VLNT and LVA was 41.4 (22.3–97.9) months. The median volume gained in the lymphedematous limb was 3836 (2505–4584) milliliters (mL). The median post-LVA follow-up period was 18 (6–30) months. Significant 6-month and 1-year post-LVA percentage volume reductions were found compared to pre-LVA volume (both p &lt, 0.001). Conclusion: Based on the results from this study, the authors recommend the use of LVA as a secondary procedure for post-VLNT patients seeking further improvement.

Background Despite the growing number of studies on the coronavirus disease-19 (COVID-19), little is known about the association of menopausal status with COVID-19 outcomes. Materials and methods In this retrospective study, we included 336 COVID-19 inpatients between February 15, 2020 and April 30, 2020 at the Taikang Tongji Hospital (Wuhan), China. Electronic medical records including patient demographics, laboratory results, and chest computed tomography (CT) images were reviewed. Results In total, 300 patients with complete clinical outcomes were included for analysis. The mean age was 65.3 years, and most patients were women (n = 167, 55.7%). Over 50% of patients presented with comorbidities, with hypertension (63.5%) being the most common comorbidity. After propensity score matching, results showed that men had significantly higher odds than premenopausal women for developing severe disease type (23.7% vs. 0%, OR 17.12, 95% CI 1.00–293.60; p = 0.003) and bilateral lung infiltration (86.1% vs. 64.7%, OR 3.39, 95% CI 1.08–10.64; p = 0.04), but not for mortality (2.0% vs. 0%, OR 0.88, 95% CI 0.04–19.12, p = 1.00). However, non-significant difference was observed among men and postmenopausal women in the percentage of severe disease type (32.7% vs. 41.7%, OR 0.68, 95% CI 0.37–1.24, p = 0.21), bilateral lung infiltration (86.1% vs. 91.7%, OR 0.56, 95% CI 0.22–1.47, p = 0.24), and mortality (2.0% vs. 6.0%, OR 0.32, 95% CI 0.06–1.69, p = 0.25). Conclusions Men had higher disease severity than premenopausal women, while the differences disappeared between postmenopausal women and men. These findings support aggressive treatment for the poor prognosis of postmenopausal women in clinical practice.

Transmission Line Pulse (TLP) is often applied for Electrostatic Discharge (ESD) devices' characteristics researches. It indicates the devices' triggering-on behaviors, holding performances and thermal run-away results. In normal cases, the thermal run-away data should correlate to ESD [1]. However, the non-correlations between TLP and ESD can be observed in the gate driving circuits [2], silicide devices [3] and poly fuses [4]. In this paper, analyses for the relations between ESD and TLP are taken into discussions for large array devices (LAD).

Large array devices are often used for big current driving capabilities in power electronic integrated circuit (IC) applications. Since these structures have big sizes, typical electrostatic discharge protection methodologies cannot be applied in such kind of IC. Otherwise, IC will become too huge to marketing. In this paper, a novel signal control switching architecture for adding large array devices' ESD performances is proposed. Only a little layout area is increased, but a huge electrostatic discharge robustness improvement can be obtained. Moreover, electrical safe operation area characteristics of large array devices are also improved very much with this new scheme. This study is processed in 0.15 μm Bipolar CMOS DMOS (BCD) with silicide technologies.

For the overweight of automatic car radiator core assembly machine crimping part, the structure was optimized and designed based on ANSYS Workbench to satisfy the double objective about reducing weight and decreasing the impact of the amount of deformation of the core assembly components. Multi-objective genetic algorithm was carried out to search the Pareto optimal solution set for optimal and design problems. It shows that the weight of crimping part reduces by 5.34% compared with the previous part, the assembly flatness of core reduces by 13.43%, and the total deformation affecting mainboard press-fit and positional accuracy of the flared reduces by 6.89%, which all meet the requirements of multi-objective optimization design.

Background CUL4A has been known for its oncogenic properties in various human cancers. However, its role in intrahepatic cholangiocarcinoma (iCCA) has not been explored. Methods We retrospectively investigated 105 iCCA cases from a single medical institution. Tissue microarrays were used for immunohistochemical analysis of CUL4A expression. CUL4A expression vectors were introduced in cell lines. Cell migration and invasion assays were used to compare the mobility potential of iCCA cells under basal conditions and after manipulation. Then we evaluated the effects of CUL4A on the cell growth by proliferation assay, and further checked the susceptibility to cisplatin in iCCA cells with or without CUL4A overexpression. Results CUL4A overexpression was detected in 34 cases (32.4%). Patients with CUL4A-overexpressing tumors exhibited shortened disease-free survival (mean, 27.7 versus 90.4 months; P = 0.011). In the multivariate analysis model, CUL4A overexpression was shown to be an independent unfavorable predictor for disease-free survival (P = 0.045). Moreover, stably transfected CUL4A-overexpressing iCCA cell lines displayed an increased mobility potential and enhanced cell growth without impact on susceptibility to cisplatin. Conclusions Our data demonstrate that overexpression of CUL4A plays an oncogenic role in iCCA and adversely affects disease-free survival. Thus, it may prove to be a powerful prognostic factor and a potential therapeutic target.

The demand for flexible resistive random access memories (ReRAM) has increased because wearable devices, such as smart watches, e-paper, and flexible displays, have become a trend. These devices have advantages such as portability, light weight, and user-friendly interfaces, which are better than the currently available rigid electronic systems. A flexible nonvolatile memory is an essential part of electronic systems. In this study, zinc oxide (ZnO) thin films were used for fabricating ReRAM devices. The fabrication was achieved by a simple solution processing method and low temperature annealing (approximately 100 °C) on a hot plate. In addition, the devices fabricated on polyimide substrates showed excellent operational characteristics with a high ratio (≥ 10 4 ) of the high resistance state to the low resistance state. The operational voltage of the ZnO ReRAM devices was

3D perception and reconstruction is an important research in the field of robot motion control and 3D manufacturing. A system for surface perception and reconstruction of the 3D area based on 2D laser scanner is outlined in this paper. Firstly, aiming at the limited work area of a single device, the “S-shaped” control strategy for scanning device is proposed to extend the effective operating range of the detection system so that the surface could be completely measured, analyzed and processed. The scanning point cloud could be registered to obtain a complete three-dimensional point cloud image. Secondly, due to the problem of the impulse noise, a weighted median filter based on the Euclidean distance is proposed to recover the correct depth information. The performance of the proposed system shows that the designed Euclidean distance-based median filtering method effectively removes impulse noise and preserves original depth information. The system can accurately get the 3D point cloud information, effectively process the scan data, and realize 3D perception and reconstruction for object.

Multirate opportunistic routing was proposed to achieve high throughput by exploiting multi-user diversity and transmission rate diversity in wireless networks. However, the performance of multirate opportunistic routing still cannot be guaranteed when participating nodes are contributed by different parties and thus have selfish behaviors. In this paper, we present the first Cooperation-Optimal protocol for Multirate Opportunistic routing and forwarding, namely COMO, which guarantee the faithfulness of each player, and thus achieve the social efficiency and strongly Pareto efficient Nash equilibrium with the faithfulness as a given property. Here, social efficiency means that the end-to-end throughput should be maximized, while in a strongly Pareto efficient Nash equilibrium, no one can improve her utility without decreasing the utility of at least one other player. We not only rigorously prove the game-theoretic properties of our incentive protocol, but also extensively evaluate its performance on the ORBIT wireless testbed. Experiment results show that our protocol can prevent participating nodes' selfish behaviors and guarantee high performance of the multirate opportunistic routing protocol with a low communication overhead.

This paper studied an effect of a new guard rail on the stability of curve tracks with CWR, and revealed a mechanism of the new guard rail for improving the stability of small radius curve tracks with CWR, and also analyze the degree of the new guard rail for enlarging the pave range of small radius curve tracks with CWR. In order to achieve these, an improved load-deformation method for calculating the stability of tracks with continuous welded rails (CWR) is suggested and verified. The results indicate that the improved load-deformation method not only has the same accuracy as the improved unified formula in specification, but also has the same clear and simple characteristics as the original load-deformation method. The mechanism of the new guard rail for improving the stability of small radius curve tracks with CWR is that the CWR stability can be greatly improved by increasing the stiffness of the track framework under conditions of maintaining the same cross-sectional area of the rails. The CWR with the new guard rail can allow the minimum laying radius from 300 m down to 230 m, i.e. the current specification limit can be relaxed 23.3%. If combined with the roadbed strengthening measures, the new guard rail can allow the minimum laying radius from 300 m down to 140 m, i.e. the current specification limit can be further relaxed 53.3%.

Magnetic sensors have been proposed for vehicle detection because they are sensitive, small and more immune to environmental factors such as rain, wind, snow, dust or fog than sensing systems based on video cameras, ultrasound or infrared radiation. In this paper, we present a novel scheme for vehicle detection by using wireless magnetic sensor nodes. The simulation model of vehicle moving in the Earth's magnetic field is proposed using a 2D transient linear motion with Ansoft Maxwell software. The simulation results show that the speed of vehicle can be detected by two magnetic sensors. The motion direction of vehicle can be detected by the Bx signal of a single magnetic sensor. Moreover, whether the parking position is empty or not can be determined by the Bx signal and the By signal. The simulation results will play a significant role for the magnetic sensor design and deployment.

Resistive random access memory (ReRAM) devices are considered to be one of the most promising candidates for the next generation of nonvolatile memory devices because of their superior properties such as low power consumption, simple structure, high integration density, and fast operation speed. In this study, we used zinc oxide (ZnO) thin films to fabricate ReRAM devices comprising Au/ZnO/Al and Al/Au/ZnO/Al structures. We observed that the operating stability of the device containing the Al/Au/ZnO/Al structure improved. The devices displayed effective and stable operational characteristics. The operational voltage of the ZnO ReRAM devices was less than 3 V, and the reset operational voltage was less than −1.5 V.

In this paper the group behavior, awareness and mental characteristics of college students in the event of unexpected crisis were analyzed, as well as the responses to the unexpected crisis were investigated. According to these investigations, we made some suggestions on the improvement of the communication modes and the model establishment of student training during the crisis. We presented a new model of crisis responses from time, space and sense three dimensions for the response management of unexpected crisis in universities.

To understand the spatiotemporal evolution of online public opinion and reveal its formation mechanism, we investigate the data from several popular online comments by means of statistical physics. Although the empirical results show that the heterogeneity of concerns exists in different areas, which follows a double power law, an obvious consistency of such concerns occurs during the evolution of online public opinion. Through correlation analysis, we reveal that the regional population and economy may have a significant influence on the concern about the event, and find that the consistency of concerns in different areas derives from the strong correlations among regions. On the other hand, the public opinion guide can significantly affect the concern about the event, and lead to the rapid increase of propagation velocity. By calculating the information entropy of propagation velocity, we find that the geographical distribution of online comments is relatively stable in most time, and the public opinion guide may help to maintain this consistency. Furthermore, the correlation analysis shows that the more developed areas tend to be more synchronized, which suggests the responses of these areas to the public opinion guide may be faster. Therefore, enhancing the guide of public opinion in developed areas can help our government to control the spread of the online public opinion.