Search

Intelligent public transport systems are a key direction for the study of intelligent transportation systems (ITSs), and they perform the following functions: location and tracking, aided navigation, dispatch and command, and dynamic information release; these systems also help travelers determine optimal routes. This paper mainly studies intelligent bus operation optimization by integrating cases and data from business chains, including the optimization of public transport vehicle scheduling according to the characteristics of vehicle scheduling, considers the interests of passengers and public transport companies, and adopts a true-value encoding method with the departure time as the variable goal optimization. In addition, this paper builds a model for the intelligent scheduling problem in public transport based on an enhanced quantum genetic algorithm (EQGA) to find the optimal timetable. This model sets the minimum waiting time cost of passengers and the maximum interests of public transport companies as the goals, restricts the departure interval and two adjacent intervals, and constrains the load factor of passengers. Moreover, based on the analysis of public transport travel characteristics and passenger flow data, this paper evaluates the efficiency of public transport operation, reasonably analyzes the utilization of public transport resources and the travel time of public transport passengers, and thoroughly studies the public transport operation system. This paper selects actual bus line data for empirical analysis, and the empirical results show that the proposed algorithm and model can meet the requirements of many aspects and provides good intelligence, applicability, and optimization.

Photocatalytic water-splitting with Z-scheme semiconductor heterojunctions is a promising way to achieve renewable solar fuels. Nevertheless, developing earth-abundant direct Z-scheme photocatalytic systems for efficient H2 production is still under-developed. In this work, porous heterostructures of S-deficient CoS/CdS hexagonal nanoplates (HNPs) were fabricated for the first time through the self-template approach combined with a solvothermal process. As indicated by the scanning Kelvin probe microscopy and ∙OH radicals measurements, such CoS/CdS heterojunction follows the Z-scheme charge transfer pathway. Noticeably, these unique CoS/CdS HNPs demonstrated excellent photocatalytic activity and stability for H2 evolution reaction (HER) under visible-light irradiation (λ > 400 nm). Specifically, the optimal HER rate is as high as 39.29 mmol∙g-1∙h-1 (corresponding to the apparent quantum yield of 14.5% at 400 nm), approximately 152, 112, and 51 times that of CoS, CdS, and 3 wt% Pt-loaded CdS, respectively. The exceptional HER capability of CoS/CdS HNPs could be associated with their outstanding visible-light harvesting, efficient Z-scheme charge separation, and abundant H2 evolution active sites. The findings indicated here could impel the rational design of high-performance Z-scheme photocatalysts for energy and environmental applications.

We report a single- and triple-wavelength Nd:GGG laser operating in the 1.3 μm wavelength range with 880 nm laser diode pumping directly into the 4F3/2 emitting level. For a pump power of 24.85 W, a single wavelength of 1331 nm is obtained with an output power of 2.95 W and a slope efficiency of 15.9%. By inserting a 0.1 mm thick BK7 glass etalon and adjusting its tilting angle, we achieve tunable lasing wavelengths of 1323, 1331, 1336, 1338, and 1346 nm with maximum output powers of 1.94, 2.46, 1.92, 1.80, and 1.17 W, as well as slope efficiencies of 8.07%, 10.25%, 7.98%, 7.48%, and 4.85%, respectively. We realize simultaneous triple-wavelength laser at 1323, 1331, and 1336 nm, for the first time, up to our knowledge, with a maximum output power of 1.66 W and a slope efficiency of 6.6%.

Two-dimensional (2D) semiconductor nanostructures have exhibited great prospect as an efficient photocatalyst for solar-to-fuel application. In this work, a unique 2D tandem heterojunction consisting of ultrathin CdxZn1−xIn2S4 nanosheets coupled with rectangular CdS flakes and defect-rich MoS2 few-layered nanosheets was constructed for the first time. Remarkably, the efficient electron transfer channels present in the CdS/CdxZn1−xIn2S4 and CdxZn1−xIn2S4/MoS2 2D tandem heterojunctions facilitate the spatial separation and directional migration of photo-induced charge carriers effectively. Moreover, such 2D tandem heterojunction CdxZn1−xIn2S4–CdS–MoS2 is provided with excellent light harvesting capacity and abundant HER active sites from the defective MoS2 co-catalyst. These distinct advantages endow the optimized C0.15ZIS–5C–3M hybrid (5 wt% CdS, 3 wt% MoS2) with an exceptional photocatalytic H2 evolution reaction (HER) activity of 27.14 mmol h−1 g−1, approximately 47 times that of pure ZnIn2S4 and it is much superior to that of Pt-decorated C0.15ZIS–5C and most ZnIn2S4-based composites reported previously. A high HER apparent quantum yield (AQY) of 19.97% is achieved at λ = 400 nm. In addition, both the cycling and long-term HER measurements evidence the prominent stability of C0.15ZIS–5C–3M for H2 production. The results indicated here could pave the way for the exploitation of new 2D heterostructures toward highly-efficient solar conversion and utilization.

The Internet of Things (IoT) is an information carrier based on network communication, and it can make all general physical objects which can be independently addressed from an interconnected network. Controller Area Network (CAN) is a kind of serial communication network which can effectively support distributed control or real-time control. This paper proposes the design of an IoT-oriented universal CAN bus. In order to build a complete CAN communication simulation model, message sending and message receiving models are constructed, respectively. The simulation experiment proves that the IoT-oriented network communication model designed in this paper not only has low power consumption, but it can also solve the front-end compatibility problems caused by different communication protocols.

Forest road network plays a key role in shortening the response time of firefighting activities. Therefore, evaluation and improvement of the ability of firefighting of the forest roads are essenti...

We report on the first passively mode-locked femtosecond-laser operation of a disordered Yb:Ca3Gd2(BO3)4 crystal using a SEmiconductor Saturable Absorber Mirror (SESAM). Pumping with a single-transverse mode fiber-coupled laser diode at 976 nm, nearly Fourier-transform-limited pulses as short as 96 fs are generated at 1045 nm with an average output power of 205 mW and a pulse repetition rate of ~67.3 MHz. In the continuous-wave regime, high slope efficiency up to 59.2% and low laser thresholds down to 25 mW are obtained. Continuous wavelength tuning between 1006–1074 nm (a tuning range of 68 nm) is demonstrated. Yb:Ca3Gd2(BO3)4 crystals are promising for the development of ultrafast lasers at ~1 μm.

The detection of urban land use is of great significance to urban planning. With the development of deep learning technology, convolutional neural networks (CNN) are widely used in remote sensing image processing. However, existing CNN models lack the ability to fuse high-dimensional semantic information and low-dimensional position information of images and thus perform poorly in feature restoration. To obtain better urban land use detection results, the cross-dimensional feature fusion network (CDFFNet) is proposed in this work. In the CDFFNet, Class Feature Attention (CFA), cross-level feature fusion (CLFF), and Same Level Feature Gate Fusion (SLFGF) are designed. The CFA aggregates multi-scale and multi-receptive field input features to capture high-dimensional semantic information. The CLFF is designed to fuse features of different resolutions. It can extract and fuse semantic information of different dimensions, aggregate contextual information of features and distinguish the contextual relevance of each pixel. The SLFGF dynamically fuses high-dimensional semantic information and low-dimensional spatial information, so it could enhance information recovery of different categories. Compared with existing methods, the CDFFNet is significantly improved in accuracy. Its mean intersection over union on the Aerial Image Segmentation Dataset reaches 0.765.

The construction of a compound talent training model is the key to deepening the reform of education and teaching in colleges and universities, and it is also the only way for higher education to achieve the "three orientations" and sustainable development. This article mainly studies the application of computer technology to assist the cultivation of art design professionals. This article takes fresh graduates as the main survey object, organizes graduate head teachers and counselors to conduct survey training to ensure the smooth development of the survey. The questionnaires were distributed and collected organized by the class teacher and counselors. The recovery rate was 92%. After screening, there were 81 valid questionnaires, and 81 people were selected as the final sample. The data needed to automatically generate the evaluation index system includes learning hours, homework information, posting status, etc. The deeper the background data is developed, the more detailed and complete the automatically generated evaluation will be. The third party outside of teaching and learning is usually the user of the design results. Through the work of the platform, students can easily accept the evaluation of the market and peers, make corrections and improvements, and truly achieve the professional standards expected by the market and users. From the results, we can see that about 53.3% of the students are not satisfied with the curriculum. Computer technology plays an active role in promoting the cultivation of talents in art design majors.

By fully utilizing the spatial gain and exploiting the multiuser diversity, cooperative spectrum sensing can enhance the sensing accuracy. In the actual wireless environment, the effect of shadowing and fading will result in the different features of signals received by the sensing nodes with different distances from primary user. As a result, some cooperative nodes in deep fading will suffer from serious missed detection, which will affect the final results during the fusing operation. To solve the above problems, a soft decision cooperative spectrum sensing with entropy weight method for cognitive radio sensor networks is presented. Initially, the sensor nodes will be organized into logical groups to obtain energy efficiency and improvement of sensing performance. After receiving the soft sensing information from all member nodes, the cluster heads employs the equal gain soft combination for inter-cluster fusion and then forwards the local decision to the fusion center. During the final decision, the entropy weight method is applied to assign optimal weight value to corresponding cluster local decisions. The simulation results show that the proposed method can outperform some typical clustering scheme for cooperative spectrum sensing in terms of the detection probability and the total error probability.

Purpose To discuss the necessity of anti-tuberculosis therapy after resection of asymptomatic pulmonary tuberculous nodules: is postoperative anti-tuberculosis therapy is over-treatment? Methods This is a single-center retrospective study. Patients with solitary pulmonary nodule (SPN) and diagnosed as tuberculosis by pathology were included. Clinical features are collected. The primary end point is tuberculosis relapse and the secondary is adverse drug reactions. Patients are divided into two groups according to the acceptance of anti-tuberculosis treatment after operation (A: treated; B: untreated). Recurrence is diagnosed by multi-disciplinary discussion. The difference of recurrence rate will be compared and the incidence of adverse drug reactions in Group A will be calculated. Results A total of 98 patients were enrolled, 66 in Group A and 32 in Group B. No significant difference between two groups was found in the past history of tuberculosis, erythrocyte sedimentation rate (ESR), T-spot positive rate, and the uptake value of 18F-glucose. No relapse of tuberculosis was found in both groups. The incidence of adverse drug reactions in Group A was 61% (40/66), and the rate of severe adverse reaction was 14% (9/66). Conclusions Postoperative recurrence of tuberculosis is rare, anti-tuberculosis treatment seems unnecessary for asymptomatic pulmonary tuberculous nodules. Adverse drug reactions should not be ignored.

In a vehicular delay tolerant network (VDTN), there is no static connection, and the network behavior is highly temporal. This makes determining the routing protocol critical for the performance of a network. However, traditional routing technology rarely considers the influence of a VDTN’s selfish nodes. Under ideal conditions, all nodes will try to store and transfer as many messages as possible. However, selfish nodes may not transfer messages to other nodes due to limited resources. Taking selfish nodes into account is necessary for improving the performance of a VDTN. In this paper, we calculate each node’s credit value by recording each node’s behavior when messages are transferring to avoid selecting selfish nodes as the relay. We present an efficient VDTN specific multi-copy routing algorithm that combines Q-learning and the credit value to determine whether a candidate node is suitable for delivering a message. Because multi-copy routing protocols require a high buffer to store messages, we also optimize the node buffer to reduce network congestion. The proposed algorithm is evaluated by a number of different performance metrics, such as delivery probability, network overhead, and message latency. The proposed algorithm achieves better results in different configurations and provides improved delivery probability, low message latency, and network overhead.

The selective fabrication of highly ordered nanowires with high aspect ratios was of low reproducibility, which remains a challenge for laboratory research. In this paper, we report a novel approach for selective fabrication of conductive nanowires on a solid surface via diffusion mixing reaction system formed by a chemical pen. The nanoscale-mixing region was achieved by appropriately adjusting the viscosity of the solution and other parameters with the aid of dyes functioned as a flow boundary indicator. Finite element simulations and analysis were performed to understand the generation of mixing regions and guide the improvement of the chemical pen design. Under the optimal parameters, high aspect ratio silver nanowires (aspect ratio ≈ 1800) were obtained. Silver nanowire arrays with uniform width, gradient width and complex patterns were successfully fabricated. The theoretical value of the temperature coefficient of resistance (TCR) for silver was 0.0038 Ω/°C. A single silver wire temperature sensor with 7-fold increase in temperature coefficient resistance (0.0261 Ω/°C) was fabricated to show the advantages of the chemical pen in the fabrication of nanosensors. With the freedom of the region, simple operability and applicability, the chemical pen was expected to a potential and advanced method for selective nanomodification and processing on subcellular interfaces.

Building and road extraction from remote sensing images is of great significance to urban planning. At present, most of building and road extraction models adopt deep learning semantic segmentation method. However, the existing semantic segmentation methods did not pay enough attention to the feature information between hidden layers, which led to the neglect of the category of context pixels in pixel classification, resulting in these two problems of large-scale misjudgment of buildings and disconnection of road extraction. In order to solve these problem, this paper proposes a Non-Local Feature Search Network (NFSNet) that can improve the segmentation accuracy of remote sensing images of buildings and roads, and to help achieve accurate urban planning. By strengthening the exploration of hidden layer feature information, it can effectively reduce the large area misclassification of buildings and road disconnection in the process of segmentation. Firstly, a Self-Attention Feature Transfer (SAFT) module is proposed, which searches the importance of hidden layer on channel dimension, it can obtain the correlation between channels. Secondly, the Global Feature Refinement (GFR) module is introduced to integrate the features extracted from the backbone network and SAFT module, it enhances the semantic information of the feature map and obtains more detailed segmentation output. The comparative experiments demonstrate that the proposed method outperforms state-of-the-art methods, and the model complexity is the lowest.

Due to the various shapes, textures, and colors of fires, forest fire detection is a challenging task. The traditional image processing method relies heavily on manmade features, which is not universally applicable to all forest scenarios. In order to solve this problem, the deep learning technology is applied to learn and extract features of forest fires adaptively. However, the limited learning and perception ability of individual learners is not sufficient to make them perform well in complex tasks. Furthermore, learners tend to focus too much on local information, namely ground truth, but ignore global information, which may lead to false positives. In this paper, a novel ensemble learning method is proposed to detect forest fires in different scenarios. Firstly, two individual learners Yolov5 and EfficientDet are integrated to accomplish fire detection process. Secondly, another individual learner EfficientNet is responsible for learning global information to avoid false positives. Finally, detection results are made based on the decisions of three learners. Experiments on our dataset show that the proposed method improves detection performance by 2.5% to 10.9%, and decreases false positives by 51.3%, without any extra latency.

Objectives The MeltPro MTB assays for detection of resistance to antituberculosis (TB) drugs perform well in genotypic drug susceptibility testing (DST) of clinical samples, but their effectiveness with formalin-fixed, paraffin-embedded (FFPE) tissues is unknown. Methods FFPE tissues were obtained from 334 patients with TB. Susceptibility to rifampicin (RIF), isoniazid (INH), and fluoroquinolones was examined using the MeltPro MTB assays, with Xpert MTB/RIF (Xpert) and/or phenotypic DST (pDST) results as references. Samples with discordant results were analyzed by multiplex polymerase chain reaction–targeted amplicon sequencing (MTA-seq). Results With pDST as the reference, the MeltPro MTB assays sensitivity for RIF, INH, levofloxacin (LVX), and moxifloxacin (MXF) was 95.00%, 96.00%, 100%, and 100%, respectively, and the specificity was 95.15%, 95.92%, 94.69%, and 89.92%, respectively. Concordance was 99.08% between the MeltPro MTB and Xpert (κ = 0.956) for RIF and 95.12% (κ = 0.834), 95.93% (κ = 0.880), 95.12% (κ = 0.744), and 90.24% (κ = 0.367) between the MeltPro MTB and pDST for RIF, INH, LVX, and MXF, respectively. MTA-seq confirmed the discordancy between the MeltPro MTB and pDST for 26 (89.66%) of 29 samples. Conclusions The MeltPro MTB assays rapidly and efficiently predict Mycobacterium tuberculosis resistance to the main first- and second-line anti-TB drugs in FFPE tissues.

Background NPC is rare but has a distinct geographic distribution, with a predominance in Southeast Asia. Favorable results with PD-1 inhibitors in NPC provide a strong rationale to investigate penpulimab in this disease. Penpulimab was engineered to eliminate FcγR binding and ADCC/ADCP completely,where ADCC/ADCP effects can induce T-cell apoptosis and clearance and then compromise anti-tumor activity. Penpulimab demonstrated a slower PD-1 antigen binding off-rate than marketed PD-1 antibodies, which result in better cellular activity and higher receptor occupancy. Penpulimab also showed numerous contacts with N58 glycosylation on the BC loop of PD-1 which could be an advantage to facilitate interaction of PD-1 antibody and may contribute to slower binding off-rate. These structural differentiations offer more robust biological effect and enhance anti-tumor activity of penpulimab. Methods AK105-202 (NCT03866967) is a multicenter, single-arm, open-label study of penpulimab in metastatic NPC patients (pts) with disease progression after ≥2 prior lines of therapy including platinum-containing chemotherapy. All patients received penpulimab 200 mg q2w until progression or unacceptable toxicity. The primary endpoint was ORR based on RECIST v1.1 as assessed by an independent review committee (IRC). Key secondary endpoints included DCR, PFS, duration of response (DoR). Archived tissues were retrieved for the analysis of PD-L1 (Shuwen SAB-028). PD-L1 expression of tumor proportion score (TPS)≥50% was regarded as positive. Plasma Epstein-Barr virus DNA were obtained for biomarker correlative analysis. Results As of 18 September 2020, the median follow-up was 7.9 months (range 0.9 to 16.9). The anti-tumor activity of penpulimab in the 111 pts with disease progression after ≥2 prior lines of therapy evaluable for efficacy (defined as pts who had an opportunity to be followed for at least 16 weeks and had measurable disease at baseline per RECIST v1.1) is shown in the table 1. Treatment-related adverse events (TRAEs, including unlikely related) occurred in 79.2% of pts (≥G3 in 14.6% [19/130], treatment discontinuation in 3.1% [4/130]). Treatment-related SAEs occurred in 10.0% [13/130]. Most frequent TRAEs (≥10%) were fever (24.5%), hypothyroidism (24.6%), anemia (23.1%), ALT increased (17.0%) and WBC decreased (10.8%). Grade ≥3 TRAEs (≥2%) were hepatic function abnormal (2.3%) and anemia (2.3%). Conclusions Penpulimab demonstrated encouraging anti-tumor activity and favorable safety profile in pts with disease progression after ≥2 prior lines of therapy. A higher proportion of objective responses was observed in NPC pts with PD-L1–positive tumors receiving penpulimab than those with PD-L1–negative tumors.

[EN]Surface channel waveguides (WGs) based on a half-ring (40–60-µm-diameter) depressed-index cladding (type III) geometry are fabricated in monoclinic Tm3+:MgWO4 by femtosecond (fs) laser writing at a repetition rate of 1 kHz. The WGs are characterized by confocal laser microscopy and 𝜇-Raman spectroscopy. A Tm3+:MgWO4 WG laser generates 320 mW at ∼2.02µm with a slope efficiency of 64.4%. The WG emits a transverse single-mode and linear polarization (𝐸||𝑁𝑚). A remarkable low loss of, Ministerio de Economía y Competitividad (FIS2017-87970-R, MAT2016-75716-C2-1-R (AEI/FEDER, UE)); Agència de Gestió d’Ajuts Universitaris i de Recerca (2017SGR755); Consejería de Educación, Junta de Castilla y León (SA287P18); National Natural Science Foundation of China (51761135115, 61575199, 61850410533, 61875199, 61975208); Ministry of Science and Higher Education of the Russian Federation (Goszadanie 2019-1080); Deutsche Forschungsgemeinschaft (PE 607/14-1).

Qiaoyu Zhang,1,* Binhua Dong,1,* Lihua Chen,1 Tingting Lin,2 Yao Tong,1 Wenyu Lin,1 Haifeng Lin,1 Yuqin Gao,1 Fen Lin,1 Pengming Sun1,3 1Laboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children’s Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Gynecology, The First Affiliated Hospital of Xiamen University, Xiamen, People’s Republic of China; 3Department of Gynecology, Fujian Provincial Maternity and Children’s Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pengming SunLaboratory of Gynecologic Oncology, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of ChinaTel +86 591 8755 8732Fax +86 591 8755 1247Email sunfemy@hotmail.comObjective: To assess the clinical value of the PCR-reverse dot blot human papillomavirus genotyping test during follow-up of patients with CIN grade 2 or worse (CIN 2+).Methods: Four hundred patients with CIN 2+ receiving treatment from January 2008 to January 2017 were included in our study. Postoperative follow-up procedures comprised HPV examination and cervical cytology every 3– 6 months for the first 2 years and then followed up every 6– 12 months. A pathology examination was performed when there was a positive funding for HPV 16/18 or an abnormal ThinPrep cytology test (TCT) with or without positive for HR-HPV according to the American Society for Coloscopy and Cervical Pathology (ASCCP) guidelines.Results: The median follow-up period was 27.10± 12.47 months (ranging from 3 to 50 months). During follow-up, 12.00% (48/400) of the women developed residual/recurrent disease. The highest risk in CIN 2+ and CIN 3+ residual/recurrence was HPV-16/-18 (hazard ratio (HR)=12.898, 95% CI= 6.849– 24.289; HR= 20.726, 95% CI= 9.64– 44.562, respectively). Among the different follow-up methods, type-specific (TP) HR-HPV persistent infection showed the highest cumulative incidence risk (CIR) (84.62%, 95% CI=73.29– 95.94) and HR (5.38, 95% CI= 2.596– 11.149) during the 4-year follow-up period. At the CIN 2+ and CIN 3+ endpoints, TP-HPV testing had relatively high sensitivity (84.62%, 95% CI=73.29– 95.94 and 89.28%, 95% CI= 77.83– 100.00, respectively) and specificity (78.07%, 95% CI= 72.70– 83.44 and 75.73%, 95% CI= 70.30– 81.17, respectively). However, at the CIN 2+/CIN 3+ endpoint, TCT follow-up had a sensitivity of 60.42%/62.16% (95% CI=46.58– 72.25/46.54– 77.79) and specificity of 90.18%/88.72% (95% CI=86.95– 93.41/85.35– 92.10).Conclusion: TP HR-HPV follow-up can provide a reliable and sensitive clinical reference for CIN 2+ postoperative patients.Keywords: papillomavirus, genotype, cell biology, histology, postoperative

It is expected that all the nodes try their best to store and forward the messages in the intermittent connection network. However, due to the limited resources, such as memory, power, and transient communication chance, selfish nodes may relay the messages without responsibility. Stimulating selfish to behave normally could improve network performance. However, usually, it is difficult to distinguish the selfish behavior from the inability to relaying the message. By monitoring the behavior of relay nodes that messages are forwarding through, this article proposes a scheme that relays messages according to the reputation of intermediate nodes. The proposed reputation estimation scheme combines selfish behavior and inability behavior, and reveals very little private information for the protocol practice. There is a trade-off between the threshold and the performance. Too low value may not distinguish the selfish nodes. On the contrary, some normal nodes may excluded and cannot join the relaying and processing. Simulation effectively demonstrates that the reputation affects the node’s performance, and an appropriate reputation threshold value is useful for improving the network performance.

Background Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China. Methods A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal–Wallis or Wilcoxon–Mann–Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software. Results Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp(a) (P 0.05). Plasma apoCIII, TNF-α and hs-CRP contributed to the development of CHD (OR = 2.554, 7.252, 6.035, P

High incidence and destructiveness of forest fire determine the importance of forest fire prediction or early detection. we find that the observation of local weather and human behaviors are the most correlated to forest fire important factors. In this paper, a fuzzy inference and big data analysis algorithm is proposed to assess fire risk and calculated the quantitative potential fire risk. These factors converted to triangular fuzzy numbers are calculated by fuzzification and output fire rating level. The continuous 24-hour weather information, which can reflect the high accurate status of forest environment, is collected by the rechargeable wireless sensor network. The fuzzy reasoning system was evaluated for Nanjing City region, the capital of Jiangsu Province, China. The high possibility of potential forest fires risk can be measured by this algorithm, therefore we need to pay more attention to prevent forest fire condition.

We report a diode-pumped continuous-wave Nd:Gd3Ga5O12 (GGG) laser operating at 1.4 μm spectral region. A dual-wavelength laser at 1423 and 1406 nm is achieved with output power of about 2.59 W at absorbed pump power of 13.4 W. Further increasing the pump power, simultaneous tri-wavelength laser at 1423, 1415 and 1406 nm is also obtained with a maximum output power of 3.96 W at absorbed pump power of 18.9 W. Single-wavelength lasing is also realized at the three emission lines using an intracavity etalon. The laser result is believed to be the highest output power achieved in Nd:GGG crystal, at present, to the best of our knowledge.

Longitudinally diode-pumped continuous-wave dual-wavelength Nd:YAG laser at 1116 and 1123 nm is achieved with maximum output power of 8.18 W and slope efficiency of 42.3%. Using WS 2 as saturable absorber, passive Q-switching of the dual-wavelength laser is also achieved with a maximum average output power of 0.41 W, the shortest pulse width of about 0.64 μs at pulse repetition rate of 100.9 kHz. The present Q-switched laser operation leads to maximum pulse energy of 4.06 μJ and pulse peak power of 6.35 W. A 2-D material WS 2 has been experimentally confirmed to be very promising as Q switcher at 1.1 μm, for the first time to our knowledge.

We report on the first Kerr-lens mode-locked laser based on the Yb3+-doped disordered strontium lanthanum aluminate crystal, Yb:SrLaAlO4 (Yb:SALLO), pumped by a high-brightness Yb fiber laser at 976 nm. Nearly Fourier-limited pulses as short as 44 fs were achieved at 1051 nm with an average output power of 277 mW and a pulse repetition rate of ∼66 MHz via soft-aperture Kerr-lens mode-locking. A higher average output power of 459 mW, corresponding to an optical efficiency of 33.8%, was obtained at the expense of a slightly longer duration (52 fs).

We report on our latest experimental results concerning laser oscillations at low-gain lines of diode-pumped Nd:YAG crystal lasers on 4F3/2 → 4I13/2 transition and MoS2 -based dual-wavelength passively Q-switched Nd:YAG laser on this transition, for the first time to our knowledge. Using an undoped YAG as etalon to promote the intracavity loss modulation, three new lasing lines of about 1333, 1334, and 1340 nm have been achieved. Especially, the 1334-nm laser can be operated at single wavelength mode with maximum output power of 2.03 W. Dual-wavelength passively Q-switched Nd:YAG laser at 1318 and 1338 nm has also been obtained with maximum average output power of 0.44 W. The shortest pulse width is about 150 ns at pulse repetition rate of 125 kHz, leading to single pulse energy of 3.5 μJ and pulse peak power of 23.4 W.

// Zhong Chen 1 , Yu Sun 2 , Zhenxiong Xu 2 , Junnv Xu 3 , Jingjie Li 4 , Mengdan Yan 4 , Jing Li 4 , Tianbo Jin 4, 5 and Haifeng Lin 3 1 Department of Thoracic Surgery, Second People’s Hospital of Hainan Province, Hainan, 572200, China 2 Department of General Surgery, Second People’s Hospital of Hainan Province, Hainan, 572200, China 3 Department of Internal Medicine-Oncology, Agricultural Reclamation General Hospital of Hainan Province, Hainan, 570311, China 4 Key Laboratory of Resource Biology and Biotechnology in Western China, Northwest University, Ministry of Education, School of Life Sciences, Northwest University, Shaanxi, 710069, China 5 Xi’an Tiangen Precision Medical Institute, Shaanxi, 710075, China Correspondence to: Haifeng Lin, email: 13322060949@163.com Keywords: ACYP2, polymorphism, liver cancer, case-control, Han Chinese population Received: October 24, 2016 Accepted: April 05, 2017 Published: June 19, 2017 ABSTRACT We explored the association between single nucleotide polymorphisms (SNPs) in ACYP2 and liver cancer risk. Thirteen SNPs were genotyped in 473 cases and 564 controls. Genetic model, linkage disequilibrium, and haplotype analyses were performed to evaluate the association between ACPY2 SNPs and liver cancer risk. We found that rs6713088 (G allele: odds ratio [OR] = 1.27, 95% confidence interval [CI]: 1.07−1.52, P = 0.007; GG vs. CC: OR = 1.49, 95% CI: 1.02−2.1, P = 0.038), rs843711 (T allele: OR = 1.29, 95% CI: 1.09−1.54, P = 0.004; TT vs. CC: OR = 1.62, 95% CI: 1.13−2.31, P = 0.008), rs843706 (A allele: OR = 1.30, 95% CI: 1.09−1.55, P = 0.003; AA vs. CC: OR = 1.62, 95% CI: 1.13−2.31, P = 0.008), and rs843645 (GG vs. AG: OR = 1.40, 95% CI: 1.07−1.82, P = 0.014) were associated with an increased risk of liver cancer. In contrast, rs1682111 (A allele: OR = 0.77, 95% CI: 0.640−0.94, P = 0.007; AT vs. TT: OR = 0.69, 95% CI: 0.53−0.91, P = 0.007), rs843720 (additive model: OR = 0.82, 95% CI: 0.68−1.00, P = 0.049), ATATCGCC and CG haplotypes (OR = 0.76, 95% CI: 0.62−0.92, P = 0.006; OR = 0.78, 95% CI: 0.65−0.93, P = 0.006, respectively) were significantly decreased liver cancer risk. Our results confirmed that rs6713088, rs843645, rs843711 and rs843706 were significantly increased liver cancer risk, but rs1682111, rs843720 and haplotypes (ATATCGCC and CG) were significantly decreased liver cancer risk in a Han Chinese population.

We demonstrate a passively Q-switched Nd: YAG quasi-three-level laser operating at 946 nm using MoS2 as saturable absorber. A maximum average output power of 210 mW is achieved at an absorbed pump power of 6.67 W with a slope efficiency of about 5.8%. The shortest pulse width and maximum pulse repetition frequency are measured to be 280 ns and 609 kHz, respectively. The maximum pulse energy and maximum pulse peak power are therefore estimated to be about 0.35 μJ and 1.23 W, respectively. This work represents the first MoS2-based Q-switched laser operating at 0.9 µm spectral region.

Background and Objective To evaluate the impact of blood clearance mechanisms on neurologic damage and functional outcomes after intracerebral hemorrhage (ICH) in rats. Methods A rat model of ICH was established through pre-cannulation and injection of autologous arterial blood into the caudate nucleus. Blood was supplemented with 6-amino-caproic acid (a procoagulant), low-molecular-weight heparin (an anticoagulant), or vehicle. Relationships between hematoma volume and edema size and neurologic damage were assessed at different times. Results At 6 hours and 24 hours, hematoma volume was greater in rats that received anticoagulant than in the other two groups (p 0.05). At 6 hours and 24 hours, the Neurological Severity Score in the procoagulant group was significantly higher than in the other two groups (comparison between groups, p 0.05). Conclusion Enhanced clearance of leaked blood was associated with larger hematomas within the first 3 days of ICH and with less neurologic damage. The capacity to clear blood is an important determinant of functional recovery after ICH. Enhanced clearance may help reduce neurologic damage.

Graphene-oxide (GO) as saturable absorber (SA) for a 1342 nm passively Q-switched Nd:YVO 4 laser is reported. This system produces laser pulse as narrow as 329 ns with a repetition rate of 214 kHz and the largest output power of 520 mW. Our results demonstrate that GO can be used as an excellent and efficient SA for Nd 3+ -doped lasers at 1.3 μm.

Monoclinic (wolframite-type) monotungstate crystals are promising for rare-earth doping. We report polarized room- and low-temperature spectroscopy and efficient high-power laser operation of such a Y b 3 + : M g W O 4 crystal featuring high stimulated emission cross section ( σ S E = 6 . 2 × 10 − 20 c m 2 at 1056.7 nm for light polarization E | | N m ), large Stark splitting of the ground state ( 765 c m − 1 ), large gain bandwidth (26.1 nm for E | | N g ), and strong Raman response (most intense mode at 916 c m − 1 ). A diode-pumped Y b 3 + : M g W O 4 laser generated 18.2 W at ∼ 1056 n m with a slope efficiency of ∼ 89 % and a linearly polarized laser output.

We demonstrate sub-100-fs Kerr-lens mode-locking of a T m : M g W O 4 laser emitting at ∼ 2 µ m assisted by a single-walled carbon-nanotube saturable absorber. A maximum average output power of 100 mW is achieved with pulse duration of 89 fs at a pulse repetition rate of ∼ 86 M H z . The shortest pulse duration derived from frequency-resolved optical gating amounts to 76 fs at 2037 nm, corresponding to nearly bandwidth-limited pulses. To the best of our knowledge, these are the shortest pulses generated from any Tm-doped tungstate crystal and the first report on saturable absorber assisted Kerr-lens mode-locking of a Tm laser at ∼ 2 µ m .

Purpose. This study investigated the infection status and relationship between other common lower genital tract infectious pathogens and high-risk human papillomavirus (HR-HPV) in the high-grade cervical lesions. Methods. Overall, 882 patients were enrolled in this retrospective study, of which 339 patients (≥HSIL group) were confirmed with high-grade squamous intraepithelial lesions (HSIL) or cervical squamous cell carcinoma (SCC), while 543 patients (≤LSIL group) were diagnosed with low-grade squamous intraepithelial lesions (LSIL) or normal cervical pathology diagnosis. Cervical swab specimens were tested for HPV, pathogenic bacteria (PB), U. urealyticum (UU), M. hominis (MH), and C. trachomatis (CT) in both groups. Results. The infection rates of HR-HPV, PB, UU (at high density), and CT were higher in the ≥HSIL group than in the ≤LSIL group (P<0.001); however, higher infection rates with MH were not observed (P>0.05). PB, UU, and CT were associated with HR-HPV infection (P<0.001). The PB and UU infection rates in the ≥HSIL group were significantly different from those in the ≤LSIL group, regardless of whether there was an HR-HPV infection at the same time (P<0.05). However, this was not the case for the CT (P>0.05). Furthermore, 259 pathogenic bacterial strains were detected in 882 cases. The difference in the distribution of pathogenic bacterial flora in the different grades of cervical lesions had no statistical significance, which was prioritized over Escherichia coli (P>0.05). Conclusion. PB, UU, and CT infection is associated with susceptibility to HR-HPV, HR-HPV coinfection with these pathogens might increase the risk of high-grade cervical lesions, and PB and UU might be independent risk factors for cervical lesions.

Wildfire is a sudden and hazardous natural disaster. Currently, many schemes based on optical spectrum analysis have been proposed to detect wildfire, but obstacles in forest areas can decrease the efficiency of spectral monitoring, resulting in a wildfire detection system not being able to monitor the occurrence of wildfire promptly. In this paper, we propose a novel wildfire detection system using sound spectrum analysis based on the Internet of Things (IoT), which utilizes a wireless acoustic detection system to probe wildfire and distinguish the difference in the sound between the crown and the surface fire. We also designed a new power supply unit: tree-energy device, which utilizes the biological energy of the living trees to generate electricity. We implemented sound spectrum analysis on the data collected by sound sensors and then combined our classification algorithms. The results describe that the sound frequency of the crown fire is about 0&ndash, 400 Hz, while the sound frequency of the surface fire ranges from 0 to 15,000 Hz. However, the accuracy of the classification method is affected by some factors, such as the distribution of sensors, the loss of energy in sound transmission, and the delay of data transmission. In the simulation experiments, the recognition rate of the method can reach about 70%.

Objective To explore the association between the degree of fibrosis in fibrotic focus (FF) and the unfavorable clinicopathological prognostic features of breast cancer. Methods A total of 169 cases of breast invasive ductal carcinoma (IDC) were included in the study. Hematoxylin and eosin (H&E) staining was performed in the primary lesion of breast IDC and the degree of fibrosis in tumor-stromal FF was assessed. The association between the degree of fibrosis in FF and the well-known clinicopathologic features of breast cancer was investigated and the influence of the degree of fibrosis in FF on the survival was analyzed. Results Tumor size >2 cm (P = 0.023), vascular invasion (P = 0.011), lymphatic vessel invasion (P P = 0.032) were positively correlated with the degree of fibrosis in FF in breast IDC. The result of multivariate analysis showed that lymphatic vessel invasion was the only independent correlation factor of high fibrosis in FF in breast IDC (OR = 3.82, 95% CI[1.13 ∼ 12.82], P = 0.031). The Nottingham prognostic index (NPI) of high fibrosis in FF was significantly higher than that of mild and moderate fibrosis in FF in the no vascular infiltration subgroup, the no nerve infiltration subgroup, and the Luminal A subgroup (P = 0.014, 0.039, and 0.018; respectively). Conclusions The high fibrosis in FF is closely associated with the strong invasiveness and the high malignancy of breast IDC. The degree of fibrosis in FF might be considered as a very practical and meaningful pathological feature of breast cancer.

Femtosecond lasers in the spectral region of ∼2 μm are essential for development of pump and seed sources in diverse optical parametric frequency conversion schemes to cover the mid-IR part of the optical spectrum [1]. Passive mode-locking in such solid-state lasers is mainly achieved by saturable absorbers (SAs). To obtain durations corresponding to ten or fewer optical cycles, materials with broadband gain spectrum extending beyond 2 μm are needed so that the structured water vapor atmospheric absorption can be avoided. The newly developed monoclinic tungstate Tm3+:MgWO 4 (Tm:MgW) crystal exhibits such a broad and smooth gain profile due to the low-symmetry structure and the distortion of the crystal field caused by the mismatch of the ionic radii of Mg2+ and Tm3+ [2]. Using a graphene SA, the first sub-100-fs pulses at 2 μιη were obtained [3] while preliminary results with single-walled carbon nanotube (SWCN)-SAs indicated a pulse duration of 168 fs [4]. We report now on further progress with a SWCNT-SA generating nearly bandwidth-limited pulses of 76 fs duration at 2037 nm.

Compared with conventional InGaN Quantum Wells (QWs), staggered InGaN QWs offer improved optical and electronic properties. This work studied the carrier concentration, band structure, overlap of hole and electron wave functions, and polarization field of three-layer staggered QWs in the blue spectral region and analyzed them in detail theoretically to explore the source and the dominant mechanism for improvement. Although theoretical studies indicate that the polarization field in QWs of staggered InGaN QWs is larger, the carrier confinement effect is stronger, and the carrier distribution is more uniform. Therefore, three-layer staggered QWs can improve overlapping of the hole and electron wave functions and then enhance the recombination rate so as to increase the optical output power and electroluminescence intensity. Moreover, the performance of the staggered structure C with the lowest indium content at the center of the well is better than that of the step-staggered structure B.

Desert segmentation of remote sensing images is the basis of analysis of desert area. Desert images are usually characterized by large image size, large-scale change, and irregular location distribution of surface objects. The multi-scale fusion method is widely used in the existing deep learning segmentation models to solve the above problems. Based on the idea of multi-scale feature extraction, this paper took the segmentation results of each scale as an independent optimization task and proposed a multi-resolution supervision network (MrsSeg) to further improve the desert segmentation result. Due to the different optimization difficulty of each branch task, we also proposed an auxiliary adaptive weighted loss function (AWL) to automatically optimize the training process. MrsSeg first used a lightweight backbone to extract different-resolution features, then adopted a multi-resolution fusion module to fuse the local information and global information, and finally, a multi-level fusion decoder was used to aggregate and merge the features at different levels to get the desert segmentation result. In this method, each branch loss was treated as an independent task, AWL was proposed to calculate and adjust the weight of each branch. By giving priority to the easy tasks, the improved loss function could effectively improve the convergence speed of the model and the desert segmentation result. The experimental results showed that MrsSeg-AWL effectively improved the learning ability of the model and has faster convergence speed, lower parameter complexity, and more accurate segmentation results.

TPS9131 Background: Preclinical and clinical evidence has demonstrated that the dual blockade of the EGFR and VEGF pathways is a viable strategy in the EGFR-mutated advanced NSCLC population. Anlotinib is an oral multi-targeted tyrosine kinase inhibitor (TKI) that effectively inhibits VEGFRs, FGFRs, PDGFRs, c-kit and MET. It has been proved to be safe and effective in advanced lung cancer after second-line standard chemotherapy failure. A cohort study of Anlotinib plus Erlotinib has shown a favorable safety profile and promising antitumor activity with an objective response rate (ORR)92.6%. This phase III study aims to evaluate the efficacy and safety of Anlotinib or placebo plus Gefitinib in patients(pts) with untreated EGFR-mutated metastatic NSCLC. Methods: Eligible pts were aged 18̃75 years old, had stage IIIB or IV NSCLC, with an EGFR 19del or 21L858R mutation, an ECOG PS of 0 or 1, measurable lesion according to RECIST v1.1 and adequate organ function. We randomly assigned eligible pts in a 1:1 ratio to receive oral Gefitinib (250 mg QD) plus either Anlotinib (12 mg QD from day 1 to 14 of a 21-day cycle) or matching placebo until progressive disease or unacceptable toxicity. Randomization was done by an interactive web response system with a computer-generated sequence and stratified by EGFR mutation status, gender, ECOG PS and pathological type. The primary endpoint is progression-free survival(PFS). Secondary endpoints include overall survival, ORR, disease control rate, time to progression, duration of response, quality of life and the safety profile. The peripheral blood of the pts will be detected three times by polygenic detection to monitor the resistance mechanism (before treatment, during the first evaluation, during tumor progression, each time 10ml peripheral blood). Independent Data Monitoring Committee and Independent Review Committee will be used in this study. According to previous report (Erlotinib plus Bevacizumab vs. Erlotinib alone: 16.0 vs. 9.7 mos, HR 0.54, Lancet Oncol, 15(11):1236-1244), the sample size was determined based on a median PFS of 15 months for the Anlotinib + Gefitinib group and median PFS of 10 months for the Placebo + Gefitinib group. To achieve 80% power at a two-sided α = 0.05 and an anticipated dropout rate of 20%, 310 patients (with 192 events required for the analyses) were needed. In total, 310 patients will be enrolled in this trial at 16 sites in China. From April 2019, 224 patients have been enrolled. Clinical trial information: NCT04028778.

We present a sub-50-fs diode-pumped Kerr-lens mode-locked laser employing a novel “mixed” monoclinic Yb:Ca4(Gd,Y)O(BO3)3 (Yb:GdYCOB) crystal as a gain medium. Nearly Fourier-limited pulses as short as 43 fs at 1036.7 nm are generated with an average power of 84 mW corresponding to a pulse repetition rate of ∼70.8 MHz. A higher average power of 300 mW was achieved at the expense of the pulse duration (113 fs) corresponding to an optical-to-optical efficiency of 35.8% representing a record-high value for any Yb-doped borate crystal. Non-phase-matched self-frequency doubling is observed in the mode-locked regime with pronounced strong spectral fringes which originate from two delayed green replicas of the fundamental femtosecond pulses in the time domain.

Exploiting visible-light-responsive photocatalysts for highly-efficient water-splitting is a very promising way to achieve the renewable hydrogen energy. To this end, the rational manipulation on the composition and structure of semiconductor nanomaterials appears extremely necessary. Herein, we construct a unique hybrid consisting of P-doped CZ0.10S-0.5P porous nano-spheres coupled with Ni2P and reduced graphene oxide (rGO) cocatalysts (CZ0.10S-0.5P@Ni2P/rGO), which exhibits an outstanding performance for H2 evolution reaction (HER) under visible-light (λ > 420 nm) irradiation. Noticeably, the CZ0.10S-0.5P@2Ni2P/1.5rGO with 2 wt%-Ni2P and 1.5 wt%-rGO delivers an exceptional HER rate of 616.8 mmol∙h−1∙g−1 (the apparent quantum efficiency reaches 77.0% at 475 nm), outperforming that of Pt-loaded CZ0.10S-0.5P and the great majority of CdS-based composites reported previously. In addition, the CZ0.10S-0.5P@2Ni2P/1.5rGO composite also presents a steady H2 generation activity under prolonged irradiation. The superior photocatalytic property of CZ0.10S-0.5P@Ni2P/rGO could be associated with the abundant active sites provided by Ni2P, excellent visible-light absorption, and effective charge transfer and separation enabled by the Schottky junctions formed between CZ0.10S-0.5P and Ni2P/rGO. The findings indicated here could promote the design and manufacture of advanced semiconductor nanostructures for sustainable energy applications.

314 Background: Hepatocellular carcinoma (HCC) is particularly prevalent in China because of the high prevalence of chronic hepatitis B infection. In the last decade, sorafenib was the first molecular target drug approved for the treatment of advanced liver cancer. Until recently, the combination of angiogenic inhibitor with anti-PD-1 /L1 monoclonal antibody has represented significant efficacy over sorafenib monotherapy in the first-line regimen of unresectable HCC. Nevertheless, there are still unmet needs in clinical practice due to limited choice of drugs. Anlotinib is a novel oral multi-targeted tyrosine kinase inhibitor that targets VEGF receptors 1/2/3, FGF receptors 1-4, PDGF receptors α and β, and c-kit, and has been approved for standard treatment of non-small cell lung cancer, small cell lung cancer and soft tissue sarcoma in China. Toripalimab, a humanized IgG4 mAb against PD-1, is the first Chinese-produced PD-1 inhibitor marketed, which has been approved as a second-line treatment for metastasis melanoma. This study aims to evaluate the efficacy and safety of anlotinib plus toripalimab as the first-line treatment for unresectable HCC. Methods: This was a single-arm, multicenter, phase II trial. 30 patients with unresectable HCC, Child-Pugh ≤7 and ECOG PS

We demonstrate a comprehensive characterization of the diode-pumped Yb:Bi4Si3O12 laser operating in the continuous-wave and soliton mode-locked regimes. Pumping with a 650 mW, single-transverse mode, fiber-coupled laser diode, a maximum continuous-wave output power amounted to 213 mW with a slope efficiency up to 57.6%. A broadband wavelength tuning range of more than 70 nm was achieved in CW regime with a fused silica prism. Applying a SESAM as mode locker, nearly transform-limited pulses as short as 113 fs were generated for a maximum average power of 53 mW and a pulse repetition rate of ∼106 MHz. To the best of our knowledge, this is the first report on passively mode-locked operation with the Yb:Bi4Si3O12 crystal.

A machine tool with 4 kinds of NC systems have been designed. The systems can control the same transmission mechanism and switch freely. The machine tool mainly used for the test of NC system function and performance. At present, the machine tool has been tested. The results show that the functions and performances of different NC systems can be compared and tested under the same condition of transmission mechanism.

Current laser technology enables table-top high flux XUV sources with photon energies from several tens to several hundreds of eV via high harmonic generation in noble gases. Here we present a compact versatile coupling unit to establish windowless, and thus lossless coupling of such light sources to ultra high vacuum (UHV). The particular coupling unit has been developed to couple a XUV laser source to a heavy ion storage ring. Three-stage differential pumping allows to reduce the input pressure of ~10−6 mbar down to the 10−12 mbar range at the output. The unit particularly reduces the partial pressure of argon, which is used to generate the XUV radiation, by 6 orders of magnitude. Measurements of the pressure distribution inside the different chambers agree well with theoretical simulations. In principle, this unit can also serve for other purposes, where a windowless vacuum coupling is needed, with a transition from High Vacuum (HV) levels to deep UHV, such as coupling to cryogenically cooled detectors, ion traps or to photoelectron emission spectroscopy experiments.

Monoclinic 1.25 at.% Yb3+:MgWO4 crystals are grown by the Top-Seeded-Solution-Growth method and their room- and low-temperature spectroscopy is studied. A diode-pumped Yb3+:MgWO4 laser generates 18.2 W at ~1056 nm with a slope efficiency of ~89%.

The 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) lung adenocarcinoma classification and the following 2015 WHO classification have both been validated for their predictive values of histologic subtypes for prognosis. We sought to investigate the clinicopathological and prognostic significance of the cribriform pattern in lung adenocarcinomas. Histologic subtypes were evaluated in 395 patients who underwent complete resection for invasive lung adenocarcinomas between 2011 and 2013. Cribriform pattern was correlated with clinicopathological factors as well as molecular and survival data. One hundred and thirty cases (33%) were present with cribriform pattern (5-100%; mean ± SD, 24% ± 22%). Thirty two (8%) of those were reclassified into cribriform predominant tumors. Presence of cribriform pattern (≥5%) was significantly associated with lymph/vascular invasion (P＜0.001), nodal positivity (P = 0.003), higher T stage(P = 0.005) and higher TNM stage (P = 0.001). Cribriform pattern (≥10%) was highly associated with worse disease-free survival (DFS) and overall survival (OS) (mean DFS: 42.6 months, P 0.001; mean OS: 64.1 months, P = 0.012). The DFS or OS for cribriform predominant tumors was similar to that for solid or micropapillary tumors. In multivariate analysis, cribriform pattern (≥10%) or cribriform predominant subtype was an independent predictor for DFS. Cribriform pattern was a specific pattern compared to other acinar patterns, presenting with more aggressive behavior. Moreover, presence of cribriform pattern was a strong predictor for worse prognosis and should be considered a high grade pattern. Our study provides further evidence for cribriform pattern to be acknowledged as an independent subtype in the future classification.