Author: "K. A. Kim" / Topic: business - Searchworks@Jio Institute Digital Library Search Results

1,194 results on '"K. A. Kim"'

1. A Novel Low-Dose Dual-Energy Imaging Method for a Fast-Rotating Gantry-Type CT Scanner

Author: Seungryong Cho, Hyoyi Kim, Seoyoung Lee, K. W. Kim, Donghyeon Lee, Jongha Lee, Sanghoon Cho, Kwon-Ha Yoon, Jong Hyun Ryu, and Kilhwan Jeong
Subjects: Scanner, Computer science, Noise reduction, Computed tomography, Iterative reconstruction, Band-stop filter, Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Image Processing, Computer-Assisted, medicine, Humans, Computer vision, Electrical and Electronic Engineering, Radiological and Ultrasound Technology, medicine.diagnostic_test, Phantoms, Imaging, business.industry, Reconstruction algorithm, Cone-Beam Computed Tomography, Computer Science Applications, Artificial intelligence, Artifacts, Tomography, X-Ray Computed, business, Head, Rotation (mathematics), Algorithms, Software, Smoothing
Abstract: CT scan by use of a beam-filter placed between the x-ray source and the patient allows a single-scan low-dose dual-energy imaging with a minimal hardware modification to the existing CT systems. We have earlier demonstrated the feasibility of such imaging method with a multi-slit beam-filter reciprocating along the direction perpendicular to the CT rotation axis in a cone-beam CT system. However, such method would face mechanical challenges when the beam-filter is supposed to cooperate with a fast-rotating gantry in a diagnostic CT system. In this work, we propose a new scanning method and associated image reconstruction algorithm that can overcome these challenges. We propose to slide a beam-filter that has multi-slit structure with its slits being at a slanted angle with the CT gantry rotation axis during a scan. A streaky pattern would show up in the sinogram domain as a result. Using a notch filter in the Fourier domain of the sinogram, we removed the streaks and reconstructed an image by use of the filtered-backprojection algorithm. The remaining image artifacts were suppressed by applying ${l}_{{0}}$ norm based smoothing. Using this image as a prior, we have reconstructed low- and high-energy CT images in the iterative reconstruction framework. An image-based material decomposition then followed. We conducted a simulation study to test its feasibility using the XCAT phantom and also an experimental study using the Catphan phantom, a head phantom, an iodine-solution phantom, and a monkey in anesthesia, and showed its successful performance in image reconstruction and in material decomposition.
Published: 2021
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2. A Study on the Improvement of Etch Uniformity in an Ion Beam Etcher with a Magnetized Inductively Coupled Plasma Source

Author: H.-W. Cheong, K.-W. Kim, Jung-ki Kim, and Hwally Lee
Subjects: 010302 applied physics, Materials science, Physics and Astronomy (miscellaneous), Electromagnet, Ion beam, business.industry, Flux, Plasma, Condensed Matter Physics, 01 natural sciences, 010305 fluids & plasmas, law.invention, Ion, Magnetic field, Optics, law, 0103 physical sciences, Dry etching, Inductively coupled plasma, business
Abstract: A magnetized inductively coupled plasma ion beam etcher (MICP-IBE) was designed by employing electromagnets around the etcher (IBE). A magnetic field can be set up such that the magnitude of the magnetic flux density on the screen grid increases or decreases with the radial distance from the screen grid center. Four different types of magnetic field conditions were considered. The plasma densities and electron temperatures were measured as functions of radial distance from the screen grid center under each condition. In addition, ion flux was measured with respect to radial distance from the substrate center using ion energy analyzer (IEA), after which the uniformity characteristics of the ion flux in the substrate were investigated. The dry etching characteristics of CoFeB, a typical alloy being used in the magnetic memory device, were investigated. The uniformity characteristics of the ion flux and the etch rate can be improved with the proper design of magnetic field conditions; however, the improvement was confirmed to be limited. In this respect, a new screen and acceleration grid were designed that have different grid hole densities with radial distance from the grid center (hereafter referred to as the proposed grid). Using the proposed grid, the ion flux and etch rate of CoFeB were measured with respect to radial distance from the substrate center, to see if the radial etch rate uniformity can be improved further. The CoFeB etch rate non-uniformity in the proposed grid (11.65%) was lower than that for the conventional grid (17.5%).
Published: 2021
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3. Evaluation of an automated specimen processing system for staining and culture for acid-fast bacilli

Author: S-H. Oh, S. H. Kang, J. B. Lee, I-S. Kim, HeeJa Lee, K. J. Kim, Chulhun L. Chang, Y. L. Ryu, and S. M. Lee
Subjects: Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Staining and Labeling, business.industry, Sputum, Mycobacterium tuberculosis, Specimen Handling, Staining, Infectious Diseases, Acid-fast, Humans, Medicine, Specimen processing, business
Published: 2021
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4. All-cause mortality, cardiovascular mortality, and incidence of cardiovascular disease according to a screening program of cardiovascular risk in South Korea among young adults: a nationwide cohort study

Author: Y.-Y. Kim, Sun Ah Choi, Gyeongsil Lee, Joung Sik Son, S.Y. Park, Su Min Jeong, K.-W. Kim, Sung Min Kim, Sun-Kyung Park, and Jae-Moon Yun
Subjects: Adult, Male, National Health Programs, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Cause of Death, Republic of Korea, Humans, Mass Screening, Medicine, 030212 general & internal medicine, Young adult, Aged, Proportional Hazards Models, Retrospective Studies, business.industry, Incidence, 030503 health policy & services, Incidence (epidemiology), Hazard ratio, Public Health, Environmental and Occupational Health, Retrospective cohort study, General Medicine, Middle Aged, Patient Acceptance of Health Care, Confidence interval, Hospitalization, Cardiovascular Diseases, Heart Disease Risk Factors, Propensity score matching, Female, 0305 other medical science, business, Psychosocial, Cohort study, Demography
Abstract: We aimed to determine whether there are any differences in all-cause and cause-specific mortality with cardiovascular disease (CVD) risk between health screening attenders and non-attenders among young adults.We performed a retrospective cohort study using claim data from the Korean National Health Insurance Service database.Individuals aged 20-39 years who had received health screening at least once between 2002 and 2005 were classified as attenders, and the others were classified as non-attenders. After propensity score matching according to attendance of health screening, 2,060,409 attenders and 2,060,409 non-attenders were included. We estimated adjusted hazard ratios (HRs) and 95% confidence interval (CI) for all-cause mortality, cause-specific mortality, and hospitalization of CVD from 2006 to 2015.Survival from all-cause mortality was greater among attenders than among non-attenders (log rank P 0.001). Similarly, death from CVD (log rank P = 0.007) and CVD events (log rank P 0.001) were less likely among attenders. The risk for all-cause mortality in attenders was significantly lower than that in non-attenders (HR = 0.83, 95% CI = 0.81 to 0.84). The risk for CVD mortality (HR = 0.80, 95% CI = 0.73 to 0.87) and hospitalization of CVD (HR = 0.92, 95% CI = 0.91 to 0.94) were lower in attenders. In stratified analyses, the risk for all-cause and cause-specific mortalities was lower among attenders regardless of insurance type.Among young adults, the risk for all-cause mortality, CVD mortality, and hospitalization of CVD were lower for those who underwent health screenings. Future studies that evaluate the cost-effectiveness of health screening with additional consideration of psychosocial aspects are needed.
Published: 2021
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5. Effect of Mobile Game-based Respiratory Exercise on Respiratory Muscle Strength and Cough Capacity in People with Severe Cervical Spinal Cord Injury: A Preliminary Case Study

Author: D. H. Kang, J. Y. Park, S. D. Eun, H. J. Park, and K. T. Kim
Subjects: Breathing exercises, business.industry, Anesthesia, Respiration, Cervical spinal cord injury, Respiratory muscle, Medicine, Game based, Respiratory system, business, medicine.disease, Spinal cord injury
Published: 2020
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6. Expanding the phenotypic spectrum of <scp> RPL13 ‐related </scp> skeletal dysplasia

Author: Pedro A. Sanchez-Lara, Katheryn Grand, Ralph S. Lachman, Harry K W Kim, and Breann Reinsch
Subjects: 0301 basic medicine, Spondyloepimetaphyseal dysplasia, Pathology, medicine.medical_specialty, business.industry, Genu varum, Disease, 030105 genetics & heredity, medicine.disease, Short stature, Phenotype, Multiple epiphyseal dysplasia, 03 medical and health sciences, 030104 developmental biology, Dysplasia, Genetics, Medicine, medicine.symptom, business, Genetics (clinical), Exome sequencing
Abstract: RPL13-related disorder is a newly described skeletal dysplasia characterized as a form of spondyloepimetaphyseal dysplasia with normal birth length, early postnatal growth deficiency, severe short stature, and genu varum. We present a 9-year-old male with a history of lower leg pain and concern for an unspecified form of multiple epiphyseal dysplasia (MED). Exome sequencing revealed a de novo heterozygous RPL13 c.477+1G>A (IVS4+1G>A) pathogenic variant. This is the first identified case of an individual with an RPL13-related skeletal dysplasia, normal height, and radiographs consistent with a form of MED and Legg-Calve-Perthes-like disease. This case expands the phenotype of RPL13-related disorders.
Published: 2020
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7. Primary hepatic extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

Author: Soyeon Choi, Ji Hye Kim, Hye-Jeong Choi, Misung Kim, K.-P. Kim, Min Jung Seo, Jae Hee Suh, Young-Min Kim, and Hee Jeong Cha
Subjects: 0301 basic medicine, Pathology, medicine.medical_specialty, Histology, medicine.medical_treatment, Mucosa-associated lymphoid tissue, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, lcsh:Pathology, medicine, Case Study, business.industry, MALT lymphoma, Gene rearrangement, medicine.disease, Lymphoma, Lymphoma, B-cell, marginal zone, 030104 developmental biology, Lymphatic system, Liver, 030220 oncology & carcinogenesis, CD5, Hepatectomy, Differential diagnosis, business, lcsh:RB1-214
Abstract: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), is one of the specific type of low-grade B-cell lymphoma not infrequently found worldwide. It typically involves mucosal sites such as stomach and conjunctiva; however, primary hepatic MALT lymphoma has been extremely rarely reported. We describe a case of hepatic MALT lymphoma in a 70-year-old male patient who underwent left hepatectomy due to the incidentally detected liver masses at a medical checkup. The resected specimen revealed multinodular masses consisting of small-to-intermediate-sized lymphoid cells with serpentine pattern and focal lymphoepithelial lesions. The tumor cells were diffusely positive for CD20 and Bcl-2 but negative for CD3, CD10, CD5, CD23, CD43, and cyclinD1. The Ki-67 labeling index was 10% and immunoglobulin heavy chain gene rearrangement study confirmed monoclonal proliferation. In this paper, we discuss several unique clinicopathologic characteristics which will be helpful to the differential diagnosis of hepatic MALT lymphoma.
Published: 2020
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8. Hydrodynamic modeling of hybrid energy devices using CFD technologies

Author: M. I. Khismatulin, S. N. Ivanov, and K. K. Kim
Subjects: business.industry, Computer science, Hybrid energy, General Medicine, Aerospace engineering, Computational fluid dynamics, business
Published: 2020
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9. Hydrodynamic simulation of hybrid energy devices using CFD technologies

Author: K. K. Kim, S. N. Ivanov, and M. I. Khismatulin
Subjects: Computer science, business.industry, Hybrid energy, General Medicine, Aerospace engineering, Computational fluid dynamics, business
Published: 2020
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10. High-Resolution Fiber-Fed Spectrograph for the 6-m Telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences: Assessment of Efficiency

Author: A. V. Perkov, S. V. Drabek, G. V. Yakopov, B.-Ch. Lee, D. E. Kukushkin, A. F. Valeev, V. D. Bychkov, M. V. Yushkin, G. A. Galazutdinov, D. A. Sazonenko, D. R. Gadelshin, A. V. Tavrov, T. E. Burlakova, Jean-Loup Bertaux, G. G. Valyavin, Oleg Korablev, E. V. Emelyanov, V. N. Aitov, K. M. Kim, Inwoo Han, V. S. Shergin, F. A. Musaev, Special Astrophysical Observatory of the Russian Academy of Sciences (SAO), Russian Academy of Sciences [Moscow] (RAS), Crimean Astrophysical Observatory (CrAO), St Petersburg State University (SPbU), National Research University of Information Technologies, Mechanics and Optics [St. Petersburg] (ITMO), The Central Astronomical Observatory of the Russian Academy of Sciences [Pulkovo], Instituto de Astronomia [Antofagasta], Universidad Católica del Norte [Antofagasta], PLANETO - LATMOS, Laboratoire Atmosphères, Milieux, Observations Spatiales (LATMOS), Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Space Research Institute of the Russian Academy of Sciences (IKI), Korea Astronomy and Space Science Institute (KASI), and Okayama University
Subjects: Physics, Aperture, business.industry, Astronomy and Astrophysics, 01 natural sciences, Collimated light, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], law.invention, Primary mirror, Telescope, 03 medical and health sciences, 0302 clinical medicine, Optical path, Optics, law, Observatory, 030225 pediatrics, 0103 physical sciences, Spectral resolution, business, 010303 astronomy & astrophysics, Instrumentation, Spectrograph
Abstract: International audience; We report the results of laboratory tests of the first version of the high-resolution fiber-fed spectrograph designed for the Special Astrophysical Observatory of the Russian Academy of Sciences (SAO RAS). During laboratory tests a spectral resolution of about 70 000 was achieved. The peak efficiency of the entire optical path of the spectrograph (without light losses at the CCD, primary mirror of the 6-m telescope, and in the atmosphere) at 620 nm and with the equivalent slit widths of the 1″.5 and 0″.75 are equal to 8% and 4%, respectively. The resolving power R = 70 000 and 100 000 can be reached with the sky aperture 0″.75 and 0″.4 respectively. In the current version of the spectrograph these regimes of operation are implemented by mechanic aperturing of the slit. A dedicated projecting camera has been developed and is currently manufactured to operate with a collimated 200-mm diameter beam, which will make it possible to increase the spectral resolution up to 100 000. A two-beam image slicer will be used to maintain the luminous efficiency of the instrument at least at the 6% level.
Published: 2020
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11. Programmed death-ligand 1 expression and its correlation with clinicopathological parameters in gallbladder cancer

Author: Hee Jeong Cha, Misung Kim, Hye-Jeong Choi, Young-Min Kim, Ji Hye Kim, K.-P. Kim, and Jae Hee Suh
Subjects: 0301 basic medicine, Oncology, programmed death-ligand 1, medicine.medical_specialty, Histology, Lymphovascular invasion, Perineural invasion, Clone (cell biology), Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal medicine, lcsh:Pathology, medicine, Cutoff, Gallbladder cancer, biology, business.industry, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Original Article, prognosis, Gallbladder Neoplasm, Antibody, business, gallbladder neoplasm, lcsh:RB1-214
Abstract: Background Immunomodulatory therapies targeting the interaction between programmed cell death protein 1 and programmed death-ligand 1 (PD-L1) have become increasingly important in anticancer treatment. Previous research on the subject of this immune response has established an association with tumor aggressiveness and a poor prognosis in certain cancers. Currently, scant information is available on the relationship between PD-L1 expression and gallbladder cancer (GBC). Methods We investigated the expression of PD-L1 in 101 primary GBC cases to determine the potential association with prognostic impact. PD-L1 expression was immunohistochemically assessed using a single PD-L1 antibody (clone SP263). Correlations with clinicopathological parameters, overall survival (OS), or progression- free survival (PFS) were analyzed. Results PD-L1 expression in tumor cells at cutoff levels of 1%, 10%, and 50% was present in 18.8%, 13.8%, and 7.9% of cases. Our study showed that positive PD-L1 expression at any cutoff was significantly correlated with poorly differentiated histologic grade and the presence of lymphovascular invasion (p < .05). PD-L1 expression at cutoff levels of 10% and 50% was significantly positive in patients with perineural invasion, higher T categories, and higher pathologic stages (p < .05). Additionally, there was a significant association noted between PD-L1 expression at a cutoff level of 50% and worse OS or PFS (p = .049 for OS, p = .028 for PFS). Other poor prognostic factors included histologic grade, T category, N category, pathologic stage, lymphovascular invasion, perineural invasion, growth pattern, and margin of resection (p < .05). Conclusions The expression of PD-L1 in GBC varies according to cutoff level but is valuably associated with poor prognostic parameters and survival. Our study indicates that the overexpression of PD-L1 in GBC had a negative prognostic impact.
Published: 2020
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12. Smart digital technologies in the operation of electric rolling stock from the electrical safety perspective

Author: E. L. Ryzhova and K. K. Kim
Subjects: General Medicine, Business, Industrial organization, Stock (geology)
Published: 2020
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13. ICRP Publication 143: Paediatric Reference Computational Phantoms

Author: Tatsuhiko Sato, J Hunt, Yeon Soo Yeom, Wesley E. Bolch, Keith F. Eckerman, K-P. Kim, A. Endo, Maria Zankl, Nina Petoussi-Henss, J. Li, Helmut Schlattl, Derek W. Jokisch, Chan Hyeong Kim, and Choonik Lee
Subjects: Male, medicine.medical_specialty, Adolescent, Radiological and Ultrasound Technology, Phantoms, Imaging, business.industry, Public Health, Environmental and Occupational Health, MEDLINE, Infant, International Agencies, Radiation Exposure, Radiation Protection, Radon, Child, Preschool, medicine, Humans, Female, Radiology, Nuclear Medicine and imaging, Medical physics, Child, Radiometry, business
Published: 2020
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14. Planning Instruments for Climate Smart and Wise Cities: A Spatial, Green and Digital Deal Approach

Author: K. G. Kim and H. S. Choi
Subjects: Architectural engineering, Conceptual framework, business.industry, Computer science, Urban planning, Smart city, New Urbanism, Mainstream, The Internet, business, License, Variety (cybernetics)
Abstract: The Smart City Council defines a smart city as one that has simple, easy, and practical digital technology embedded across all city functions. Though cities and communities around the world have elaborated a variety of climate actions and plans, their development and implementation often follow a project-based approach with no network connections between projects. Climate smart and wise cities extends the concept and approach of smart cities to include the diverse dimensions of climate actions in a holistic manner. This chapter describes how climate smart and wise cities can support climate actions with a variant of the New Urbanism called the climate smart and wise urbanism., which is intended to be more climate-oriented and nature-based. The chapter argues that our task now is to mainstream climate city planning into urban planning and development policy. The contents of this chapter include new issues and solutions for climate emergency which need a new tenet of planning, a conceptual framework, and key components of the planning system for integrated climate smart and wise cities, planning procedure, and planning methodology. The models include holistic planning models, sub-system planning models, and sectoral dynamic platform models with the use of automation and Internet control system technology development. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Published: 2021
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15. Market Mechanisms in the Building Sector from an Urban Perspective: Creative Building Solutions

Author: H. S. Choi and K. G. Kim
Subjects: Consumption (economics), education.field_of_study, Resource (biology), Market mechanism, business.industry, Population, Solar water heating, Energy consumption, Business, Environmental economics, education, License, Renewable energy
Abstract: The global contribution from buildings toward energy consumption, both residential and commercial, has steadily increased reaching features between 20 and 40% in developing countries and has exceeded the other major sectors: industrial and transportation. In European countries, buildings account for 40% of total energy consumption. Growth in population, increasing demand for building services, and comfort levels, together with the rise in time spent inside buildings due to COVID-19 pandemic, assure the upward trend in energy demand will continue in the future. Market mechanism in the building sector from an urban perspective is essential as reducing building sector emissions will have to be a critical part of any effective global effort to reduce climate risks. This chapter explores how to build the market mechanism in the building sector from an urban perspective. The first section of this chapter overviews the issues when combining different market mechanisms within building sector and energy market-. The second section describes a framework for integrating renewable energy sources, solar water heating, lighting and cooling, centralized air conditioning, and the use of energy-efficient equipment at different component and spatial levels such as each component, a whole building and at a site or district level. The third section covers the methodologies for the market mechanisms in the building sector, while the fourth section addresses a testbed approach for a new modality and procedure of market mechanism in the building sector as a guide for a Blockchain-based community smart and resource wise market mechanism. The fifth and final section addresses the cases at residential community, site, and a whole building levels. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Published: 2021
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16. EPV081/#509 Sentinel lymph node mapping using intra-abdominal indocyanine green injection in open surgery for cervical cancer: a novel technique of indocyanine green injection by abdominal approach

Author: S-W Lee, Jun-Sang Kim, D.Y. Kim, HH Choi, CK Lim, J-Y Park, Y-T. Kim, K-R Kim, and Yong Min Kim
Subjects: Novel technique, Cervical cancer, medicine.medical_specialty, business.industry, Open surgery, Abdominal approach, medicine.disease, Sentinel lymph node mapping, chemistry.chemical_compound, chemistry, medicine, Radiology, business, Indocyanine green
Published: 2021
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17. Poster Abstracts

Author: J. A. Seo, H. J. Yoo, Sei Hyun Baik, J. H. Bae, J. H. Yu, N. H. Kim, J. Y. Kim, K. J. Kim, S. G. Kim, H. Y. Kim, and K. M. Choi
Subjects: Mechanical ventilation, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Hazard ratio, General Medicine, medicine.disease, Intensive care unit, Obesity, law.invention, law, Internal medicine, Diabetes mellitus, Poster Abstracts, Internal Medicine, medicine, Extracorporeal membrane oxygenation, business, Body mass index
Abstract: OBJECTIVE: This study aimed to determine the relative and independent contributions of impaired metabolic health and obesity to coronavirus disease 2019 (COVID-19) outcomes. METHODS: We analyzed 4,069 COVID-19 patients between January and June 2020 in South Korea, classified into four groups according to metabolic health status and body mass index (BMI): metabolically healthy normal weight (MHNW), metabolically unhealthy normal weight (MUNW), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO). The primary outcome was a composite of intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), extracorporeal membrane oxygenation (ECMO), and death. Multivariable Cox proportional hazard regression models were used to estimate the hazard ratio (HR) for the outcome. RESULTS: The incidence rate (per 100 person-months) of severe COVID-19 outcomes was the lowest in the MHNW group (0.90), followed by the MHO (1.64), MUNW (3.37), and MUO (3.37) groups. Compared with MHNW, a significantly increased risk of severe COVID-19 was observed in MUNW (HR, 1.41;95% CI, 1.01-1.98) and MUO (HR, 1.77;95% CI, 1.39-2.44) but not in MHO (HR, 1.48;95% CI, 0.98-2.23). The risk of ICU admission or IMV/ECMO was increased only in MUO;however, the risk of death was significantly higher in MUNW and MUO. The risk of severe COVID-19 increased insignificantly by 2% per 1 kg/m2 BMI increase but significantly by 13% per 1 metabolically unhealthy component increase, even after mutually adjusting for BMI and metabolic health status. CONCLUSION: Metabolic health is more important to COVID-19 outcomes than obesity.
Published: 2021

18. Association between body composition indices and prevalence of chronic rhinosinusitis in Koreans

Author: K. Lee, Sunil Lee, K. L. Kim, and T. Kim
Subjects: medicine.medical_specialty, business.industry, Chronic rhinosinusitis, General Medicine, Otorhinolaryngology, Internal medicine, Chronic Disease, Republic of Korea, Body Composition, Prevalence, Medicine, Humans, Sinusitis, business, Rhinitis
Published: 2021

19. Successful Infusion of Obinutuzumab by Desensitization: A Case of Anaphylactic Shock During Desensitization

Author: Sung Yeon Lee, Seonghae Yoon, H.R. Kang, Sun Gun Chung, and K.-W. Kim
Subjects: business.industry, medicine.medical_treatment, Immunology, Antibodies, Monoclonal, Humanized, medicine.disease, Drug Hypersensitivity, chemistry.chemical_compound, Antineoplastic Agents, Immunological, chemistry, Desensitization, Immunologic, Obinutuzumab, Anesthesia, medicine, Anaphylactic shock, Humans, Immunology and Allergy, business, Adverse effect, Anaphylaxis, Desensitization (medicine)
Published: 2020
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20. Clinical characteristics of diabetic ketoacidosis in users and non-users of SGLT2 inhibitors

Author: S.O. Song, Da Hea Seo, Soon-Sun Hong, Bo Yeon Kim, Jung Hyun Noh, Dae Jung Kim, Chul-Hee Kim, S.O. Park, K.-S. Kim, Ji A Seo, Jun-Won Yun, Ja Young Jeon, and S.-K. Kim
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Diabetic ketoacidosis, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, 030204 cardiovascular system & hematology, Non users, Diabetic Ketoacidosis, law.invention, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, law, Internal medicine, Diabetes Mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, In patient, Hospital Mortality, Sodium-Glucose Transporter 2 Inhibitors, Retrospective Studies, Plasma glucose, business.industry, Medical record, Mortality rate, nutritional and metabolic diseases, General Medicine, Middle Aged, medicine.disease, Intensive care unit, Treatment Outcome, Female, business
Abstract: Aim This study investigated the clinical characteristics of diabetic ketoacidosis (DKA) and compared the DKA characteristics between patients treated with and without SGLT2 inhibitors. Methods Data were collected from patients aged ≥ 18 years admitted for DKA at nine centres in Korea between September 2014 and April 2017. The electronic medical records of these subjects were retrospectively reviewed. Based on their history of medications taken before admission, subjects were classified as either users or non-users of SGLT2 inhibitors and their clinical characteristics of DKA were compared. Results During the study, the main subtype of DKA episodes (n = 523) was identified as type 2 diabetes (51%). Average hospitalization duration was 11 days, and average intensive care unit (ICU) time was 2.5 days. The in-hospital mortality rate was 3%, but no users of SGLT2 inhibitors died during DKA treatment. In patients taking SGLT2 inhibitors (n = 15), DKA manifested at 124 days, on average, after starting the inhibitors (range: 7–380 days). Also, SGLT2 inhibitors users had significantly lower plasma glucose levels (413 mg/dL) compared with non-users (554 mg/dL), and longer ICU stays (4 vs. 2 days; P = 0.019). Conclusion In this report of recent data on the clinical features of DKA in Korea, patients using SGLT2 inhibitors needed longer treatment in ICUs compared with non-users and had lower levels of blood glucose, whereas DKA associated with SGLT2 inhibitors was rare.
Published: 2019
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21. Phase lag entropy as a hypnotic depth indicator during propofol sedation

Author: Jiyoun Bang, Gyu-Jeong Noh, K. M. Kim, Byung Moon Choi, Yong Hun Lee, and S. Ki
Subjects: Adult, Male, Correlation coefficient, medicine.drug_class, Entropy, Sedation, Conscious Sedation, Propofol sedation, Hypnotic, 03 medical and health sciences, 0302 clinical medicine, 030202 anesthesiology, medicine, Humans, Hypnotics and Sedatives, Entropy (information theory), 030212 general & internal medicine, Propofol, Aged, business.industry, Electroencephalography, Middle Aged, Phase lag, Logistic Models, Anesthesiology and Pain Medicine, Anesthesia, Bispectral index, Female, medicine.symptom, business, medicine.drug
Abstract: Phase lag entropy, an electro-encephalography-based hypnotic depth indicator, calculates diversity in temporal patterns of phase relationship. We compared the performance of phase lag entropy with the bispectral index™ in 30 patients scheduled for elective surgery. We initiated a target-controlled infusion of propofol using the Schnider model, and assessed sedation levels using the Modified Observer's Assessment of Alertness/Sedation scale every 30 s with each stepwise increase in the effect-site propofol concentration. Phase lag entropy and bispectral index values were recorded. The correlation coefficient and prediction probability between phase lag entropy or bispectral index and the sedation level or effect-site propofol concentration were analysed. We calculated baseline variabilities of phase lag entropy and bispectral index. In addition, we applied a non-linear mixed-effects model to obtain the pharmacodynamic relationships among the effect-site propofol concentration, phase lag entropy or bispectral index and sedation level. As sedation increased, phase lag entropy and bispectral index both decreased. The prediction probability values of phase lag entropy and bispectral index for sedation levels were 0.697 and 0.700 (p = 0.261) and for the effect-site concentration of propofol were 0.646 and 0.630 (p = 0.091), respectively. Baseline variability in phase lag entropy and bispectral index was 3.3 and 5.7, respectively. The predicted propofol concentrations, using the Schnider pharmacokinetic model, producing a 50% probability of moderate and deep sedation were 1.96 and 3.01 μg.ml-1 , respectively. Phase lag entropy was found to be useful as a hypnotic depth indicator in patients receiving propofol sedation.
Published: 2019
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22. Abstract P1-11-16: Efficacy and safety of acupuncture for the hot flashes in breast cancer patients taking adjuvant tamoxifen: A multicenter study in Korean women

Author: H Choi, S-H Park, K-S Kim, Song-Yi Park, Y-J Jeong, Young Y. Lee, and M-A Kwak
Subjects: Cancer Research, medicine.medical_specialty, business.industry, Visual analogue scale, Estrogen receptor, Cancer, medicine.disease, Breast cancer, Oncology, Hot flash, Internal medicine, medicine, Acupuncture, medicine.symptom, business, Adverse effect, Tamoxifen, medicine.drug
Abstract: Background : Tamoxifen is widely used in premenopausal patients with estrogen receptor positive (ER+) breast cancer. Among the side-effects of tamoxifen, hot flashes is a common and challenging one. Previous pilot study suggested the effectiveness of acupuncture for relief of symptoms. This study was performed to evaluate the efficacy and safety of acupuncture for treatment of hot flashes in Korean women breast cancer patients taking tamoxifen as adjuvant endocrine therapy. Methods : Thirty(30) breast cancer patients taking tamoxifen and reported moderate to severe hot flashes were enrolled from two institutes. Patients were randomly assigned into acupuncture group(n=15) and control group(n=15). The acupuncture group received acupuncture 3 times a week for 4 consecutive weeks, at 5 predefined points(GV 20, M-HN-3, HT 8, KI 10 and LV 2) for 20 ± 5minutes at each session. Control group received no treatment. The score of hot flash visual analogue scale(VAS) and total hot flash score, EORTC QLQ-C30 and QLQ-BR 23 questionnaire were recorded before treatment, once every treatment week and 4 weeks after treatment for both groups. Results : Acupuncture group showed significantly reduced severity of hot flashes during treatment assessed with either VAS and total hot flash score (p=0.000 and p=0.008, respectively). Also, acupuncture group showed improvement of global health status and physical functioning score assessed with EORTC QLQ-C30 (p=0.004 and p=0.027, respectively). Four weeks after the treatment, these trends were retained. No adverse events were notified Conclusion : Acupuncture may have feasibility and safety for alleviate hot flashes of Korean women breast cancer patients taking tamoxifen as an adjuvant endocrine therapy. Long-term follow up results and further study with a larger sample size is required. Citation Format: Choi H, Jeong Y-j, Park S-H, Kwak M-A, Kim K-S, Lee Y, Park S. Efficacy and safety of acupuncture for the hot flashes in breast cancer patients taking adjuvant tamoxifen: A multicenter study in Korean women [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P1-11-16.
Published: 2019
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23. Improving the bioavailability of manganese and meat quality of broilers by using hot-melt extrusion nano method

Author: JunHyung Lee, Abdolreza Hosseindoust, JunYoung Mun, Byung-Jo Chae, Tae Gyun Kim, MinJu Kim, Joseph Moturi, and K Y Kim
Subjects: Meal, Manganese, Meat, Chemistry, business.industry, Thiobarbituric acid, Broiler, Biological Availability, General Medicine, Poultry farming, Animal Feed, Bioavailability, Diet, Excretion, chemistry.chemical_compound, Animal science, Dietary Supplements, TBARS, Animals, Animal Science and Zoology, Animal Nutritional Physiological Phenomena, Intramuscular fat, business, Chickens, Food Science
Abstract: 1. Mineral excretion is an issue in the poultry industry. The use of micro minerals in nano form can increase bioavailability and decrease excretion rate. However, information concerning the bioavailability of nano manganese (Mn) in broiler chicks is limited.2. This experiment studied the influences of hot-melt extrusion (HME)-processed manganese sulphate on body weight gain, Mn bioavailability, nutrient digestibility and meat quality in broiler chicks fed a corn-soybean meal-based diet as a starter and grower phase. A total of 700 birds (Ross 308, 1-day-old) were randomly placed in 35 cages (20 birds per cage). The broiler chicks were fed one of seven experimental diets, which consisted of a control (without supplemental Mn), different levels of MnSO4 (IN-Mn60; 60, 120, and 200 mg/kg), or HME MnSO4 (HME-Mn; 60, 120, and 200 mg/kg).3. There was an increased serum Mn content in broilers fed diet supplemented with HME-Mn. In the grower phase, increased dietary Mn levels elevated the concentrations in the serum, liver, and tibia. There were increases in the excreta Mn content of broilers fed increasing levels. The supplementation of HME-Mn showed a lower percentage of abdominal fat compared with the IN-Mn treatment diets. Supplementation with HME-Mn decreased intramuscular fat compared with the diets supplemented with IN-Mn. The supplementation of HME-Mn decreased the thiobarbituric acid reactive substances (TBARS) at d 6 of age. The HME-Mn source showed a greater decrease in TBARS compared with the IN-Mn treatment.4. In conclusion, HME processing increased bioavailability and could be used as an environmentally friendly method to facilitate lower levels of Mn in the diet of broiler chickens.
Published: 2021

24. The effect of rebalancing on LDA in imbalanced classification

Author: Hyunwoo Chung and Arlene K. H. Kim
Subjects: Statistics and Probability, Class imbalance, Computer science, business.industry, Pattern recognition, Artificial intelligence, Statistics, Probability and Uncertainty, F1 score, business
Published: 2021
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25. Bioinformatic Analysis for Influential Core Gene Identification and Prognostic Significance in Advanced Serous Ovarian Carcinoma

Author: Shin Kim, Changho Song, Jae-Ho Lee, and K.-S. Kim
Subjects: Oncology, medicine.medical_specialty, Medicine (General), Cell Cycle Proteins, Disease, Article, R5-920, Internal medicine, Ovarian carcinoma, CDCA3, medicine, Biomarkers, Tumor, Humans, prognostic biomarker, Gene, Survival analysis, Ovarian Neoplasms, biology, business.industry, CENPF, Computational Biology, serous ovarian carcinoma, General Medicine, medicine.disease, Prognosis, Gene Expression Regulation, Neoplastic, Repressor Proteins, Serous fluid, biology.protein, UBE2C, KIF4A, Female, Neoplasm Recurrence, Local, Ovarian cancer, business
Abstract: Background and objectives: Ovarian cancer is one of the leading causes of death among women worldwide. Most newly diagnosed ovarian cancer patients are diagnosed in advanced stages of the disease. Despite various treatments, most patients with advanced stage ovarian cancer, including serous ovarian cancer (the most common subtype of ovarian cancer), experience recurrence, which is associated with extremely poor prognoses. In the present study, we aimed to identify core genes involved in ovarian cancer and their associated molecular mechanisms, as well as to investigate related clinicopathological implications in ovarian cancer. Materials and methods: Three gene expression cohorts (GSE14407, GSE36668, and GSE38666) were obtained from the Gene Expression Omnibus databases to explore potential therapeutic biomarkers for ovarian cancer. Nine up-regulated and six down-regulated genes were screened. Three publicly available gene expression datasets (GSE14407, GSE36668, and GSE38666) were analyzed. Results: A total of 14 differently expressed genes (DEGs) were identified, among which nine genes were upregulated (BIRC5, CDCA3, CENPF, KIF4A, NCAPG, RRM2, UBE2C, VEGFA, and NR2F6) and were found to be significantly enriched in cell cycle regulation by gene ontology analysis. Further protein–protein interaction network analysis revealed seven hub genes among these DEGs. Moreover, Kaplan–Meier survival analysis showed that a higher expression of CDCA3 and UBE2C was associated with poor overall patient survival regardless of tumor stage and a higher tumor histologic grade. Conclusion: Altogether, our study suggests that CDCA3 and UBE2C may be valuable biomarkers for predicting the outcome of patients with advanced serous ovarian cancer.
Published: 2021

26. Measurements of partial branching fractions of inclusive B→Xuℓ+νℓ decays with hadronic tagging

Author: M. Uchida, L. K. Li, G. De Nardo, M. T. Hedges, T. Matsuda, T. Pang, S. Uno, R. Itoh, S Choudhury, G. Bonvicini, A. Rostomyan, Zhukova, S. Cunliffe, B. G. Fulsom, D. Ferlewicz, A. Vinokurova, S. Dubey, S. Al Said, D. Matvienko, Y Choi, Pavel Krokovny, Florian Urs Bernlochner, C. Kiesling, M. Bračko, M Merola, K. H. Kang, B. H. Kim, C. Z. Yuan, K. Miyabayashi, Popov, Samo Korpar, Steve K. Choi, S Ogawa, Deepak Kumar Sahoo, J. MacNaughton, T. Kawasaki, R. Mussa, H. B. Jeon, A. Ishikawa, M. Nakao, W. S. Hou, Alexei Kuzmin, GB Mohanty, Yongsun Kim, K. Lalwani, S-H Park, M. Takizawa, S.-J. Cho, U. Tamponi, D Cinabro, K. Trabelsi, S. Jia, E. Prencipe, E. Wang, F. Tenchini, R. Mizuk, K. Chilikin, D. Epifanov, T. Podobnik, T. Sumiyoshi, Martin Ritter, T. Sanuki, Matthias Bauer, S. Paul, C. Schwanda, L. Li Gioi, S. Pardi, C. P. Shen, S. Nishida, J. Schueler, C. MacQueen, A. J. Schwartz, T. K. Pedlar, W. B. Yan, M. Campajola, C. W. Park, E. Won, K. Kumara, K. Tanida, P. Krizan, L. Nayak, A. K. Giri, BG Cheon, G. Schnell, P. Oskin, T. Ferber, Z. Natkaniec, Andrey Sokolov, S. Wehle, R. Ayad, A. Bozek, Z. S. Stottler, K. Cho, S. E. Vahsen, X. P. Xu, T. Iijima, M. Rozanska, G. Varner, H. Atmacan, T. Uglov, M. Masuda, D. Kotchetkov, D. Červenkov, K. Nishimura, C. W. Joo, H. Kichimi, Villanueva, MH[Villanueva, M. Hernandez], A. Sangal, Phillip Urquijo, J. H. Yin, Z. J. Liptak, J. F. Strube, Zhilich, H Aihara, Rahul Kumar, T. Bilka, L. Cao, Semen Eidelman, J. Wiechczynski, M. Watanabe, F. Di Capua, A. Garmash, J. C. Dingfelder, Vorobyev, Y. Sakai, N. K. Nisar, Bhardwaj, Y. Iwasaki, Babu, P. Wang, Sudhanwa Patra, Samo Stanič, K. Lieret, J. S. Lange, I. Adachi, Bruce Yabsley, R. Kroeger, C.-L. Hsu, Y-J Kwon, D. Liventsev, DY Kim, Chekelian, Y. Jin, M. E. Sevior, I. S. Lee, A. Frey, K Kinoshita, P. Goldenzweig, M. Nayak, W. Sutcliffe, C. Sharma, Peter Kodys, W. W. Jacobs, E. Solovieva, Tagir Aushev, Y. Onuki, H. Ono, Leo Piilonen, E.-J. Jang, Zdenek Dolezal, T. Kuhr, Seongbae Yang, A. Vossen, Frank Simon, Y. Unno, H. E. Cho, N. Rout, G. Karyan, TE Browder, K. Belous, M Iwasaki, S. C. Lee, N. Dash, Y. Guan, M. Mrvar, Zhiqing Zhang, Chunjie Wang, P. Chang, P Behera, M. Niiyama, M. C. Chang, E. Waheed, Martin Florian Bessner, J. Libby, D. M. Asner, K. Hayasaka, E. Kovalenko, H Ye, S. Sandilya, Y. Seino, Shoichi Watanuki, M. Starič, K. Senyo, S. Das, Kevin Varvell, J. V. Bennett, T. Mori, Y. Usov, G. Pakhlova, S. H. Kim, J. Li, Mukesh Kumar, T. J. Moon, M. T. Prim, C. H. Li, T. Konno, H. Hayashii, Hyunyong Kim, C. H. Kim, M. Z. Wang, Felix Metzner, A. Chen, K. K. Joo, M. Shapkin, Yang Li, T. V. Dong, M. Röhrken, T. Hara, L. Santelj, Gaur, O. Hartbrich, R. Pestotnik, A. Natochii, K. Inami, A. Korobov, Savinov, Y. Yusa, R. Van Tonder, R. B. Garg, J-G Shiu, K.-H. Kim, J. Biswal, Zhulanov, C. Hadjivasiliou, P. Pakhlov, Philip Lewis, G. Russo, and H. Park
Subjects: Physics, Research program, Higher education, 010308 nuclear & particles physics, business.industry, Atomic energy, media_common.quotation_subject, Library science, 01 natural sciences, Excellence, 0103 physical sciences, media_common.cataloged_instance, European union, 010306 general physics, China, business, National laboratory, Research center, media_common
Abstract: We thank Kerstin Tackmann, Frank Tackmann, Zoltan Ligeti, Ian Stewart, Thomas Mannel, and Keri Voss for useful discussions about the subject matter of this manuscript. L. C., W. S., R. V. T., and F. B. were supported by the DFG Emmy-Noether Grant No. BE 6075/1-1. W. S. was supported by the Alexander von Humboldt Foundation. We thank the KEKB group for the excellent operation of the accelerator, the KEK cryogenics group for the efficient operation of the solenoid, and the KEK computer group and the Pacific Northwest National Laboratory (PNNL) Environmental Molecular Sciences Laboratory (EMSL) computing group for strong computing support, and the National Institute of Informatics and Science Information NETwork 5 (SINET5) for valuable network support. We acknowledge support from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, the Japan Society for the Promotion of Science (JSPS), and the Tau-Lepton Physics Research Center of Nagoya University; the Australian Research Council including Grants No. DP180102629, No. DP170102389, No. DP170102204, No. DP150103061, and No. FT130100303; Austrian Federal Ministry of Education, Science and Research (FWF) and FWF Austrian Science Fund No. P 31361-N36; the National Natural Science Foundation of China under Contracts No. 11435013, No. 11475187, No. 11521505, No. 11575017, No. 11675166, and No. 11705209; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS), Grant No. QYZDJ-SSW-SLH011; the CAS Center for Excellence in Particle Physics (CCEPP); the Shanghai Pujiang Program under Grant No. 18PJ1401000; the Shanghai Science and Technology Committee (STCSM) under Grant No. 19ZR1403000; the Ministry of Education, Youth and Sports of the Czech Republic under Contract No. LTT17020; Horizon 2020 ERC Advanced Grant No. 884719 and ERC Starting Grant No. 947006 "InterLeptons" (European Union); the Carl Zeiss Foundation, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Universe, and the VolkswagenStiftung; the Department of Atomic Energy (Project Identification No. RTI 4002) and the Department of Science and Technology of India; the Istituto Nazionale di Fisica Nucleare of Italy; National Research Foundation (NRF) of Korea Grants No. 2016R1D1A1B01010135, No. 2016R1D1A1B02012900, No. 2018R1A2B3003643, No. 2018R1A6A1A06024970, No. 2018R1D1A1B07047294, No. 2019K1A3A7A09033840, andNo. 2019R1I1A3A01058933; Radiation Science Research Institute, Foreign Large-size Research Facility Application Supporting project, the Global Science Experimental Data Hub Center of the Korea Institute of Science and Technology Information and KREONET/GLORIAD; the Polish Ministry of Science and Higher Education and the National Science Center; the Ministry of Science and Higher Education of the Russian Federation, Agreement 14.W03.31.0026, and the HSE University Basic Research Program, Moscow; University of Tabuk research Grants No. S-1440-0321, No. S-02561438, and No. S-0280-1439 (Saudi Arabia); the Slovenian Research Agency Grants No. J1-9124 and No. P1-0135; Ikerbasque, Basque Foundation for Science, Spain; the Swiss National Science Foundation; the Ministry of Education and the Ministry of Science and Technology of Taiwan; and the U.S. Department of Energy and the National Science Foundation
Published: 2021
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27. Test of Lepton-Flavor Universality in B→K*ℓ+ℓ− Decays at Belle

Author: H. Ono, G. Schnell, T. Iijima, H. Miyata, J. Biswal, Y. Sakai, A. K. Giri, BG Cheon, Massimo Berger, V.N. Zhilich, C. Z. Yuan, M. Masuda, A. Kuzmin, W. Sutcliffe, V. Babu, Y. Guan, Z Liptak, K. Kumara, Y. Unno, P Behera, S. Jia, T. Ferber, J-G Shiu, T. Matsuda, G. De Nardo, M. T. Hedges, M. C. Chang, S Ogawa, P. K. Resmi, S. Uno, C.-L. Hsu, S Choudhury, D. M. Asner, K. Hayasaka, V. Savinov, Daniel Greenwald, A. Garmash, Iki Adachi, G. Pakhlova, M. Z. Wang, N. K. Nisar, K. Trabelsi, S. Dubey, W. W. Jacobs, J. Libby, J. S. Lange, O. Hartbrich, T. Kuhr, DY Kim, K. Adamczyk, H. Kichimi, Tao Luo, K. Tanida, Y. Seino, Rakesh Kumar, M Merola, A. J. Schwartz, X. P. Xu, M. Uchida, V. Bhardwaj, Y Choi, G. Karyan, M. Niiyama, H Ye, J. F. Strube, S. H. Kim, D. Epifanov, Pavel Krokovny, X. L. Wang, H Aihara, GB Mohanty, S. Wehle, M. Campajola, R. Itoh, R. Van Tonder, H. Hayashii, A. Sangal, Jihwa Lee, Y. I. Kim, Leo Piilonen, L. Cao, C. Schwanda, A. B. Kaliyar, Takeo Higuchi, J. Kahn, T. K. Pedlar, R. Ayad, A. Rostomyan, Dipak Kumar Sahoo, S. Cunliffe, D Cinabro, R. Kulasiri, S. Nishida, J. MacNaughton, J. T. McNeil, B. G. Fulsom, K. Cho, Samo Korpar, J. Schueler, V. Gaur, E. Won, Seongbae Yang, U. Tamponi, G. Russo, H. Park, K. Senyo, A. Bozek, Kevin Varvell, Y. Ushiroda, Kohei Ogawa, W-S Hou, G. Varner, A. Natochii, F. Tenchini, K Kinoshita, K. Inami, B.A. Shwartz, S. E. Vahsen, TE Browder, T. Podobnik, T. Sumiyoshi, G. Inguglia, E. Prencipe, T. Uglov, Y. Tao, Martin Ritter, N. Dash, E. Solovieva, Y. Iwasaki, F. Di Capua, Y-J Kwon, Vladimir Zhulanov, Y. Jin, M Iwasaki, O. Schneider, N. Rout, S. C. Lee, D. Kotchetkov, M. E. Sevior, P. Goldenzweig, Zhiqing Zhang, Chunjie Wang, P. Wang, J. Haba, C. Niebuhr, Tagir Aushev, V. Zhukova, Y. Onuki, S. Sandilya, P. Pakhlov, M. Starič, Semen Eidelman, R. Mussa, V.M. Aulchenko, A. Ishikawa, M. Nakao, I. Komarov, R. Kroeger, D. Liventsev, R. Mizuk, K. Chilikin, J. H. Yin, M. Bračko, N. Gabyshev, Rocky Bala Garg, S-H Park, M. Takizawa, K. T. Kim, M. Nayak, T. J. Moon, Felix Metzner, H. Atmacan, D. Joffe, V. Vorobyev, Yang Li, V. Popov, L. Santelj, A. Chen, M. Shapkin, R. Pestotnik, and M. T. Prim
Subjects: Research program, Higher education, business.industry, media_common.quotation_subject, General Physics and Astronomy, Library science, 7. Clean energy, 01 natural sciences, Chinese academy of sciences, Excellence, 0103 physical sciences, Natural science, Christian ministry, 010306 general physics, business, China, Research center, media_common
Abstract: We acknowledge support from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan, the Japan Society for the Promotion of Science (JSPS), and the Tau-Lepton Physics Research Center of Nagoya University; the Australian Research Council including Grants No. DP180102629, No. DP170102389, No. DP170102204, No. DP150103061, No. FT130100303; Austrian Science Fund (FWF); the National Natural Science Foundation of China under Contracts No. 11435013, No. 11475187, No. 11521505, No. 11575017, No. 11675166, No. 11705209; Key Research Program of Frontier Sciences, Chinese Academy of Sciences (CAS), Grant No. QYZDJ-SSWSLH011; the CAS Center for Excellence in Particle Physics (CCEPP); the Shanghai Pujiang Program under Grant No. 18PJ1401000; the Ministry of Education, Youth and Sports of the Czech Republic under Contract No. LTT17020; the Carl Zeiss Foundation, the Deutsche Forschungsgemeinschaft, the Excellence Cluster Universe, and the VolkswagenStiftung; the Department of Science and Technology of India; the Istituto Nazionale di Fisica Nucleare of Italy; National Research Foundation (NRF) of Korea Grants No. 2016R1D1A1B01010135, No. 2016R1D1A1B02012900, No. 2018R1A2B3003643, No. 2018R1A6A1A06024970, No. 2018R1D1A1B07047294, No. 2019K1A3A7A09033840, No. 2019R1I1A3A01058933; Radiation Science Research Institute, Foreign Large-size Research Facility Application Supporting project, the Global Science Experimental Data Hub Center of the Korea Institute of Science and Technology Information, and KREONET/GLORIAD the Polish Ministry of Science and Higher Education and the National Science Center; the Ministry of Science and Higher Education of the Russian Federation, Agreement No. 14.W03.31.0026; University of Tabuk research Grants No. S-1440-0321, No. S-0256-1438, and No. S-0280-1439 (Saudi Arabia); the Slovenian Research Agency; Ikerbasque, Basque Foundation for Science, Spain; the Swiss National Science Foundation; the Ministry of Education and the Ministry of Science and Technology of Taiwan; and the U.S. Department of Energy and the National Science Foundation.
Published: 2021
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28. Immunogenicity and safety of a quadrivalent meningococcal tetanus toxoid-conjugate vaccine administered concomitantly with other paediatric vaccines in toddlers: a phase III randomised study

Author: J. Ojeda, José Luis Arredondo-García, Kriengsak Limkittikul, Danaya Chansinghakul, K. H. Kim, Emilia Jordanov, J. Park, Matthew Bonaparte, W. Jantarabenjakul, O. Perminova, Mandeep S. Dhingra, Siham B’Chir, C. W. Bae, David Neveu, L. Namazova-Baranova, and I. A.R. Kobashi
Subjects: Male, Epidemiology, paediatric vaccines, Meningococcal Vaccines, Neisseria meningitidis, Antibodies, Viral, Serogroup, Measles, Rubella, complex mixtures, Coadministration, Pneumococcal conjugate vaccine, Chickenpox Vaccine, Pneumococcal Vaccines, Immunogenicity, Vaccine, Conjugate vaccine, medicine, Humans, Hepatitis B Vaccines, Vaccines, Combined, toddlers, Diphtheria-Tetanus-Pertussis Vaccine, Haemophilus Vaccines, Original Paper, Tetanus, business.industry, Immunogenicity, Diphtheria, Toxoid, Infant, MenACYW-TT, medicine.disease, Antibodies, Bacterial, Meningococcal Infections, Poliovirus Vaccine, Inactivated, Infectious Diseases, Immunology, Female, Safety, business, Measles-Mumps-Rubella Vaccine, medicine.drug
Abstract: Invasive meningococcal disease has high morbidity and mortality, with infants and young children among those at greatest risk. This phase III, open-label, randomised study in toddlers aged 12–23 months evaluated the immunogenicity and safety of meningococcal tetanus toxoid-conjugate vaccine (MenACYW-TT), a tetanus toxoid conjugated vaccine against meningococcal serogroups A, C, W and Y, when coadministered with paediatric vaccines (measles, mumps and rubella [MMR]; varicella [V]; 6-in-1 combination vaccine against diphtheria, tetanus, pertussis, polio, hepatitis B and Haemophilus influenzae type b [DTaP-IPV-HepB-Hib] and pneumococcal conjugate vaccine [PCV13])(NCT03205371). Immunogenicity to each meningococcal serogroup was assessed by serum bactericidal antibody assay using human complement (hSBA). Vaccine safety profiles were described up to 30 days post-vaccination. A total of 1183 participants were enrolled. The proportion with seroprotection (hSBA ≥1:8) to each meningococcal serogroup at Day 30 was comparable between the MenACYW-TT and MenACYW-TT + MMR + V groups (≥92 and ≥96%, respectively), between the MenACYW-TT and MenACYW-TT + DTaP-IPV-HepB-Hib groups (≥90% for both) and between the MenACYW-TT and MenACYW-TT + PCV13 groups (≥91 and ≥84%, respectively). The safety profiles of MenACYW-TT, and MMR + V, DTaP-IPV-HepB-Hib, and PCV13, with or without MenACYW-TT, were generally comparable. Coadministration of MenACYW-TT with paediatric vaccines in toddlers had no clinically relevant effect on the immunogenicity and safety of any of the vaccines.
Published: 2021

29. Capecitabine plus temozolomide in patients with grade 3 unresectable or metastatic gastroenteropancreatic neuroendocrine neoplasms with Ki-67 index55%: single-arm phase II study

Author: Baek-Yeol Ryoo, K.-P. Kim, Seung-Mo Hong, Hyehyun Jeong, Cheol-In Yoo, Jong-Hyeon Jeong, Ji Hoon Shin, Jin-Sook Ryu, and Yong Il Kim
Subjects: Cancer Research, medicine.medical_specialty, Nausea, Anemia, medicine.medical_treatment, Phases of clinical research, Gastroenterology, Capecitabine, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Clinical endpoint, Temozolomide, Humans, Adverse effect, Chemotherapy, business.industry, capecitabine, medicine.disease, Neuroendocrine Tumors, Ki-67 Antigen, Oncology, Original Article, medicine.symptom, business, MGMT, neuroendocrine tumor, medicine.drug
Abstract: Background Grade 3 neuroendocrine neoplasms (NENs) of gastroenteropancreatic (GEP) origin with Ki-67 indices, Highlights • Patients with grade 3 neuroendocrine neoplasms with a Ki-67 index
Published: 2021

30. Thermal and optical performance of cryogenically cooled laser diode bars mounted on pin-finned microcoolers

Author: Avram Bar-Cohen, K. J. Kim, and Bongtae Han
Subjects: Materials science, Physics and Astronomy (miscellaneous), Laser diode, business.industry, Bar (music), Thermal resistance, General Engineering, General Physics and Astronomy, Optical power, 01 natural sciences, Fin (extended surface), law.invention, 010309 optics, Operating temperature, law, 0103 physical sciences, Thermal, Comparison study, Optoelectronics, 010306 general physics, business
Abstract: This study investigates the thermal performance of cryogenic micro-pin fin coolers for high-power laser diode (LD) bars. An open-loop liquid nitrogen cooling system, used to operate LD bars at cryogenic temperatures, is developed and characterized. The comparison study demonstrates that the total thermal resistance value of the micro-pin fin cooler, ranging from 0.03 to 0.04 °C/W, is only 1/3 of that of the micro-gap cooler and, thus, contributes significantly to reducing the LD operating temperature and enhancing its efficiency. In this study, the peak optical power of 68.8 W was observed at an LD bar package base temperature of − 100 °C, providing a 20% increase relative to the optical power of 57.3 W for a nominal operating condition with an LD bar package base temperature of 41 °C. This result clearly illustrates the enhancement in optical performance made possible by cryogenic cooling with a pin fin microcooler.
Published: 2021
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31. Reduced Interaction of Aggregated α-Synuclein and VAMP2 by Environmental Enrichment Alleviates Hyperactivity and Anxiety in a Model of Parkinson's Disease

Author: Sung Rae Cho, K. H. Kim, Soonil Pyo, Soohyun Wi, and Jung Hwa Seo
Subjects: 0301 basic medicine, medicine.medical_specialty, Parkinson's disease, lcsh:QH426-470, Tyrosine 3-Monooxygenase, Vesicle-Associated Membrane Protein 2, nucleus accumbens, animal diseases, alpha-synuclein, Mice, Transgenic, Nucleus accumbens, Anxiety, Neuroprotection, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, Genetics, medicine, Animals, Humans, heterocyclic compounds, Cognitive decline, Genetics (clinical), Alpha-synuclein, Environmental enrichment, Tyrosine hydroxylase, business.industry, Parkinson Disease, medicine.disease, Anxiety Disorders, nervous system diseases, lcsh:Genetics, Disease Models, Animal, 030104 developmental biology, Endocrinology, chemistry, nervous system, Synaptic plasticity, Parkinson’s disease, environmental enrichment, business, 030217 neurology & neurosurgery, Locomotion
Abstract: Parkinson’s disease (PD) is a prevalent motor disease caused by the accumulation of mutated α-synuclein (α-Syn), however, its early stages are also characterized by non-motor symptoms, such as olfactory loss, cognitive decline, depression, and anxiety. The therapeutic effects of environmental enrichment (EE) on motor recovery have been reported, but its effects on non-motor symptoms remain unclear. Herein, we reveal the beneficial effects of EE on PD-related non-motor symptoms and changes in synaptic plasticity in the nucleus accumbens. To investigate its therapeutic effects in the early phase of PD, we randomly assigned eight-month-old mice overexpressing human A53T (hA53T) α-Syn to either the EE or standard condition groups for two months. Next, we performed behavioral tests and biochemical and histological analyses at 10 months of age. EE significantly alleviated locomotor hyperactivity and anxiety during the early stages of PD. It normalized the levels of tyrosine hydroxylase, phosphorylated and oligomeric α-Syn, and soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex-forming proteins, including synaptosomal-associated protein, 25 kDa, syntaxin1, and vesicle-associated membrane protein 2 (VAMP2). Moreover, the interactions between VAMP2 and pSer129 α-Syn were markedly reduced following EE. The restoration of synaptic vesicle transportation status may underlie the neuroprotective effects of EE in hA53T α-Syn mice.
Published: 2020

32. Usefulness of diastolic dysfunction score in predicting long-term prognosis of acute myocardial infarction patients with preserved ejection fraction

Author: Jong Chun Park, K H Kim, Hyukjin Park, H Y Kim, Jin-Hyoung Cho, SungA Bae, and H J Yoon
Subjects: medicine.medical_specialty, Ejection fraction, business.industry, Internal medicine, medicine, Cardiology, Diastole, cardiovascular diseases, Myocardial infarction, Cardiology and Cardiovascular Medicine, medicine.disease, business, Term (time)
Abstract: Background To investigate the usefulness of left ventricular diastolic dysfunction (LVDD) score in the prediction of future major cardiovascular events (MACEs) in acute myocardial infarction (AMI) patients with preserved ejection fraction (EF). Methods Among 2,539 AMI patients from January 2012 to December 2015, a total of 1,374 patients with preserved EF and no atrial fibrillation were enrolled and were followed up for 3 years. Four parameters which were used for the categorization of DD in the current 2016 recommendation of American Society of Echocardiography (ASE) (septal e' 14, tricuspid regurgitation velocity >2.8m/s, and LAD >40mm) were used for DD scoring. The integer score was assigned to each parameter as 1 point. The development of MACEs including death, recurrent MI, any revascularization, or hospitalization due to heart failure (HHF) was evaluated. Results Study subjects were divided into 5 groups by the current 2016 ASE criteria; LVDD score 0 (n=354), score 1 (n=496), score 2 (n=333), score 3 (n=139), and score 4 (n=52). During 3 years of clinical follow up, MACEs were developed in 271 patients; 142 death, 74 recurrent MI, 99 revascularization, and 32 HHF. MACEs were significantly increased as LVDD scores were increased; MACEs in LVDD score 0 (n=43, 12.1%), score 1 (n=73, 14.7%), score 2 (n=73, 21.9%), score 3 (n=51, 36.7%), and score 4 (n=31, 59.6%), (ptrend Conclusion The present study demonstrated that MACEs were significantly increased as LVDD scores were increased in AMI patients with preserved EF. Therefore, it is suggested that this novel scoring system by using the current 2016 ASE criteria for diastolic function evaluation may provide comprehensive risk assessment and thus would be useful in predicting upcoming CV events in AMI patients with preserved EF. MACE free survival according to the LVDD Funding Acknowledgement Type of funding source: None
Published: 2020
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33. Characteristics of silicon nitride deposited by very high frequency (162 MHz)-plasma enhanced atomic layer deposition using bis(diethylamino)silane

Author: K H Kim, Albert R. Ellingboe, Ki Seok Kim, J Y Byun, Y J Ji, Hyun Woo Tak, and Geun Young Yeom
Subjects: Materials science, Silicon, chemistry.chemical_element, Bioengineering, 02 engineering and technology, Nitride, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Atomic layer deposition, General Materials Science, Capacitively coupled plasma, Electrical and Electronic Engineering, business.industry, Mechanical Engineering, General Chemistry, Semiconductor device, Plasma, 021001 nanoscience & nanotechnology, Silane, 0104 chemical sciences, chemistry, Silicon nitride, Mechanics of Materials, Optoelectronics, 0210 nano-technology, business
Abstract: Silicon nitrides, deposited by capacitively coupled plasma (CCP)-type plasma enhanced atomic layer deposition (PEALD), are generally applied to today’s nanoscale semiconductor devices, and are currently being investigated in terms of their potential applications in the context of flexible displays, etc. During the PEALD process, 13.56 MHz rf power is generally employed for the generation of reactive gas plasma. In this study, the effects of a higher plasma generation frequency of 162 MHz on both plasma and silicon nitride film characteristics are investigated for the purpose of silicon nitride PEALD, using bis(diethylamino)silane (BDEAS) as the silicon precursor, and N2 plasma as the reactant gas. The PEALD silicon nitride film deposited using the 162 MHz CCP exhibited improved film characteristics, such as reduced surface roughness, a lower carbon percentage, a higher N/Si ratio, a lower wet etch rate in a diluted HF solution, lower leakage current, and higher electric breakdown field, and more uniform step coverage of the silicon nitride film deposited in a high aspect ratio trench, as compared to silicon nitride PEALD using 13.56 MHz CCP. These improved PEALD silicon nitride film characteristics are believed to be related to the higher ion density, higher reactive gas dissociation, and lower ion bombardment energy to the substrate observed in N2 plasma with a 162 MHz CCP.
Published: 2020

34. Reduced Interaction of VAMP2 and Aggregated α-synuclein by Environmental Enrichment Alleviates Hyperactivity and Anxiety in a Model of Parkinson’s Disease

Author: Jung Hwa Seo, Soonil Pyo, Soohyun Wi, K. H. Kim, and Sung Rae Cho
Subjects: medicine.medical_specialty, Environmental enrichment, Endocrinology, Parkinson's disease, VAMP2, business.industry, Internal medicine, Medicine, Anxiety, α synuclein, medicine.symptom, business, medicine.disease
Abstract: BackgroundAlthough Parkinson’s disease (PD) is one of the prevalent motor diseases caused by the accumulation of mutated α-Synuclein (α-Syn), it is characterized by non-motor symptoms such as olfactory loss, cognitive decline, depression and anxiety in the early stage of the disease. Environmental enrichment (EE) provides a complex environment comprising physical, cognitive, and social stimuli that improve synaptic plasticity and behavioral functions. The therapeutic effects of EE on behavioral recovery of motor function in a mouse model of PD pathology have been reported. However, the effects of EE on non-motor symptoms in human A53T α-Syn overexpressing transgenic (hA53T α-Syn) mice have yet to be determined. In this study, we revealed the beneficial effect of EE on changes in synaptic plasticity in the striatum and nucleus accumbens (NAc) during the initial phase of PD.MethodTo investigate therapeutic effects of EE in abnormalities during the early phase of PD, we randomly assigned eight-month-old hA53T α-Syn mice to either EE (PD-EE) or standard conditions (PD-SC) for two months. Next, we performed behavioral tests, biochemical and histological analysis at 10 months of age.ResultsEE significantly alleviated locomotor hyperactivity and anxiety in the early stage of PD. EE normalized the level of tyrosine hydroxylase (TH), phosphorylated and oligomeric forms of α-Syn (pSer129 α-Syn), and SNARE complex-forming proteins including SNAP-25, Syntaxin1 and VAMP2. Moreover, the close link between VAMP2 and pSer129 α-Syn was significantly reduced after exposure to EE.ConclusionsOur results showed that EE attenuates aversive mood state on the early stage of PD mouse model. These results were parallel with the reduced expression of pathological α-Syn and the increased expression of neurotransmitter transporter proteins in EE. Interestingly, the interaction between pSer129 α-Syn and VAMP2 also decreased in EE. The restoration of synaptic vesicle transportation status may be responsible for the neuroprotective effects of EE in hA53T α-Syn mice.
Published: 2020
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35. Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia

Author: Gleb Haynatzki, George P. Casale, Matthew Fuglestad, Julian K S Kim, Holly DeSpiegelaere, Gregory Willcockson, Constance J. Mietus, Petros Karvelis, Panagiotis Koutakis, Christina Shields, Hernan Hernandez, Nicholas Lambert, Timothy J Lackner, and Iraklis I. Pipinos
Subjects: Pathology, medicine.medical_specialty, αSMA+ pericytes, basement membrane thickening, lcsh:Medicine, 030204 cardiovascular system & hematology, Article, Masson's trichrome stain, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, medicine, Myocyte, microvascular pathology, Pathological, 030304 developmental biology, Basement membrane, 0303 health sciences, business.industry, fibrosis, lcsh:R, General Medicine, Critical limb ischemia, medicine.disease, medicine.anatomical_structure, Pericyte, medicine.symptom, Claudication, business
Abstract: Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50&ndash, 150 &mu, m) remodeling, and collagenous investment of terminal micro-vessels (diameter &le, 15 &micro, m) in the calf muscle of patients with Peripheral Artery Disease (PAD). In this study, we evaluate the hypothesis that the vascular pathology associated with the legs of PAD patients encompasses pathologic changes to the smallest micro-vessels in calf muscle. Biopsies were collected from the calf muscle of control subjects and patients with Fontaine Stage II and Stage IV PAD. Slide specimens were evaluated by Quantitative Multi-Spectral and Fluorescence Microscopy. Inter-myofiber collagen, stained with Masson Trichrome (MT), was increased in Stage II patients, and more substantially in Stage IV patients in association with collagenous thickening of terminal micro-vessel walls. Evaluation of the Basement Membrane (BM) of these vessels reveals increased thickness in Stage II patients, and increased thickness, diameter, and Collagen I deposition in Stage IV patients. Coverage of these micro-vessels with pericytes, key contributors to fibrosis and BM remodeling, was increased in Stage II patients, and was greatest in Stage IV patients. Vascular pathology of the legs of PAD patients extends beyond atherosclerotic main inflow arteries and affects the entire vascular tree&mdash, including the smallest micro-vessels.
Published: 2020

36. Biochemical Markers for Alzheimer Disease as Reflection of the Neuropathology in Cerebrospinal Fluid

Author: H. M. Wisniewski, Inge Grundke-Iqbal, Pankaj D. Mehta, K. Iqbal, K. S. Kim, and C. Bancher
Subjects: Pathology, medicine.medical_specialty, Cerebrospinal fluid, business.industry, Reflection (physics), Medicine, Neuropathology, Alzheimer's disease, business, medicine.disease, Biochemical markers
Published: 2020
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37. Development and Validation of Risk Prediction Model on Novel Clinical Sepsis Phenotype for Personalized Management and Precise Care for Sepsis

Author: S.-W. Lee, K.-K. Kim, D.K. Yon, H.E. Lee, D. Kim, J. Park, H.Y. Yu, E.Y. Jeon, J.H. Lee, Y.J. Lee, J. Heo, C.O. Song, and S.J. Moon
Subjects: Sepsis, medicine.medical_specialty, business.industry, medicine, medicine.disease, business, Intensive care medicine, Phenotype
Published: 2020
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38. A Comparative Study of Classification Methods Using Data with Label Noise

Author: Arlene K. H. Kim and Kwon So Young
Subjects: Noise, Discriminant, Computer science, business.industry, Classification methods, Pattern recognition, Artificial intelligence, business
Published: 2018
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39. Association between melanoma and renal-cell carcinoma for sequential diagnoses: A single-center retrospective study

Author: Carol J. Etzel, Patrick Hwu, K. B. Kim, Sapna Pradyuman Patel, Kevin B. Kim, Hyunjin Ryu, Mei Liu, Jinhyun Kim, Wen-Jen Hwu, Dae Won Kim, and Tong Han Chung
Subjects: Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Epidemiology, medicine.medical_treatment, urologic and male genital diseases, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Internal medicine, medicine, Carcinoma, Humans, Medical history, 030212 general & internal medicine, Carcinoma, Renal Cell, Melanoma, neoplasms, Aged, Retrospective Studies, business.industry, Incidence, Incidence (epidemiology), Cancer, Neoplasms, Second Primary, Retrospective cohort study, Middle Aged, medicine.disease, Kidney Neoplasms, female genital diseases and pregnancy complications, Radiation therapy, 030220 oncology & carcinogenesis, Female, business
Abstract: Background: Melanoma and renal-cell carcinoma (RCC) are known to be immunological neoplasms. Previous studies have shown increased risks in patients with melanoma of developing RCC and in those with RCC of developing melanoma. However, data regarding immunocompromised status in these patients are lacking. Methods: We conducted a retrospective review of patients who had a diagnosis of melanoma and/or RCC. Using summary statistics, we calculated total person-years at risk for developing melanoma among patients with RCC and for developing RCC among patients with melanoma, and compared the results with the SEER data. We also assessed medical history related to immune status and the use of immunosuppressive drugs. Results: Among 13,879 patients with melanoma and 7597 patients with RCC, 89 had diagnoses of both melanoma and RCC (0.6% and 1.2% of melanoma and RCC patients, respectively): eight were diagnosed with both cancers concurrently, 54 were diagnosed with melanoma first, and 27 were diagnosed with RCC first. Standardized incidence ratios (SIRs) were 2.87 (95%CI 2.16–3.74) for developing RCC among the melanoma patients and 2.31 (95%CI 1.52–3.37) for developing melanoma among the RCC patients, compared to age-, sex-, race-, and calendar-specific adjusted incidence rates of each cancer in the SEER registry. None of the 81 patients with sequential diagnoses had a history of immunocompromised disease, nor did they receive chronic immunosuppressive drugs. Only two received chemotherapy and/or radiotherapy. Conclusion: We demonstrated a strong association between the diagnoses of melanoma and RCC. These increased risks could not be attributed to either immune status or previous antineoplastic treatment.
Published: 2018
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40. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry

Author: Jitendra PS. Sawhney, Veerappa A. Kothiwale, Vikas Bisne, Rajashekhar Durgaprasad, Praveen Jadhav, Manoj Chopda, Velam Vanajakshamma, Ramdhan Meena, Govindan Vijayaraghavan, Kamaldeep Chawla, Jagan Allu, Karen S. Pieper, A. John Camm, Ajay K. Kakkar, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Lorenzo G. Mantovani, Frank Misselwitz, Alexander G.G. Turpie, Martin van Eickels, Freek W.A. Verheugt, Gloria Kayani, Keith A.A. Fox, Bernard J. Gersh, Hector Lucas Luciardi, Harry Gibbs, Marianne Brodmann, Frank Cools, Antonio Carlos Pereira Barretto, Stuart J. Connolly, Alex Spyropoulos, John Eikelboom, Ramon Corbalan, Dayi Hu, Petr Jansky, Jørn Dalsgaard Nielsen, Hany Ragy, Pekka Raatikainen, Jean-Yves Le Heuzey, Harald Darius, Matyas Keltai, Sanjay Kakkar, Jitendra Pal Singh Sawhney, Giancarlo Agnelli, Giuseppe Ambrosio, Yukihiro Koretsune, Carlos Jerjes Sánchez Díaz, Hugo Ten Cate, Dan Atar, Janina Stepinska, Elizaveta Panchenko, Toon Wei Lim, Barry Jacobson, Seil Oh, Xavier Viñolas, Marten Rosenqvist, Jan Steffel, Pantep Angchaisuksiri, Ali Oto, Alex Parkhomenko, Wael Al Mahmeed, David Fitzmaurice, D.Y. Hu, K.N. Chen, Y.S. Zhao, H.Q. Zhang, J.Z. Chen, S.P. Cao, D.W. Wang, Y.J. Yang, W.H. Li, Y.H. Yin, G.Z. Tao, P. Yang, Y.M. Chen, S.H. He, Ying Wang, Yong Wang, G.S. Fu, X. Li, T.G. Wu, X.S. Cheng, X.W. Yan, R.P. Zhao, M.S. Chen, L.G. Xiong, P. Chen, Y. Jiao, Y. Guo, L. Xue, F.Z. Wang, H. Li, Z.M. Yang, C.L. Bai, J. Chen, J.Y. Chen, X. Chen, S. Feng, Q.H. Fu, X.J. Gao, W.N. Guo, R.H. He, X.A. He, X.S. Hu, X.F. Huang, B. Li, J. Li, L. Li, Y.H. Li, T.T. Liu, W.L. Liu, Y.Y. Liu, Z.C. Lu, X.L. Luo, T.Y. Ma, J.Q. Peng, X. Sheng, X.J. Shi, Y.H. Sun, G. Tian, K. Wang, L. Wang, R.N. Wu, Q. Xie, R.Y. Xu, J.S. Yang, L.L. Yang, Q. Yang, Y. Ye, H.Y. Yu, J.H. Yu, T. Yu, H. Zhai, Q. Zhan, G.S. Zhang, Q. Zhang, R. Zhang, Y. Zhang, W.Y. Zheng, B. Zhou, Z.H. Zhou, X.Y. Zhu, S. Kakkar, J.P.S. Sawhney, P. Jadhav, R. Durgaprasad, A.G. Ravi Shankar, R.K. Rajput, K. Bhargava, R. Sarma, A. Srinivas, D. Roy, U.M. Nagamalesh, M. Chopda, R. Kishore, G. Kulkarni, P. Chandwani, R.A. Pothiwala, M. Padinhare Purayil, S. Shah, K. Chawla, V.A. Kothiwale, B. Raghuraman, G. Vijayaraghavan, V.M. Vijan, G. Bantwal, V. Bisne, A. Khan, J.B. Gupta, S. Kumar, D. Jain, S. Abraham, D. Adak, A. Barai, H. Begum, P. Bhattacharjee, M. Dargude, D. Davies, B. Deshpande, P. Dhakrao, V. Dhyani, S. Duhan, M. Earath, A. Ganatra, S. Giradkar, V. Jain, R. Karthikeyan, L. Kasala, S. Kaur, S. Krishnappa, A. Lawande, B. Lokesh, N. Madarkar, R. Meena, P. More, D. Naik, K. Prashanth, M. Rao, N.M. Rao, N. Sadhu, D. Shah, M. Sharma, P. Shiva, S. Singhal, S. Suresh, V. Vanajakshamma, S.G. Panse, Y. Koretsune, S. Kanamori, K. Yamamoto, K. Kumagai, Y. Katsuda, K. Sadamatsu, F. Toyota, Y. Mizuno, I. Misumi, H. Noguchi, S. Ando, T. Suetsugu, M. Minamoto, Hiroshi Oda, K. Shiraishi, S. Adachi, K. Chiba, H. Norita, M. Tsuruta, T. Koyanagi, H. Ando, T. Higashi, K. Okada, S. Azakami, S. Komaki, K. Kumeda, T. Murayama, J. Matsumura, Y. Oba, R. Sonoda, K. Goto, K. Minoda, Y. Haraguchi, H. Suefuji, H. Miyagi, H. Kato, Tadashi Nakamura, Tsugihiro Nakamura, H. Nandate, R. Zaitsu, Yoshihisa Fujiura, A. Yoshimura, H. Numata, J. Ogawa, H. Tatematsu, Y. Kamogawa, K. Murakami, Y. Wakasa, M. Yamasawa, H. Maekawa, S. Abe, H. Kihara, S. Tsunoda, Katsumi Saito, Kazuyuki Saito, T. Fudo, K. Obunai, H. Tachibana, I. Oba, T. Kuwahata, S. Higa, M. Gushiken, T. Eto, H. Yoshida, D. Ikeda, Yoshitake Fujiura, M. Ishizawa, M. Nakatsuka, K. Murata, C. Ogurusu, M. Shimoyama, M. Akutsu, I. Takamura, F. Hoshino, N. Yokota, T. Iwao, K. Tsuchida, M. Takeuchi, Y. Hatori, Y. Kitami, Yoichi Nakamura, R. Oyama, M. Ageta, Hiroyuki Oda, Y. Go, K. Mishima, T. Unoki, S. Morii, Yuhei Shiga, H. Sumi, T. Nagatomo, K. Sanno, K. Fujisawa, Y. Atsuchi, T. Nagoshi, T. Seto, T. Tabuchi, M. Kameko, K. Nii, K. Oshiro, H. Takezawa, S. Nagano, N. Miyamoto, M. Iwaki, Yuichiro Nakamura, M. Fujii, M. Okawa, Masahiko Abe, Masatake Abe, Mitsunori Abe, T. Saito, T. Mito, K. Nagao, J. Minami, T. Mita, I. Sakuma, T. Taguchi, S. Marusaki, H. Doi, M. Tanaka, T. Fujito, M. Matsuta, T. Kusumoto, S. Kakinoki, K. Ashida, N. Yoshizawa, J. Agata, O. Arasaki, M. Manita, M. Ikemura, S. Fukuoka, H. Murakami, S. Matsukawa, Y. Hata, T. Taniguchi, T. Ko, H. Kubo, M. Imamaki, M. Akiyama, M. Inagaki, H. Odakura, T. Ueda, Y. Katsube, A. Nakata, H. Watanabe, M. Techigawara, M. Igarashi, K. Taga, T. Kimura, S. Tomimoto, M. Shibuya, M. Nakano, K. Ito, T. Seo, S. Hiramitsu, H. Hosokawa, M. Hoshiai, M. Hibino, K. Miyagawa, Hajime Horie, N. Sugishita, Yukio Shiga, A. Soma, K. Neya, Tetsuro Yoshida, Tomoki Yoshida, M. Mizuguchi, M. Ishiguro, T. Minagawa, M. Wada, H. Mukawa, F. Okuda, S. Nagasaka, Y. Abe, Sen Adachi, Susumu Adachi, T. Adachi, K. Akahane, T. Amano, K. Aoki, T. Aoyama, H. Arai, S. Arima, T. Arino, H. Asano, T. Asano, J. Azuma, T. Baba, T. Betsuyaku, H. Chibana, H. Date, J. Doiuchi, Y. Emura, M. Endo, Y. Fujii, R. Fujiki, A. Fujisawa, Y. Fujisawa, T. Fukuda, T. Fukui, N. Furukawa, T. Furukawa, W. Furumoto, T. Goto, M. Hamaoka, N. Hanazono, K. Hasegawa, T. Hatsuno, Y. Hayashi, K. Higuchi, K. Hirasawa, H. Hirayama, M. Hirose, S. Hirota, M. Honda, Hideki Horie, T. Ido, O. Iiji, H. Ikeda, K. Ikeda, K. Ikeoka, M. Imaizumi, H. Inaba, T. Inoue, F. Iseki, A. Ishihara, N. Ishioka, N. Ito, T. Iwase, H. Kakuda, J. Kamata, H. Kanai, H. Kanda, M. Kaneko, H. Kano, T. Kasai, T. Kato, Y. Kato, Y. Kawada, K. Kawai, K. Kawakami, S. Kawakami, T. Kawamoto, S. Kawano, J. Kim, T. Kira, H. Kitazawa, H. Kitazumi, T. Kito, T. Kobayashi, T. Koeda, J. Kojima, H. Komatsu, I. Komatsu, Y. Koshibu, T. Kotani, T. Kozuka, Y. Kumai, T. Kumazaki, I. Maeda, K. Maeda, Y. Maruyama, S. Matsui, K. Matsushita, Y. Matsuura, K. Mineoi, H. Mitsuhashi, N. Miura, S. Miyaguchi, S. Miyajima, H. Miyamoto, A. Miyashita, S. Miyata, I. Mizuguchi, A. Mizuno, T. Mori, O. Moriai, K. Morishita, O. Murai, Sho Nagai, Shunichi Nagai, E. Nagata, H. Nagata, A. Nakagomi, S. Nakahara, M. Nakamura, R. Nakamura, N. Nakanishi, T. Nakayama, R. Nakazato, T. Nanke, J. Nariyama, Y. Niijima, H. Niinuma, Y. Nishida, Y. Nishihata, K. Nishino, H. Nishioka, K. Nishizawa, I. Niwa, K. Nomura, S. Nomura, M. Nozoe, T. Ogawa, N. Ohara, M. Okada, K. Okamoto, H. Okita, M. Okuyama, H. Ono, T. Ono, Y. Onuki Pearce, S. Oriso, A. Ota, E. Otaki, Y. Saito, H. Sakai, N. Sakamoto, Y. Sakamoto, Y. Samejima, Y. Sasagawa, H. Sasaguri, A. Sasaki, T. Sasaki, Kazuki Sato, Kiyoharu Sato, M. Sawano, S. Seki, Y. Sekine, Y. Seta, K. Sezaki, N. Shibata, Y. Shiina, H. Shimono, Y. Shimoyama, T. Shindo, H. Shinohara, R. Shinohe, T. Shinozuka, T. Shirai, T. Shiraiwa, Y. Shozawa, T. Suga, C. Sugimoto, Kazuo Suzuki, Keita Suzuki, Shu Suzuki, Shunji Suzuki, Susumu Suzuki, Y. Suzuki, M. Tada, A. Taguchi, T. Takagi, Y. Takagi, K. Takahashi, S. Takahashi, H. Takai, C. Takanaka, S. Take, H. Takeda, K. Takei, K. Takenaka, T. Tana, G. Tanabe, K. Taya, H. Teragawa, S. Tohyo, S. Toru, Y. Tsuchiya, T. Tsuji, K. Tsuzaki, H. Uchiyama, O. Ueda, Y. Ueyama, N. Wakaki, T. Wakiyama, T. Washizuka, M. Watanabe, T. Yamada, T. Yamagishi, H. Yamaguchi, Kenichi Yamamoto, Kentaro Yamamoto, Kunihiko Yamamoto, T. Yamamoto, M. Yamaura, M. Yamazoe, K. Yasui, Y. Yokoyama, K. Yoshida, T.W. Lim, C.K. Ching, C.G. Foo, J.H. Chow, D.D. Chen, F.R. Jaufeerally, Y.M. Lee, G. Lim, W.T. Lim, S. Thng, S.Y. Yap, C. Yeo, S. Oh, H.N. Pak, J.-B. Kim, J.H. Kim, S.-W. Jang, D.H. Kim, D.R. Ryu, S.W. Park, D.-K. Kim, D.J. Choi, Y.S. Oh, M.-C. Cho, S.-H. Kim, H.-K. Jeon, D.-G. Shin, J.S. Park, H.K. Park, S.-J. Han, J.H. Sung, J.-G. Cho, G.-B. Nam, Y.K. On, H.E. Lim, J.J. Kwak, T.-J. Cha, T.J. Hong, S.H. Park, J.H. Yoon, N.-H. Kim, K.-S. Kim, B.C. Jung, G.-S. Hwang, C.-J. Kim, D.B. Kim, J.J. Ahn, H.J. An, H. Bae, A.L. Baek, W.J. Chi, E.A. Choi, E.H. Choi, H.K. Choi, H.S. Choi, S. Han, E.S. Heo, K.O. Her, S.W. Hwang, E.M. Jang, H.-S. Jang, S. Jang, H.-G. Jeon, S.R. Jeon, Y.R. Jeon, H.K. Jeong, I.-A. Jung, Hyeon Jeong Kim, Hyun Ju Kim, Ji Seon Kim, Jung Sook Kim, J.A. Kim, K.T. Kim, M.S. Kim, Sang Hee Kim, Sang Hyun Kim, Y.-I. Kim, C.S. Lee, E.H. Lee, G.H. Lee, H.Y. Lee, H.-Y. Lee, K.H. Lee, K.R. Lee, M.S. Lee, M.-Y. Lee, R.W. Lee, S.E. Lee, S.H. Lee, S. Lee, W.Y. Lee, I.K. Noh, A.R. Park, B.R. Park, H.N. Park, J.H. Park, M. Park, Y. Park, S.-Y. Seo, J. Shim, J.H. Sim, Y.M. Sohn, W.S. Son, Y.S. Son, H.J. Song, H.K. Wi, J.J. Woo, S. Ye, K.H. Yim, K.M. Yoo, E.J. Yoon, S.Y. Yun, P. Angchaisuksiri, S. Chawanadelert, P. Mongkolwongroj, K. Kanokphatcharakun, S. Cheewatanakornkul, T. Laksomya, S. Pattanaprichakul, T. Chantrarat, S. Rungaramsin, S. Silaruks, W. Wongcharoen, K. Siriwattana, K. Likittanasombat, P. Katekangplu, W. Boonyapisit, D. Cholsaringkarl, B. Chatlaong, P. Chattranukulchai, Y. Santanakorn, P. Hutayanon, P. Khunrong, T. Bunyapipat, S. Jai-Aue, P. Kaewsuwanna, P. Bamungpong, S. Gunaparn, S. Hongsuppinyo, R. Inphontan, R. Khattaroek, K. Khunkong, U. Kitmapawanont, C. Kongsin, B. Naratreekoon, S. Ninwaranon, J. Phangyota, A. Phrommintikul, P. Phunpinyosak, K. Pongmorakot, S. Poomiphol, N. Pornnimitthum, S. Pumprueg, S. Ratchasikaew, K. Sanit, K. Sawanyawisuth, B. Silaruks, R. Sirichai, A. Sriwichian, W. Suebjaksing, P. Sukklad, T. Suttana, A. Tangsirira, O. Thangpet, W. Tiyanon, Y. Vorasettakarnkij, T. Wisaratapong, W. Wongtheptien, A. Wutthimanop, S. Yawila, A. Oto, A. Altun, I. Ozdogru, K. Ozdemir, O. Yilmaz, A. Aydinlar, M.B. Yilmaz, E. Yeter, Z. Ongen, M. Cayli, H. Pekdemir, M. Ozdemir, M. Sucu, T. Sayin, M. Demir, H. 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Subjects: Registrie, Male, Time Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, 030204 cardiovascular system & hematology, Electrocardiography, 0302 clinical medicine, Risk Factors, Anticoagulant therapy, Arrhythmia, Atrial fibrillation, GARFIELD-AF, Aged, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Incidence, India, Prevalence, Prognosis, Prospective Studies, Survival Rate, Thromboembolism, Registries, Risk Assessment, Medicine, 030212 general & internal medicine, Prospective cohort study, Incidence (epidemiology), cardiovascular system, medicine.symptom, Cardiology and Cardiovascular Medicine, Risk assessment, Human, medicine.medical_specialty, Time Factor, RD1-811, Prognosi, Follow-Up Studie, 03 medical and health sciences, Internal medicine, Diseases of the circulatory (Cardiovascular) system, cardiovascular diseases, Risk factor, Survival rate, Fibrillation, business.industry, Risk Factor, ta3121, medicine.disease, Clinical trial, Prospective Studie, RC666-701, Surgery, Clinical and Preventive Cardiology, business
Abstract: Background: The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. Methods and results: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012–2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P
Published: 2018
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41. CFD Approach to Wagner Number Estimation for a Current Distribution Uniformity in a Rotating Cylinder Hull Cell

Author: K R. Kim
Subjects: Physics, Current distribution, business.industry, Electrochemistry, Hull cell, Cylinder, Mechanics, Computational fluid dynamics, business
Published: 2018
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42. Juvenile myoclonic epilepsy: neurophysiological aspects

Author: D. V. Dmitrenko, O. S. Shilkina, K. T. Kim, and N. A. Shnaider
Subjects: 0301 basic medicine, medicine.medical_specialty, diagnosis, review, Primary care, Focal discharges, Electroencephalography, Audiology, juvenile myoclonic epilepsy, 03 medical and health sciences, 0302 clinical medicine, medicine, RC346-429, medicine.diagnostic_test, business.industry, Neurophysiology, medicine.disease, Psychiatry and Mental health, Clinical Psychology, 030104 developmental biology, Russian federation, Neurology. Diseases of the nervous system, Neurology (clinical), neurophysiology, Juvenile myoclonic epilepsy, business, electroencephalography, 030217 neurology & neurosurgery
Abstract: The review presents an update on the electroencephalographic characteristics and neurophysiology of juvenile myoclonic epilepsy (JME) in Russia and foreign countries.Materials and methods.The authors have performed a literary search for the full-text publications on JME electroencephalography and neurophysiology worldwide and in the Russian Federation, which are available in Russian and foreign databases.Results and discussion. Analysis of the literature suggests that JME patients have some electroencephalographic pattern features that include the atypical morphology of spike-and-slow-wave complexes, as well as amplitude asymmetry, focal discharges, focal onset of paroxysms, focal paroxysmal shift, and generalized paroxysmal fast rhythm.The analysis of the literature also indicates that primary care neurologists, clinical neurophysiologists, and epileptologists should be informed about the electroencephalographic characteristics of JME to timely diagnose the disease and to rule out the use of inadequate therapy.
Published: 2018
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43. EphA3 maintains radioresistance in head and neck cancers through epithelial mesenchymal transition

Author: Won Hyeok Lee, Sang Yoon Kim, Song Hee Kim, Hyoung Uk Je, Hyo Won Chang, Seong Who Kim, K.-P. Kim, Myung Woul Han, Jong Cheol Lee, and Young Min Kim
Subjects: Male, 0301 basic medicine, Epithelial-Mesenchymal Transition, medicine.medical_treatment, Transplantation, Heterologous, Mice, Nude, Radiation Tolerance, Metastasis, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, Radioresistance, medicine, Animals, Humans, Epithelial–mesenchymal transition, Radiosensitivity, RNA, Small Interfering, business.industry, Receptor, EphA3, Head and neck cancer, Erythropoietin-producing hepatocellular (Eph) receptor, Receptor Protein-Tyrosine Kinases, Cell Biology, medicine.disease, Radiation therapy, 030104 developmental biology, Gamma Rays, Head and Neck Neoplasms, Cell culture, 030220 oncology & carcinogenesis, Cancer research, RNA Interference, Neoplasm Recurrence, Local, business
Abstract: Radiotherapy is a well-established therapeutic modality used in the treatment of many cancers. However, radioresistance remains a serious obstacle to successful treatment. Radioresistance can cause local recurrence and distant metastases in some patients after radiation treatment. Thus, many studies have attempted to identify effective radiosensitizers. Eph receptor functions contribute to tumor development, modulating cell-cell adhesion, invasion, neo-angiogenesis, tumor growth and metastasis. However, the role of EphA3 in radioresistance remains unclear. In the current study, we established a stable radioresistant head and neck cancer cell line (AMC HN3R cell line) and found that EphA3 was expressed predominantly in the radioresistant head and neck cancer cell line through DNA microarray, real time PCR and Western blotting. Additionally, we found that EphA3 was overexpressed in recurrent laryngeal cancer specimens after radiation therapy. EphA3 mediated the tumor invasiveness and migration in radioresistant head and neck cancer cell lines and epithelial mesenchymal transition- related protein expression. Inhibition of EphA3 enhanced radiosensitivity in the AMC HN 3R cell line in vitro and in vivo study. In conclusion, our results suggest that EphA3 is overexpressed in radioresistant head and neck cancer and plays a crucial role in the development of radioresistance in head and neck cancers by regulating the epithelial mesenchymal transition pathway.
Published: 2018
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44. Incarceration history, social network composition, and substance use among homeless youth in Los Angeles

Author: Hsin-Yi Hsiao, B. K. Elizabeth Kim, Eric Rice, Qianwei Zhao, and Wen Li
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Substance-Related Disorders, Medicine (miscellaneous), Article, Injection drug use, Social Networking, Heroin, Homeless Youth, Young Adult, 03 medical and health sciences, Homeless youths, Surveys and Questionnaires, medicine, Humans, 0501 psychology and cognitive sciences, Psychiatry, High rate, 030505 public health, Social network, biology, business.industry, 05 social sciences, Stressor, General Medicine, biology.organism_classification, Los Angeles, Psychiatry and Mental health, Clinical Psychology, Female, Crime, Cannabis, Substance use, 0305 other medical science, business, Psychology, 050104 developmental & child psychology, medicine.drug
Abstract: BACKGROUND: Homeless youth in the United States have high rates of substance use. Existing research has identified social network composition and street-associated stressors as contributing factors. Incarceration is a highly prevalent stressor for homeless youth. Its effect on youth’s social network composition and substance use, however, has been neglected. AIMS: This study investigated the direct and indirect associations between incarceration history and substance use (through social networks) among homeless youth in Los Angeles, California. METHODS: A sample of 1,047 homeless youths were recruited between 2011 and 2013. Computerized self-administrated surveys and social network interviews were conducted to collect youth’s sociodemographic characteristics, incarceration history, social network composition, and substance use. Bootstrapping was used to identify the direct and indirect associations between youth’s incarceration history and substance use. RESULTS: Incarceration history was positively associated with youth’s cannabis, methamphetamine, and injection drug use. The percentage of cannabis-using peers partially mediated the associations between incarceration history and youth’s cannabis, cocaine, and heroin use. The percentage of methamphetamine-using peers partially mediated the associations between incarceration history and youth’s methamphetamine, cocaine, and injection drug use. The percentage of heroin-using peers partially mediated the association between incarceration history and youth’s heroin use. Moreover, the percentage of peers who inject drugs partially mediated the associations between incarceration history and youth’s methamphetamine, heroin, and injection drug use. DISCUSSION: Incarceration history should be taken to a more central place in future research and practice with homeless youth in the United States.
Published: 2018
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45. Epidural Fluid Collection After Percutaneous Endoscopic Lumbar Discectomy

Author: K. Hwan Kim, Hyeon Seon Park, Sang-Ho Lee, Amy M. Kwon, Wei-Chiang Liu, Gun Choi, and Jeeyoung Park
Subjects: Adult, Epidural Space, Male, medicine.medical_specialty, Disc herniation, Percutaneous, Lumbar discectomy, medicine.medical_treatment, Intervertebral Disc Degeneration, 030218 nuclear medicine & medical imaging, Lesion, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Epidural hematoma, Image Processing, Computer-Assisted, medicine, Humans, Diskectomy, Percutaneous, Saline, Aged, Retrospective Studies, Cerebrospinal Fluid Leak, Cerebrospinal fluid leak, medicine.diagnostic_test, business.industry, Incidence, Magnetic resonance imaging, Middle Aged, Hematoma, Epidural, Spinal, medicine.disease, Magnetic Resonance Imaging, Surgery, Drainage, Female, Neurology (clinical), medicine.symptom, business, Intervertebral Disc Displacement, 030217 neurology & neurosurgery
Abstract: Objective The frequency and extent of epidural fluid collection after percutaneous endoscopic lumbar discectomy (PELD) have not been previously described. The purpose of this study was to evaluate the significance of epidural fluid collection after PELD. Methods From March 2008 to November 2015, immediate postoperative magnetic resonance imaging (MRI) of 464 consecutive patients, comprising 284 men and 180 women, were obtained after PELD. The mean age of the patients at the time of admission was 43.1 years (range, 18–81 years). We also performed 24-hour follow-up MRIs after PELD in 35 patients to evaluate the morphologic changes on epidural fluid collection and to identify whether the collection was due to saline accumulation or cerebrospinal fluid leak. Results The level of disc herniation was at L4–5, L5–S1, L3–4, and L2–3 in 245 (52.8%), 173 (37.3%), 37 (8.0%), and 9 (1.9%) patients, respectively. Of 464 patients, 418 (90.1%) had abnormal epidural fluid collection, 404 (87.1%) patients had ventral epidural fluid collection, 393 (84.7%) patients had dorsal epidural fluid collection, and 10 patients had epidural hematoma as per immediate postoperative MRI. According to the 24-hour follow-up MRI findings, 30 patients had epidural fluid collection; the epidural fluid collection in 28 patients (93.3%) resolved with time, and a minimal amount of fluid remained in 2 patients, but the lesion size decreased compared with that on the previous day. Conclusions Epidural fluid collection usually occurs after percutaneous endoscopic discectomy, which is mainly due to saline accumulation and typically resolves with time, without treatment or complications.
Published: 2018
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46. Advantages of Digital Radiography in Improving the Efficiency of Radiology Departments

Author: S. I. Udakova, K. A. Kim, N. N. Vetsheva, and Sergey Morozov
Subjects: medicine.medical_specialty, Engineering, business.industry, medicine, Medical physics, business, Digital radiography
Published: 2018
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47. CO2 Emissions by Agricultural Machines in South Korea

Author: C S Shin and K U Kim
Subjects: 010504 meteorology & atmospheric sciences, Agricultural machinery, business.industry, Fossil fuel, Global warming, General Engineering, Climate change, 04 agricultural and veterinary sciences, Combustion, 01 natural sciences, Agriculture, Environmental protection, 040103 agronomy & agriculture, Fuel efficiency, 0401 agriculture, forestry, and fisheries, Environmental science, Electricity, business, 0105 earth and related environmental sciences
Abstract: The burning of fossil fuels and the resulting CO2 emissions are related to climate change and global warming. In order to help meet international goals of preventing irreversible climate change, South Korea must reduce its gross CO2 emission level from its 2015 level of 680 Mt. Knowing current sources of CO2 productions is essential for accomplishing this reduction. This study calculated the level of CO2 emissions by agricultural tractors, heaters, and dryers which are accounted for consuming 88.6% of the tax-free fuels allocated for agricultural use in South Korea. After the amount of fuel and electricity consumed by each machine was determined, CO2 emissions from each were estimated using the combustion equations. The total annual amount of CO2 emissions produced by these agricultural machines was estimated to be 4,334.2 kt which is less than 1% of the gross CO2 emissions in South Korea in 2015. Keywords: Agricultural dryer, Agricultural heater, Agricultural tractor, CO2 emissions.
Published: 2018
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48. Anthropometric Changes in Spaceflight

Author: K. Han Kim, Karen S. Young, and Sudhakar Rajulu
Subjects: medicine.medical_specialty, Waist, Anthropometric data, business.industry, Space suit, Human Factors and Ergonomics, Anthropometry, Spaceflight, Circumference, law.invention, Behavioral Neuroscience, Physical medicine and rehabilitation, law, medicine, business, Applied Psychology
Abstract: Objective This study aims to identify the change in anthropometric measurements during spaceflight due to microgravity exposure. Background Comprehensive and accurate anthropometric measurements are crucial to assess body shape and size changes in microgravity. However, only limited anthropometric data have been available from the astronauts in spaceflight. Methods A new photogrammetry-based technique in combination with a tape-measure method was used for anthropometric measurements from nine crewmembers on the International Space Station. Measurements included circumference and height for body segments (chest, waist, bicep, thigh, calf). The time-dependent variations were also assessed across pre-, in-, and postflight conditions. Results Stature showed a biphasic change with up to 3% increase at the early flight phase, followed by a steady phase during the remaining flight. Postflight measurements returned to a similar level of the preflight. Other linear measurements, including acromion height, showed similar trends. The chest, hip, thigh, and calf circumferences show overall decrease during the flight up to 11%, then returned close to the preflight measurement at postflight. Conclusion The measurements from this study provide critical information for the spacesuit and hardware design. The ground-based assessments for spacesuit fit needs to be revalidated and adjusted for in-flight extravehicular activities from this data. Application These data can be useful for space suit design as well as habitat, vehicle, and additional microgravity activities such as exercise, where the body shape changes can affect fit, performance, and human factors of the overall design.
Published: 2021
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49. 1048P Baseline and post-treatment biomarkers of resistance to anti-PD-1 (aPD1) therapy in acral and mucosal melanoma

Author: I. Shui, X.Q. Liu, Y. Sun, Razvan Cristescu, Andrea L. Webber, Jennifer H. Yearley, Qing Zhao, T. Choudhury, S.T. Kim, Clemens Krepler, J.W. Lee, and K-M. Kim
Subjects: medicine.medical_specialty, Oncology, business.industry, Internal medicine, Anti pd 1, Mucosal melanoma, medicine, Hematology, Post treatment, medicine.disease, business, Gastroenterology
Published: 2021
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50. 1690P A multicenter randomized phase II open label study to compare the safety and efficacy of direct oral anticoagulants versus subcutaneous dalteparin for cancer-associated venous thromboembolism in patients with advanced upper gastrointestinal, hepatobiliary and pancreatic cancer

Author: Cheol-In Yoo, Jae Hyun Kim, K-P. Kim, J.S. Kim, B-Y. Ryoo, K-W. Lee, Sook Ryun Park, J. Cheon, Hyewon Ryu, J.B. Lee, Jae Ho Jeong, Seyoung Seo, I.A. Kim, and M. Kang
Subjects: medicine.medical_specialty, business.industry, Cancer, Hematology, medicine.disease, Gastroenterology, Oncology, Open label study, Internal medicine, Pancreatic cancer, medicine, Upper gastrointestinal, In patient, business, Venous thromboembolism
Published: 2021
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