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Introduction Gerstmann–Sträussler–Scheinker disease P105L (GSS105) is a rare variant of GSS caused by a point mutation of the prion protein (PrP) gene at codon 105 (proline to leucine substitution). It is clinically characterized by spastic paraparesis and dementia and histopathologically defined by PrP‐plaques in the brain. This report describes a clinicopathological analysis of three autopsied kindred from a Japanese GSS105 family, plus a topological analysis of PrP, hyperphosphorylated tau (p‐tau), and beta‐amyloid (Aβ). Methods Using paraffin‐embedded sections, we applied histology and single‐ and multiple‐labeling immunohistochemistry for PrP, p‐tau, and Aβ to the three cases. Comparative semi‐quantitative analyses of tissue injuries and PrP‐plaques were also employed. Results Case 1 (45 years old (yo)) and Case 2 (56 yo) are sisters, and Case 3 (49 yo) is the son of Case 2. Case 1 and Case 2 presented with spastic paraparesis followed by dementia, whereas Case 3 presented, not with spastic paraparesis, but with psychiatric symptoms. In Case 1 and Case 2, the brain showed tissue injuries with many PrP‐plaques in the cerebral cortices, and the pyramidal tract showed myelin loss/pallor. In Case 3, the brain was least degenerated with a number of PrP‐plaques; however, the pyramidal tract remained intact. In addition, p‐tau was deposited in all cases, where p‐tau was present in or around PrP‐plaques. By double‐labeling immunohistochemistry, the colocalization of p‐tau with PrP‐plaques was confirmed. Moreover in Case 2, Aβ was deposited in the cerebral cortices. Interestingly, not only p‐tau but also Aβ was colocalized with PrP‐plaques. In all cases, both three repeat tau and four repeat tau were associated with PrP‐plaques. Conclusions The clinicopathological diversity of GSS105, which is possible even in the same family, was ascertained. Not only p‐tau but also Aβ could be induced by PrP (“secondary degeneration”), facilitating the kaleidoscopic symptoms of GSS.

The patient was born at 38 weeks gestation with body weight of 2700 g from non-consanguineous parents. She was the third child with two healthy brothers. At 2 months of age, she had afebrile seizures. She was admitted to hospital because of an epileptic state. Her chromosomal pattern was 46XX by G-band analysis. A deletion in the Miller-Dieker syndrome (MDS) region was confirmed by fluorescence in situ hybridization (FISH) for chromosomal testing. Brain CT/MRI revealed lissencephaly and dysgenesis of corpus callosum: the absence of rostrum and splenium (Fig. 1). Radiologically, no abnormalities were found in the body except the brain. At the age of 4 years, she was hospitalized at a nursing center. Profound mental and motor retardation, seizures and hypertonia were found. She suffered from repeated episodes of bronchitis/ pneumonia, depletion of carnitine, and chronic insufficiency of digestion. Gastrostomy was performed at 6 years of age owing to feeding problems. She died of pneumonia at 14 years of age.

症例は72歳，男性．嚥下障害から食道癌と診断され，手術を施行した．最終診断はbasaloid carcinoma，T1b（SM3），ly1，v1，N0，M0，StageIであった．術後4カ月で肝転移を認め，肝動注化学療法を開始し，術後12カ月でComplete Responseを得た．術後15カ月で腸閉塞を発症し，CTにて下腹部に腫瘤を認めたため緊急手術を施行した．Treitz靱帯より40cmほどの空腸に腫瘤を認め，上行結腸に浸潤していたため，腫瘤を含む空腸部分切除と右結腸切除を行った．腹膜播種は認めなかった．術後経過は良好であったが，肺転移・骨転移をきたし，食道癌術後40カ月で死亡した．食道癌の小腸転移は検索しえた限りでは本例が17例目であり，類基底細胞癌によるものは本症例が1例目である．非常に稀な症例を経験したので若干の文献的考察を加え報告する．

This report describes the clinical and pathologic findings of 21 patients with subacute necrotizing lymphadenitis (N.L.). Clinical features of all but 2 patients were as typically described in the literature; young age, enlargement of cervical or axillary lymph nodes, slight to moderate fever with poor response to antibiotics, and invariable spontaneous resolution. Two patients showed atypical clinical findings; remittent high fever with profound prostration in both patients, generalized lymphadenopathy in one, and being a Caucasian in the other. Systemic symptoms resolved gradually, and both patients are now doing well. One patient, however, underwent a staging laparotomy due to a misdiagnosis as unclassiflable lymphoma of the lymph node biopsy. Biopsies of the lymph nodes from all patients demonstrated the typical pathologic features of NL.; i.e., an intensive proliferation of activated lymphocytes mottled by necrotic foci in which polymorphonuclear leukocytes were characteristically absent. Bacteriologic and serologic studies were negative. We conclude that some patients with N.L. run a protracted course with remittent high fever before spontaneous resolution and that a correct pathologic diagnosis helps precluding unnecessary diagnostic or therapeutic measures on such patients.

穿刺吸引細胞診Pap. 染色標本を用いて, 浸潤性乳管癌通常型142例 (乳頭腺管癌23例, 充実腺管癌47例, 硬癌72例) の小型細胞癌例の頻度, 浸潤性小葉癌14例の特徴を分析した. 95%以上の細胞が小型細胞から成る通常型乳管癌例を142例中29例20.4%に認めた. 最も多いのは硬癌で72例中18例25-0%であった. 小型細胞癌例か否かの認識は, 組織標本との問に乖離がみられた.組織で淡明豊富な胞体をもつ細胞が小型核を有する場合, 細胞診では小型細胞癌例として認識される例を乳頭腺管癌, 充実腺管癌でみられた. 細胞診で小型細胞とされるのは核径に左右されることが明らかとなった. 小葉癌細胞の出現パターンをTYPE-IからTYPE-Vに分類した.組織型推定上, TYPE-II: 敷石状の疎な結合を示す立方状・多辺形細胞, TYPE-V: 索状配列が特に有用と考えられたが, それぞれ28.6%, 35.7%と低出現率であった.小型明瞭な核小体を含む, スリガラス状から細顆粒状クロマチンの細胞と, 出現パターンとの組み合わせが大切である.

This paper proposes a stock price prediction model, which extracts features from time series data, news, and comments on the news, for prediction of stock price and evaluates its performance. In this research, we do not take account of text contents of news and user comments, but just consider numerical features of news and communication dynamics appeared in comments on the Web as well as historical time series data. We model the stock price movements as a function of these input features and solve it as a regression problem in a Multiple Kernel Learning regression framework. Experimental results show that our proposed method consistently outperforms other baseline methods in terms of magnitude prediction measures such as MAE, MAPE and RMSE for three companies' stocks. They specifically show that the features other than stock prices themselves improved the performance.

全身性コクシジオイデス症患者の頸部穿刺細胞診標本に認めたC.immitisの球状体について報告した. 化膿性炎症像を示す背景に, 5～100μ のオレンジG, あるいはエオジン好性を示す各種成熟段階の球状体は二重壁構造を有し, 形態的に花粉と類似していた. 未熟な球状体の内部は無構造な多糖体物質で満たされ, 成熟したものは2～5μ の内生胞子で満たされていた. 球状体には免疫反応により生じるSplendore-Hoepllieffectを認めるものもあった.輸入真菌症に遭遇する機会が増えることが予想されるが, 本症例はC.immitisの形態的特徴を把握するうえで, 貴重な症例である.

Specimens of the extrahepatic biliary trees and wedge liver biopsies were studied in 11 cases of biliary atresia. The hepatic arteries at the porta hepatis were examined with ultrasound in five of the 11 cases. The basic histopathological features were found to be epithelial damage and an inflammatory, sclerosing change of both the intrahepatic and the extrahepatic biliary trees, combined with an arteriopathy manifesting as hyperplasia and hypertrophy of the hepatic arteries in all cases. Based on the results of ultrasonography and histological examination, this arteriopathy was thought to affect the arteries from the trunk of the common hepatic artery to its peripheral branches supplying the entire biliary tree. To determine whether these morphologically abnormal hepatic arteries are related to the pathogenesis of biliary atresia in association with abnormal blood flow and pressure requires further investigation.

子宮頸管ポリープは中年女性の子宮頸部にしぼしばみられる疾患で, その大部分が良性であり, 悪性像を呈することはきわめてまれである.われわれは子宮頸管ポリープに発生した上皮内癌の1例を経験したので報告する.症例は55歳, 主婦. 主訴は不正性器出血. 子宮頸部の擦過細胞診に異型細胞が出現し, 検査のため来院した. 子宮口より有茎ポリープの突出が認められ除去された. 組織学的に上皮内癌は子宮頸管ポリープに限局していることがわかり, その後に行われた切除子宮のどこにも癌は証明されなかった.

a Department of Pediatrics, Tokyo Kita Shakai Hoken Hospital, 4-17-56 Akabanedai, Kita-ku, Tokyo 115-0053, Japan b Department of Pediatrics, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan c Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2-6 Musashidai, Fuchu-shi, Tokyo 183-8526, Japan d Department of Pediatrics, Tokyo Metropolitan Fuchu Medical Center for the Disabled, 2-9-2 Musashidai, Fuchu-shi, Tokyo 183-8553, Japan e Department of Neuropathology, Saitama Medical College, 38 Morohongo, Moroyamamachi, Iruma-gun, Saitama 350-0495, Japan