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1. The May-Hegglin anomaly: a rare cause of a common complaint

Author: Priyanka Reddy, Revathi Kollipara, Jerome Loew, and Jamile M. Shammo
Subjects: 0301 basic medicine, Blood Platelets, medicine.medical_specialty, Myh9 gene, Hearing Loss, Sensorineural, Case Report, 030105 genetics & heredity, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, In patient, business.industry, Platelet Count, Large Platelets, General Medicine, medicine.disease, Dermatology, Thrombocytopenia, Easy Bleeding, Mutation, May–Hegglin anomaly, Female, Presentation (obstetrics), business, 030217 neurology & neurosurgery, Qualitative platelet disorder
Abstract: May-Hegglin anomaly is the presentation of a qualitative platelet disorder characterised by large platelets, thrombocytopenia and granulocyte inclusions as a result of mutations in the MYH9 gene. Though often overlooked given its rarity, it should be considered in patients who present with epistaxis, bruising, menorrhagia and easy bleeding as it can be mistaken for other diagnoses resulting in unnecessary treatments and tests. Our case study reports one presentation of this anomaly and can help broaden awareness of the presentation of this type of patient.
Published: 2023

2. What to Do When Corps Of Engineers Turns You Down

Author: Walsh, Michael and Loew, Gary
Subjects: United States. Army. Corps of Engineers, Real estate development, Environmental permits, Business, Petroleum, energy and mining industries
Abstract: 'Therefore, the Corps finds that the project, as currently proposed, cannot be permitted under Section 404 of the Clean Water Act.' These are words every federal environmental permit applicant dreads. [...]
Published: 2022

3. Unmasking a Privacy Concern: Potential Identification of Patients in an Immobilization Mask from 3-Dimensional Reconstructions of Simulation Computed Tomography

Author: Sharad Goyal, Murray H. Loew, Destie Provenzano, and Y.J. Rao
Subjects: medicine.medical_specialty, business.industry, Facial hair, Facial recognition system, Computer algorithm, Immobilization, Identification (information), Imaging, Three-Dimensional, medicine.anatomical_structure, Oncology, Privacy, Radiation oncology, medicine, Humans, Radiology, Nuclear Medicine and imaging, Radiology, Tomography, X-Ray Computed, Head and neck, Radiation treatment planning, business, Head, Algorithms, Neck, Radiation oncologist
Abstract: Previous studies have demonstrated that patients can be identified from 3-dimensional (3D) reconstructions of computed tomography (CT) or magnetic resonance imaging data of the brain or head and neck. This presents a privacy and security concern for scan data released to public data sets. It is unknown whether thermoplastic immobilization masks used for treatment planning in radiation therapy are sufficient to prevent facial recognition. Our study sought to evaluate whether patients with an immobilization mask could be identified on 3D reconstructions of scan data. Our study reconstructed 3D images from simulation CT (SIM-CT) scans of 35 patients and compared these to original patient photographs to test if the thermoplastic mask obfuscated facial features. Blind review from 4 facial recognition algorithms and a human (radiation oncologist) was evaluated for the ability to match 3D reconstructions of patients scans to patient images. The matching procedure was repeated against an expanded testing data set of the 35 patient photographs plus 13,233 facial photographs from the "Labeled Faces in the Wild" data set (13,268 photographs in total). Facial recognition algorithms were able to match a maximum of 83% (range, 60%-83%) of patients to the corresponding images. Radiation Oncologist blinded review correctly matched 80% of patients to the corresponding images. Ethnicity and facial hair were the most common reasons for patient mismatch. In the expanded testing data set, algorithms were also able to match a maximum of 83% (range, 57%-83%) of patients. The majority of patients were able to be identified through computer algorithm or human review even under a SIM-CT mask. These results suggest there is a potential privacy and security concern when SIM-CT data are released to publicly available data sets.
Published: 2022

4. Associations of Post-Acute COVID syndrome with physiological and clinical measures 10 months after hospitalization in patients of the first wave

Author: Anna Staudt, Thomas H. Loew, N. Lehnen, Rudolf A. Jörres, Thilo Hinterberger, and Stephan Budweiser
Subjects: Male, medicine.medical_specialty, Disease, Logistic regression, Article, Post-Acute COVID-19 Syndrome, Quality of life, Internal medicine, Internal Medicine, medicine, Humans, Depression (differential diagnoses), Aged, Post-Acute COVID Syndrome, HrQoL, Depression, business.industry, COVID-19, Middle Aged, Physical Functional Performance, medicine.disease, Comorbidity, Lung function, Hospitalization, Psychosocial Functioning, Somatization, Symptoms, Quality of Life, Etiology, Female, business, Psychosocial
Abstract: Background For a better understanding of the factors underlying the Post-Acute COVID Syndrome, we studied the relationship between symptoms and functional alterations in COVID-19 patients 10 months after hospitalization. Methods One-hundred-one patients hospitalized between March 1st and June 30th 2020 participated in a follow-up visit for an assessment of clinical history, comorbidities, lung function, physical capacity and symptoms, including the SGRQ for health-related quality of life, PHQ-9-D for depression, and SOMS-2 J for somatoform disorders. Data were analyzed by univariate comparisons and multiple logistic regression analyses. Results Median age was 60 years, 42% were female, 76% had at least one comorbidity, the median length of the hospital stay was 8 days, 19% had been on the ICU. The most prevalent symptoms included shortness of breath (49%), fatigue (49%) and cognitive impairment (39%). Signs of major depression (PHQ-9-D ≥ 10) occurred in 28%/2% (p
Published: 2022

5. Die Versorgungsrealität des kolorektalen Karzinoms im Bundesland Brandenburg

Author: Maik Sahm, Andreas Becker, Rainer Kube, René Mantke, Kristoph Jahnke, Andreas Loew, Marlis Günther, Stephan Gretschel, and Constanze Schneider
Subjects: Gynecology, medicine.medical_specialty, Transplant surgery, Cardiothoracic surgery, business.industry, medicine, Surgery, business
Abstract: Die Analyse der Versorgungsqualitat beim kolorektalen Karzinom ist ein wesentlicher Baustein fur deren Weiterentwicklung und basiert auf dem Vergleich der gesteckten Ziele mit der tatsachlichen Versorgungsqualitat. In dieser Publikation soll die Versorgungsrealitat im Bundesland Brandenburg in der gesamten Breite aller versorgenden Kliniken auf der Basis der Daten des Klinischen Krebsregisters dargestellt werden. Analysiert wurden die Anzahl der entnommenen und untersuchten Lymphknoten, die TME(totale mesorektale Exzision)-Qualitat, die R0(Residualtumor)-Resektionsrate und der Anteil der adjuvanten Therapie des Kolonkarzinoms im UICC(Union internationale contre le cancer)-Stadium III in Abhangigkeit von der Operationszahl der Krankenhauser bzw. deren Zertifizierung als Darmkrebszentrum nach Onkozert. Die Analysen zeigten bis auf den R‑Status keine Unterschiede in den vom Klinischen Krebsregister erfassten qualitativen Operationsdaten in Abhangigkeit vom Hospitalvolumen.
Published: 2021

6. Climate-Induced Tradeoffs in Planning and Operating Costs of a Regional Electricity System

Author: Nathalie Voisin, Edson Severnini, Aviva Loew, J. R. Yearsley, Francisco Ralston Fonseca, Michael T. Craig, Paulina Jaramillo, Yifan Cheng, Haibo Zhai, Mario Berges, and Bart Nijssen
Subjects: business.industry, Climate Change, Uncertainty, Electricity system, Climate change, General Chemistry, Environmental economics, Investment (macroeconomics), Electric power system, Electricity, Electricity grid, Environmental Chemistry, Power grid, Business, Energy economics
Abstract: Electricity grid planners design the system to supply electricity to end-users reliably and affordably. Climate change threatens both objectives through potentially compounding supply- and demand-side climate-induced impacts. Uncertainty surrounds each of these future potential impacts. Given long planning horizons, system planners must weigh investment costs against operational costs under this uncertainty. Here, we developed a comprehensive and coherent integrated modeling framework combining physically based models with cost-minimizing optimization models in the power system. We applied this modeling framework to analyze potential tradeoffs in planning and operating costs in the power grid due to climate change in the Southeast U.S. in 2050. We find that planning decisions that do not account for climate-induced impacts would result in a substantial increase in social costs associated with loss of load. These social costs are a result of under-investment in new capacity and capacity deratings of thermal generators when we included climate change impacts in the operation stage. These results highlight the importance of including climate change effects in the planning process.
Published: 2021

7. Aktuelle Entwicklungen der Diagnostik und Therapie des Peniskarzinoms: Update 2021

Author: M. Haccius, M. May, C. Haberl, S. Lebentrau, A. Loew, and A. Buchali
Subjects: Gynecology, medicine.medical_specialty, Oncology, business.industry, medicine, business
Abstract: Das Management von Patienten mit Peniskarzinom bleibt aufgrund seiner Seltenheit in den westlichen Industrienationen eine Herausforderung und ist zudem haufig nur durch Studien mit unzureichendem Evidenzgrad abgesichert. Anhand der deutschen S3-Leitlinie und erganzender aktueller Studien werden aktuelle Behandlungspfade zur stadiengerechten Diagnostik und Therapie des Peniskarzinoms dargestellt. Den entscheidenden Risikofaktor stellen humane Papillomaviren mit hohem Risiko (High-Risk-HPV) dar, die bei knapp 50 % aller Peniskarzinome nachweisbar sind. Diese Assoziation fuhrte zu einer Impfempfehlung durch die Standige Impfkommission (STIKO) fur alle Jungen im Alter von 9–14 Jahren. Patienten im lokalisierten Erkrankungsstadium konnen gemas der Infiltrationstiefe mit topischer Therapie, Lasertherapie, Strahlentherapie und/oder chirurgischer Therapie behandelt werden, wobei hier der chirurgische Grundsatz „so viel wie notig, so wenig wie moglich“ gilt. Peniskarzinome metastasieren fruhzeitig in die inguinalen Lymphknoten, sodass dem chirurgischen Lymphknotenstaging eine entscheidende prognostische Bedeutung zukommt. Fortgeschrittene Tumorstadien benotigen eine multimodale Therapie, deren optimale Sequenz der hierfur geeigneten Therapiepartner Gegenstand aktueller Studien ist. Fur das metastasierte Peniskarzinom stellen cisplatinbasierte Chemotherapien den Standard dar. Aufgrund der schlechten Ergebnisse und der hohen Toxizitat einer konventionellen Chemotherapie werden derzeit neue systemische Therapieansatze gepruft. Konsequente histologische Abklarung peniler Lasionen, leitlinienkonforme Abklarung der inguinalen Lymphknoten und multimodale Therapiekonzepte sind der Schlussel zum Erfolg in der Therapie des Peniskarzinoms.
Published: 2021

8. Deep Clustering for Improved Inter-Cluster Separability and Intra-Cluster Homogeneity with Cohesive Loss

Author: Byeonghak Kim, David K. Han, Murray H. Loew, and Hanseok Ko
Subjects: Artificial Intelligence, Hardware and Architecture, Computer science, business.industry, Homogeneity (statistics), Cluster (physics), Pattern recognition, Computer Vision and Pattern Recognition, Artificial intelligence, Electrical and Electronic Engineering, business, Cluster analysis, Software
Published: 2021

9. Correction of the CSA does not decrease the re-tear rate after SSP repair

Author: Sven Lichtenberg, Marc Schnetzke, Markus Loew, Christoph Lücke, Janis Storg, and Jennifer Engelke
Subjects: 030222 orthopedics, medicine.medical_specialty, medicine.diagnostic_test, Acromioplasty, business.industry, Magnetic resonance imaging, 030229 sport sciences, Normal values, Supraspinatus tendon, Surgery, 03 medical and health sciences, 0302 clinical medicine, Surgical reduction, Orthopedic surgery, medicine, Orthopedics and Sports Medicine, In patient, Constant score, business
Abstract: Background The re-tear rate after supraspinatus tendon (SSP) repair is high despite optimization of surgical techniques. The critical shoulder angle (CSA) > 35° has been identified as a risk for re-tear. Surgical reduction of the CSA performing additional lateral acromioplasty (ALAP) is intended to reduce the risk. Objective We aimed to evaluate the effect of ALAP on the re-tear rate in patients with a CSA > 35° after SSP repair. Patients and methods The study included 49 shoulders fulfilling predefined inclusion criteria. The patients were assigned to two groups; group I (25 SSP) was additionally treated with an ALAP. In group II (24 SSP) standard acromioplasty was performed during reconstruction. Magnetic resonance imaging and a clinical examination (Constant Score; CS) were performed 12 months after surgery. Results After 15 months group I showed a re-tear rate of 20%, a decreased CSA (mean 38.0° preoperatively vs. 34.5° postoperatively) and an increase in CS (mean 53.9 vs. 84.6). After 16 months group II showed a re-tear rate of 16.7%, no difference between pre- and postoperative CSA (37.8° vs. 37.6°), and an increase in CS (48.9 vs. 84.5). There was no difference between the groups in terms of re-tears and postoperative CS (p = 0.4557), but there was a significant difference in postoperative CSA (p 35° did not have a worse clinical outcome and no increased rate of re-tears compared with patients with a mechanically reduced CSA. Conclusion Additive lateral acromioplasty does not decrease the re-tear rate after arthroscopic SSP repair. However, ALAP significantly decreases the CSA to normal values.
Published: 2021

10. Visualizing the Occult: Nosferatu (1922)

Author: Katharina Loew
Subjects: medicine.medical_specialty, business.industry, medicine, Radiology, business, Occult
Abstract: Public enthusiasm for occult themes was rife in the decades around 1900 and many German filmmakers and intellectuals were occupied with esoteric concepts. Constitutive of occultist thought is a belief in secret realities beyond our perceptual abilities. The vampire tale Nosferatu does not advocate for specific doctrines, but many of the film’s idiosyncratic aspects, particularly the appearance, behaviour, and powers of the vampire, become intelligible in novel ways when examined from an occultist perspective. The film externalizes the vampire’s nature through cinematic devices and most notably special effects. The materialization of the intangible by means of technology constitutes an essentially techno-romantic project. In Nosferatu, it served to consolidate objectives of occultists and cinephiles for the purpose of film art.
Published: 2021

11. Supraspinatus tear—a mechanical outlet impingement lesion?

Author: Sven Lichtenberg, Marc Schnetzke, S. Sulzer, J. Engelke, and Markus Loew
Subjects: Orthodontics, 030222 orthopedics, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Arthroscopy, 030229 sport sciences, Lesion, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Radiological weapon, Impingement sign, Orthopedic surgery, medicine, Tears, Orthopedics and Sports Medicine, Surgery, In patient, Acromion, medicine.symptom, business
Abstract: Background The etiology of degenerative supraspinatus tendon (SSP) tear is still subject to discussion. Objectives Our objective was to correlate clinical, radiological, and intraoperative signs of mechanical outlet impingement in patients with degenerative SSP tears. Materials and methods This prospective study included 100 patients with degenerative SSP tears that required surgery. Preoperatively, clinical impingement signs and radiological parameters (critical shoulder angle [CSA], acromion type according to Bigliani, acromion index [AI]) were recorded. Intraoperatively, the extent of the rupture and grinding marks on the bottom of the acromion were assessed. Results Of the 100 patients, 59 had clinical impingement signs preoperatively; 90 patients had at least one positive radiological sign (CSA > 35°, AI > 0.67, acromion type II or III). In 23 patients a partial tear, in 55 patients a full thickness tear, and in 22 patients an additional infraspinatus tendon tear were found. In 10 cases no grinding marks at the bottom of the acromion during arthroscopy were found. In 75 cases moderate grinding marks and in 15 cases severe marks with bare bone at the bottom of the acromion were found. There was no statistically significant correlation between preoperative impingement signs and arthroscopic grinding marks (p = 0.83) or between clinical signs and radiological parameters (p = 0.44). There was no significant correlation between extent of the rupture, extent of grinding marks or radiological impingement parameters (p = 0.16; p = 0.26). Conclusion We could not verify a correlation between clinical and radiological impingement sign and arthroscopic impingement parameters. Based on our study, degenerative SSP tear cannot be characterized as the result of a mechanical outlet impingement.
Published: 2021

12. Traumatische vs. degenerative Rotatorenmanschettenläsion

Author: Marc Schnetzke, F. Porschke, and Markus Loew
Subjects: Gynecology, 030222 orthopedics, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, medicine, Orthopedics and Sports Medicine, 030229 sport sciences, business
Abstract: Fur die Unterscheidung zwischen degenerativen und traumatischen Rotatorenmanschettenlasionen (RML) sind Kenntnisse uber Anatomie und Biomechanik sowie der Atiologie mit aktuellem wissenschaftlichem Hintergrund unabdingbar. Ziel ist eine Aufstellung der Evidenz zur Unterscheidung traumatischer und degenerativer RML in Form von praktischen Entscheidungshilfen. Es erfolgte eine Auswertung der Literatur bezuglich traumatischer RML und deren Differenzierung zu degenerativen Schaden unter besonderer Berucksichtigung der Evidenz. Im Rahmen einer strukturierten Analyse sollten 4 Themenfelder unabhangig voneinander auf Indizien gepruft werden. Wahrend die Vorgeschichte und das Unfallereignis meistens nur schwache Indizien fur eine degenerative Veranderung vor dem Trauma aufweisen, konnen das klinische Verletzungsbild (mit zeitlichem Verlauf) und v. a. pathomorphologische Zeichen in der Magnetresonanztomographie (MRT) sowie intraoperativ und histologisch gewonnene Befunde als praktische Entscheidungshilfen dienen. Zur Begutachtung von RML mussen multimodale Faktoren unter Berucksichtigung ihrer wissenschaftlichen Belastbarkeit berucksichtigt werden.
Published: 2021

13. Surgical reconstruction of the anterolateral acromion with a tricortical iliac crest bone graft after extensive acromioplasty

Author: Sven Lichtenberg, Philip-C. Nolte, Markus Loew, Marc Schnetzke, and Anna-K. Tross
Subjects: 030222 orthopedics, medicine.medical_specialty, Shoulder surgery, business.industry, Acromioplasty, medicine.medical_treatment, Subacromial decompression, Iliac crest, Surgery, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Deltoid muscle, Orthopedic surgery, Medicine, Orthopedics and Sports Medicine, 030212 general & internal medicine, Acromion, Complication, business
Abstract: Subacromial decompression is one of the most frequently performed procedures in the setting of arthroscopic shoulder surgery and typically includes acromioplasty. However, the indication for acromioplasty remains a subject of debate. Possible complications involve deltoid muscle insufficiency due to an excessive removal of the anterior acromion. This case report is intended to draw attention to this particular complication and its management.
Published: 2021

14. Primary reverse shoulder replacement with a short stem: A systematic literature review

Author: Philip C. Nolte, Markus Loew, Thomas E. Woolson, Marc Schnetzke, Anna K. Tross, and Peter J. Millett
Subjects: Short-stem, Short-term follow-up, medicine.medical_specialty, RD1-811, business.industry, Shoulders, Radiography, medicine.medical_treatment, Aseptic stem loosening, Arthroplasty, Surgery, Systematic review, Reverse shoulder arthroplasty, Scapula, Radiological weapon, medicine, Bone adaptions, business, Complication, Range of motion, Cuff tear arthropathy
Abstract: Background Total shoulder arthroplasty implant designs have continued to evolve over the years. One recent change has been the shortening of the humeral component to preserve bone stock and to facilitate revision surgery. Despite promising clinical results, radiographic bone adaptions occur frequently in short-stem total shoulder arthroplasty, and limited data exist on short-stem reverse shoulder arthroplasty (RSA). The purpose of this systematic review was to provide an overview about the functional and radiographic outcomes after an uncemented short-stem RSA, as well as identify areas of clinical importance that are underreported in the current literature. Methods A systematic review of the literature was performed in accordance with the PRISMA guidelines using PubMed, Cochrane Central Register of Controlled Trials, and EMBASE. Clinical outcome studies reporting on short-stem RSA outcomes with evidence level I-IV were included. Demographics, clinical and radiological outcomes, as well as complications and revision data were systematically analyzed and described. Results Ten studies, published between 2014 and 2019, reporting on 555 shoulders with a mean follow-up of 32 months (range, 20-99.6 months) met the inclusion criteria. For all studies cuff tear arthropathy was the main indication for RSA (36%), followed by primary osteoarthritis (20%). Clinical outcome was reported in nine of ten studies, with range of motion improving in all studies. Six of the seven studies that used the Constant score (CS) demonstrated significant improvement (27.9 points to 69.3 points in weighted means). All studies reported on radiographic changes and bone adaptions. Among these, scapular notching was the most commonly observed (60 out of 327 cases, 18%) but without any described implication on clinical outcomes. No stem loosening was recorded at any final follow-up. A total of 63 complications (12.9%) were reported, with scapula fractures being the most commonly reported complication. Revision surgery was necessary in 24 cases (4.9%). Conclusion Good clinical results, comparable with long-stem RSAs, are reported at short-term follow-up for short-stem RSAs. Humeral bone adaptions occur frequently but aseptic stem loosening is not a matter of concern at short-term follow-up. An area of clinical importance that is under-reported is the relation between filling ratio and stem alignment in short-stem RSA.
Published: 2021

15. Current treatment concepts of calcifying tendinitis of the shoulder

Author: Markus Loew, Sven Lichtenberg, and Marc Schnetzke
Subjects: 030222 orthopedics, medicine.medical_specialty, Nonsteroidal, Exacerbation, business.industry, Treatment options, 030229 sport sciences, musculoskeletal system, Tendon, Surgery, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.anatomical_structure, chemistry, Orthopedic surgery, medicine, Calcifying tendinitis, Orthopedics and Sports Medicine, Rotator cuff, Presentation (obstetrics), business
Abstract: Calcifying tendinitis is a very common pathology in the shoulder region, which may be acute or chronic. The rotator cuff, particularly the supraspinatus tendon, is most frequently affected. The tendons of the rotator cuff undergo a natural cycle of destruction and regeneration. The development of calcifying tendinitis is caused by defective tendon repair. Typical is a chronic course with acute pain exacerbation, which leads to medical presentation. Treatment options range from conservative therapy including rest, physical therapy, nonsteroidal anti-inflammatory drugs, and shock wave therapy, to surgical therapy with arthroscopic removal of the calcific focus. This article discusses the current stage-dependent therapeutic concepts and provides a treatment recommendation.
Published: 2021

16. Efficacy of dimethyl fumarate treatment for moderate-to-severe plaque psoriasis: presentation extracts from the 29(th) EADV virtual congress, 29-31 October 2020

Author: Ina Hadshiew, Ignasi Pau-Charles, Pablo de la Cueva, Matthias Augustin, Ulrich Mrowietz, Meritxell Guilà, Andreu Schoenenberger, Mar Llamas-Velasco, Anna Ryzhkova, Sebastian Diemert, Astrid Kirsch, L. Salgado-Boquete, Christine Loew-Juettner, Francisco Javier Fernández-Soriano, Peter C.M. van de Kerkhof, Esteban Daudén, and José Manuel Carrascosa
Subjects: 0301 basic medicine, Moderate to severe, medicine.medical_specialty, Immunology, efficacy, BRIDGE, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Quality of life, Psoriasis Area and Severity Index, Psoriasis, medicine, Immunology and Allergy, skill, 030203 arthritis & rheumatology, Plaque psoriasis, dimethyl fumarate, Dimethyl fumarate, business.industry, psoriasis, medicine.disease, Dermatology, Safety profile, dimeskin 1, 030104 developmental biology, chemistry, Inflammatory diseases Radboud Institute for Health Sciences [Radboudumc 5], Body region, business
Abstract: Contains fulltext : 235283.pdf (Publisher’s version ) (Open Access) Background: The 29th EADV Virtual Congress took place between the 29th-31st of October 2020. On October 29th, there was a Session on systemic treatment in which Professors Ulrich Mrowietz and Mar Llamas-Velasco presented the latest research on the efficacy of dimethyl fumarate (DMF) treatment for moderate-to-severe plaque psoriasis (BRIDGE and DIMESKIN 1 studies, respectively). The accepted DMF abstract from Professor Matthias Augustin, on the SKILL study, is also presented here. Results: Data from either prospective interventional (BRIDGE) or non-interventional (DIMESKIN 1, SKILL) studies among patients with moderate-to-severe psoriasis showed that DMF provides a positive efficacy profile in all four body regions included in the Psoriasis Area and Severity Index assessment (head and neck, trunk, upper and lower extremities) and a particularly interesting profile (strong efficacy) in the head and neck region. These findings may be of special interest to patients with scalp psoriasis who have been using topical therapies for a long time. Patient-reported outcomes (quality of life, pruritus) also improved during the 24 weeks of DMF treatment. The safety profile of DMF was similar to the previously described with fumaric acid esters. Conclusions: In summary, these results confirm the favorable efficacy and safety profile of DMF in long-term treatment.
Published: 2021

17. A screen-printed three-electrode-type sticker device with an accurate liquid junction-type reference electrode

Author: Kaishi Miyazaki, Masayuki Itagaki, Noya Loew, Yoshinao Hoshi, Isao Shitanda, and Ryosuke Esaka
Subjects: Auxiliary electrode, Materials science, Working electrode, 020209 energy, Alloy, chemistry.chemical_element, 02 engineering and technology, engineering.material, 01 natural sciences, Reference electrode, Catalysis, 0202 electrical engineering, electronic engineering, information engineering, Materials Chemistry, Polarization (electrochemistry), business.industry, 010401 analytical chemistry, Metals and Alloys, General Chemistry, Copper, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Electrode, Ceramics and Composites, engineering, Optoelectronics, business
Abstract: We developed a novel sticker device that can convert any metal or alloy into the working electrode of a three-electrode system, enabling simple and accurate measurement. The sticker, containing a counter electrode and a stable and accurate liquid junction-type reference electrode, is attached to the metal or alloy; meanwhile the surface exposed from a hole in the device functions as the working electrode. This sticker device was fabricated by screen-printing. The polarization curve of the copper and tin-plated copper measured using the sticker device exhibited approximately the same behavior as that obtained for the conventional three-electrode system. The characteristics of various materials can be easily evaluated using this system by only dropping a small amount of solution.
Published: 2021

18. Use of Wise Device Technology to Measure Adherence to Hydroxyurea Therapy in Youth With Sickle Cell Disease

Author: Jane S. Hankins, Lisa M. Ingerski, Jerlym S. Porter, Hui Zhang, Megan Loew, Winfred C. Wang, and Yin Su
Subjects: Male, medicine.medical_specialty, Research use, Adolescent, Pilot Projects, Anemia, Sickle Cell, Disease, Health outcomes, Medication Adherence, 03 medical and health sciences, 0302 clinical medicine, Antisickling Agents, Internal medicine, medicine, Humans, Hydroxyurea, Longitudinal Studies, Child, Device failure, Monitoring, Physiologic, Young child, Pill count, business.industry, Infant, Newborn, Infant, Hematology, Device use, Prognosis, Medication possession ratio, Oncology, Child, Preschool, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Feasibility Studies, Female, business, Wireless Technology, Follow-Up Studies, 030215 immunology
Abstract: Despite broad support for hydroxyurea (HU) therapy, suboptimal adherence is reported for youth with sickle cell disease. Valid adherence measurement is crucial to understanding the relationship between medication behavior, disease response, and patient-centered health outcomes. The current pilot study examined the feasibility of the Wise electronic device for longitudinal HU adherence measurement in a sample of 36 youths prescribed HU. The study also explored the association between HU adherence, as measured by the Wise device, with other adherence measures (ie, family report, lab values, pill count, and medication possession ratio). A measure of family-reported acceptability was also completed. Overall, results supported the feasibility of the Wise device (rate of consent=82%, device use=75%, device failure=3%) for HU adherence measurement and most families rated their experience using their device positively (favorable responses ranged from 67% to 100%). Associations between HU adherence, as measured by the Wise device, and other adherence measures were not significant. Overall, the feasibility was supported. The Wise device allows longitudinal measurement of adherence with HU from initiation as a young child (ie, with liquid formulations) through adolescence and provides a novel means of adherence measurement for both clinical and research use.
Published: 2020

19. Volume IV The DUNE far detector single-phase technology

Author: L. Di Giulio, J. Martin-Albo, S. Ravat, W. Mu, D. Marfatia, T. Kosc, D. Autiero, Poonam Mehta, A. Borkum, N. McConkey, G. Karagiorgi, Robert Wilson, L. M. Cremaldi, Stephen P. Gent, T. Young, Julián Félix, D. MacFarland, Andrew Smith, M. Manrique Plata, J. Freestone, D. Rivera, B. Stillwell, Marco Verzocchi, A. Lambert, Orlando L. G. Peres, K. Gollwitzer, E. Kemp, G. Yang, I. Kreslo, F. Varanini, M. Chalifour, A. Holin, S. J. Patton, R. J. Nichol, Giovanni Bellettini, V. A. Kudryavtsev, M. Sorel, E. Church, S. Kasai, H. O. Back, A. Lister, S. Santana, C. Mariani, Carlos Escobar, J. C. Freeman, Kaushik De, M. J. Rodriguez Alonso, M. A. Acero, A. Christensen, G. S. Varner, S. Sacerdoti, D. Shooltz, Seodong Shin, M. Santos-Maldonado, T. Schaffer, Jeremy Wolcott, J. Vasel, J. A. Gonzalez-Cuevas, J. Franc, C. Mossey, Jonas Rademacker, G. P. Zeller, Joshua Barrow, John Marshall, Alessandro Thea, H. A. Tanaka, W. C. Louis, E. Hazen, Armin Karcher, D. Smargianaki, Christopher L. Marshall, M. Soderberg, A. C. Weber, Christopher J. Milne, E. Brianne, A. Aranda-Fernandez, J. Calcutt, K. Warburton, M. Nalbandyan, Dave Sankey, J. Asaadi, F. Diaz, E. Valencia, B. Kirby, A. Bross, K. Koehler, M. A. Uchida, Y. Bezawada, D. Warner, C. E. Thorn, Srubabati Goswami, Z. Williams, Gregory Iles, A. Friedland, K. M. Heeger, V. P. Luzio, G. C. Blazey, J. Barranco Monarca, Carl Grace, A. M. Gago, E. James, M. Newcomer, H. W. Sobel, Roberto Gutiérrez, C. Vignoli, R. Hatcher, M. Zhao, F. Cavalier, M. A. Hernandez Morquecho, N. Poonthottathil, Ara Ioannisian, W. Metcalf, T. Wongjirad, H. T. Rakotondramanana, D. Cherdack, M. A. Ramirez Delgado, R. Diurba, G. Christodoulou, S. Calvez, T. Durkin, H. Y. Wei, M. Muether, S. Roy, A. Caminata, A. Scarpelli, Christopher Brew, Pavel Snopok, Y. Rigaut, L. Escudero Sanchez, K. Kothekar, W. Flanagan, V. Papadimitriou, S. J. Brice, Nicolas Lurkin, M. V. Diwan, Andrew White, S. Berkman, H. Muramatsu, Z. Pavlovic, A. A. Machado, Christian Farnese, A. Mastbaum, Alfredo G. Cocco, G. Zhu, S. Centro, S. Henry, J. Rout, P. de Jong, H. Carranza, Milos Lokajicek, K. Nishimura, A. Delbart, N. J. C. Spooner, C. McGrew, E. Pantic, Mario Campanelli, David Cussans, B. T. Fleming, K. Negishi, F. Spagliardi, J. Nesbit, André Rubbia, Akitaka Ariga, Marvin L Marshak, F. Pietropaolo, F. D. M. Blaszczyk, T. Hasegawa, Kate Scholberg, O. Gogota, R. Poling, Simon Jones, A. Tonazzo, M. P. Andrews, R. Petti, S. Bertolucci, M. Bonesini, A. F. Moor, C. Barnes, A. S. Hesam, S. H. Kettell, M. Bongrand, M. R. While, D. J. Payne, C. Gotti, A. Chiriacescu, Paul Keener, Leigh H. Whitehead, James Stewart, A. Mazzacane, L. W. Koerner, T. Rehak, C. Andreopoulos, F. Terranova, Jaroslaw Pasternak, E. Raguzin, L. C. J. Rice, J. L. Bazo Alba, S. Li, J. Hartnell, M. Potekhin, N. Moggi, D. J. Summers, J. Berger, L. Cremonesi, Katsuya Yonehara, T. E. Coan, Claire Shepherd-Themistocleous, B. Radics, Karol Hennessy, S. Söldner-Rembold, C. S. Lin, L. Greenler, B. Guo, Frank Filthaut, R. B. Patterson, E. Pennacchio, E. Zhivun, C. Cuesta, T. Loew, G. Prior, D. Duchesneau, Lina Necib, S. Rescia, W. Gu, Andrés Castillo, N. Kazaryan, O. G. Miranda, C. Patrick, Robert Shrock, José W. F. Valle, J. Reichenbacher, D. A. Sanders, John F. Beacom, S. Tufanli, S. Ventura, Riccardo Papaleo, J. Zennamo, A. De Roeck, M. Calin, P. Ding, Alessandro Menegolli, B. V. K. S. Potukuchi, T. Le, T. Wachala, L. O. Arnold, J. R. Macier, A. M. Teklu, E. Blucher, L. Hertel, F. W. Sippach, S. Childress, T. Miao, P. Fernandez Menendez, J. Han, R. Gandrajula, C. Y. Chi, Marzio Nessi, Aldo Penzo, Ina Sarcevic, Kendall Mahn, Jorge Molina, F. Bonini, Eric W. Hoppe, M. Groh, Barry King, R. Mazza, Keith Rielage, Patrick Dunne, M. Mellinato, D. Lorca, R. Guenette, F. Bento Neves, L. Pickering, Manuel Alejandro Segura Delgado, J. J. Russell, H. R. Gallagher, J. Zuklin, Steven Gardiner, P. Madigan, D. Douglas, Daniel Gastler, S. Manly, P. Hamilton, L. Montaño Zetina, R. G. Van de Water, S. Dennis, M. Tenti, N. Dokania, Kim Siyeon, E. Fernandez-Martinez, P. P. Koller, D. Whittington, T. Li, M. C. Sanchez, S. Biagi, C. Sarasty, Juraj Bracinik, A. N. Khotjantsev, N. Tsverava, Yasaman Farzan, M. Tzanov, J. G. Boissevain, J. Smolik, Andrew Brandt, J. Hoff, D. A. Harris, C. Distefano, Ornella Palamara, H. S. Budd, Alastair Grant, A. K. Giri, Thorsten Lux, C. E. Lane, J. Marteau, Irakli Lomidze, E. Kearns, Zviad Tsamalaidze, L. S. Gomez Fajardo, H. da Motta, J. S. Real, Sukalyan Chattopadhyay, B. Viren, J. Mousseau, Ihn Sik Seong, C. M. Sutera, A. C. Ezeribe, F. Ferraro, Marco Adinolfi, Nikolaos Simos, A. Stuart, D. Brailsford, N. Solomey, Laura Manenti, L. V. Gomez Bermeo, Andrea Zani, Kristian Harder, Timothy M. Shaw, J. Hewes, Sandro Palestini, D. Braga, D. Garcia-Gamez, J. Stock, S. Bolognesi, D. Belver, Laura Paulucci, J. Ahmed, Narendra Sahu, Sandip Pakvasa, L. Pasqualini, D. Mladenov, M. Kordosky, S. Zucchelli, L. Stanco, M. Torti, B. Jargowsky, E. Smith, C. J. Solano Salinas, N.V. Mokhov, D. Vanegas Forero, C. Jesús-Valls, Andrew Blake, L. Jiang, F. Andrianala, W. Ketchum, Matthaeus Leitner, K. Fahey, Marco Pallavicini, Bindu A. Bambah, K. Francis, M. H. Shaevitz, N. Barros, I. Caro Terrazas, R. Itay, G. Sirri, H. Steiner, Laura Dominé, S. Lockwitz, G. Savage, N. Bostan, J. A. Nowak, A. Scarff, Konstantinos Manolopoulos, R. K. Plunkett, B. Morgan, A. Rafique, Cari L. Johnson, M. Parvu, L. Patrizii, James A. Anderson, L. Corwin, A. Hourlier, S. L. Mufson, S. Martynenko, V. J. Guarino, B. Carlus, D. Boyden, F. Marinho, David Delepine, J. Bremer, Paola Sala, P. Cotte, J.V. Dawson, G. Mandrioli, O. Goodwin, Jitendra Kumar, Ph. Lebrun, J. Soto-Oton, K. K. Guthikonda, Evgueni Goudzovski, Gabriella Carini, S. Gao, M. Dabrowski, Sudarshan Paramesvaran, G. Pessina, S. Davini, R. L. Talaga, Francesco Gonnella, A. Joglekar, G. Sinev, S. Gwon, A. Surdo, M. O. Wascko, R. Bajou, Pedro A. N. Machado, Massimo Rossella, G. S. Davies, I. De Bonis, K. S. McFarland, C. T. Macias, T. Alion, O. V. Mineev, M. Bishai, R. Northrop, Chao Zhang, R. Van Berg, L. Di Noto, Kam-Biu Luk, J. Chaves, J. Wang, K. Qi, W. E. Sondheim, Sergei Striganov, B. Paulos, Janice L. Thompson, M. Rai, P. N. Ratoff, T. Kutter, D. Totani, J. A. B. Coelho, F. Stocker, T. Gamble, J. J. Grudzinski, I. Gil-Botella, T. Yang, Wayne A. Barkhouse, C. E. Tull, H. Mendez, Z. Ghorbani-Moghaddam, Y.-J. Jwa, F. Cavanna, F. Kamiya, V. Basque, R. Sipos, V. Bellini, C. Alt, Sandhya Choubey, B. Abi, A. Mefodiev, V. A. Kostelecky, A. L. Renshaw, Giuseppe Benedetto Cerati, S. Balasubramanian, M. Biassoni, D. Pershey, J. Maricic, K. Lande, A. Muir, L.S. Rochester, A. Papanestis, A. Aurisano, F. Bay, R. Nandakumar, T. L. Usher, Bo Yu, A. V. Waldron, A. Filkins, Y. Cui, P. A. Rodrigues, Daijin Kim, G.D. Barr, Junwei Huang, V. De Romeri, H.E. Rogers, Andrea Dell'Acqua, A. Cervera Villanueva, Robert Svoboda, Yu. Onishchuk, T. Hamernik, A. P. Furmanski, M. Wetstein, P.T. Smith, G. Brunetti, Mariam Tórtola, Matthew L Strait, G. Barenboim, P. Guzowski, J. D. Eisch, N. Gallice, D. Newhart, A. J. Roeth, H. Berns, E. Granados, A. Weinstein, A. Falcone, D. Caratelli, L. Bellantoni, Wei Wu, J. Mills, A. Hackenburg, D. Caiulo, Chia-Chan Chang, Dave M Newbold, C. K. Jung, F. Krennrich, G. Testera, S. Rosauro-Alcaraz, A. Sitraka, L. Bagby, J. M. LoSecco, S. Tariq, C. Mauger, J. J. Back, J. Yu, R. Acciarri, B. Behera, P. Lasorak, Karol Lang, Irina Mocioiu, H. Schellman, Han Wang, Sergey A. Kulagin, A. Bashyal, Beatriz B. Siffert, C. N. Booth, L. Zambelli, M. T. Graham, A. Mann, Rakesh Kumar, Y. Xiao, Gregory J Pawloski, T. Prakash, Arsen Khvedelidze, A.S. Dyshkant, Paolo Carniti, C. Rubbia, M. Reggiani-Guzzo, M. M. Khabibullin, D. Wenman, S. C. Timm, R. Sharma, R. Saakyan, Marcelo M. Guzzo, P. Baesso, M. Pozzato, T. R. Junk, C. Morris, A. Cervelli, A. Heavey, Grzegorz Deptuch, M. Á. García-Peris, B. Bhuyan, M. Kabirnezhad, Pierre Baldi, M. Mooney, E. Tyley, A. Hahn, V. Susic, S. D. Reitzner, M. P. Decowski, V. Galymov, E. Chardonnet, B. R. Littlejohn, B. Ramson, B. Russell, M. Vagins, L. Fields, V. Zutshi, Sandeep Miryala, Enrique Calvo, V. Radeka, P. Debbins, J. Sinclair, B. Bilki, C. Touramanis, J. I. Crespo-Anadón, J. M. Paley, Antonio Ereditato, N. Yershov, C. J. Densham, D. W. Schmitz, A. Gallego-Ros, N. Buchanan, N. Mauri, A. Lawrence, K. Cho, S. Narita, X. Luo, A. Booth, D. A. Dwyer, S. Prince, J. Haiston, Jianbei Liu, T. J. Langford, E. Gamberini, Matheus Hostert, Dario Gnani, P. Vahle, G. A. Horton-Smith, A. Marchionni, I. K. Furic, John Matthews, K. Mason, M. Bhattacharjee, Randall P. Johnson, Amelia Maio, E. Motuk, C. Castromonte, Paolo Calafiura, Q. David, T. Miedema, S. Magill, Z. Ahmad, John Evans, Yi Chen, E. Ewart, S. Gollapinni, K. V. Tsang, J. Maneira, R.A. Rameika, A. de Gouvea, M. A. Vermeulen, R. M. Berner, J. J. De Vries, S. Shafaq, L. Da Silva Peres, A. McNab, G. Vasseur, A. Verdugo, C. Petta, Kenneth Long, H. S. Chen, K. Mavrokoridis, M. J. Dolinski, Yu. Kudenko, D. Gratieri, Alexandru Jipa, J. R. T. de Mello Neto, Olga Beltramello, J. T. Haigh, B. Gelli, Gregory J. Michna, A. M. Iliescu, Alex Reynolds, K. Biery, Yanchu Wang, V. Aushev, J. Zalesak, L. Simard, Ionel Lazanu, L. Pagani, J. Rodriguez Rondon, Alec Habig, M. Nebot-Guinot, R. Illingworth, G. Petrillo, J. S. Díaz, P. Novella, K. Grzelak, A. Gendotti, A. Himmel, M. Rajaoalisoa, P. Bour, L. Mualem, D. Pugnere, E. Niner, C. A. Moura, A. D. Marino, S. Bordoni, James Mueller, W. Fox, Jordan Ott, Niki Saoulidou, M. Oberling, E. Mazzucato, Silvia Pascoli, K. Herner, Hem Raj Sharma, M. Betancourt, T. Lord, L. Zazueta, Alexander Deisting, B. Rebel, Joleen Pater, David H. Adams, I. L. De Icaza Astiz, Stefan Antusch, M. Worcester, A. Higuera Pichardo, C. Kuruppu, Janet Conrad, Z. Parsa, Francesco Tortorici, L. Suter, J. Moon, P. E. L. Clarke, C. Palomares, Sofia Andringa, F. Jediny, J. Urheim, D. Montanari, Giorgio Riccobene, A. Rappoldi, J. Migenda, S. Matsuno, Y. Karyotakis, Jürgen Pozimski, Artur M. Ankowski, D. Edmunds, T. Safford, E. Tatar, Utku Kose, Z. Djurcic, D. Vargas, C. Wret, F. Sergiampietri, Rex Tayloe, F. Barao, I. Rakhno, Rukmani Mohanta, Andrew Norman, V. N. Solovov, X. Pons, V. Paolone, V. Pec, J. Pillow, S. Vergani, V. Savinov, P. Melas, Simon Lin, K. Wood, E. D. Zimmerman, M. A. Leigui de Oliveira, A. Olivier, Kevin J. Kelly, D. Sgalaberna, M. Gold, M. Spanu, Xiaolu Ji, A. M. Szelc, Gareth J. Barker, C. Cattadori, J. Fowler, S. J. M. Peeters, Raj Gandhi, M. Masud, R. LaZur, C. Grant, A. Olivares Del Campo, Joshua R. Klein, Vasundhara Singh, Ranjan Dharmapalan, Lynn Wood, E. Bechetoille, Patrick Green, Gustaaf Brooijmans, R. Howell, K. Moffat, J. G. Learned, J. Spitz, E. McCluskey, T. Patzak, M. D. Messier, J. A. Musser, R. Raboanary, P. Schlabach, C. Lastoria, D. Naples, Kazuhiro Terao, A. Paudel, Michael Mulhearn, S. B. Boyd, T. Hill, G. A. Valdiviesso, S. Emery, M. C. Goodman, D. C. Christian, S. Alonso Monsalve, B. Howard, G. Ge, Alexander Tapper, Thomas Strauss, J. Hugon, M. Kirby, K. Zeug, A. Laundrie, B. Szczerbinska, R. Flight, H. Vieira de Souza, D. M. DeMuth, A. Chatterjee, S. Kohn, F. Drielsma, A. Bitadze, B. Zamorano, Warner A. Miller, Yichen Li, Wladyslaw Henryk Trzaska, F. Piastra, C. Wilkinson, M. Greenwood, C. Girerd, R.J. Staley, R. Cross, S. Di Domizio, G. Meng, A. Mislivec, A. Sousa, K. Spurgeon, R. Gran, M. Roda, G.L. Raselli, R. S. Fitzpatrick, L. Rakotondravohitra, A. C. Kaboth, Matthew Mewes, Kai Loo, J. Trevor, T. Vrba, S. P. Kasetti, Y. Penichot, M. J. Wilking, M. Zito, S. Pordes, P. Weatherly, James John Brooke, M. Wallbank, F. F. Wilson, Nektarios Benekos, Renato Potenza, M. Toups, H. Y. Liao, Haleh Khani Hadavand, D. Redondo, S. R. Mishra, R. A. Gomes, E. Gramellini, S. Menary, P. C. de Holanda, D. Gibin, M. Stancari, B. J. P. Jones, C. Vilela, B. Tapia Oregui, N. Nayak, Sofia Vallecorsa, K. E. Duffy, E. Segreto, Xin Qian, T. A. Mohayai, Olga Mena, N. Martinez, O.V. Dvornikov, Filippo Resnati, M. B. Smy, K. Soustruznik, Diana Navas-Nicolas, S. Jiménez, R. Zwaska, William J. Marciano, C. Hohl, R. Haenni, Piera Sapienza, M. Shamma, N. P. Samios, H. Duyang, G. Lehmann Miotto, H. Meyer, A. Schukraft, C. S. Mishra, Vlastimil Kus, S. Murphy, Jianming Bian, C. Backhouse, Stephen J. Parke, J. Perry, Stephen Hillier, A. Guglielmi, D. Franco, M. Soares Nunes, A. Maddalena, M. Antonova, T. Boschi, J. L. Raaf, J. Singh, Alan Watson, F. Muheim, R. Milincic, P. Bernardini, Ralf Lehnert, T. A. Bolton, J. Greer, Y. T. Tsai, Mafalda Dias, L. Camilleri, S. Nagu, J. A. Maloney, Z. Vallari, J. Sensenig, I. Kadenko, D. Waters, S. Prakash, D. Ruterbories, Antonino Sergi, L. Kashur, M. Eads, C. Montanari, E. Conley, A. Scaramelli, S. Fuess, E. Cristaldo, H. Razafinime, Alessandro Montanari, T. Stokes, L. Li, Marc Weber, C. Bromberg, M. Leyton, M. E. Convery, S. Green, Jack Fried, P. De Lurgio, George Adamov, C. A. Ternes, Jane Nachtman, Y. A. Ramachers, D. A. Martinez Caicedo, E. T. Worcester, R. M. de Almeida, Yasar Onel, Mingshui Chen, A. Izmaylov, Claudia Brizzolari, C. Griffith, J. K. Nelson, K. Vaziri, M. A. Arroyave, F. Azfar, M. Karolak, Deywis Moreno, L. Molina Bueno, Science and Technology Facilities Council (STFC), Abi, B, Acciarri, R, Acero, M, Adamov, G, Adams, D, Adinolfi, M, Ahmad, Z, Ahmed, J, Alion, T, Monsalve, S, Alt, C, Anderson, J, Andreopoulos, C, Andrews, M, Andrianala, F, Andringa, S, Ankowski, A, Antonova, M, Antusch, S, Aranda-Fernandez, A, Ariga, A, Arnold, L, Arroyave, M, Asaadi, J, Aurisano, A, Aushev, V, Autiero, D, Azfar, F, Back, H, Back, J, Backhouse, C, Baesso, P, Bagby, L, Bajou, R, Balasubramanian, S, Baldi, P, Bambah, B, Barao, F, Barenboim, G, Barker, G, Barkhouse, W, Barnes, C, Barr, G, Monarca, J, Barros, N, Barrow, J, Bashyal, A, Basque, V, Bay, F, Alba, J, Beacom, J, Bechetoille, E, Behera, B, Bellantoni, L, Bellettini, G, Bellini, V, Beltramello, O, Belver, D, Benekos, N, Neves, F, Berger, J, Berkman, S, Bernardini, P, Berner, R, Berns, H, Bertolucci, S, Betancourt, M, Bezawada, Y, Bhattacharjee, M, Bhuyan, B, Biagi, S, Bian, J, Biassoni, M, Biery, K, Bilki, B, Bishai, M, Bitadze, A, Blake, A, Siffert, B, Blaszczyk, F, Blazey, G, Blucher, E, Boissevain, J, Bolognesi, S, Bolton, T, Bonesini, M, Bongrand, M, Bonini, F, Booth, A, Booth, C, Bordoni, S, Borkum, A, Boschi, T, Bostan, N, Bour, P, Boyd, S, Boyden, D, Bracinik, J, Braga, D, Brailsford, D, Brandt, A, Bremer, J, Brew, C, Brianne, E, Brice, S, Brizzolari, C, Bromberg, C, Brooijmans, G, Brooke, J, Bross, A, Brunetti, G, Buchanan, N, Budd, H, Caiulo, D, Calafiura, P, Calcutt, J, Calin, M, Calvez, S, Calvo, E, Camilleri, L, Caminata, A, Campanelli, M, Caratelli, D, Carini, G, Carlus, B, Carniti, P, Terrazas, I, Carranza, H, Castillo, A, Castromonte, C, Cattadori, C, Cavalier, F, Cavanna, F, Centro, S, Cerati, G, Cervelli, A, Villanueva, A, Chalifour, M, Chang, C, Chardonnet, E, Chatterjee, A, Chattopadhyay, S, Chaves, J, Chen, H, Chen, M, Chen, Y, Cherdack, D, Chi, C, Childress, S, Chiriacescu, A, Cho, K, Choubey, S, Christensen, A, Christian, D, Christodoulou, G, Church, E, Clarke, P, Coan, T, Cocco, A, Coelho, J, Conley, E, Conrad, J, Convery, M, Corwin, L, Cotte, P, Cremaldi, L, Cremonesi, L, Crespo-Anadon, J, Cristaldo, E, Cross, R, Cuesta, C, Cui, Y, Cussans, D, Dabrowski, M, Motta, H, Peres, L, David, Q, Davies, G, Davini, S, Dawson, J, De, K, Almeida, R, Debbins, P, Bonis, I, Decowski, M, Gouvea, A, Holanda, P, Astiz, I, Deisting, A, Jong, P, Delbart, A, Delepine, D, Delgado, M, Dell'Acqua, A, Lurgio, P, Neto, J, Demuth, D, Dennis, S, Densham, C, Deptuch, G, Roeck, A, Romeri, V, Vries, J, Dharmapalan, R, Dias, M, Diaz, F, Diaz, J, Domizio, S, Giulio, L, Ding, P, Noto, L, Distefano, C, Diurba, R, Diwan, M, Djurcic, Z, Dokania, N, Dolinski, M, Domine, L, Douglas, D, Drielsma, F, Duchesneau, D, Duffy, K, Dunne, P, Durkin, T, Duyang, H, Dvornikov, O, Dwyer, D, Dyshkant, A, Eads, M, Edmunds, D, Eisch, J, Emery, S, Ereditato, A, Escobar, C, Sanchez, L, Evans, J, Ewart, E, Ezeribe, A, Fahey, K, Falcone, A, Farnese, C, Farzan, Y, Felix, J, Fernandez-Martinez, E, Menendez, P, Ferraro, F, Fields, L, Filkins, 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D., Renshaw, A., Rescia, S., Resnati, F., Reynolds, A., Riccobene, G., Rice, L. C., Rielage, K., Rigaut, Y., Rivera, D., Rochester, L., Roda, M., Rodrigues, P., Alonso, M. Rodriguez, Rondon, J. Rodriguez, Roeth, A., Rogers, H., Rosauro-Alcaraz, S., Rossella, M., Rout, J., Roy, S., Rubbia, A., Rubbia, C., Russell, B., Russell, J., Ruterbories, D., Saakyan, R., Sacerdoti, S., Safford, T., Sahu, N., Sala, P., Samios, N., Sanchez, M., Sanders, D. A., Sankey, D., Santana, S., Santos-Maldonado, M., Saoulidou, N., Sapienza, P., Sarasty, C., Sarcevic, I., Savage, G., Savinov, V., Scaramelli, A., Scarff, A., Scarpelli, A., Schaffer, T., Schellman, H., Schlabach, P., Schmitz, D., Scholberg, K., Schukraft, A., Segreto, E., Sensenig, J., Seong, I., Sergi, A., Sergiampietri, F., Sgalaberna, D., Shaevitz, M., Shafaq, S., Shamma, M., Sharma, H. 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A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M., Vahle, P., Valdiviesso, G., Valencia, E., Vallari, Z., Valle, J. W., Vallecorsa, S., Berg, R. Van, de Water, R. G. Van, Forero, D. Vanega, Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. 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J., Stillwell B., Stock J., Stocker F., Stokes T., Strait M., Strauss T., Striganov S., Stuart A., Summers D., Surdo A., Susic V., Suter L., Sutera C., Svoboda R., Szczerbinska B., Szelc A., Talaga R., Tanaka H., Oregui B.T., Tapper A., Tariq S., Tatar E., Tayloe R., Teklu A., Tenti M., Terao K., Ternes C.A., Terranova F., Testera G., Thea A., Thompson J.L., Thorn C., Timm S., Tonazzo A., Torti M., Tortola M., Tortorici F., Totani D., Toups M., Touramanis C., Trevor J., Trzaska W.H., Tsai Y.T., Tsamalaidze Z., Tsang K., Tsverava N., Tufanli S., Tull C., Tyley E., Tzanov M., Uchida M.A., Urheim J., Usher T., Vagins M., Vahle P., Valdiviesso G., Valencia E., Vallari Z., Valle J.W., Vallecorsa S., Berg R.V., De Water R.G.V., Forero D.V., Varanini F., Vargas D., Varner G., Vasel J., Vasseur G., Vaziri K., Ventura S., Verdugo A., Vergani S., Vermeulen M.A., Verzocchi M., De Souza H.V., Vignoli C., Vilela C., Viren B., Vrba T., Wachala T., Waldron A.V., Wallbank M., Wang H., Wang J., Wang Y., Warburton K., Warner D., Wascko M., Waters D., Watson A., Weatherly P., Weber A., Weber M., Wei H., Weinstein A., Wenman D., Wetstein M., While M.R., White A., Whitehead L.H., Whittington D., Wilking M.J., Wilkinson C., Williams Z., Wilson F., Wilson R.J., Wolcott J., Wongjirad T., Wood K., Wood L., Worcester E., Worcester M., Wret C., Wu W., Xiao Y., Yang G., Yang T., Yershov N., Yonehara K., Young T., Yu B., Yu J., Zalesak J., Zambelli L., Zamorano B., Zani A., Zazueta L., Zeller G., Zennamo J., Zeug K., Zhang C., Zhao M., Zhivun E., Zhu G., Zimmerman E.D., Zito M., Zucchelli S., Zuklin J., Zutshi V., and Zwaska R.
Subjects: Technology, 530 Physics, media_common.quotation_subject, Neutrino oscillations, liquid Argon TPC, DUNE technical design report, single phase LArTPC, Electrons, FREE-ELECTRONS, 01 natural sciences, 7. Clean energy, 09 Engineering, 030218 nuclear medicine & medical imaging, Standard Model, 03 medical and health sciences, neutrino, 0302 clinical medicine, LIQUID ARGON, 0103 physical sciences, Grand Unified Theory, High Energy Physics, Aerospace engineering, Instrumentation, Instruments & Instrumentation, Mathematical Physics, media_common, Physics, Science & Technology, 02 Physical Sciences, 010308 nuclear & particles physics, business.industry, Detector, Lıquıd Argonfree, Nuclear & Particles Physics, Symmetry (physics), Universe, Long baseline neutrino experiment, CP violation, Antimatter, Neutrino, business, Event (particle physics)
Abstract: This document was prepared by the DUNE collaboration using the resources of the Fermi National Accelerator Laboratory (Fermilab), a U.S. Department of Energy, Office of Science, HEP User Facility. Fermilab is managed by Fermi Research Alliance, LLC (FRA), acting under Contract No. DE-AC02-07CH11359. The DUNE collaboration also acknowledges the international, national, and regional funding agencies supporting the institutions who have contributed to completing this Technical Design Report., The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. Central to achieving DUNE's physics program is a far detector that combines the many tens-of-kiloton fiducial mass necessary for rare event searches with sub-centimeter spatial resolution in its ability to image those events, allowing identification of the physics signatures among the numerous backgrounds. In the single-phase liquid argon time-projection chamber (LArTPC) technology, ionization charges drift horizontally in the liquid argon under the influence of an electric field towards a vertical anode, where they are read out with fine granularity. A photon detection system supplements the TPC, directly enhancing physics capabilities for all three DUNE physics drivers and opening up prospects for further physics explorations. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume IV presents an overview of the basic operating principles of a single-phase LArTPC, followed by a description of the DUNE implementation. Each of the subsystems is described in detail, connecting the high-level design requirements and decisions to the overriding physics goals of DUNE., Fermi Research Alliance, LLC (FRA) DE-AC02-07CH11359
Published: 2020

20. Volume I. Introduction to DUNE

Author: E. Hazen, Armin Karcher, D. Smargianaki, Christopher L. Marshall, K. Spurgeon, M. Gold, C. Vignoli, C. J. Solano Salinas, M. J. Wilking, K. Kothekar, G. Sirri, Evgueni Goudzovski, H. Mendez, W. Flanagan, V. Papadimitriou, D. Redondo, S. R. Mishra, Y.-J. Jwa, G. Petrillo, M. Spanu, Xiaolu Ji, O. V. Mineev, M. Bishai, S. Menary, L. Molina Bueno, P. C. de Holanda, H. Berns, A. Gendotti, A. M. Szelc, R. Gandhi, A. Himmel, M. Rajaoalisoa, P. Bour, N. Kazaryan, L. Mualem, Gareth J. Barker, C. Cattadori, S. Ravat, W. Mu, D. Marfatia, T. Miedema, Kendall Mahn, Jorge Molina, Filippo Resnati, S. Magill, E. Niner, D. Autiero, Poonam Mehta, John Evans, J. S. Díaz, P. Novella, J. Fowler, G. Karagiorgi, S. J. M. Peeters, William J. Marciano, S. Bordoni, James Mueller, J. Martín-Albo, W. Fox, K. Grzelak, C. Hohl, R. Haenni, S. Alonso Monsalve, B. Howard, G. Ge, Alexander Tapper, Thomas Strauss, Silvia Pascoli, B. Stillwell, A. Lambert, A. Holin, K. V. Tsang, J. Maneira, R.A. Rameika, Juraj Bracinik, C. Wret, M. Tenti, Alberto Cervelli, Sukalyan Chattopadhyay, Laura Dominé, K. Herner, Hem Raj Sharma, S. Kasai, A. Higuera Pichardo, M. Betancourt, A. Scarff, R. Northrop, M. V. Diwan, D. J. Payne, C. Gotti, M. A. Vermeulen, R. M. Berner, J. J. De Vries, S. Shafaq, Yu. G. Kudenko, L. Pickering, B. Bhuyan, C. Kuruppu, Janet Conrad, D. Brailsford, R. Van Berg, J. Chaves, B. Paulos, R. Sipos, E. Pennacchio, F. W. Sippach, T. Li, S. Striganov, Laura Paulucci, S. Manly, P. Hamilton, R. G. Van de Water, R. Nandakumar, B. Szczerbinska, D. Cherdack, H. Carranza, Milos Lokajicek, K. Nishimura, E. Kearns, A. C. Ezeribe, J. Hoff, A. McNab, A. Stuart, G. Vasseur, C. Petta, M. Wetstein, M. M. Khabibullin, A. Bitadze, Yichen Li, G. Brunetti, L. Suter, L. Pasqualini, S. Martynenko, Ph. Lebrun, B. Morgan, L. Patrizii, A. Guglielmi, D. Wenman, S. C. Timm, R. Sharma, R. Saakyan, R. Gran, C. McGrew, C. Andreopoulos, A. Mann, F. Terranova, C. Cuesta, O. G. Miranda, C. Patrick, José W. F. Valle, A. Booth, G. Mandrioli, J. A. Nowak, S. Tufanli, R. Bajou, J. Urheim, J. Bian, Yasaman Farzan, M. Roda, J. G. Boissevain, J. Smolik, Thorsten Lux, L. Fields, D. Franco, S. P. Kasetti, M. Soares Nunes, A. Maddalena, M. Antonova, E. Kemp, N. Solomey, Laura Manenti, K. Francis, M. H. Shaevitz, N. Barros, C. Booth, I. Caro Terrazas, R. Itay, E. Ewart, R. J. Nichol, D. Totani, P. Snopok, M. Sorel, Kaushik De, M. Soderberg, A. C. Weber, Jonas Rademacker, E. Brianne, M. J. Rodriguez Alonso, T. Boschi, Sandhya Choubey, D. Montanari, Giorgio Riccobene, A. Mefodiev, M. A. Acero, A. Rappoldi, F. F. Wilson, Nektarios Benekos, Piera Sapienza, V. Savinov, P. Melas, Kenneth Long, Jianbei Liu, C. Mossey, Renato Potenza, M. Shamma, N. P. Samios, Y. Penichot, C. Bromberg, W. C. Louis, V. Paolone, V. Pec, J. Pillow, S. Vergani, S. Balasubramanian, B. Carlus, D. Boyden, Kam-Biu Luk, Simon Lin, Sofia Andringa, F. Jediny, K. Qi, K. Wood, M. Toups, Haleh Khani Hadavand, B. Tapia Oregui, G. P. Zeller, Gregory Iles, S. Gollapinni, A. Friedland, K. M. Heeger, P. Debbins, R. LaZur, J. A. B. Coelho, Jeremy Wolcott, Kevin J. Kelly, D. Sgalaberna, Joshua Barrow, John Marshall, M. Zito, K. Koehler, S. Pordes, P. Weatherly, E. D. Zimmerman, M. A. Leigui de Oliveira, N. Nayak, J. Sinclair, J. I. Crespo-Anadón, H. S. Chen, James John Brooke, A. Olivier, R. Milincic, P. Bernardini, Jim Freeman, L. Kashur, L.S. Rochester, Dario Gnani, Andrea Zani, M. Wallbank, Giuseppe Benedetto Cerati, T. Kosc, Dave Sankey, Patrick Green, Olga Mena, N. Martinez, F. Pietropaolo, S. Narita, A. Scaramelli, C. Grant, T. L. Usher, A. Marchionni, D. A. Dwyer, S. Prince, J. Haiston, T. J. Langford, A. M. Gago, Artur M. Ankowski, E. Gamberini, J. Asaadi, E. Valencia, Roberto Gutiérrez, T. Hasegawa, T. R. Junk, Y. A. Ramachers, D. A. Martinez Caicedo, R. Howell, R. M. de Almeida, Yasar Onel, Matheus Hostert, D. Duchesneau, J. A. Musser, F. Sergiampietri, D. W. Schmitz, E. Zhivun, Marzio Nessi, D. Lorca, Dave M Newbold, C. K. Jung, A. Olivares Del Campo, F. Krennrich, G. Testera, Alexandru Jipa, S. Rescia, Andrés Castillo, Joshua R. Klein, Olga Beltramello, Srubabati Goswami, Z. Williams, Vasundhara Singh, C. Mauger, J. Yu, M. Bonesini, Jack Fried, P. De Lurgio, C. A. Ternes, H. Y. Liao, K. Mason, N. Poonthottathil, A. Scarpelli, E. T. Worcester, J. T. Haigh, H. Muramatsu, G. C. Blazey, Rex Tayloe, R. Diurba, G. Christodoulou, F. Barao, S. Calvez, H. Duyang, L. M. Cremaldi, E. Motuk, H. Meyer, R. Guenette, C. Castromonte, A. Schukraft, Julián Félix, D. MacFarland, K. Gollwitzer, F. Varanini, Ranjan Dharmapalan, Lynn Wood, M. Pozzato, G. Zhu, S. Centro, Francesco Tortorici, S. Henry, R. A. Gomes, E. Gramellini, D. Vanegas Forero, Z. Pavlovic, D. A. Sanders, Christian Farnese, John F. Beacom, P. Vahle, G. A. Horton-Smith, T. Durkin, H. Y. Wei, L. Escudero Sanchez, Mingshui Chen, I. K. Furic, J. Moon, T. Young, John Matthews, E. James, B. Gelli, Gregory J. Michna, Steven Gardiner, P. Madigan, A. Izmaylov, D. Douglas, D. Gibin, M. Stancari, Shibaji Roy, I. Rakhno, J. Barranco Monarca, Paolo Calafiura, Q. David, Akitaka Ariga, Marvin L Marshak, Rukmani Mohanta, P. E. L. Clarke, C. Palomares, K. Cho, M. A. Arroyave, Andrew Norman, Claudia Brizzolari, J. Nachtman, Daniel Gastler, J. Hugon, M. Karolak, H. O. Back, Z. Ahmad, Gabriella Carini, M. Dabrowski, Paul Keener, Leigh H. Whitehead, Karol Hennessy, S. Söldner-Rembold, C. S. Lin, D. Edmunds, A. Chiriacescu, M. Oberling, T. Rehak, Katsuya Yonehara, T. E. Coan, L. V. Gomez Bermeo, F. Andrianala, Francesco Gonnella, T. Safford, E. Tatar, Utku Kose, M. Bhattacharjee, F. Cavanna, A. Muir, A. L. Renshaw, Orlando L. G. Peres, Amelia Maio, Carl Grace, J. Migenda, B. Viren, M. Muether, A. Mastbaum, Alfredo G. Cocco, C. Griffith, J. Mousseau, Paolo Carniti, L. Greenler, J. Rout, W. Ketchum, B. Radics, Ionel Lazanu, A. Laundrie, V. N. Solovov, David Cussans, X. Pons, N. Gallice, J. G. Learned, R. Flight, M. Nebot-Guinot, H. Vieira de Souza, S. Sacerdoti, J. Calcutt, K. Warburton, M. Nalbandyan, A. P. Furmanski, P. de Jong, B. T. Fleming, R. Poling, P.T. Smith, M. Worcester, Wei Wu, B. Guo, Frank Filthaut, J. Reichenbacher, S. Ventura, M. Graham, Riccardo Papaleo, A. M. Teklu, D. Newhart, P. Fernandez Menendez, J. Han, Deywis Moreno, C. Densham, Matthaeus Leitner, K. Fahey, Bindu A. Bambah, E. Blucher, S. Childress, T. Miao, Shiroman Prakash, Jason Kumar, Yi Chen, M. Kirby, P. Cotte, A. J. Roeth, R. Acciarri, E. Bechetoille, Gustaaf Brooijmans, K. Moffat, B. V. K. S. Potukuchi, S. Li, K. Vaziri, Sudarshan Paramesvaran, Seodong Shin, M. Santos-Maldonado, J.V. Dawson, Aldo Penzo, Ara Ioannisian, S. Rosauro-Alcaraz, H. T. Rakotondramanana, F. Piastra, N.V. Mokhov, S. Davini, R. L. Talaga, A. Caminata, G. Bellettini, J. Hartnell, C. Y. Chi, M. Groh, Karol Lang, C. Girerd, F. Diaz, F. Azfar, Alastair Grant, R. Hatcher, M. Zhao, J. Marteau, Irakli Lomidze, F. Stocker, T. Gamble, J. J. Grudzinski, L. Montaño Zetina, A. Heavey, Grzegorz Deptuch, F. Cavalier, R. Illingworth, I. Gil-Botella, N. Bostan, A. Gallego-Ros, T. Schaffer, N. Buchanan, G. Lehmann Miotto, Robert Shrock, J. Zennamo, Zviad Tsamalaidze, N. Mauri, H. da Motta, David Delepine, M. Torti, A. De Roeck, M. Calin, A. Lawrence, P. N. Ratoff, T. Kutter, B. Jargowsky, J. K. Nelson, Cari L. Johnson, C. S. Mishra, Vlastimil Kus, R.J. Staley, R. Cross, S. Murphy, S. Dennis, P. P. Koller, D. Whittington, D. Garcia-Gamez, K. Lande, R. B. Patterson, Anjan K. Giri, Wayne A. Barkhouse, A. Filkins, Daijin Kim, G.D. Barr, Junwei Huang, V. De Romeri, A. Mislivec, Manuela Campanelli, Y. Rigaut, Matthew L Strait, G. Barenboim, G. Prior, P. Guzowski, A. Cervera Villanueva, Robert Svoboda, C. Backhouse, A. Falcone, M. R. While, V. Bellini, C. Alt, J. Spitz, Stephen J. Parke, E. McCluskey, M. Mellinato, Jürgen Pozimski, D. Caratelli, L. Bellantoni, M. Rai, D. Mladenov, J. Stock, T. Lord, L. Zazueta, Alexander Deisting, R. Raboanary, T. Patzak, B. Rebel, M. D. Messier, B. Abi, A. de Gouvea, V. A. Kostelecky, K. Zeug, Joleen Pater, A. Hackenburg, K. Negishi, M. A. Hernandez Morquecho, J. Perry, Stephen Hillier, David H. Adams, D. Caiulo, S. Bolognesi, D. Belver, S. Zucchelli, F. Marinho, R. Petti, G.L. Raselli, Han Wang, Sergey A. Kulagin, A. Bashyal, J. Berger, A. Papanestis, A. Aurisano, F. Bay, Beatriz B. Siffert, E. Granados, B. Behera, H.E. Rogers, A. Rafique, J. Nesbit, Chris Brew, A. C. Kaboth, T. Vrba, P. Lasorak, Kim Siyeon, Andrea Dell'Acqua, Timothy M. Shaw, D. Braga, J. Ahmed, Yu. Onishchuk, Kate Scholberg, Alessandro Menegolli, T. Hamernik, Konstantinos Manolopoulos, R. K. Plunkett, V. Susic, Pedro A. N. Machado, T. Alion, N. Simos, O. Gogota, I. L. De Icaza Astiz, Narendra Sahu, F. Muheim, Ralf Lehnert, S. Gao, Andrew White, S. Berkman, André Rubbia, J. L. Raaf, J. Singh, C. Barnes, A. S. Hesam, S. D. Reitzner, T. Le, L. Hertel, R. Gandrajula, D. Vargas, L. Corwin, S. L. Mufson, B. J. P. Jones, C. Vilela, S. H. Kettell, B. Ramson, Chia-Chan Chang, P. Schlabach, C. Lastoria, Alan Watson, Z. Ghorbani-Moghaddam, Marcelo M. Guzzo, P. Baesso, S. Gwon, A. Surdo, Ina Sarcevic, Eric W. Hoppe, M. O. Wascko, T. A. Bolton, J. Greer, Y. T. Tsai, L. Camilleri, Sofia Vallecorsa, K. E. Duffy, S. Nagu, J. A. Maloney, Z. Vallari, J. Sensenig, L. Da Silva Peres, Manuel Alejandro Segura Delgado, A. Joglekar, M. P. Andrews, K. S. McFarland, C. T. Macias, D. Naples, Chao Zhang, D. M. DeMuth, Kazuhiro Terao, A. Paudel, M. Biassoni, D. Pershey, Rakesh Kumar, M. Bongrand, Michael Mulhearn, N. Moggi, E. Segreto, Xin Qian, Mafalda Dias, Claire Shepherd-Themistocleous, A. Chatterjee, S. Kohn, T. A. Mohayai, O.V. Dvornikov, L. Di Giulio, T. Yang, V. Zutshi, Sandeep Miryala, Enrique Calvo, V. Radeka, B. Bilki, I. Kadenko, D. Waters, D. Ruterbories, Antonino Sergi, M. Tzanov, C. Touramanis, F. Drielsma, Y. Xiao, A. Verdugo, J. M. Paley, Antonio Ereditato, C. E. Lane, M. J. Dolinski, C. Rubbia, A. Borkum, N. McConkey, J. Wang, X. Luo, Y. Karyotakis, M. Eads, S. Biagi, L. O. Arnold, J. J. Back, C. Morris, S. Bertolucci, V. Basque, A. Mazzacane, C. Montanari, E. Conley, N. Yershov, Marco Adinolfi, M. B. Smy, S. Fuess, M. Kordosky, T. Stokes, J. J. Russell, H. R. Gallagher, D. Pugnere, D. Gratieri, J. R. T. de Mello Neto, L. Li, K. Soustruznik, M. E. Convery, L. Stanco, B. Zamorano, Warner A. Miller, C. A. Moura, A. D. Marino, Wladyslaw Henryk Trzaska, C. Jesús-Valls, Andrew Blake, S. B. Boyd, T. Hill, L. Jiang, Diana Navas-Nicolas, G. A. Valdiviesso, S. Emery, S. Jiménez, E. Cristaldo, H. Razafinime, Stephen P. Gent, Alessandro Montanari, R. Zwaska, S. Green, D. C. Christian, F. Bonini, J. Zuklin, M. Masud, Kristian Harder, J. Hewes, Sandro Palestini, Marc Weber, D. A. Harris, C. Distefano, Ornella Palamara, George Adamov, Andrew Smith, M. Manrique Plata, V. J. Guarino, C. Sarasty, J. Bremer, R. A. Johnson, H. S. Budd, G. Yang, I. Kreslo, M. Parvu, James A. Anderson, V. A. Kudryavtsev, G. S. Davies, I. De Bonis, L. Di Noto, W. E. Sondheim, C. E. Tull, M. Leyton, C. Wilkinson, M. Greenwood, O. Goodwin, K. K. Guthikonda, Simon Jones, S. Di Domizio, G. Meng, A. Lister, A. Christensen, Mariam Tórtola, J. Mills, A. Sousa, Irina Mocioiu, L. Zambelli, A. F. Moor, A. M. Iliescu, Alex Reynolds, K. Biery, Yanchu Wang, Christopher J. Milne, A. Aranda-Fernandez, M. Potekhin, R. S. Fitzpatrick, V. Aushev, L. Rakotondravohitra, J. Zalesak, L. Simard, L. Pagani, Matthew Mewes, J. Rodriguez Rondon, Kai Loo, J. Trevor, Alec Habig, S. Matsuno, D. J. Summers, L. Cremonesi, A. Tonazzo, J. R. Macier, F. Ferraro, J. Freestone, D. Rivera, K. Mavrokoridis, S. Santana, C. Mariani, Carlos Escobar, J. Vasel, J. A. Gonzalez-Cuevas, J. Franc, H. A. Tanaka, B. Kirby, A. Bross, D. Warner, C. E. Thorn, Robert Wilson, Marco Verzocchi, S. J. Patton, E. Church, Sandip Pakvasa, G. S. Varner, A. Hourlier, Paola Sala, D. Shooltz, Zelimir Djurcic, Alessandro Thea, Y. Bezawada, V. P. Luzio, Janice L. Thompson, F. Kamiya, E. Raguzin, L. C. J. Rice, Bo Yu, A. V. Waldron, J. L. Bazo Alba, Y. Cui, P. A. Rodrigues, M. C. Goodman, T. Loew, P. Ding, J. D. Eisch, A. Weinstein, A. Sitraka, L. Bagby, J. M. LoSecco, F. Bento Neves, Andrew Brandt, Ihn Sik Seong, C. M. Sutera, E. Smith, W. Metcalf, T. Wongjirad, A. Delbart, N. J. C. Spooner, E. Pantic, James Stewart, L. W. Koerner, T. Wachala, Barry King, R. Mazza, Keith Rielage, N. Dokania, L. S. Gomez Fajardo, M. P. Decowski, V. Galymov, E. Chardonnet, B. R. Littlejohn, B. Russell, M. Vagins, Jordan Ott, Niki Saoulidou, E. Mazzucato, S. Tariq, Gregory J Pawloski, T. Prakash, Arsen Khvedelidze, A.S. Dyshkant, M. A. Uchida, M. Reggiani-Guzzo, M. Á. García-Peris, M. Kabirnezhad, Pierre Baldi, M. Mooney, E. Tyley, A. Hahn, F. Spagliardi, M. Newcomer, H. W. Sobel, F. D. M. Blaszczyk, Lina Necib, Enrique Fernandez-Martinez, J. S. Real, M. A. Ramirez Delgado, H. Steiner, S. Lockwitz, G. Sinev, Massimo Rossella, S. J. Brice, Nicolas Lurkin, A. A. Machado, Jaroslaw Pasternak, W. Gu, J. Maricic, H. Schellman, Stefan Antusch, Z. Parsa, Patrick Dunne, M. C. Sanchez, A. N. Khotjantsev, N. Tsverava, Marco Pallavicini, G. Savage, J. Soto-Oton, G. Pessina, M. Chalifour, Abi B., Acciarri R., Acero M.A., Adamov G., Adams D., Adinolfi M., Ahmad Z., Ahmed J., Alion T., Monsalve S.A., Alt C., Anderson J., Andreopoulos C., Andrews M., Andrianala F., Andringa S., Ankowski A., Antonova M., Antusch S., Aranda-Fernandez A., Ariga A., Arnold L.O., Arroyave M.A., Asaadi J., Aurisano A., Aushev V., Autiero D., Azfar F., Back H., Back J.J., Backhouse C., Baesso P., Bagby L., Bajou R., Balasubramanian S., Baldi P., Bambah B., Barao F., Barenboim G., Barker G., Barkhouse W., Barnes C., Barr G., Monarca J.B., Barros N., Barrow J.L., Bashyal A., Basque V., Bay F., Alba J.B., Beacom J.F., Bechetoille E., Behera B., Bellantoni L., Bellettini G., Bellini V., Beltramello O., Belver D., Benekos N., Neves F.B., Berger J., Berkman S., Bernardini P., Berner R.M., Berns H., Bertolucci S., Betancourt M., Bezawada Y., Bhattacharjee M., Bhuyan B., Biagi S., Bian J., Biassoni M., Biery K., Bilki B., Bishai M., Bitadze A., Blake A., Siffert B.B., Blaszczyk F., Blazey G., Blucher E., Boissevain J., Bolognesi S., Bolton T., Bonesini M., Bongrand M., Bonini F., Booth A., Booth C., Bordoni S., Borkum A., Boschi T., Bostan N., Bour P., Boyd S., Boyden D., Bracinik J., Braga D., Brailsford D., Brandt A., Bremer J., Brew C., Brianne E., Brice S.J., Brizzolari C., Bromberg C., Brooijmans G., Brooke J., Bross A., Brunetti G., Buchanan N., Budd H., Caiulo D., Calafiura P., Calcutt J., Calin M., Calvez S., Calvo E., Camilleri L., Caminata A., Campanelli M., Caratelli D., Carini G., Carlus B., Carniti P., Terrazas I.C., Carranza H., Castillo A., Castromonte C., Cattadori C., Cavalier F., Cavanna F., Centro S., Cerati G., Cervelli A., Villanueva A.C., Chalifour M., Chang C., Chardonnet E., Chatterjee A., Chattopadhyay S., Chaves J., Chen H., Chen M., Chen Y., Cherdack D., Chi C., Childress S., Chiriacescu A., Cho K., Choubey S., Christensen A., Christian D., Christodoulou G., Church E., Clarke P., Coan T.E., Cocco A.G., Coelho J., Conley E., Conrad J., Convery M., Corwin L., Cotte P., Cremaldi L., Cremonesi L., Crespo-Anadon J.I., Cristaldo E., Cross R., Cuesta C., Cui Y., Cussans D., Dabrowski M., Motta H.D., Peres L.D.S., David Q., Davies G.S., Davini S., Dawson J., De K., Almeida R.M.D., Debbins P., Bonis I.D., Decowski M., Gouvea A.D., Holanda P.C.D., Astiz I.L.D.I., Deisting A., Jong P.D., Delbart A., Delepine D., Delgado M., Dell'acqua A., Lurgio P.D., Neto J.R.D.M., Demuth D.M., Dennis S., Densham C., Deptuch G., Roeck A.D., Romeri V.D., Vries J.D., Dharmapalan R., Dias M., Diaz F., Diaz J., Domizio S.D., Giulio L.D., Ding P., Noto L.D., Distefano C., Diurba R., Diwan M., Djurcic Z., Dokania N., Dolinski M., Domine L., Douglas D., Drielsma F., Duchesneau D., Duffy K., Dunne P., Durkin T., Duyang H., Dvornikov O., Dwyer D., Dyshkant A., Eads M., Edmunds D., Eisch J., Emery S., Ereditato A., Escobar C., Sanchez L.E., Evans J.J., Ewart E., Ezeribe A.C., Fahey K., Falcone A., Farnese C., Farzan Y., Felix J., Fernandez-Martinez E., Menendez P.F., Ferraro F., Fields L., Filkins A., Filthaut F., Fitzpatrick R.S., Flanagan W., Fleming B., Flight R., Fowler J., Fox W., Franc J., Francis K., Franco D., Freeman J., Freestone J., Fried J., Friedland A., Fuess S., Furic I., Furmanski A.P., Gago A., Gallagher H., Gallego-Ros A., Gallice N., Galymov V., Gamberini E., Gamble T., Gandhi R., Gandrajula R., Gao S., Garcia-Gamez D., Garcia-Peris M.A., Gardiner S., Gastler D., Ge G., Gelli B., Gendotti A., Gent S., Ghorbani-Moghaddam Z., Gibin D., Gil-Botella I., Girerd C., Giri A., Gnani D., Gogota O., Gold M., Gollapinni S., Gollwitzer K., Gomes R.A., Bermeo L.G., Fajardo L.S.G., Gonnella F., Gonzalez-Cuevas J., Goodman M.C., Goodwin O., Goswami S., Gotti C., Goudzovski E., Grace C., Graham M., Gramellini E., Gran R., Granados E., Grant A., Grant C., Gratieri D., Green P., Green S., Greenler L., Greenwood M., Greer J., Griffith C., Groh M., Grudzinski J., Grzelak K., Gu W., Guarino V., Guenette R., Guglielmi A., Guo B., Guthikonda K., Gutierrez R., Guzowski P., Guzzo M.M., Gwon S., Habig A., Hackenburg A., Hadavand H., Haenni R., Hahn A., Haigh J., Haiston J., Hamernik T., Hamilton P., Han J., Harder K., Harris D.A., Hartnell J., Hasegawa T., Hatcher R., Hazen E., Heavey A., Heeger K.M., Hennessy K., Henry S., Morquecho M.H., Herner K., Hertel L., Hesam A.S., Hewes J., Pichardo A.H., Hill T., Hillier S.J., Himmel A., Hoff J., Hohl C., Holin A., Hoppe E., Horton-Smith G.A., Hostert M., Hourlier A., Howard B., Howell R., Huang J., Hugon J., Iles G., Iliescu A.M., Illingworth R., Ioannisian A., Itay R., Izmaylov A., James E., Jargowsky B., Jediny F., Jesus-Valls C., Ji X., Jiang L., Jimenez S., Jipa A., Joglekar A., Johnson C., Johnson R., Jones B., Jones S., Jung C., Junk T., Jwa Y., Kabirnezhad M., Kaboth A., Kadenko I., Kamiya F., Karagiorgi G., Karcher A., Karolak M., Karyotakis Y., Kasai S., Kasetti S.P., Kashur L., Kazaryan N., Kearns E., Keener P., Kelly K.J., Kemp E., Ketchum W., Kettell S., Khabibullin M., Khotjantsev A., Khvedelidze A., Kim D., King B., Kirby B., Kirby M., Klein J., Koehler K., Koerner L.W., Kohn S., Koller P.P., Kordosky M., Kosc T., Kose U., Kostelecky V., Kothekar K., Krennrich F., Kreslo I., Kudenko Y., Kudryavtsev V., Kulagin S., Kumar J., Kumar R., Kuruppu C., Kus V., Kutter T., Lambert A., Lande K., Lane C.E., Lang K., Langford T., Lasorak P., Last D., Lastoria C., Laundrie A., Lawrence A., Lazanu I., Lazur R., Le T., Learned J., Lebrun P., Miotto G.L., Lehnert R., De Oliveira M.L., Leitner M., Leyton M., Li L., Li S., Li T., Li Y., Liao H., Lin C., Lin S., Lister A., Littlejohn B.R., Liu J., Lockwitz S., Loew T., Lokajicek M., Lomidze I., Long K., Loo K., Lorca D., Lord T., Losecco J., Louis W.C., Luk K., Luo X., Lurkin N., Lux T., Luzio V.P., MacFarland D., MacHado A., MacHado P., MacIas C., MacIer J., Maddalena A., Madigan P., Magill S., Mahn K., Maio A., Maloney J.A., Mandrioli G., Maneira J.C., Manenti L., Manly S., Mann A., Manolopoulos K., Plata M.M., 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A., Terranova, F., Testera, G., Thea, A., Thompson, J. L., Thorn, C., Timm, S., Tonazzo, A., Torti, M., Tortola, M., Tortorici, F., Totani, D., Toups, M., Touramanis, C., Trevor, J., Trzaska, W. H., Tsai, Y. T., Tsamalaidze, Z., Tsang, K., Tsverava, N., Tufanli, S., Tull, C., Tyley, E., Tzanov, M., Uchida, M. A., Urheim, J., Usher, T., Vagins, M., Vahle, P., Valdiviesso, G., Valencia, E., Vallari, Z., Valle, J. W., Vallecorsa, S., Berg, R. Van, de Water, R. G. Van, Forero, D. Vanega, Varanini, F., Vargas, D., Varner, G., Vasel, J., Vasseur, G., Vaziri, K., Ventura, S., Verdugo, A., Vergani, S., Vermeulen, M. A., Verzocchi, M., de Souza, H. Vieira, Vignoli, C., Vilela, C., Viren, B., Vrba, T., Wachala, T., Waldron, A. V., Wallbank, M., Wang, H., Wang, J., Wang, Y., Warburton, K., Warner, D., Wascko, M., Waters, D., Watson, A., Weatherly, P., Weber, A., Weber, M., Wei, H., Weinstein, A., Wenman, D., Wetstein, M., While, M. R., White, A., Whitehead, L. H., Whittington, D., Wilking, M. J., Wilkinson, C., Williams, Z., Wilson, F., Wilson, R. J., Wolcott, J., Wongjirad, T., Wood, K., Wood, L., Worcester, E., Worcester, M., Wret, C., Wu, W., Xiao, Y., Yang, G., Yang, T., Yershov, N., Yonehara, K., Young, T., Yu, B., Yu, J., Zalesak, J., Zambelli, L., Zamorano, B., Zani, A., Zazueta, L., Zeller, G., Zennamo, J., Zeug, K., Zhang, C., Zhao, M., Zhivun, E., Zhu, G., Zimmerman, E. D., Zito, M., Zucchelli, S., Zuklin, J., Zutshi, V., and Zwaska, R.
Subjects: detector: technology, deep underground detector [neutrino], 530 Physics, Physics::Instrumentation and Detectors, Data management, media_common.quotation_subject, far detector, Long baseline neutrino experiment CP violation, 01 natural sciences, 030218 nuclear medicine & medical imaging, Neutrino oscillations. Neutrino Detectors. CP violation. Matter stability, design [detector], 03 medical and health sciences, neutrino, neutrino: deep underground detector, 0302 clinical medicine, near detector, 0103 physical sciences, Deep Underground Neutrino Experiment, ddc:610, Neutrino oscillation, Instrumentation, detector: design, Mathematical Physics, activity report, media_common, 010308 nuclear & particles physics, business.industry, Detector, Volume (computing), Modular design, time projection chamber: liquid argon, Universe, technology [detector], liquid argon [time projection chamber], Systems engineering, High Energy Physics::Experiment, Neutrino oscillations, DUNE technical design report, executive summary, detector technologies, data management, Neutrino, business
Abstract: Journal of Instrumentation 15(08), T08008 (1-228) (2020). doi:10.1088/1748-0221/15/08/T08008, The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay—these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. The Deep Underground Neutrino Experiment (DUNE) is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. This TDR is intended to justify the technical choices for the far detector that flow down from the high-level physics goals through requirements at all levels of the Project. Volume I contains an executive summary that introduces the DUNE science program, the far detector and the strategy for its modular designs, and the organization and management of the Project. The remainder of Volume I provides more detail on the science program that drives the choice of detector technologies and on the technologies themselves. It also introduces the designs for the DUNE near detector and the DUNE computing model, for which DUNE is planning design reports. Volume II of this TDR describes DUNE's physics program in detail. Volume III describes the technical coordination required for the far detector design, construction, installation, and integration, and its organizational structure. Volume IV describes the single-phase far detector technology. A planned Volume V will describe the dual-phase technology., Published by Inst. of Physics, London
Published: 2020

21. Fossil fuel–fired power plant operations under a changing climate

Author: Paulina Jaramillo, Aviva Loew, Yifan Cheng, Haibo Zhai, Bart Nijssen, Rahim Ali, and Kelly Klima
Subjects: Atmospheric Science, Global and Planetary Change, 010504 meteorology & atmospheric sciences, Power station, business.industry, 0208 environmental biotechnology, Global warming, Fossil fuel, Climate change, 02 engineering and technology, Environmental economics, 01 natural sciences, 020801 environmental engineering, Electric power system, Electricity generation, Climate change scenario, Environmental science, Coal, business, 0105 earth and related environmental sciences
Abstract: Climate change introduces an uncertain risk to power plant operations as ambient conditions potentially constrain generation through thermodynamic limitations. Previous studies aiming to quantify this risk have suggested a wide range of results, from minimal to disastrous capacity loss. In this analysis, we used a power plant modeling tool to study how a variety of power plant configurations respond to varying meteorological conditions. We developed tools that enable the analysis of the climate impacts on power plant operations for a spectrum of geographic situations and technological configurations. We also used these tools to conduct a case study for US coal and natural gas power plants in 2050, under climate change scenario representative concentration pathway 4.5. Our study indicates that rising air temperatures are unlikely to seriously threaten capacity and efficiency at power plants at most locations, provided that wet recirculating and dry cooling systems are designed adequately. Our results allow for simpler modeling of power plant capacity deratings given ambient conditions, highlight potential regions of risk, and underscore the importance of incorporating climate factors into the electric power system’s design and planning.
Published: 2020

22. Best Practices for Approaching Cognitive Processing Therapy and Prolonged Exposure During the COVID‐19 Pandemic

Author: Joseph Wielgosz, Dorene Loew, Jaclyn Kraemer, Hong V. Nguyen, Sarah L. Hagerty, and Debra Kaysen
Subjects: 050103 clinical psychology, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Attitude of Health Personnel, Best practice, Pneumonia, Viral, MEDLINE, Implosive Therapy, Context (language use), Stress Disorders, Post-Traumatic, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Intervention (counseling), Pandemic, medicine, Humans, 0501 psychology and cognitive sciences, Intensive care medicine, Pandemics, Cognitive Behavioral Therapy, SARS-CoV-2, business.industry, Public health, 05 social sciences, COVID-19, Continuity of Patient Care, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Cognitive processing therapy, Patient Compliance, Coronavirus Infections, business, Delivery of Health Care
Abstract: The COVID-19 pandemic presents major challenges for mental health care providers. In particular, providers who treat posttraumatic stress disorder (PTSD) are now tasked with determining whether to initiate trauma-focused therapy during the pandemic and, if so, whether and how to adapt treatment. The purpose of this communication is to identify and organize key considerations for whether and how to deliver commonly used evidence-supported therapy protocols for trauma treatment-specifically, cognitive processing therapy (CPT) and prolonged exposure (PE) therapy-during the ongoing COVID-19 pandemic for adults who currently meet the criteria for PTSD. Based on relevant public health and clinical literature, we present a structured guide that can be used by treatment teams and individual providers to evaluate whether initiating CPT or PE is indicated given a particular patient-provider pair and system context amidst pandemic conditions. In addition, we suggest appropriate action steps, including problem-solving strategies, evidence-informed modifications to CPT and PE, and alternative intervention approaches.
Published: 2020

23. Arrhythmia susceptibility in a rat model of acute atrial dilation

Author: Elisabetta Cerbai, Leslie M. Loew, Leonardo Sacconi, Samantha Cannazzaro, Claudia Crocini, Laura Sartiani, Ping Yan, Marina Scardigli, Cecilia Ferrantini, Francesco S. Pavone, and Raffaele Coppini
Subjects: medicine.medical_specialty, Atrial Fibrillation, Fibrosis, Structural remodeling, Biophysics, Hemodynamics, 030204 cardiovascular system & hematology, Nerve conduction velocity, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Atrial Fibrillation, medicine, Animals, Heart Atria, cardiovascular diseases, Molecular Biology, 030304 developmental biology, 0303 health sciences, business.industry, Voltage imaging, Cardiac arrhythmia, Atrial fibrillation, Reentry, medicine.disease, Dilatation, Electrophysiological Phenomena, Rats, 3. Good health, Coronary arteries, Disease Models, Animal, medicine.anatomical_structure, Heart failure, cardiovascular system, Cardiology, Disease Susceptibility, business, Perfusion
Abstract: Atrial fibrillation (AF) is the most common cardiac arrhythmia, associated with an increased risk of stroke and heart failure. Acute AF occurs in response to sudden increases of atrial hemodynamic load, leading to atrial stretch. The mechanisms of stretch-induced AF were investigated in large mammals with controversial results. We optimized an approach to monitor rat atrial electrical activity using a red-shifted voltage sensitive dye (VSD). The methodology includes cauterization of the main ventricular coronary arteries, allowing improved atrial staining by the VSD and appropriate atrial perfusion for long experiments. Next, we developed a rat model of acute biatrial dilation (ABD) through the insertion of latex balloons into both atria, which could be inflated with controlled volumes. A chronic model of atrial dilation (spontaneous hypertensive rats; SHR) was used for comparison. ABD was performed on atria from healthy Wistar-Kyoto (WKY) rats (WKY-ABD). The atria were characterized in terms of arrhythmias susceptibility, action potential duration and conduction velocity. The occurrence of arrhythmias in WKY-ABD was significantly higher compared to non-dilated WKY atria. In WKY-ABD we found a reduction of conduction velocity, similar to that observed in SHR atria, while action potential duration was unchanged. Low-dose caffeine was used to introduce a drop of CV in WKY atria (WKY-caff), quantitatively similar to the one observed after ABD, but no increased arrhythmia susceptibility was observed with caffeine only. In conclusion, CV decrease is not sufficient to promote arrhythmias; enlargement of atrial surface is essential to create a substrate for acute reentry-based arrhythmias.
Published: 2020

24. Negative pressure wound therapy with instillation and dwell time ( <scp>NPWTi</scp> ‐d) with V. A. C. <scp>VeraFlo</scp> in traumatic, surgical, and chronic wounds—A helpful tool for decontamination and to prepare successful reconstruction

Author: Julia Loew, Gabriel Hundeshagen, Benjamin Ziegler, Christoph Hirche, Patrick A. Will, Ulrich Kneser, Yannick Diehm, Sebastian Fischer, and Emre Gazyakan
Subjects: medicine.medical_specialty, Bacterial decontamination, integumentary system, business.industry, medicine.medical_treatment, Granulation tissue, Surgical wound, Dermatology, Patient data, Surgery, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Bacterial colonization, Wound bed preparation, Negative-pressure wound therapy, Medicine, 030212 general & internal medicine, business, Saline
Abstract: For nearly two decades, Negative Pressure Wound Therapy (NPWT) has been used for temporary wound coverage as well as wound bed preparation. The addition of instillation and dwell time as an adjunct to NPWT (NPWTi-d) enables wound bed cleaning and improved wound bed granulation. Thirty patients with different types of colonised wounds (traumatic, surgical, and chronic) were treated with NPWTi-d using saline for instillation. Patient data, microbiological data and wound characteristics were collected and analysed. Endpoints were bacterial decontamination (count and type), effect on wound bed granulation, and successful reconstruction. Additionally, subgroup analyses for traumatic, surgical, and chronic wounds as well as patients pretreated with conventional NPWT or isolated gram-positive or negative germs were performed. NPWTi-d was applied on average for 13 days with a total hospitalisation time of 51 days. After NPWTi-d, decontaminated wounds were detected in 23% of cases. The number of different bacteria as well as bacterial count could be significantly reduced from 2.38 to 1.16 and 3.9 to 1.3, respectively. This was similar for all subgroups except surgical wounds, in which NPWTi-d did not lead to a significant reduction of the bacterial count. NPWTi-d resulted in a significant stimulation of granulation tissue. Successful reconstruction was achieved in 90% of cases. NPWTi-d enabled wound pre-conditioning by powerfully reducing or decontaminating the bacterial load and spectrum in most of the wounds. The wound bed integrity was re-established to prepare successful reconstruction.
Published: 2020

25. Stationäre Psychosomatik in Zeiten des Coronavirus

Author: Thomas H. Loew, Maximilian Krinninger, and Christian Kettler
Subjects: 050103 clinical psychology, medicine.medical_specialty, Psychotherapie Aktuell, Coronavirus disease 2019 (COVID-19), Patient care, Persönliche Schutzausrichtung, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, Personal protective equipment, medicine, 0501 psychology and cognitive sciences, Coronavirus, Gynecology, Coronavirus disease 2019, business.industry, 05 social sciences, Patientenversorgung, Hygiene, Checklist, 030227 psychiatry, Clinical Psychology, Check-Liste, business, „Coronavirus disease 2019“
Abstract: Die aktuelle Coronavirus-Pandemie stellt psychosomatische Kliniken vor neue Herausforderungen. Damit auch niedergelassene Psychotherapeuten sich für ihre Patientinnen und Patienten ein Bild machen können, wurden im Folgenden zentrale hygienische Aspekte aufbereitet. Drei grundsätzliche Versorgungsmuster und Angebote der Einrichtungen können unterschieden werden: Umwidmung, schrittweise Räumung und Stand-by für die Umwidmung sowie Fortsetzung des Betriebs unter seuchenmedizinischen Rahmenbedingungen. Inhaltlich werden folgende Themen relevant: Beratungsbedarf in Sachen Angst vor dem Coronavirus sowie zwischenmenschliche psychische und psychosomatische Probleme im Zuge der notwendigen sozialen Distanz, Versorgung insbesondere bei prekären Wohnsituationen, veränderte Kommunikationsstrukturen (Telefon, Videosprechstunde) und Betreuung der mit dem Thema „coronavirus disease 2019“ (COVID-19) Beschäftigten. Alle Patientinnen und Patienten durchlaufen vor der Aufnahme einen klinischen und virologischen Diagnoseprozess und werden, evtl. unter Quarantänebedingungen beginnend, psychosomatisch-psychotherapeutisch stationär versorgt. Abschließend wird dargestellt, was den Patientinnen und Patienten mithilfe eines einfachen Merkschemas mitgeteilt wird: Abstand (mindestens 2 m), Abreibung (oft und wenigstens 20 s lang Händewaschen mit Seife), Ausweichen (freundliches Aneinander-vorbei-Gehen), alternative Kommunikation, Aussetzen (es geht auch ohne Shopping), Abwischen (regelmäßig alle Flächen, durch das Reinigungspersonal, aber auch Tablet und Handy durch die Patientin oder den Patienten) und möglichst außen bewegen, allein oder zusammensitzen (mit Sicherheitsabstand). Das psychosomatische Angebot wurden entsprechend umgewandelt.
Published: 2020

26. The Punatsangchhu-I dam landslide illuminated by InSAR multitemporal analyses

Author: Andrea Manconi, Simon Loew, Benedetta Dini, and Jamyang Chophel
Subjects: Synthetic aperture radar, 010504 meteorology & atmospheric sciences, Science, 0211 other engineering and technologies, Site selection, 02 engineering and technology, 01 natural sciences, Article, Natural (archaeology), Natural hazard, Interferometric synthetic aperture radar, Hydropower, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, Multidisciplinary, business.industry, Natural hazards, Landslide, Environmental sciences, Gravity dam, Medicine, business, Seismology, Geology
Abstract: We use multitemporal analyses based on Synthetic Aperture Radar differential interferometry (DInSAR) to study the slope adjacent to the large Punatsangchhu-I hydropower plant, a concrete gravity dam under construction in Bhutan since 2009. Several slope failures affected the site since 2013, probably as a consequence of toe undercutting of a previously unrecognised active landslide. Our results indicate that downslope displacement, likely related to the natural instability, was already visible in 2007 on various sectors of the entire valley flank. Moreover, the area with active displacements impinging on the dam site has continuously increased in size since 2007 and into 2018, even though stabilization measures have been implemented since 2013. Stabilisation measures currently only focus on a small portion of the slope, however, the unstable area is larger than previously evaluated. Highly damaged rock is present across many areas of the entire valley flank, indicating that the volumes involved may be orders of magnitude higher than the area on which stabilisation efforts have been concentrated after the 2013 failure. The results highlight that satellite-based DInSAR could be systematically used to support decision making processes in the different phases of a complex hydropower project, from the feasibility study, to the dam site selection and construction phase., Scientific Reports, 10 (1), ISSN:2045-2322
Published: 2020

27. Cemented all-polyethylene glenoid with standard or individualized backside curvature

Author: Markus Loew, Marc Schnetzke, Susan Sulzer, and Jennifer Engelke
Subjects: Orthodontics, 030222 orthopedics, medicine.medical_specialty, business.industry, medicine.medical_treatment, Radiodensity, Radiography, 030229 sport sciences, All polyethylene, Curvature, Prosthesis, 03 medical and health sciences, 0302 clinical medicine, Orthopedic surgery, medicine, Orthopedics and Sports Medicine, Surgery, Range of motion, business, Shoulder replacement
Abstract: Background The clinical and radiographic results of an all-polyethylene glenoid with variable backside curvature adapted to the individual anatomy were compared with a standard all-polyethylene glenoid. Methods This retrospective study included 87 patients with primary glenohumeral osteoarthritis and anatomic shoulder replacement with a short-stem prosthesis and cemented all-polyethylene glenoid. In all, 42 patients with a mean age of 67 ± 8 years were treated with an all-polyethylene glenoid without variable curvature (group 1) and 45 patients with a mean age of 68 ± 10 years were treated with an all-polyethylene glenoid with individualized curvature (group 2). Clinical outcome was determined by range of motion, Constant Score (CS) age- and sex-adjusted Constant Score (CS%), and Subjective Shoulder Value (SSV). Radiographs were analyzed for the occurrence of radiolucent lines according to the method of Mole. Results After a mean follow-up of 31 months (range, 24–50) a significant improvement was achieved in all clinical parameters in both groups (p p = 0.713). At the final follow-up, the radiolucent line scores were 1.2 ± 2.0 in group 1 and 0.9 ± 1.1 in group 2 (p = 0.410). In five patients (12%) from group 1 and four patients from group 2 (9%), the radiolucent line score increased over time. One patient in group 1 (2%) exhibited radiographic glenoid loosening. Conclusion The all-polyethylene glenoid with individualized curvature showed promising short-term clinical and radiographic results. Further studies with a longer follow-up are necessary to evaluate whether the new all-polyethylene glenoid is superior to the standard all-polyethylene glenoid.
Published: 2020

28. Genauigkeit der konventionellen Röntgendiagnostik bei der Beurteilung der Daumensattelgelenkarthrose

Author: Hans-Guenther Machens, Philipp Moog, Daniel Schmauss, Michael Cerny, Holger Erne, Steffen Loew, and Julia Betzl
Subjects: Gynecology, 030222 orthopedics, medicine.medical_specialty, business.industry, Diagnostic accuracy, Osteoarthritis, 030230 surgery, medicine.disease, ddc, 03 medical and health sciences, Conventional X-Ray, 0302 clinical medicine, Emergency Medicine, medicine, Orthopedics and Sports Medicine, Surgery, business
Abstract: Zusammenfassung Hintergrund Die Daumensattelgelenkarthrose ist ein häufiges und schmerzhaftes Krankheitsbild, das mittels konventioneller Röntgenbildgebung und Arthroskopie diagnostiziert und ggf. therapiert werden kann. Dabei stellt die Röntgenklassifikation oft den arthroskopisch dargestellten Knorpelschaden nicht angemessen dar. Ziel der Arbeit (Fragestellung) Das Ziel dieser Arbeit war, die Genauigkeit von konventioneller Röntgendiagnostik im Vergleich zu Arthroskopie bei Daumensattelgelenkarthrose zu beurteilen. Material und Methoden Die präoperativen konventionellen Röntgenbilder von 23 Patienten wurden 10 erfahrenen Handchirurgen vorgelegt, die gegenüber den dazugehörigen Arthroskopiebefunden verblindet waren. Ihre Beurteilungen wurden anschließend mit den Befunden der Arthroskopien verglichen. Ergebnisse Elf Patienten wiesen Läsionen 4. Grades nach der Outerbridge-Klassifikation auf, 8 Läsionen 3. Grades, 4 Läsionen 2. Grades und keiner Läsionen 1. Grades. Insgesamt wurden 43 % (95 %-KI[Konfidenzintervall] 37–49 %) der Knorpelläsionen mittels konventionellen Röntgens korrekt diagnostiziert. Für die Läsionen 4. Grades stellten 73 % (95 %-KI 65–81 %) der Untersucher korrekte Diagnosen, für die 3. Grades 38 % (95 %-KI 27–49 %) und für die 2. Grades 13 % (95 %-KI 3–23 %). Schlussfolgerung Diese Studie präsentiert ein arthroskopisches Klassifikationssystem, das spezifisch für die Daumensattelgelenkarthrose ist und eine weitere Beurteilungsmöglichkeit darstellen kann, falls die Bilder für die röntgenologischen Klassifikation nach Eaton und Littler zu unspezifisch sind. Hier kann die Arthroskopie eine genauere Einteilung in therapierelevante Stadien ermöglichen und umfasst zudem auch therapeutische Optionen.
Published: 2020

29. Texture analysis and machine learning algorithms accurately predict histologic grade in small (< 4 cm) clear cell renal cell carcinomas: a pilot study

Author: James Earls, Anishsanjay Nayak, Shawn Haji-Momenian, Bhumi Patel, Adam Michalak, Zixian Lin, Nicole Law, and Murray H. Loew
Subjects: Male, False discovery rate, Urology, Pilot Projects, Texture (music), Machine learning, computer.software_genre, 030218 nuclear medicine & medical imaging, Machine Learning, 03 medical and health sciences, 0302 clinical medicine, Histogram, Humans, Medicine, Radiology, Nuclear Medicine and imaging, Carcinoma, Renal Cell, Retrospective Studies, Radiological and Ultrasound Technology, Receiver operating characteristic, business.industry, Gastroenterology, Middle Aged, medicine.disease, Kidney Neoplasms, Random forest, Support vector machine, Clear cell renal cell carcinoma, Feature (computer vision), 030220 oncology & carcinogenesis, Radiographic Image Interpretation, Computer-Assisted, Female, Artificial intelligence, Neoplasm Grading, Tomography, X-Ray Computed, business, Algorithm, computer
Abstract: To predict the histologic grade of small clear cell renal cell carcinomas (ccRCCs) using texture analysis and machine learning algorithms. Fifty-two noncontrast (NC), 26 corticomedullary (CM) phase, and 35 nephrographic (NG) phase CTs of small (
Published: 2019

30. The Adolescent and Caregiver Sickle Cell Disease Self-management Skills Checklist: Preliminary Reliability and Validity

Author: Jerlym S. Porter, Rebecca Rupff, Jane S. Hankins, Justin L Williams, Megan Loew, and Kathryn M. Russell
Subjects: Adult, Male, Adolescent, Psychometrics, MEDLINE, Anemia, Sickle Cell, Disease, 03 medical and health sciences, 0302 clinical medicine, Cronbach's alpha, Health care, Humans, Medicine, Child, Reliability (statistics), business.industry, Retrospective cohort study, Hematology, Checklist, Self Care, Caregivers, Oncology, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Female, business, 030215 immunology, Clinical psychology
Abstract: Adolescents with sickle cell disease (SCD) need assistance in developing the knowledge and skills that contribute to increased disease self-management and successful transition to adult-based health care. This study evaluated the preliminary psychometric properties of the Self-Management Skills Checklist (SMSC and SMSC-C; Adolescent and Caregiver versions), a measure of perceived SCD-specific knowledge and skills. A retrospective cohort study included 114 adolescents (mean=15.6 y) and their caregivers. We examined internal structure and reliability, score changes over time, and group differences. Cronbach coefficient alphas were 0.79 and 0.74 for caregiver-reported Skills and caregiver-reported knowledge, respectively, and 0.77 and 0.44 for adolescent-reported skills and adolescent-reported knowledge, respectively, indicating good internal consistency for 3 of the subscales. Poor reliability in the adolescent-reported knowledge summary score and factor analysis suggest an interpretation item-by-item, independent of one another. Participant group differences in age and chronic transfusion treatment existed in both summary and subscale scores of the SMSC and SMSC-C. Follow-up administrations of the scales indicated an increase in caregiver-reported skills for their adolescents from time 1 scores (M=3.72±0.83) to time 2 scores (M=3.99±0.63) (t16=2.178, P=0.045). Findings provide preliminary support for the usage of the SMSC and continued development to improve its psychometrics.
Published: 2019

31. Acute kidney injury in patients treated with immune checkpoint inhibitors

Author: Enriqueta Felip, Sophie Papa, Shuchi Anand, Karolina Benesova, Ala Abudayyeh, Omar Mamlouk, Umut Selamet, Grace Cherry, Sunandana Chandra, Sandra M Herrmann, Maria Jose Soler, Abhijat Kitchlu, Jamie S Lin, Kerry L Reynolds, Osama E Rahma, Elizabeth M Gaughan, Eva Muñoz-Couselo, Jamie S Hirsch, Pablo Garcia, Meghan D Lee, Harish Seethapathy, Ian A Strohbehn, Meghan E Sise, Wei-Ting Chang, Els Wauters, Lucy Flanders, Deborah Schrag, Thibaud Koessler, Mark Eijgelsheim, Shruti Gupta, Frank B Cortazar, Samuel A P Short, Jason M Prosek, Sethu M Madhavan, Ilya Glezerman, Shveta S Motwani, Naoka Murakami, Rimda Wanchoo, David I Ortiz-Melo, Arash Rashidi, Ben Sprangers, Vikram Aggarwal, A Bilal Malik, Sebastian Loew, Christopher A Carlos, Pazit Beckerman, Zain Mithani, Chintan V Shah, Amanda D Renaghan, Sophie De Seigneux, Luca Campedel, Daniel Sanghoon Shin, Sunil Rangarajan, Priya Deshpande, Gaia Coppock, Dwight H. Owen, Marium Husain, Clara Garcia-Carro, Sheila Bermejo, Nuttha Lumlertgul, Nina Seylanova, Busra Isik, Aydin Kaghazchi, Yuriy Khanin, Sheru K Kansal, Kai M Schmidt-Ott, Raymond K Hsu, Maria C Tio, Suraj Sarvode Mothi, Harkarandeep Singh, Kenar D Jhaveri, David E Leaf, Corinne Isnard Bagnis, Suraj S Mothi, Weiting Chang, Vipulbhai Sakhiya, Daniel Stalbow, Sylvia Wu, Armando Cennamo, Anne Rigg, Nisha Shaunak, Zoe A Kibbelaar, Harish S Seethapathy, Meghan Lee, Ian A Strohbhen, Ilya G Glezerman, Dwight H Owen, Sharon Mini, Andrey Kisel, Nicole Albert, Katherine Carter, Vicki Donley, Tricia Young, Heather Cigoi, Els Wauters Ben Sprangers, Javier A Pagan, Jonathan J Hogan, Valda Page, Samuel AP Short, Maria Josep Carreras, Institut Català de la Salut, [Gupta S] Division of Renal Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA. [Short SAP] University of Vermont Larner College of Medicine, Burlington, Vermont, USA. [Sise ME] Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA. [Prosek JM, Madhavan SM] Division of Nephrology, Department of Internal Medicine, The Ohio State University Medical Center, Columbus, Ohio, USA. [Soler MJ, Bermejo S] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ostermann M] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Nephrology Department, San Carlos Clinical University Hospital, Madrid, Spain, and Vall d'Hebron Barcelona Hospital Campus
Subjects: Male, Cancer Research, ACUTE INTERSTITIAL NEPHRITIS, Immunoteràpia, Other subheadings::Other subheadings::/drug therapy [Other subheadings], urologic and male genital diseases, THERAPY, Gastroenterology, Cohort Studies, Risk Factors, Immunology and Allergy, Immune Checkpoint Inhibitors, RC254-282, RISK, Clinical/Translational Cancer Immunotherapy, Kidney, medicine.diagnostic_test, terapéutica::terapia biológica::inmunomodulación::inmunoterapia [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Acute kidney injury, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Acute Kidney Injury, Middle Aged, female genital diseases and pregnancy complications, medicine.anatomical_structure, Oncology, Molecular Medicine, Female, immunotherapy, Life Sciences & Biomedicine, CTLA-4 antigen, medicine.medical_specialty, enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::insuficiencia renal::lesión renal aguda [ENFERMEDADES], medicine.drug_class, Immunology, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Proton-pump inhibitor, Renal function, programmed cell death 1 receptor, EVENTS, Internal medicine, Biopsy, medicine, Humans, Adverse effect, Acute tubulointerstitial nephritis, Aged, Pharmacology, Science & Technology, Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], urogenital system, business.industry, Proportional hazards model, CLINICAL-FEATURES, medicine.disease, Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Renal Insufficiency::Acute Kidney Injury [DISEASES], business, Ronyons - Malalties - Tractament
Abstract: BackgroundImmune checkpoint inhibitor-associated acute kidney injury (ICPi-AKI) has emerged as an important toxicity among patients with cancer.MethodsWe collected data on 429 patients with ICPi-AKI and 429 control patients who received ICPis contemporaneously but who did not develop ICPi-AKI from 30 sites in 10 countries. Multivariable logistic regression was used to identify predictors of ICPi-AKI and its recovery. A multivariable Cox model was used to estimate the effect of ICPi rechallenge versus no rechallenge on survival following ICPi-AKI.ResultsICPi-AKI occurred at a median of 16 weeks (IQR 8–32) following ICPi initiation. Lower baseline estimated glomerular filtration rate, proton pump inhibitor (PPI) use, and extrarenal immune-related adverse events (irAEs) were each associated with a higher risk of ICPi-AKI. Acute tubulointerstitial nephritis was the most common lesion on kidney biopsy (125/151 biopsied patients [82.7%]). Renal recovery occurred in 276 patients (64.3%) at a median of 7 weeks (IQR 3–10) following ICPi-AKI. Treatment with corticosteroids within 14 days following ICPi-AKI diagnosis was associated with higher odds of renal recovery (adjusted OR 2.64; 95% CI 1.58 to 4.41). Among patients treated with corticosteroids, early initiation of corticosteroids (within 3 days of ICPi-AKI) was associated with a higher odds of renal recovery compared with later initiation (more than 3 days following ICPi-AKI) (adjusted OR 2.09; 95% CI 1.16 to 3.79). Of 121 patients rechallenged, 20 (16.5%) developed recurrent ICPi-AKI. There was no difference in survival among patients rechallenged versus those not rechallenged following ICPi-AKI.ConclusionsPatients who developed ICPi-AKI were more likely to have impaired renal function at baseline, use a PPI, and have extrarenal irAEs. Two-thirds of patients had renal recovery following ICPi-AKI. Treatment with corticosteroids was associated with improved renal recovery.
Published: 2021

32. Asymmetric leaflet tethering is associated with worse outcomes after edge-to-edge mitral valve repair for secondary mitral regurgitation

Author: L Stolz, M Orban, D Braun, P Doldi, T Stocker, M Mehr, J Steffen, K Loew, C Hagl, S Massberg, M Naebauer, and J Hausleiter
Subjects: medicine.medical_specialty, Mitral valve repair, Mitral regurgitation, Leaflet (botany), Tethering, business.industry, Internal medicine, medicine.medical_treatment, Cardiology, Medicine, Edge (geometry), Cardiology and Cardiovascular Medicine, business
Abstract: Background The impact of mitral valve (MV) tethering patterns on outcomes of patients undergoing transcatheter edge-to-edge mitral valve repair (TEER) for severe secondary mitral regurgitation (SMR) is unknown. Purpose The purpose of this study was to evaluate the impact of asymmetric postero-anterior and medio-lateral MV leaflet tethering on procedural and survival outcomes after TEER for SMR. Methods Symmetry of postero-anterior leaflet tethering was defined as the ratio of the posterior to anterior MV leaflet angle (PLA/ALA) in the central MV segment 2. The ratio of the tenting area between MV segments 3 and 1 (S3/S1 ratio) was defined as medio-lateral tethering symmetry. We used receiver operating characteristics and a proportional Cox model to identify cut-off values of asymmetric postero-anterior and medio-lateral tethering for prediction of two-year survival after TEER. Results 178 patients receiving TEER for SMR were included. Asymmetric postero-anterior tethering was observed in 67 patients (37.6%, PLA/ALA ratio cut-off >1.54). Medio-lateral tethering was asymmetric in 49 patients (27.5%, S3/S1 ratio cut-off >1.49). MR was reduced to MR ≤2+ in 91.6% of patients, while postprocedural MR remained higher in the presence of asymmetric postero-anterior tethering (p=0.01). After adjustment for potential clinical and echocardiographic confounders, multivariable Cox regression analysis confirmed asymmetric postero-anterior tethering (HR=2.77, CI=1.43–5.38, p Conclusions Asymmetric postero-anterior and medio-lateral MV leaflet tethering patterns independently increase two-year all-cause mortality in patients undergoing TEER for SMR. Detailed echocardiographic patient selection might improve outcomes after TEER. Funding Acknowledgement Type of funding sources: None. Postero-anterior tetheringMedio-lateral tethering
Published: 2021

33. CFPNET: Channel-Wise Feature Pyramid For Real-Time Semantic Segmentation

Author: Ange Lou and Murray H. Loew
Subjects: business.industry, Computer science, Feature (computer vision), Inference, Pattern recognition, Segmentation, Artificial intelligence, Pyramid (image processing), business, Mobile device, Image (mathematics), Communication channel, Convolution
Abstract: Real-time semantic segmentation is playing a more important role in computer vision, due to the growing demand for mobile devices and autonomous driving. Therefore, it is very important to achieve a good trade-off among performance, model size and inference speed. In this paper, we propose a Channel-wise Feature Pyramid (CFP) module to balance those factors. Based on the CFP module, we built CFPNet for real-time semantic segmentation which applied a series of dilated convolution channels to extract effective features. Experiments on Cityscapes and CamVid datasets show that the proposed CFPNet achieves an effective combination of those factors. For the Cityscapes test dataset, CFPNet achieves 70.1% class-wise mIoU with only 0.55 million parameters and 2.5 MB memory. The inference speed can reach 30 FPS on a single RTX 2080Ti GPU with a 1024x2048-pixel image.
Published: 2021

34. Context and Culture affect the Psychometrics of Questionnaires evaluating Speech-based Assistants

Author: Frederik Naujoks, Andreas Keinath, Alexandra Loew, Ina Koniakowsky, and Yannick Forster
Subjects: Structure (mathematical logic), Psychometrics, Cronbach's alpha, User experience design, Computer science, business.industry, Applied psychology, Context (language use), Sample (statistics), Usability, Affect (psychology), business
Abstract: Intelligent Personal Assistants (IPAs) have grown into technologically mature systems. However, instruments used for evaluating the usability and user experience of IPAs were developed two decades ago. This bears the danger for research and development to apply inadequate measurements to a novel technology. In this study, more recent scales from human-robot-interaction were used for evaluating speech-based assistants in vehicles in a Chinese sample. However, it cannot be assumed, that adapting a questionnaire from another context and culture leads to objective, reliable and valid measurements. Therefore, data was examined regarding internal consistency and factor structure. Cronbach's alpha was considerably high. However, a factor analysis did not support the assumed four-factor structure but rather a two-factorial solution. Findings suggest that adapting a questionnaire from a different context and culture, can affect its psychometrics. Consequently, the underlying postulated constructs should be treated with caution.
Published: 2021

35. A Complete and Low-Cost Cardiac Optical Mapping System in Translational Animal Models

Author: Manuel Marina-Breysse, Alba García-Escolano, Joaquín Vila-García, Gabriel Reale-Nosei, José M. Alfonso-Almazán, Ping Yan, Jorge G. Quintanilla, Leslie M. Loew, Peter Lee, and David Filgueiras-Rama
Subjects: Computer science, business.industry, Cardiac electrophysiology, Physiology, Translational research, Brief Research Report, Data science, animal models, optical mapping, Software, calcium sensitive dyes, voltage sensitive dyes, Optical mapping, Physiology (medical), QP1-981, Research questions, Spatiotemporal resolution, business, cardiac electrophysiology, Cytosolic calcium
Abstract: Clinicians, biologists, physicists, engineers, and computer scientists are coming together to better understand heart disease, which is currently the leading cause of death globally. Optical mapping, a high-speed fluorescence imaging technique that visualizes and measures key cardiac parameters such as action potentials, cytosolic calcium transients, and fibrillation dynamics, is a core research tool that has arisen from such interdisciplinary collaborations. In an effort to broaden its use, especially among clinical scientists and students, we developed a complete and low-cost optical mapping system, including a constant-flow Langendorff perfusion system, which minimizes the economic threshold to widespread use of this powerful tool in cardiac electrophysiology research. The system described here provides high spatiotemporal resolution data about action potentials, intracellular calcium transients and fibrillation wave dynamics in isolated Langendorff-perfused hearts (pigs and rabbits), relevant for translational research. All system components and software elements are fully disclosed with the aim of increasing the use of this affordable and highly versatile tool among clinicians, basic scientists and students wishing to tackle their own research questions with their own customizable systems.
Published: 2021

36. SBML Level 3: an extensible format for the exchange and reuse of biological models

Author: Edda Klipp, Marco Antoniotti, Frank Bergmann, James C. Schaff, Peter D. Karp, Daniel Lucio, Kedar Nath Natarajan, Thomas M. Hamm, Leandro Watanabe, Henning Hermjakob, David Tolnay, John Wagner, Joerg Stelling, Alida Palmisano, Falk Schreiber, Yukiko Matsuoka, Harold F. Gómez, Huaiyu Mi, Carole J. Proctor, Ulrike Wittig, Neil Swainston, Jan Červený, Denis Thieffry, Piero Dalle Pezze, Julio Saez-Rodriguez, Maciej J. Swat, Bin Hu, Martina Kutmon, Thomas Pfau, Bas Teusink, Sarah M. Keating, Fedor A. Kolpakov, Andreas Dräger, Pedro Mendes, Martin Scharm, Emek Demir, Ioannis Xenarios, Christoph Flamm, Axel von Kamp, Darren J. Wilkinson, Nick Juty, Fengkai Zhang, Leonard A. Harris, Michael Schubert, Dagmar Waltemath, Lucian P. Smith, Steffen Klamt, Herbert M. Sauro, Ali Ebrahim, Wolfram Liebermeister, Christian Knüpfer, Nicolas Rodriguez, Tramy Nguyen, Naoki Tanimura, Christopher Cox, Stuart C. Sealfon, Nicholas Alexander Allen, Clemens Wrzodek, Bastian R. Angermann, Martin Meier-Schellersheim, Anna Zhukova, Jean-Baptiste Pettit, Hovakim Grabski, Devin P. Sullivan, Claudine Chaouiya, Michael L. Blinov, John Doyle, Ilya Kiselev, Roman Schulte, Alex Gutteridge, Mélanie Courtot, Eric Mjolsness, Finja Wrzodek, Rahuman S Malik-Sheriff, Ronan M. T. Fleming, Bruce E. Shapiro, Kimberly Begley, Leslie M. Loew, Colin S. Gillespie, Ibrahim Vazirabad, Michael Hucka, Akira Funahashi, Bernhard O. Palsson, Hamid Bolouri, Tomáš Helikar, Camille Laibe, William S. Denney, Chris T. Evelo, Florian Mittag, William S. Hlavacek, Ron Henkel, Harish Dharuri, Julien Dorier, Karthik Raman, Martina Fröhlich, Conor Lawless, Rainer Machné, Falko Krause, Damon Hachmeister, Matthias König, Clifford A. Shaffer, Benjamin D. Heavner, Douglas B. Kell, Jonathan R. Karr, Mihai Glont, Lukas Endler, Melanie I. Stefan, Robert Phair, Lu Li, Henning Schmidt, Dirk Drasdo, Johan Elf, Allyson L. Lister, Hiroaki Kitano, Richard R. Adams, Oliver A. Ruebenacker, Roland Keller, Sven Sahle, Ion I. Moraru, Gary D. Bader, Poul M. F. Nielsen, Johann M. Rohwer, Johannes Eichner, Daniel R. Hyduke, James R. Faeder, Stefan Hoops, Emanuel Gonçalves, Yuichiro Inagaki, Aurélien Naldi, Koichi Takahashi, Sylvain Soliman, Brett G. Olivier, Kieran Smallbone, Stuart L. Moodie, Pedro T. Monteiro, Chris J. Myers, Martin Golebiewski, Tomas Radivoyevitch, Jeremy Zucker, Hidde de Jong, Andrew Finney, Keating, S, Waltemath, D, König, M, Zhang, F, Dräger, A, Chaouiya, C, Bergmann, F, Finney, A, Gillespie, C, Helikar, T, Hoops, S, Malik-Sheriff, R, Moodie, S, Moraru, I, Myers, C, Naldi, A, Olivier, B, Sahle, S, Schaff, J, Smith, L, Swat, M, Thieffry, D, Watanabe, L, Wilkinson, D, Blinov, M, Begley, K, Faeder, J, Gómez, H, Hamm, T, Inagaki, Y, Liebermeister, W, Lister, A, Lucio, D, Mjolsness, E, Proctor, C, Raman, K, Rodriguez, N, Shaffer, C, Shapiro, B, Stelling, J, Swainston, N, Tanimura, N, Wagner, J, Meier-Schellersheim, M, Sauro, H, Palsson, B, Bolouri, H, Kitano, H, Funahashi, A, Hermjakob, H, Doyle, J, Hucka, M, Adams, R, Allen, N, Angermann, B, Antoniotti, M, Bader, G, Červený, J, Courtot, M, Cox, C, Dalle Pezze, P, Demir, E, Denney, W, Dharuri, H, Dorier, J, Drasdo, D, Ebrahim, A, Eichner, J, Elf, J, Endler, L, Evelo, C, Flamm, C, Fleming, R, Fröhlich, M, Glont, M, Gonçalves, E, Golebiewski, M, Grabski, H, Gutteridge, A, Hachmeister, D, Harris, L, Heavner, B, Henkel, R, Hlavacek, W, Hu, B, Hyduke, D, Jong, H, Juty, N, Karp, P, Karr, J, Kell, D, Keller, R, Kiselev, I, Klamt, S, Klipp, E, Knüpfer, C, Kolpakov, F, Krause, F, Kutmon, M, Laibe, C, Lawless, C, Li, L, Loew, L, Machne, R, Matsuoka, Y, Mendes, P, Mi, H, Mittag, F, Monteiro, P, Natarajan, K, Nielsen, P, Nguyen, T, Palmisano, A, Jean-Baptiste, P, Pfau, T, Phair, R, Radivoyevitch, T, Rohwer, J, Ruebenacker, O, Saez-Rodriguez, J, Scharm, M, Schmidt, H, Schreiber, F, Schubert, M, Schulte, R, Sealfon, S, Smallbone, K, Soliman, S, Stefan, M, Sullivan, D, Takahashi, K, Teusink, B, Tolnay, D, Vazirabad, I, Kamp, A, Wittig, U, Wrzodek, C, Wrzodek, F, Xenarios, I, Zhukova, A, Zucker, J, European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Heidelberg University Hospital [Heidelberg], Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL), European Molecular Biology Laboratory (EMBL), University of Connecticut (UCONN), National Institutes of Health [Bethesda] (NIH), Chercheur indépendant, Amazon Web Services [Seattle] (AWS), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), University of Toronto, Masaryk University [Brno] (MUNI), Terry Fox Laboratory, BC Cancer Agency (BCCRC)-British Columbia Cancer Agency Research Centre, The University of Tennessee [Knoxville], The Babraham Institute [Cambridge, UK], Oregon Health and Science University [Portland] (OHSU), Human Predictions LLC, Illumina, Swiss-Prot Group, Swiss Institute of Bioinformatics [Genève] (SIB), Modelling and Analysis for Medical and Biological Applications (MAMBA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Jacques-Louis Lions (LJLL (UMR_7598)), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of California [San Diego] (UC San Diego), University of California (UC), Center for Bioinformatics (ZBIT), Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen, Uppsala University, Institut für Populationsgenetik [Vienna], Veterinärmedizinische Universität Wien, Maastricht University [Maastricht], Alpen-Adria-Universität Klagenfurt [Klagenfurt, Austria], Medizinische Universität Wien = Medical University of Vienna, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Heidelberg Institute for Theoretical Studies (HITS ), Russian-Armenian University (RAU), GlaxoSmithKline [Stevenage, UK] (GSK), GlaxoSmithKline [Headquarters, London, UK] (GSK), Microsoft Technology Licensing (MTL), Microsoft Corporation [Redmond, Wash.], Vanderbilt University School of Medicine [Nashville], University of Washington [Seattle], University of Rostock, Los Alamos National Laboratory (LANL), Lorentz Institute, Universiteit Leiden, Tegmine Therapeutics, Modeling, simulation, measurement, and control of bacterial regulatory networks (IBIS), Laboratoire Adaptation et pathogénie des micro-organismes [Grenoble] (LAPM), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Jean Roget, SRI International [Menlo Park] (SRI), Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Liverpool, Universitätsklinikum Tübingen - University Hospital of Tübingen, Institute of Information and Computational Technologies (IICT), Max Planck Institute for Dynamics of Complex Technical Systems, Max-Planck-Gesellschaft, Max-Planck-Institut für Molekulare Genetik (MPIMG), Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Humboldt University Of Berlin, Newcastle University [Newcastle], École polytechnique (X), Heinrich Heine Universität Düsseldorf = Heinrich Heine University [Düsseldorf], The Systems Biology Institute [Tokyo] (SBI), Centro de Quimica Estrutural (CQE), Instituto Superior Técnico, Universidade Técnica de Lisboa (IST), University of Southern California (USC), Instituto Gulbenkian de Ciência [Oeiras] (IGC), Fundação Calouste Gulbenkian, University of Southern Denmark (SDU), University of Auckland [Auckland], University of Utah, Virginia Tech [Blacksburg], University of Luxembourg [Luxembourg], Integrative Bioinformatics Inc [Mountain View], Cleveland Clinic, Stellenbosch University, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Universität Heidelberg [Heidelberg] = Heidelberg University, Leibniz Institute of Plant Genetics and Crop Plant Research [Gatersleben] (IPK-Gatersleben), Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de la Mer de Villefranche (IMEV), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Mount Sinai School of Medicine, Department of Psychiatry-Icahn School of Medicine at Mount Sinai [New York] (MSSM), University of Manchester [Manchester], Computational systems biology and optimization (Lifeware), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), California Institute of Technology (CALTECH), Encodia Inc [San Diego], Shinshu University [Nagano], University of Amsterdam [Amsterdam] (UvA), Versiti Blood Center of Wisconsin, Greifswald University Hospital, Bioinformatique évolutive - Evolutionary Bioinformatics, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Pacific Northwest National Laboratory (PNNL), National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), Department of Bioengineering, University of California (UC)-University of California (UC), ANSYS, Virginia Polytechnic Institute and State University [Blacksburg], Eight Pillars Ltd, Center for Integrative Genomics - Institute of Bioinformatics, Génopode (CIG), Université de Lausanne = University of Lausanne (UNIL)-Université de Lausanne = University of Lausanne (UNIL), Universität Heidelberg, Bioquant, Applied Biomathematics [New York], SimCYP Ltd, Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Utah School of Medicine [Salt Lake City], University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Mizuho Information and Research Institute, Mathématiques et Informatique Appliquées du Génome à l'Environnement [Jouy-En-Josas] (MaIAGE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Oxford, Computer Science (North Carolina State University), North Carolina State University [Raleigh] (NC State), University of North Carolina System (UNC)-University of North Carolina System (UNC), University of California [Irvine] (UC Irvine), Indian Institute of Technology Madras (IIT Madras), California State University [Northridge] (CSUN), Biotechnology and Biological Sciences Research Council (BBSRC), IBM Research [Melbourne], Benaroya Research Institute [Seattle] (BRI), Okinawa Institute of Science and Technology Graduate University, Keio University, Department of Computing and Mathematical sciences, members, SBML Level 3 Community, Université de Lausanne (UNIL), Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), University of California, Universiteit Leiden [Leiden], Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Inria Grenoble - Rhône-Alpes, Humboldt University of Berlin, Universität Heidelberg [Heidelberg], Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Humboldt-Universität zu Berlin, University of California-University of California, Université de Lausanne (UNIL)-Université de Lausanne (UNIL), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Oxford [Oxford], University of California [Irvine] (UCI), Biotechnology and Biological Sciences Research Council, Computer Science, Institut de biologie de l'ENS Paris (UMR 8197/1024) (IBENS), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS Paris)
Subjects: computational modeling, Medicine (General), Markup language, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, INFORMATION, Interoperability, interoperability, Review, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], ANNOTATION, 0302 clinical medicine, Software, file forma, Models, Biology (General), 0303 health sciences, Computational model, Applied Mathematics, Systems Biology, systems biology, File format, 3. Good health, Networking and Information Technology R&D, Networking and Information Technology R&D (NITRD), Computational Theory and Mathematics, SIMULATION, General Agricultural and Biological Sciences, STANDARDS, REPOSITORY, Information Systems, QH301-705.5, Bioinformatics, Systems biology, Software ecosystem, Reviews, Bioengineering, Methods & Resources, Biology, MARKUP LANGUAGE, Models, Biological, SBML Level 3 Community members, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, R5-920, Animals, Humans, SBML, reproducibility, 030304 developmental biology, ENVIRONMENT, General Immunology and Microbiology, file format, business.industry, Computational Biology, Biological, ONTOLOGY, Metabolism, Logistic Models, Biochemistry and Cell Biology, Other Biological Sciences, Software engineering, business, 030217 neurology & neurosurgery
Abstract: Systems biology has experienced dramatic growth in the number, size, and complexity of computational models. To reproduce simulation results and reuse models, researchers must exchange unambiguous model descriptions. We review the latest edition of the Systems Biology Markup Language (SBML), a format designed for this purpose. A community of modelers and software authors developed SBML Level 3 over the past decade. Its modular form consists of a core suited to representing reaction‐based models and packages that extend the core with features suited to other model types including constraint‐based models, reaction‐diffusion models, logical network models, and rule‐based models. The format leverages two decades of SBML and a rich software ecosystem that transformed how systems biologists build and interact with models. More recently, the rise of multiscale models of whole cells and organs, and new data sources such as single‐cell measurements and live imaging, has precipitated new ways of integrating data with models. We provide our perspectives on the challenges presented by these developments and how SBML Level 3 provides the foundation needed to support this evolution., Over the past two decades, scientists from different fields have been developing SBML, a standard format for encoding computational models in biology and medicine. This article summarizes recent progress and gives perspectives on emerging challenges.
Published: 2020

37. Crafting an Adversarial Example in the DNN Representation Space by Minimizing the Distance from the Decision Boundary

Author: Li Li, Murray H. Loew, and Milos Doroslovacki
Subjects: Adversarial system, Range (mathematics), Robustness (computer science), Computer science, business.industry, Computation, Computer Science::Neural and Evolutionary Computation, Decision boundary, Magnitude (mathematics), Artificial intelligence, Space (commercial competition), Representation (mathematics), business
Abstract: Although deep neural networks (DNNs) achieve state-of-the-art performances in a wide range of machine learning (ML) applications, they are vulnerable: when small intentional perturbations are added to inputs, the network would misclassify them with high confidence. This phenomenon attracts broad attention because it is a security issue. In this paper, we study the geometric properties of the decision boundaries in the representation space of DNNs and propose novel adversarial approaches by moving the representations of the inputs toward the decision boundaries and thus change the predictions of the DNN. Our experimental results show that the proposed algorithms are on par or better than state-of-the-art adversarial approaches in terms of the magnitude of perturbation and computation time.
Published: 2021

38. Quality standards in proteomics research facilities

Author: Paolo Nanni, Teresa Mendes Maia, Mariette Matondo, Eduard Sabidó, Francis Impens, Karl Mechtler, Karel Stejskal, Anna Shevchenko, Damarys Loew, Dominic Helm, Thibaut Douché, Cristina Chiva, Mandy Rettel, Christian Panse, Barcelona Institute of Science and Technology (BIST), Universitat Pompeu Fabra [Barcelona] (UPF), VIB Proteomics Core, Ghent, Belgium, VIB-UGent Center for Medical Biotechnology, Universiteit Gent = Ghent University (UGENT), Swiss Institute of Bioinformatics [Lausanne] (SIB), Université de Lausanne = University of Lausanne (UNIL), Functional Genomics Center Zurich, Universität Zürich [Zürich] = University of Zurich (UZH)- Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Institute of Molecular Biotechnology (IMBA), Austrian Academy of Sciences (OeAW), Research Institute of Molecular Pathology (IMP), Spectrométrie de Masse pour la Biologie – Mass Spectrometry for Biology (UTechS MSBio), Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Spectrométrie de Masse Protéomique, Institut Curie [Paris], European Molecular Biology Laboratory [Heidelberg] (EMBL), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Gregor Mendel Institute (GMI) - Vienna Biocenter (VBC), Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG), Max-Planck-Gesellschaft, The CRG/UPF Proteomics Unit is part of the Spanish Infrastructure for Omics Technologies (ICTS OmicsTech) and it is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I + D+i 2013-2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. We acknowledge support from the Spanish Ministry of Science, Innovation and Universities, 'Centro de Excelencia Severo Ochoa 2013-2017', SEV-2012- 0208, and 'Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya' (2017SGR595). The VIB Proteomics Core acknowledges support from the VIB Tech Watch Fund and FWO-SBO Project S006617N. Research in the Mechtler lab was supported by the ERA-CAPS I 3686 project of the Austrian Science Fund. We acknowledge support from the European Union's Horizon 2020 research and innovation program under grant agreement No 823839 (EPIC-XS)., European Project: 823839,H2020-INFRAIA-2018-1,EPIC-XS(2019), Universiteit Gent = Ghent University [Belgium] (UGENT), Université de Lausanne (UNIL), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich)-Universität Zürich [Zürich] = University of Zurich (UZH), Institut Pasteur [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of Zurich, Nanni, Paolo, Shevchenko, Anna, and Sabidó, Eduard
Subjects: Proteomics, 1303 Biochemistry, Centres d'investigació, GeneralLiterature_INTRODUCTORYANDSURVEY, media_common.quotation_subject, 610 Medicine & health, 10071 Functional Genomics Center Zurich, Proteòmica, Biochemistry, Mass Spectrometry, 03 medical and health sciences, 0302 clinical medicine, 1311 Genetics, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], 1312 Molecular Biology, Genetics, Quality (business), Science & Society, Molecular Biology, 030304 developmental biology, media_common, 0303 health sciences, 3. Good health, Engineering management, ComputingMethodologies_PATTERNRECOGNITION, 570 Life sciences, biology, Business, 030217 neurology & neurosurgery
Abstract: Proteomics research infrastructures and core facilities within the Core for Life alliance advocate for community policies for quality control to ensure high standards in proteomics services. The CRG/UPF Proteomics Unit is a member of the ProteoRed PRB3 consortium which is supported by grant PT17/0019 of the PE I + D+i 2013‐2016 from the Instituto de Salud Carlos III (ISCIII) and ERDF. We acknowledge support from the Spanish Ministry of Science, Innovation and Universities, “Centro de Excelencia Severo Ochoa 2013‐2017”, SEV‐2012‐ 0208, and “Secretaria d’Universitats i Recerca del Departament d’Economia i Coneixement de la Generalitat de Catalunya” (2017SGR595). The VIB Proteomics Core acknowledges support from the VIB Tech Watch Fund and FWO‐SBO Project S006617N. Research in the Mechtler lab was supported by the ERA‐CAPS I 3686 project of the Austrian Science Fund. We acknowledge support from the European Union's Horizon 2020 research and innovation program under grant agreement No 823839 (EPIC‐XS)
Published: 2021

39. Expedited Partner Therapy in Female Adolescents: A Study of Acceptance and the Impact on Reinfection Rates

Author: Kathryn E. Gannon-Loew, Emily Alexy, Cynthia Holland-Hall, Kenneth Jackson, Ashley M. Ebersole, and Andrea E. Bonny
Subjects: Microbiology (medical), medicine.medical_specialty, Adolescent, Sexually Transmitted Diseases, Chlamydia trachomatis, Dermatology, medicine.disease_cause, Gonorrhea, Young Adult, Chart review, Internal medicine, Medicine, Humans, Positive test, Prospective Studies, Young adult, Retrospective Studies, business.industry, Public Health, Environmental and Occupational Health, Chlamydia Infections, Infectious Diseases, Sexual Partners, Reinfection, Cohort, Trichomonas vaginalis, Female, Contact Tracing, business
Abstract: BACKGROUND Given the high risk of sexually transmitted infections (STIs) in adolescents and young adults (AYAs), this study evaluated expedited partner therapy (EPT) acceptance and STI reinfection rates in female AYA before and after availability of EPT. METHODS The pre-EPT cohort was a 3-year (November 2012 to November 2015) retrospective chart review of female AYA positive for Chlamydia trachomatis (CT) and/or Trichomonas vaginalis (TV) before introduction of EPT. An EPT protocol for CT and TV infections was implemented after legalization in Ohio in 2016. The post-EPT cohort was a prospective review of patients positive for CT and TV for 2 years (5/2016-5/2018) after EPT introduction. We evaluated EPT acceptance and compared reinfection rates (positive test 1-6 months after initial infection) in the pre-EPT versus post-EPT cohorts and by EPT acceptance. RESULTS Among patients offered EPT, 28% (67/237) with CT and 25% (24/97) with TV accepted EPT. There were no significant differences in the reinfection rates for CT or TV in the pre-EPT versus post-EPT cohorts (CT: 24% (57/240) vs 20% (38/192), P = 0.42; TV: 23% (22/97) versus 14% (12/87), P = 0.11). Although lower, reinfections rates were not significantly different among patients who accepted versus did not accept EPT (CT, 13% (6/48) vs 21% (23/110), P = 0.50 and TV, 6% (1/18) vs 18% (9/49), P = 0.69). CONCLUSIONS Despite the implementation of an EPT protocol, STI reinfection rates among female AYA remained high, and many declined EPT. Further research is needed to identify barriers to the provision and acceptance of EPT and ways to address these factors.
Published: 2021

40. Risk factors for loosening of cemented glenoid components in anatomical shoulder arthroplasty

Author: Pascal Boileau, Patric Raiss, Markus Loew, Thomas Bruckner, Luc Favard, and Gilles Walch
Subjects: musculoskeletal diseases, medicine.medical_specialty, business.industry, medicine.medical_treatment, Radiography, Dentistry, musculoskeletal system, Arthroplasty, medicine.anatomical_structure, Patient age, Orthopedic surgery, medicine, Orthopedics and Sports Medicine, Surgery, Rotator cuff, Implant, Risk factor, business, Shoulder replacement
Abstract: Several risk factors leading to loosening of the glenoid have been described; however, there is no detailed information available on the exact numbers or percentages for each patient-related risk factor, implant-related risk factor, or risk factors related to surgical technique. Therefore, the aim of this multicenter study was to analyze these risk factors in a large cohort of patients treated with a 3rd-generation cemented total shoulder arthroplasty. Four-hundred seventy-one shoulder arthroplasties with a mean follow-up of 8.1 years were included. There were 318 women and 153 men. The mean age at the time of arthroplasty was 68 (range 35–90) years. The dominant shoulder was treated in 294 cases and the nondominant in 177. The following risk factors for loosening of the cemented keeled glenoid component were examined: gender, age, hand dominance, glenoid morphology, reaming on the glenoid side (reaming down the complete subchondral bone layer), glenohumeral mismatch, glenoid component design, and fatty degeneration of the rotator cuff. No influence on radiographic glenoid loosening was found for patient age at surgery, gender, hand dominance, preparation technique on the glenoid side, or fatty degeneration of the rotator cuff (p > 0.067). Excessive reaming on the native glenoid led to a 3.7-fold higher risk for glenoid component loosening (p
Published: 2019

41. Essays on Burton Richter and His Impact on the Field of Accelerator Physics

Author: Jonathan Dorfan, Herman Winick, Claudio Pellegrini, Nan Phinney, Greg Loew, Tor Raubenheimer, Robert Byer, James E. Paterson, and D. L. Burke
Subjects: Accelerator physics, Engineering, Field (physics), 010308 nuclear & particles physics, business.industry, 05 social sciences, Art history, 050905 science studies, 01 natural sciences, 0103 physical sciences, 0509 other social sciences, Spear, business, Earth-Surface Processes
Abstract: Burton Richter had an enormous impact on the field of accelerator science and technology. This paper recounts some of that impact through seven short essays from people who viewed his contributions to aspects of the field with topics ranging from colliding beam rings, linear colliders to Free Electron Lasers.
Published: 2019

42. Application of fiber optic reflectance spectroscopy for the detection of historical glass deterioration

Author: Stephanie Zaleski, Elizabeth Montagnino, Lynn Brostoff, Isabelle Muller, Andrew Buechele, Carol Lynn Ward‐Bamford, Fenella France, and Murray Loew
Subjects: Materials science, Optical fiber, business.industry, law, Reflectance spectroscopy, Materials Chemistry, Ceramics and Composites, Optoelectronics, Degradation (geology), business, Spectroscopy, law.invention
Published: 2019

43. Automated Detection of Lunar Rockfalls Using a Convolutional Neural Network

Author: Simon Loew, Charis Lanaras, Urs Mall, Valentin Tertius Bickel, and Andrea Manconi
Subjects: business.industry, Computer science, Detector, Feature extraction, 0211 other engineering and technologies, Pattern recognition, Ranging, 02 engineering and technology, Overfitting, Convolutional neural network, Data set, General Earth and Planetary Sciences, Artificial intelligence, Electrical and Electronic Engineering, business, Image resolution, 021101 geological & geomatics engineering
Abstract: This paper implements a novel approach to automatically detect and classify rockfalls in Lunar Reconnaissance Orbiter narrow angle camera (NAC) images using a single-stage dense object detector (RetinaNet). The convolutional neural network has been trained with a data set of 2932 original rockfall images. In order to avoid overfitting, the initial training data set has been augmented during training using random image rotation, scaling, and flipping. Testing images have been labelled by human operators and have been used for RetinaNet performance evaluation. Testing shows that RetinaNet is capable to reach recall values between 0.98 and 0.39, precision values between 1 and 0.25, and average precisions ranging from 0.89 to 0.69, depending on the used confidence threshold and intersection-over-union values. Mean processing time of a single NAC image in RetinaNet is around 10 s using a GeForce GTX 1080 Ti and GeForce Titan Xp, which is in orders of magnitudes faster than a human operator. The processing speed allows to efficiently exploit the currently available NAC data stack with more than 1 million images in a reasonable timeframe. The combination of speed and detection performance can be used to produce lunar rockfall distribution maps on large spatial scales for utilization by the scientific and engineering community.
Published: 2019

44. Assessing the relationship between movement and airflow in the upper airway using computational fluid dynamics with motion determined from magnetic resonance imaging

Author: Jason C. Woods, Charles L. Dumoulin, Keith McConnell, Andreas Schuh, Robert J. Fleck, Raouf S. Amin, Gabriel Amine-Eddine, Alister J. Bates, and Wolfgang Loew
Subjects: Adult, Male, Models, Anatomic, Movement, 0206 medical engineering, Airflow, Biophysics, Image registration, 02 engineering and technology, Computational fluid dynamics, Models, Biological, Motion, 03 medical and health sciences, 0302 clinical medicine, Medical imaging, Humans, Computer Simulation, Orthopedics and Sports Medicine, Lung, Simulation, Pressure drop, business.industry, Respiration, Mechanics, respiratory system, Magnetic Resonance Imaging, 020601 biomedical engineering, respiratory tract diseases, Trachea, Hydrodynamics, Breathing, business, Airway, 030217 neurology & neurosurgery, Geology, Large eddy simulation
Abstract: Background Computational fluid dynamics simulations of respiratory airflow in the upper airway reveal clinically relevant information, including sites of local resistance, inhaled particle deposition, and the effect of pathological constrictions. Unlike previous simulations, which have been performed on rigid anatomical models from static medical imaging, this work utilises cine imaging during respiration to create dynamic models and more closely represent airway physiology. Methods Airway movement maps were obtained from non-rigid image registration of fast-cine MRI and applied to high-spatial-resolution airway surface models. Breathing flowrates were recorded simultaneously with imaging. These data formed the boundary conditions for large eddy simulation computations of the airflow from exterior mask to bronchi. Simulations with rigid geometries were performed to demonstrate the resulting airflow differences between airflow simulations in rigid and dynamic airways. Findings In the analysed rapid breathing manoeuvre, incorporating airway movement significantly changed the findings of the CFD simulations. Peak resistance increased by 19.8% and occurred earlier in the breath. Overall pressure loss decreased by 19.2%, and the proportion of flow in the mouth increased by 13.0%. Airway wall motion was out-of-phase with the air pressure force, demonstrating the presence of neuromuscular motion. In total, the anatomy did 25.2% more work on the air than vice versa. Interpretations Realistic movement of the airway is incorporated into CFD simulations of airflow in the upper airway for the first time. This motion is vital to producing clinically relevant computational models of respiratory airflow and will allow novel analysis of dynamic conditions, such as sleep apnoea.
Published: 2019

45. Short-stem anatomical shoulder replacement—a systematic review

Author: Markus Loew, Gilles Walch, Marc Schnetzke, and Patric Raiss
Subjects: medicine.medical_specialty, Short stem, Calcar, business.industry, medicine.medical_treatment, Radiography, Arthroplasty, Surgery, Orthopedic surgery, medicine, Orthopedics and Sports Medicine, Revision rate, business, Range of motion, Shoulder replacement
Abstract: In shoulder arthroplasty, there is a trend for shorter humeral implants to facilitate stem revision and preserve bone stock. This review evaluates the clinical and radiographic outcome of anatomical total shoulder replacement with uncemented humeral short stems. A systematic review was performed using PubMed and Cochrane databases. The search terms “short stem” (all) and “shoulder” (title/abstract) were used. The minimum follow-up was 20 months. The demographic data, clinical outcome (pain, range of motion, outcome scores), radiographic outcome (humeral bone adaptations, humeral loosening, glenoid loosening), risk for high radiographic bone adaptations, complications, and revision were determined. Ten studies comprising 653 shoulder arthroplasties were included in the analysis. At an average follow-up of 20–64 months, the clinical parameters of pain, range of motion, and outcome scores improved significantly in all studies. The most frequent radiographic finding was calcar resorption in 15–71% of patients. High filling ratio, lack of metaphyseal porous coating, and poor bone quality were associated with high bone adaptation. The radiographic changes did not influence the clinical outcome in any study. In 13 of 653 patients (2%), humeral stem loosening was observed leading to stem revision in nine patients, with one study reporting eight of 73 patients with humeral stem loosening. The average weighted complication rate was 6% and the average weighted revision rate was 4%. The short- to medium-term results of uncemented anatomical short-stem shoulder arthroplasty are encouraging and the clinical results are comparable to other 3rd- and 4th-generation shoulder arthroplasties. Further studies with longer follow-up are needed to evaluate and understand why the radiographic changes occur and to prove the theory of bone-sparing revision surgeries.
Published: 2019

46. Omega-3 fatty acid supplementation – A possible dietary adjunct to enhance immune checkpoint inhibition therapy in cancer?

Author: Nadine Rohwer, Nikolaus Wachtel, Karsten H. Weylandt, Anne Pietzner, and Andreas Loew
Subjects: business.industry, Omega 3 fatty acid supplementation, Medicine, Cancer, Pharmacology, business, medicine.disease, Molecular Biology, Applied Microbiology and Biotechnology, Adjunct, Immune checkpoint, Biotechnology
Published: 2019

47. Threshold for Tonic Motor Effects from Random Waveform in a Rat Experimental Model of Frontal Cortex Stimulation

Author: Murray H. Loew, Zhixing Ye, Michaela Lee, and James W. Leiphart
Subjects: Male, Frontal cortex, Stimulation, Motor Activity, Tonic (physiology), Rats, Sprague-Dawley, otorhinolaryngologic diseases, Animals, Humans, Waveform, Medicine, Motor threshold, Experimental model, business.industry, Square wave, Models, Theoretical, Electric Stimulation, Electrodes, Implanted, Frontal Lobe, Rats, Sensory Thresholds, Brain stimulation, Models, Animal, Surgery, Neurology (clinical), business, Biomedical engineering
Abstract: Background: Brain stimulation is utilized to treat a variety of neurological disorders. Clinical brain stimulation technologies currently utilize charge-balanced pulse stimulation. The brain may better respond to other stimulation waveforms. This study was designed to evaluate the motor threshold of the brain to stimulation with various waveforms. Methods: Three stimulation waveforms were utilized on rats with surgically implanted brain electrodes: pulses, square waves, and random waveform. The peak-to-peak stimulation voltage was increased in a step-wise manner until motor signs were elicited. Results: The random waveform had the highest motor threshold with brain stimulation compared to the other waveforms. Random waveform stimulation reached maximum voltage without motor side effects while stimulating through both 1 and 8 electrodes. In contrast, the stimulation thresholds for motor side effects of the other two waveforms were on average less than half of the maximum voltage and lower for stimulation through 8 electrodes than stimulation through 1 electrode (p < 0.0005). Conclusion: The random waveform was better tolerated than the other waveforms and may allow for the use of higher stimulation voltage without side effects.
Published: 2019

48. Trends in Guideline-Adherent Chemoradiation Therapy for Locally Advanced Cervical Cancer Before and After the Affordable Care Act

Author: M. Lopez-Acevedo, B. Long, R.J. Thomas, Destie Provenzano, Murray H. Loew, Sharad Goyal, and Y.J. Rao
Subjects: Cervical cancer, Cancer Research, medicine.medical_specialty, Univariate analysis, education.field_of_study, Radiation, business.industry, Population, Cancer, Guideline, medicine.disease, Oncology, Internal medicine, Cohort, medicine, Carcinoma, Adenocarcinoma, Radiology, Nuclear Medicine and imaging, business, education
Abstract: PURPOSE/OBJECTIVE(S) This study assessed trends in guideline-adherent chemoradiation therapy (GA-RT) for advanced-stage cervical cancer relative to Patient Protection and Affordable Care Act (ACA) implementation in the year 2010. MATERIALS/METHODS National Cancer Database patients treated with definitive chemoradiation for locally advanced cervical cancer (FIGO 2018 Stage IB3-IVA) from 2004-2016 were included. GA-RT was defined according to NCCN guidelines and included: 1) delivery of external beam radiation, 2) brachytherapy, and 3) chemotherapy, 4) no radical hysterectomy. Univariable and multivariable logistic regression were used to determine trends in GA-RT relative to the ACA and identify patient factors independently associated with GA-RT. Survival of GA-RT was also estimated using Kaplan-Meier analysis. RESULTS Thirty-seven thousand seven hundred and seventy-two patients met inclusion criteria (Pre-ACA: 16,169; Post-ACA: 21,673). A total of 33,116 patients had squamous cell carcinoma, and 4,626 patients had other histologies. Forty-five percent of patients were node positive. A total of 14.6% of patients were Stage I, 41.8% were Stage II, 36.4% were Stage III, and 7.9% were Stage IVA. Compared to commercial insurance, patients with Medicare had decreased odds of receiving GA-RT (OR = 0.65; 95% CI:0.61-0.69). Black patients (OR = 0.9; 95% CI:0.85-0.95) were associated with decreased odds of receiving GA-RT. Compared to squamous cell carcinoma, adenocarcinoma and carcinoma NOS were associated with decreased receipt of GA-RT (OR = 0.87; 95% CI: 0.80-0.93 and OR = 0.64; 95% CI: 0.55-0.75, respectively). Increasing T-stage was associated with greater receipt of GA-RT (stages 1B2 [OR = 1.89, 95% CI: 1.53-2.37], 2A2 [OR = 2.29, 95% CI: 1.81-2.92], 2B [OR = 2.1, 95% CI: 1.71-2.61], and 3B [OR = 1.47, 95% CI: 1.19-1.83]). Patients with nodal stage NX were less likely to receive GA-RT compared to N0 (OR = 0.6, 95% CI: 0.52-0.68). Increasing Charlson-Deyo score was associated with decreased receipt of GA-RT (OR = 0.86, 95% CI: 0.82-0.89). In multivariate analysis, all factors remained statistically significant except for race. The percentage of population that was guideline adherent significantly increased post-ACA (pre-ACA 28%; post-ACA 34%; P < 0.001). On univariate analysis, patients were 34% more likely to receive GA-RT after the ACA compared to before the ACA. In the multivariate model, receipt of GA-RT increased by 30% (P < 0.001). Adherence to treatment guidelines increased 2-year overall survival by 15% (GA 76%; Not GA 61%; P < 0.001). The post-ACA cohort was associated with increased 2-year overall survival compared to the pre-ACA cohort (pre-ACA 62%; post-ACA 69%; P < 0.001). CONCLUSION Patients were more likely to be guideline adherent and receive GA-RT after the implementation of the ACA. This increase in guideline adherence was also associated with an increase in 2-year survival, indicating implementation of the ACA may have improved patient outcomes. AUTHOR DISCLOSURE R.J. Thomas: None. D. Provenzano: None. S. Goyal: Partner; Center for Rheumatic Diseases. M. Loew: None. B. Long: None. M. Lopez-Acevedo: None. Y.J. Rao: None.
Published: 2021

49. The 88-Inch Cyclotron: A one-stop facility for electronics radiation and detector testing

Author: Stephen B. Cronin, D. S. Todd, Adam Bushmaker, L. W. Phair, J. Y. Benitez, L. A. Bernstein, E. F. Matthews, T. A. Laplace, K. P. Harrig, T. Perry, Vanessa Oklejas, B.F. Ninemire, Michael B. Johnson, Alan R. Hopkins, J. A. Brown, D. L. Bleuel, Tim Loew, R.A. Albright, James E. Bevins, Don Walker, M. Harasty, A. Hodgkinson, Jihan Chen, M. Kireeff Covo, D. Z. Xie, and Bethany L. Goldblum
Subjects: Nuclear engineering, Cyclotron, 02 engineering and technology, 01 natural sciences, law.invention, Nuclear physics, law, 0103 physical sciences, Microelectronics, Neutron, Electronics, Electrical and Electronic Engineering, Nuclear Experiment, 010306 general physics, Instrumentation, Radiation hardening, Physics, business.industry, Applied Mathematics, Detector, Particle accelerator, Neutron radiation, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Physics::Accelerator Physics, 0210 nano-technology, business
Abstract: In outer space down to the altitudes routinely flown by larger aircrafts, radiation can pose serious issues for microelectronics circuits. The 88-Inch Cyclotron at Lawrence Berkeley National Laboratory is a sector-focused cyclotron and home of the Berkeley Accelerator Space Effects Facility, where the effects of energetic particles on sensitive microelectronics are studied with the goal of designing electronic systems for the space community. This paper describes the flexibility of the facility and its capabilities for testing the bombardment of electronics by heavy ions, light ions, and neutrons. Experimental capabilities for the generation of neutron beams from deuteron breakups and radiation testing of carbon nanotube field effect transistor will be discussed.
Published: 2018

50. DC-UNet: rethinking the U-Net architecture with dual channel efficient CNN for medical image segmentation

Author: Shuyue Guan, Murray H. Loew, and Ange Lou
Subjects: Jaccard index, Channel (digital image), business.industry, Computer science, Deep learning, Pattern recognition, Artificial intelligence, Image segmentation, Architecture, Similarity measure, business, Convolutional neural network, Encoder
Abstract: Recently, deep learning has become much more popular in computer vision applications. The Convolutional Neural Network (CNN) has brought a breakthrough in image segmentation, especially for medical images. In this regard, the UNet is the predominant approach to the medical image segmentation task. The U-Net not only performs well in segmenting multimodal medical images generally, but also in some difficult cases. We found, however, that the classical U-Net architecture has limitations in several respects. Therefore, we applied modifications: 1) designed efficient CNN architecture to replace encoder and decoder, 2) applied residual module to replace skip connection between encoder and decoder to improve, based on the-state-of-the-art U-Net model. Following these modifications, we designed a novel architecture -- DC-UNet, as a potential successor to the U-Net architecture. We created a new effective CNN architecture and built the DC-UNet based on this CNN. We have evaluated our model on three datasets with difficult cases and have obtained a relative improvement in performance of 2.90%, 1.49%, and 11.42% respectively compared with classical UNet. In addition, we used the Tanimoto similarity measure to replace the Jaccard measure for gray-to-gray image comparisons.
Published: 2021

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