1. Outcomes of surgical resection of gallbladder cancer in patients presenting with jaundice: A systematic review and meta-analysis
- Author
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James Hodson, Timothy M. Pawlik, Ravi Marudanayagam, Bobby V.M. Dasari, Keith J. Roberts, Mihnea I. Ionescu, Paolo Muiesan, Darius F. Mirza, John Isaac, and Robert P. Sutcliffe
- Subjects
medicine.medical_specialty ,Jaundice ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Carcinoma ,Hepatectomy ,Humans ,Radical surgery ,Gallbladder cancer ,Contraindication ,business.industry ,Gallbladder ,Hazard ratio ,General Medicine ,Odds ratio ,medicine.disease ,Prognosis ,Surgery ,Survival Rate ,medicine.anatomical_structure ,Oncology ,Bile Duct Neoplasms ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Gallbladder Neoplasms ,medicine.symptom ,business - Abstract
INTRODUCTION Preoperative jaundice is considered a relative contraindication to radical gallbladder cancer (GBC) resection due to poor prognosis and high postoperative morbidity. Recent reports have indicated that aggressive surgery may improve long-term survival for patients with advanced GBC who present with obstructive jaundice. The current systematic review and meta-analysis aimed to compare postoperative outcomes among jaundiced and non-jaundiced patients with resectable GBC. METHODS An electronic search was performed using several Medical Subject Headings terms: cholecyst, gallbladder, tumor, cancer, carcinoma, adenocarcinoma, neoplasia, neoplasm, jaundice, and icterus. Overall survival after surgery was the primary outcome; resectability and postoperative morbidity were the secondary outcomes. RESULTS Overall survival was shorter among patients who presented with jaundice (Hazard ratio [HR]: 2.21, 95% confidence interval [CI], 1.64-2.97; P
- Published
- 2018