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1. International Business and Trade in the Next Decade: Report from a Delphi Study

Author: Czinkota, Michael R. and Ronkainen, Ilkka A.
Published: 1997

2. Effectiveness and cost-effectiveness of a people-centred care model for community-living older people versus usual care ─ A randomised controlled trial

Author: Jukka Ronkainen, Raisa Laaksonen, Nelli Äijö-Jensen, Marjo Yliperttula, Marja Blom, Hanna Kortejärvi, Heini Kari, Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Drug Research Program, Biopharmaceutics Group, Divisions of Faculty of Pharmacy, Teachers' Academy, Clinical Pharmacy Group, and Pharmacoeconomics
Subjects: medicine.medical_specialty, Community-living older people, Cost effectiveness, Cost-Benefit Analysis, people-centred care, Pharmacist, Pharmaceutical Science, Pharmacy, Clinically trained pharmacist, law.invention, Clinical medication review, 03 medical and health sciences, 0302 clinical medicine, PRIMARY CARE, Quality of life, Randomized controlled trial, law, Intervention (counseling), Health care, Humans, health outcomes, Medicine, 030212 general & internal medicine, cost-effectiveness, Aged, clinically trained pharmacist, business.industry, 030503 health policy & services, Health outcomes, Primary care, People-centred care, 317 Pharmacy, community-living, Usual care, Quality of Life, Physical therapy, Cost-effectiveness, Quality-Adjusted Life Years, Older people, 0305 other medical science, business
Abstract: Background There is a need for effective and cost-effective interprofessional care models that support older people to maintain their quality of life (QoL) and physical performance to live longer independently in their own homes. Objectives The objectives were to evaluate effectiveness, QoL and physical performance, and cost-utility of a people-centred care model (PCCM), including the contribution of clinically trained pharmacists, compared with that of usual care in primary care. Methods A randomised controlled trial (RCT) with a two-year follow-up was conducted. The participants were multimorbid community-living older people, aged ≥75 years. The intervention comprised an at-home patient interview, health review, pharmacist-led clinical medication review, an interprofessional team meeting, and nurse-led care coordination and health support. At the baseline and at the 1-year and 2-year follow-ups, QoL (SF-36, 36-Item Short-Form Health Survey) and physical performance (SPPB, Short Performance Physical Battery) were measured. Additionally, a physical dimension component summary in the SF-36 was calculated. The SF-36 data were transformed into SF-6D scores to calculate quality-adjusted life-years (QALYs). Healthcare resource use were collected and transformed into costs. A healthcare payer perspective was adopted. Incremental cost-effectiveness ratio (ICER) was calculated, and one-way sensitivity analysis was performed. Results No statistically or clinically significant differences were observed between the usual care (n = 126) and intervention group (n = 151) patients in their QoL; at the 2-year follow-up the mean difference was −0.02, (95 % CI -0.07; 0.04,p = 0.56). While the mean difference between the groups in physical performance at the 2-year follow-up was −1.02, (−1.94;-0.10,p = 0.03), between the physical component summary scores it was −7.3, (−15.2; 0.6,p = 0.07). The ICER was −73 638€/QALY, hence, the developed PCCM dominated usual care, since it was more effective and less costly. Conclusions The cost-utility analysis showed that the PCCM including pharmacist-led medication review dominated usual care. However, it had no effect on QoL and the effect towards physical performance remained unclear.
Published: 2022
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3. Serological Biomarker Panel in Diagnosis of Atrophic Gastritis andHelicobacter pyloriInfection in Gastroscopy Referral Patients: Clinical Validation of the New-Generation GastroPanel®Test

Author: Janne Hukkanen, Henri Lumme, Olli Kettunen, Kari Syrjänen, Timo Blomster, Jukka Ronkainen, Markus J. Mäkinen, Antti Ala-Rämi, Ritva Koskela, Tuomo J. Karttunen, and Olli-Pekka Koivurova
Subjects: Cancer Research, medicine.medical_specialty, biology, Referral, Atrophic gastritis, business.industry, Cancer, General Medicine, Helicobacter pylori, biology.organism_classification, medicine.disease, Gastroenterology, Serology, Oncology, Gastro, Internal medicine, medicine, biology.protein, Antibody, business, Blood sampling
Abstract: BACKGROUND/AIM Prompted by the increasing demand of non-invasive diagnostic tools for screening of gastric cancer (GC) risk conditions, i.e., atrophic gastritis (AG) and Helicobacter pylori (Hp) infection, the GastroPanel® test (GP: biomarker panel of PGI, PGII, G-17, Hp IgG ELISA) that was developed in the early 2000's, was recently updated to a new-generation (unified GP) test version. This clinical validation study evaluated the diagnostic accuracy of the new-generation GP test in detection of AG and Hp among gastroscopy referral patients in a University Clinic. PATIENTS AND METHODS Altogether, 522 patients were enrolled among the patients referred for gastroscopy at the Gastro Center, Oulu University Hospital (OUH). All patients underwent gastroscopy with biopsies classified using the Updated Sydney System (USS), and blood sampling for GP testing. RESULTS Biopsy-confirmed AG was found in 10.2% (53/511) of the patients. The overall agreement between the GP and the USS classification was 92.4% (95%CI=90.0-94.6%), with the weighted kappa (κw) of 0.861 (95%CI=0.834-0.883). In ROC analysis using moderate/severe AG of the corpus (AGC2+) as the endpoint, AUC=0.952 (95%CI=0.891-1.000) and AUC=0.998 (95%CI=0.996-1.000) for PGI and PGI/PGII, respectively. Hp IgG antibody ELISA detected biopsy-confirmed Hp-infection with AUC=0.993 (95%CI=0.987-0.999). CONCLUSION The new generation GastroPanel® is a precise test for non-invasive diagnosis of atrophic gastritis and Hp-infection in dyspeptic patients referred for diagnostic gastroscopy.
Published: 2021
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4. Neutrophils, eosinophils, and intraepithelial lymphocytes in the squamous esophagus in subjects with and without gastroesophageal reflux symptoms

Author: Lars Agréus, Jukka Ronkainen, Marjorie M. Walker, Michael Vieth, Nicholas J. Talley, Michael P. Jones, Anna Andreasson, Pertti Aro, and Mudar Zand Irani
Subjects: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Esophageal Mucosa, Neutrophils, Asymptomatic, Gastroenterology, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Reference Values, Internal medicine, medicine, Humans, Reflux esophagitis, Esophagus, Intraepithelial Lymphocytes, Aged, medicine.diagnostic_test, business.industry, Reflux, Middle Aged, medicine.disease, Endoscopy, Eosinophils, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Gastroesophageal Reflux, Intraepithelial lymphocyte, Female, medicine.symptom, business, Esophagitis, Spongiosis
Abstract: Whilst intraepithelial lymphocytes (IELs) are considered normal within the distal esophageal mucosa, they have an increasingly recognised role in the pathogenesis of reflux esophagitis, and IEL quantification establishes the diagnosis of lymphocytic esophagitis. Knowledge regarding the upper limit of a normal IEL count in health is lacking. We studied 117 non-healthcare seeking adult volunteers from a random community sample (the Kalixanda study) with esophageal biopsies 2 cm above the gastroesophageal junction. Subjects were divided into four groups based on the presence or absence of gastro-esophageal reflux symptoms and/or esophagitis on endoscopy. Asymptomatic subjects with no endoscopic esophagitis were selected as controls, and the cell counts in this group were used to define the upper limit of normal of IELs, eosinophils and neutrophils. The entire sample was used to identify independent predictors of increased cellular counts by logistic regression analysis. None of the healthy controls had an IEL count of more than three per five high power fields (HPF), and therefore this was considered as the upper limit of normal; no controls had eosinophils or neutrophils in esophageal biopsies. Independent predictors of an elevated IEL count were spongiosis on histology (OR 11.17, 95% CI 3.32-37.58, P < 0.01) and current smoking (OR 4.84, 95% CI 1.13-2.71, P = 0.03). A receiver operating characteristics analysis concluded that a threshold of 3 IELs/5HPFs performs best in predicting reflux symptoms when a normal esophageal mucosa is visualized on endoscopy (sensitivity = 100.0%, specificity = 35.2%). The healthy esophageal mucosa does not contain more than three IELs per five HPF in the distal esophagus.
Published: 2021
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5. Transition to Targeted Therapies Improved the Prognosis and Increased the Utilization of Medical Treatments among Patients with Synchronous Metastatic Renal Cell Cancer

Author: Hanna Ronkainen, Markku H. Vaarala, and Lauri Laru
Subjects: Vascular Endothelial Growth Factor A, Oncology, medicine.medical_specialty, Article Subject, medicine.medical_treatment, Neoplasms, Multiple Primary, Pharmacotherapy, Internal medicine, Epidemiology, medicine, Carcinoma, Humans, Molecular Targeted Therapy, Carcinoma, Renal Cell, RC254-282, Aged, Chemotherapy, Performance status, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Prognosis, medicine.disease, Kidney Neoplasms, Confidence interval, Cancer registry, Treatment Outcome, Cohort, Surgery, business, Research Article
Abstract: Since the introduction of targeted therapies (TTs) for metastatic renal cell cancer (mRCC) in 2005, a limited amount of epidemiological data on efficacy of modern drug therapies for synchronous mRCC has been published. We present a comprehensive nationwide cohort including all cases of primarily metastasized renal cell cancer among adults diagnosed between 2005 and 2010, based on data from the Finnish Cancer Registry and patient records from treating hospitals. Applied treatment protocols and survival outcomes were analyzed. A total of 977 patients were included in the analysis; 499 patients were diagnosed between 2005 and 2007 and 478 patients were diagnosed between 2008 and 2010. The median overall survival (OS) was 8.80 months (95% confidence interval (CI): 7.60–10.02). The median OS of the patients diagnosed at the latter era was significantly better (11.1; 95% CI: 8.8–13.4 vs. 7.0; 95% CI: 5.7–8.3 months, p ≤ 0.001 ). A total number of 524 (53.8%) patients received drug therapy. Altogether, TTs including tyrosine kinase inhibitors, mammalian target of rapamycin inhibitors (mTORi), and vascular endothelial growth factor inhibitor covered 331 (63.2%) of first-line treatments, whereas interferon and its combinations with chemotherapy were used for 186 (35.5%) patients. The median OS rates for TT and interferon as first-line therapy groups were 19.9 (16.9–22.8) and 14.9 (12.3–17.4) months, respectively. The OS for patients who did not receive drug therapy after cytoreductive nephrectomy was dismal. We found that the OS estimate of mRCC patients in Finland has improved since the introduction of tyrosine kinase inhibitors. However, the prognosis remains poor for frail, elderly patients with an impaired performance status.
Published: 2021
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6. Role of smoking in functional dyspepsia and irritable bowel syndrome: three random population‐based studies

Author: Jukka Ronkainen, Anna Forsberg, Lars Agréus, Anna Andreasson, Marjorie M. Walker, Nicholas J. Talley, Per M. Hellström, Lars Kjellström, Nick Powell, Pertti Aro, Michael P. Jones, and Bengt Wallner
Subjects: education.field_of_study, medicine.medical_specialty, Constipation, Hepatology, business.industry, medicine.medical_treatment, Population, Gastroenterology, Logistic regression, medicine.disease, 03 medical and health sciences, Distress, 0302 clinical medicine, Postprandial, Internal medicine, medicine, Smoking cessation, 030211 gastroenterology & hepatology, Pharmacology (medical), 030212 general & internal medicine, Risk factor, medicine.symptom, education, business, Irritable bowel syndrome
Abstract: Background It is uncertain if functional dyspepsia (FD) or irritable bowel syndrome (IBS) are linked to smoking, and smoking cessation is not part of the routine advice provided to these patients. Aim To assess if smoking is an independent risk factor for FD and IBS. Methods Three population-based endoscopy studies in Sweden with 2560 community individuals in total (mean age 51.5 years, 46% male). IBS (14.9%), FD (33.5%), and associated symptoms were assessed using the validated abdominal symptom questionnaire, and smoking (17.9%) was obtained from standardised questions during a clinic visit. The effect of smoking on symptom status was analysed in an individual person data meta-analysis using mixed effect logistic regression, adjusted for snuffing, age and sex. Results Individuals smoking cigarettes reported significantly higher odds of postprandial distress syndrome (FD-PDS) (OR 10-19 cig/day = 1.42, 95% CI 1.04-1.98 P = 0.027, OR ≥20 cig/day = 2.16, 95% CI 1.38-3.38, P = 0.001) but not epigastric pain. Individuals smoking 20 or more cigarettes per day reported significantly higher odds of IBS-diarrhoea (OR = 2.40, 95% CI 1.12-5.16, P = 0.025), diarrhoea (OR = 2.01, 95%CI 1.28-3.16, P = 0.003), urgency (OR = 2.21, 95%CI 1.41-3.47, P = 0.001) and flatus (OR = 1.77, 95%CI 1.14-2.76, P = 0.012) than non-smokers. Smoking was not associated with IBS-constipation or IBS-mixed. Conclusion Smoking is an important environmental risk factor for postprandial distress syndrome, the most common FD subgroup, with over a twofold increased odds of PDS in heavy smokers. The role of smoking in IBS-diarrhoea, but not constipation, is also likely important.
Published: 2021
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7. The EU Child Cohort Network's core data

Author: Rachel E. Foong, Marie Pedersen, Johan G. Eriksson, Barbara Heude, Faryal Zariouh, Johan Lerbech Vinther, Theano Roumeliotaki, John Wright, Veit Grote, Kathrin Guerlich, Anne-Marie Nybo Andersen, Tiffany Yang, Anne Cathrine Jørgensen, Martine Vrijheid, Ellis Voerman, Liesbeth Duijts, Marjo-Riitta Järvelin, Sido Haakma, Ahmed Elhakeem, Hazel Inskip, Angela Pinot de Moira, Maja Popovic, Sílvia Fernández-Barrés, Eva Corpeleijn, Anne Forhan, Tuija M. Mikkola, Sylvain Sebert, Morris A. Swertz, Rae-Chi Huang, Theodosia Salika, Justiina Ronkainen, Esther van Enckevort, Vincent W. V. Jaddoe, Lorenzo Richiardi, Tim Cadman, Marloes Cardol, Katrine Strandberg-Larsen, Marjolein N. Kooijman, Janine F. Felix, Marie-Aline Charles, Johanna L. Nader, Sarah Crozier, Nina Rautio, Department of Public Health [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), University Medical Center Groningen [Groningen] (UMCG), Erasmus University Medical Center [Rotterdam] (Erasmus MC), University of Bristol [Bristol], University of Southampton, University of Helsinki, Yong Loo Lin School of Medicine [Singapore], Folkhälsan Research Center, Faculty of Medecine [Helsinki], University of Helsinki-University of Helsinki, Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Curtin University [Perth], Planning and Transport Research Centre (PATREC), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Oulu, Imperial College London, Norwegian Institute of Public Health [Oslo] (NIPH), University of Turin, University of Crete [Heraklion] (UOC), Etude longitudinale française depuis l'enfance (UMS : Ined-Inserm-EFS) (ELFE), EFS-Institut national d'études démographiques (INED)-Institut National de la Santé et de la Recherche Médicale (INSERM), European Project: 733206,H2020,H2020-SC1-2016-RTD,LIFECYCLE(2017), Pediatrics, Clinicum, Research Programs Unit, Johan Eriksson / Principal Investigator, Department of General Practice and Primary Health Care, HUS Helsinki and Uusimaa Hospital District, Faculty of Medicine, Reproductive Origins of Adult Health and Disease (ROAHD), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Università degli studi di Torino = University of Turin (UNITO), and Institut national d'études démographiques (INED)-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: 0301 basic medicine, Databases, Factual, Epidemiology, [SDV]Life Sciences [q-bio], Interoperability, Cohort Studies, Data harmonisation, 0302 clinical medicine, Resource (project management), Medicine, 030212 general & internal medicine, Child, DNA METHYLATION, Lifecourse epidemiology, 3142 Public health care science, environmental and occupational health, Europe, PREGNANCY, Child, Preschool, Cohort, GROWTH, HEALTH, Public Health, Birth cohort, Cohort study, Cross-cohort collaboration, FAIR (findable, accessible, interoperable and reusable) principles, Humans, Information Dissemination, DATA HARMONIZATION, PRETERM BIRTH, FAIR (findable, PROFILE, accessible, 03 medical and health sciences, Databases, interoperable and reusable) principles, Product (category theory), Preschool, Factual, Protocol (science), business.industry, NORWEGIAN MOTHER, AIR-POLLUTION, Data science, BIRTH-WEIGHT, Replication (computing), 030104 developmental biology, business, Data Resource
Abstract: The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network's core variables. These are a set of basic variables, derivable by the majority of participating cohorts and frequently used as covariates or exposures in lifecourse research. First, we describe the process by which the list of core variables was established. Second, we explain the protocol according to which these variables were harmonised in order to make them interoperable. Third, we describe the catalogue developed to ensure that the network's data are findable and reusable. Finally, we describe the core data, including the proportion of variables harmonised by each cohort and the number of children for whom harmonised core data are available. EU Child Cohort Network data will be analysed using a federated analysis platform, removing the need to physically transfer data and thus making the data more accessible to researchers. The network will add value to participating cohorts by increasing statistical power and exposure heterogeneity, as well as facilitating cross-cohort comparisons, cross-validation and replication. Our aim is to motivate other cohorts to join the network and encourage the use of the EU Child Cohort Network by the wider research community. The LifeCycle project received funding from the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 733206 LifeCycle). All study specific acknowledgements and funding are presented in the supplementary material. This manuscript reflects only the author’s view and the Commission is not responsible for any use that may be made of the information it contains.
Published: 2021
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8. National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio : a pooled analysis of 458 population-based studies in Asian and Western countries

Author: NCD Risk Factor Collaboration (NCD-RisC), [missing], Taddei, Cristina, Jackson, Rod, Zhou, Bin, Bixby, Honor, Danaei, Goodarz, Di Cesare, Mariachiara, Kuulasmaa, Kari, Hajifathalian, Kaveh, Bentham, James, Bennett, James E, Aekplakorn, Wichai, Cifkova, Renata, Dallongeville, Jean, DeBacquer, Dirk, Giampaoli, Simona, Gudnason, Vilmundur, Khang, Young-Ho, Laatikainen, Tiina, Mann, JimI, Marques-Vidal, Pedro, Mensah, George A, Müller-Nurasyid, Martina, Ninomiya, Toshiharu, Petkeviciene, Janina, Rodríguez-Artalejo, Fernando, Servais, Jennifer, Söderberg, Stefan, Stavreski, Bill, Wilsgaard, Tom, Zdrojewski, Tomasz, Zhao, Dong, Stevens, Gretchen A, Savin, Stefan, Cowan, Melanie J, Riley, Leanne M, Ezzati, Majid, Adams, Robert J, Ahrens, Wolfgang, Amouyel, Philippe, Amuzu, Antoinette, Anderssen, Sigmund A, Ariansen, Inger, Arveiler, Dominique, Aspelund, Thor, Auvinen, Juha, Avdicová, Mária, Banach, Maciej, Bandosz, Piotr, Banegas, José R, Barbagallo, Carlo M, Bata, Iqbal, Baur, Louise A, Beaglehole, Robert, Bernotiene, Gailute, Bi, Yufang, Bienek, Asako, Björkelund, Cecilia, Bo, Simona, Boehm, Bernhard O, Bonaccio, Marialaura, Bongard, Vanina, Borchini, Rossana, Borghs, Herman, Breckenkamp, Juergen, Brenner, Hermann, Bruno, Graziella, Busch, Markus A, Cabrera de León, Antonio, Capuano, Vincenzo, Casanueva, Felipe F, Casas, Juan-Pablo, Caserta, Carmelo A, Censi, Laura, Chen, Fangfang, Chen, Shuohua, Chirlaque, María-Dolores, Cho, Belong, Cho, Yumi, Chudek, Jerzy, Claessens, Frank, Clarke, Janine, Clays, Els, Cooper, Cyrus, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Crujeiras, Ana B, Cui, Liufu, D'Arrigo, Graziella, Dauchet, Luc, De Backer, Guy, De Bacquer, Dirk, de Gaetano, Giovanni, De Henauw, Stefaan, De Smedt, Delphine, Dennison, Elaine, Deschamps, Valérie, DiCastelnuovo, Augusto, Dobson, Annette J, Donfrancesco, Chiara, Döring, Angela, Drygas, Wojciech, Du, Yong, Dziankowska-Zaborszczyk, Elzbieta, Eggertsen, Robert, Ekelund, Ulf, Elosua, Roberto, Eriksson, Johan G, Evans, Alun, Faeh, David, Felix-Redondo, Francisco J, Fernández-Bergés, Daniel, Ferrari, Marika, Ferrieres, Jean, Finn, Joseph D, Forslund, Ann-Sofie, Forsner, Maria, Frontera, Guillermo, Fujita, Yuki, Gaciong, Zbigniew, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garnett, Sarah P, Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Gianfagna, Francesco, Gill, Tiffany K, Giovannelli, Jonathan, Goltzman, David, GonzalezGross, Marcela, Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dušan, Gregor, Ronald D, Grodzicki, Tomasz, Grosso, Giuseppe, Gruden, Grabriella, Gu, Dongfeng, Guallar-Castillón, Pilar, Gudmundsson, Elias F, Guessous, Idris, Gunnlaugsdottir, Johanna, Gutzwiller, Felix, Hardy, Rebecca, Hata, Jun, Haugsgjerd, Teresa, Hayes, Alison J, He, Jiang, He, Yuna, Herrala, Sauli, TapaniHihtaniemi, Ilpo, Hobbs, Michael, Hopman, Wilma M, MaríaHuerta, José, Huybrechts, Inge, Iacoviello, Licia, Iannone, Anna G, Ikeda, Nayu, Iwasaki, Masanori, Jamrozik, Konrad, Janszky, Imre, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jennings, Garry, Jeong, Seung-lyeal, QiangJiang, Chao, Joffres, Michel, Jokelainen, Jari J, Jonas, Jost B, Jóźwiak, Jacek, Kajantie, Eero O, Kauhanen, Jussi, Keil, Ulrich, Keinänen-Kiukaanniemi, Sirkka, Kersting, Mathilde, Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Kim, Jeongseon, Kim, Yeon-Yong, Klumbiene, Jurate, Knoflach, Michael, Ko, Stephanie, Kolle, Elin, Korpelainen, Raija, Koskinen, Seppo, Kouda, Katsuyasu, Kratzer, Wolfgang, Kriemler, Susi, Krokstad, Steinar, Kujala, Urho M, Kurjata, Pawel, HingLam, Tai, Lanska, Vera, Lappas, Georg, Laugsand, Lars E, Lee, Jeonghee, Lehtimäki, Terho, Li, Yanping, Lilly, Christa L, Lin, Xu, Lind, Lars, Lissner, Lauren, Liu, Jing, Lopez-Garcia, Esther, Lorbeer, Roberto, EugenioLozano, José, Luksiene, Dalia, Lundqvist, Annamari, Lundqvist, Robert, Lytsy, Per, Ma, Guansheng, Machi, Suka, Maggi, Stefania, Magliano, Dianna J, Manzato, Enzo, Mathiesen, Ellisiv B, McLachlan, Stela, McLean, Rachael M, McLean, Scott B, Meirhaeghe, Aline, Meisinger, Christa, Metcalf, Patricia, Mi, Jie, Miller, Jody C, Moreno, Luis A, Morin, Suzanne, Mossakowska, Malgorzata, Muiesan, Maria L, Mursu, Jaakko, Nakamura, Harunobu, Námešná, Jana, Nauck, Matthias, MariaNavarrete-Muñoz, Eva, Neal, William A, Nenko, Ilona, Niiranen, Teemu J, Ning, Guang, Noale, Marianna, Norie, Sawada, Noto, Davide, O'Neill, Terence, O'Reilly, Dermot, Oh, Kyungwon, Olafsson, Örn, MichelPaccaud, Fred, Pajak, Andrzej, Palmieri, Luigi, Panza, Francesco, Parnell, Winsome R, Peltonen, Markku, Peters, Annette, Petersmann, Astrid, Pigeot, Iris, Pilotto, Lorenza, Piwonska, Aleksandra, Plans-Rubió, Pedro, Porta, Miquel, Price, Jacqueline F, Puder, Jardena J, Puhakka, Soile E, Radisauskas, Ricardas, Raitakari, Olli, Ramos, Rafel, Redon, Josep, Rigo, Fernando, Rodriguez-Perez, MaríadelCristo, Romaguera, Dora, Ronkainen, Kimmo, Rosengren, Annika, Roy, Joel G R, Ruidavets, Jean-Bernard, Rutkowski, Marcin, Salanave, Benoit, Salmerón, Diego, Salomaa, Veikko, Salonen, Jukka T, Salvetti, Massimo, Sans, Susana, Saramies, Jouko L, Saum, Kai-Uwe, Scheidt-Nave, Christa, Schienkiewitz, Anja, Schipf, Sabine, Schmidt, Carsten O, Schöttker, Ben, Sebert, Sylvain, Sen, Abhijit, Shaw, Jonathan E, Shibuya, Kenji, WookShin, Dong, Shiri, Rahman, Simons, Judith, Simons, Leon A, Sjöström, Michael, Slowikowska-Hilczer, Jolanta, Slusarczyk, Przemyslaw, Solfrizzi, Vincenzo, Sonestedt, Emily, Soumare, Aicha, Staessen, Jan A, Stathopoulou, Maria G, Steene-Johannessen, Jostein, Stehle, Peter, Stieber, Jutta, Stöckl, Doris, Stokwiszewski, Jakub, Sundström, Johan, Suriyawongpaisal, Paibul, Tamosiunas, Abdonas, JooTan, Eng, Taylor, Anne, Tell, Grethe, Thijs, Lutgarde, Tolonen, HannaK, Topór-Madry, Roman, JoséTormo, María, Torrent, Maties, Tsugane, Shoichiro, Tuomainen, Tomi-Pekka, Tuomilehto, Jaakko, Tzourio, Christophe, Uusitalo, Hannu M T, Van Herck, Koen, Vanderschueren, Dirk, Vanuzzo, Diego, Vatten, Lars, Vega, Tomas, Veronesi, Giovanni, Vioque, Jesus, Virtanen, JyrkiK, Visvikis-Siest, Sophie, Vollenweider, Peter, Voutilainen, Sari, Vrijheid, Martine, Wagner, Aline, Wagner, Anne, Wang, Ming-Dong, Wang, Qian, XingWang, Ya, Wannamethee, S Goya, Wei, Wenbin, Whincup, Peter H, Wiecek, Andrzej, Willeit, Johann, Willeit, Peter, Wojtyniak, Bogdan, Wong, Andrew, Woodward, Mark, GiwercmanWu, Aleksander, Wu, Frederick C, Wu, Shouling, Xu, Haiquan, Xu, Liang, Yan, Weili, Yang, Xiaoguang, Ye, Xingwang, Yoshihara, Akihiro, Zambon, Sabina, Zhao, Wenhua, Imperial College London, University of Auckland [Auckland], Harvard T.H. Chan School of Public Health, Middlesex University, National Institute for Health and Welfare [Helsinki], Weill Medical College of Cornell University [New York], University of Kent [Canterbury], Mahidol University [Bangkok], Charles University [Prague] (CU), Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Universiteit Gent = Ghent University [Belgium] (UGENT), Istituto Superiore di Sanita [Rome], Icelandic Heart Association [Kopavogur, Iceland] (IHA), Seoul National University [Seoul] (SNU), University of Otago [Dunedin, Nouvelle-Zélande], Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Helmholtz-Zentrum München (HZM), Kyushu University [Fukuoka], Universidad Autonoma de Madrid (UAM), CIBER de Epidemiología y Salud Pública (CIBERESP), Umeå University, The Arctic University of Norway (UiT), Medical University of Gdańsk, Capital University of Medical Sciences [Beijing] (CUMS), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), University of Adelaide, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Leibniz Association, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), London School of Hygiene and Tropical Medicine (LSHTM), Norwegian School of Sport Sciences = Norges idrettshøgskole [Oslo] (NIH), Norwegian Institute of Public Health [Oslo] (NIPH), Université de Strasbourg (UNISTRA), University of Iceland [Reykjavik], University of Oulu, Regional Authority of Public Health [Slovaquia] (RAPH), Ministry of Health of the Slovak Republic [Slovaquia], Medical University of Łódź (MUL), Università degli studi di Palermo - University of Palermo, Dalhousie University [Halifax], The University of Sydney, Public Health Agency of Canada, University of Gothenburg (GU), University of Turin, Nanyang Technological University [Singapour], Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Faculté de Médecine [Rangueil], Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse], Universität Bielefeld = Bielefeld University, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Robert Koch Institute [Berlin] (RKI), Universidad de La Laguna [Tenerife - SP] (ULL), Universidade de Santiago de Compostela [Spain] (USC ), University College of London [London] (UCL), University of Silesia in Katowice, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), University of Southampton, Biomolécules et inflammation pulmonaire, Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Santé publique France - French National Public Health Agency [Saint-Maurice, France], University of Queensland [Brisbane], IMIM-Hospital del Mar, Generalitat de Catalunya, Queen's University [Belfast] (QUB), Universität Zürich [Zürich] = University of Zurich (UZH), Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, University of Manchester [Manchester], Kindai University, Medical University of Warsaw - Poland, Università degli studi di Catania [Catania], Geneva University Hospital (HUG), Universitá degli Studi dell’Insubria, McGill University = Université McGill [Montréal, Canada], Universidad Politécnica de Madrid (UPM), Lille Inflammation Research International Center - U 995 (LIRIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institute for Clinical and Experimental Medicine (IKEM), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), University of Bergen (UiB), Tulane University, Chinese Center for Disease Control and Prevention, Oulu University Hospital [Oulu], The University of Western Australia (UWA), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Niigata University, Norwegian University of Science and Technology (NTNU), Simon Fraser University (SFU.ca), University of Eastern Finland, Westfälische Wilhelms-Universität Münster (WWU), Innsbruck Medical University [Austria] (IMU), Universitätsklinikum Ulm - University Hospital of Ulm, University of Jyväskylä (JYU), The University of Hong Kong (HKU), Sahlgrenska Academy at University of Gothenburg [Göteborg], Tampere University Hospital, University of Tampere [Finland], West Virginia University [Morgantown], University of Chinese Academy of Sciences [Beijing] (UCAS), Uppsala Universitet [Uppsala], Universität Greifswald - University of Greifswald, Peking University [Shenzhen], The Jikei University School of Medicine, Baker Heart and Diabetes Institute (AUSTRALIA), Universita degli Studi di Padova, University of Edinburgh, University of Zaragoza - Universidad de Zaragoza [Zaragoza], International Institute of Molecular and Cell Biology [Warsaw] (IIMCB), Università degli Studi di Brescia [Brescia], Konan University [Kobe, Japan], University of Turku, Shanghai Jiao Tong University School of Medicine, Department of Epidemiology and Biostatistics, Imperial College London-School of public health, The University of Hong Kong (HKU)-The University of Hong Kong (HKU), Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, Department of Epidemiology, Health Economics and Public Health, UMR 558 INSERM, Université de Toulouse, Centre Hospitalier Universitaire de Toulouse, Unité de Surveillance et d'Epidémiologie Nutritionnelle (USEN), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Institut de Veille Sanitaire (INVS)-Université Paris 13 (UP13), Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain, parent, Department of Chronic Disease Prevention, Institute for plasma research, Institute for Plasma Research, Department of Biosciences and Nutrition, Karolinska Institutet [Stockholm], Department of Reproductive Endocrinology, University of Bari Aldo Moro (UNIBA), Nutritional Epidemiology, Department of Clinical Sciences, Clinical Research Center, Lund University [Lund]-Lund University [Lund], Neuroépidémiologie, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Applied Food Science, Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University Hospital, Research Unit Hypertension and Cardiovascular Epidemiology [Louvain, Belgique], Studies Coordinating Centre [Louvain, Belgique], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven)-Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), National Cancer Center, University of Kuopio, Epidémiologie cardiovasculaire et métabolique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Université Bordeaux Segalen - Bordeaux 2, Tampere University, Department of Andrology and Endocrinology, Katholieke Universiteit Leuven, Norwegian University of Science and Technology [Trondheim] (NTNU), Departamento de Salud Pública, Universidad Miguel Hernández [Elche] (UMH), Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire (IGE-PCV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Department of Internal Medicine, School of Public Health and Clinical Nutrition, Epidemiologia Ambiental, Centre for Research in Environmental Epidemiology (CREAL)-Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP) of Pamplona-Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Department of Epidemiology and Public Health, EA 3430, Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Medical University of Silesia (SUM), University of Innsbruck, National Institute of Hygiene Warsaw, The Georges Institute for International Health, Naval Research Laboratory (NRL), Grant numbers 101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z, Ministry of Health of the Czech Republic (grant number 15-27109A), UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología, HUS Children and Adolescents, Department of Public Health, Universidad Autónoma de Madrid (UAM), Università degli studi di Torino = University of Turin (UNITO), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Westfälische Wilhelms-Universität Münster = University of Münster (WWU), CHU Toulouse [Toulouse], Université Paris 13 (UP13)-Institut de Veille Sanitaire (INVS)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université (HESAM)-HESAM Université (HESAM), Taddei, C, Zhou, B, Bixby, H, Danaei, G, Di Cesare, M, Kuulasmaa, K, Hajifathalian, K, Bentham, J, Bennett, JE, Aekplakorn, W, Cifkova, R, Dallongeville, J, DeBacquer, D, Giampaoli, S, Gudnason, V, Khang, Y-O, Laatikainen, T, Mann, JI, Marques-Vidal, P, Mensah, GA, Müller-Nurasyid, M, Ninomiya, T, Petkeviciene, J, Rodríguez-Artalejo, F, Servais, J, Söderberg, S, Stavreski, B, Wilsgaard, T, Zdrojewski, T, Zhao, D, Stevens, GA, Savin, S, Cowan, Mj, Riley, LM, Ezzati, M, Adams, R, Ahrens, W, Amouyel, P, Amuzu, A, Anderssen, SA, Ariansen, I, Arveiler, D, Aspelund, T, Auvinen, A, Avdicová, M, Banach, M, Bandosz, P, Banegas. JR, Barbagallo, CM, Bata, I, Baur, LA, Beaglehole, R, Bennet, JE, Bernotiene, G, Bi, Y, Bienek, A, Björkelund, C, Bo, S, Boehm, BO, Bonaccio, M, Bongard, V, Borchini, R, Borghs, H, Breckenkamp, J, Brenner, H, Bruno, G, Busch, MA, CabreradeLeón, A, Capuano, V, Casanueva, FF, Casas, J-P, Caserta, CA, Censi, L, Chen, F, Chen, S, Chirlaque, M-D, Cho, B, Cho, Y, Chudek, J, Claessens, F, Clarke, J, Clays, E, Cooper, C, Costanzo, S, Cottel, D, Cowell C, Crujeiras, AB, Cui, L, D'Arrigo, G, Dauchet, L, De Backer, G, De Bacquer, D, de Gaetano, G, De Henauw, S, De Smedt, D, Dennison, E, Desschamps, V, Di Castelnuovo, A, Dobson, AJ, Donfrancesco, C, Döring, A, Doua, K, Drygas, W, Du, Y, Dziankowska-Zaborszczyk, E, Eggertsen, R, Ekelund, U, Elousa, R, Eriksson, JG, Evans, A, Faeh, D, Felix-Redondo, FJ, Fernández-Bergés, D, Ferrari, M, Ferrieres, J, Finn, JD, Forslund, A-S, Forsner, M, Frontera, G, Fujita, Y, Gaciong, Z, Galvano, F, Gao, J, Garcia-de-la-Hera, M, Garnett, SP, Gaspoz, J-M, Gasul, L, Gates, L, Gianfagna, F, Gill, TK, Giovannelli, J, Goltzman, D, GonzalezGross, M, Gottrand, F, Graff-Iversen, S, Grafnetter, D, Gregor, RD, Grodzicki, T, Grosso, G, Gruden, G, Gu, D, Guallar-Castillón, P, Gudmundsson, EF, Guessous, I, Gunnlaugsdottir J, Gutzwiller, F, Hardy, R, Hata, J, Haugsgjerd, T, Hayes, AJ, He, H, He, Y, Herrala, S, Hihtaniemi, IP, Hobbs, M, Hopman, WM, Huerta, JM, Huybrechts, I, Iacoviello, L, Iannone, AG, Ikeda, N, Iwasaki, M, Jackson, R, Jamrozi, K, Janszky, I, Jarvelin, M-R, Jasienska, G, Jennings, G, Jeong, S-L, Jiang, CQ, Joffres, M, Jokelainen, JJ, Jonas, JB, Jóźwiak, J, Kajantie, EO, Kauhanen, K, Keil, U, Keinänen-Kiukaanniemi, S, Kersting, M, Khang, Y-H, Kiechl-Kohlendorfer, U, Kiechl, S, Kim, J, Kim, Y-Y, Klumbiene, J, Knoflach, M, Ko, S, Kolle, E, Korpelainen, R, Koskinen, S, Kouda, K, Kratzer, W, Kriemler, S, Krokstad, S, Kujala,UM, Kurjata, P, Lam, TH, Lanska, V, Lappas , G, Laugsand, LE, Lee, J, Lehtimäki, T, Li, Y, Lilly, C, Lin, X, Lind, L, Lissner, L, Liu, J, Lopez-Garcia, E, Lorbeer, R, Lozano, JE, Luksiene, D, Lundqvist, A, Lundqvist, R, Lytsy, P, Ma, G, Machi, S, Maggi, S, Magliano, DJ, Manzato, E, Mathiesen, EB, McLachlan, S, McLean, RM, Meirhaeghe, A, Metcalf, P, Mi, JM, Miller, JC, Moreno, LA, Morin, S, Mossakowska, M, Muiesan, ML, Mursu, J, Nakamura, H, Námešná, J, Navarrete-Muñoz, EM, Neal, WA, Nenko, I, Niiranen, T, Ning, G, Noale, M, Norie, S, Noto, Davide, O’Neill, T, O'Reilly, D, Oh, K, Olafsson, O, Paccaud, F, Pajak, A, Palmieri, L, Panza, F, Parnell, WR, Peltonen, M, Peters, A, Petersmann, A, P Pigeot, I, Pilotto, L, Piwonska, A, Pedro Plans-Rubió, P, Porta, M, Price, JF, Puder, JJ, Puhakka, SE, Radisauskas, R, Raitakari, O, Ramos, R, Redon, J, Rigo, F, Rodriguez-Perez, MdC, Romaguera, D, Ronkainen, K, Rosengren, A, Roy, JGR, Ruidavets, JB, Rutkowski, M, Salanave, B, Salmeron, D, Salomaa, V, Salonen, JT, Salvetti, M, Sans, S, Saramies, JL, Saum, K-U, Scheidt-Nave, C, Schienkiewitz, A, Schipf, S, Schmidt, CO, Schottker, B, Sebert S, Sen, A, Shaw, JE, Shibuya, K, Shin, DO, Shiri, R, Simons, J, Simons, LA, Sjostrom, M, Slowikowska-Hilczer, J, Slusarczyk, P, Solfrizzi, V, Sonestedt, E, Soumare, A, Staessen, JA, Stathopoulou, MG, Steene-Johannessen, J, Stehle, P, Stieber, J, Stöckl, D, Stokwiszewski, J, Sundström, J, Suriyawongpaisal, P, Tamosiunas, A, Tan, E, Taylor, A, Tell, G, Thijs, L, Tolonen, HK, Topór-Madry, R, Tormo, MJ, Torrent, M, Tsugane, S, Tuomainen, T-P, Tuomilehto, J, Tzourio, C, Uusitalo, HMT, Van Herck, K, Vanderschueren, D, Vanuzzo, D, Vatten, L, Vega, T, Veronesi, G, Vioque, P, Virtanen, JK, Visvikis-Siest, S, Vollenweider, P, Voutilainen, S, Vrijheid, M, Wagner, A, Wang, M-D, Wang, Q, Wang YX, Wannamethee, SG, Wei, W, Whincup, PH, Wiecek, A, Willeit, J, Willeit, P, Wojtyniak, B, Wong, A, Woodward, M, Wu, FC, JianFeng Wu, JF, Wu, SL, Xu, H, Xu, L, Yan, W, Yang, X, Ye, X, Yoshihara, A, Zambon, S, Zhao, W, NCD Risk Factor Collaboration (NCD-RisC), Jackson, R., Zhou, B., Bixby, H., Danaei, G., Di Cesare, M., Kuulasmaa, K., Hajifathalian, K., Bentham, J., Bennett, J.E., Aekplakorn, W., Cifkova, R., Dallongeville, J., DeBacquer, D., Giampaoli, S., Gudnason, V., Khang, Y.H., Laatikainen, T., Mann, J., Marques-Vidal, P., Mensah, G.A., Müller-Nurasyid, M., Ninomiya, T., Petkeviciene, J., Rodríguez-Artalejo, F., Servais, J., Söderberg, S., Stavreski, B., Wilsgaard, T., Zdrojewski, T., Zhao, D., Stevens, G.A., Savin, S., Cowan, M.J., Riley, L.M., Ezzati, M., Adams, R.J., Ahrens, W., Amouyel, P., Amuzu, A., Anderssen, S.A., Ariansen, I., Arveiler, D., Aspelund, T., Auvinen, J., Avdicová, M., Banach, M., Bandosz, P., Banegas, J.R., Barbagallo, C.M., Bata, I., Baur, L.A., Beaglehole, R., Bernotiene, G., Bi, Y., Bienek, A., Björkelund, C., Bo, S., Boehm, B.O., Bonaccio, M., Bongard, V., Borchini, R., Borghs, H., Breckenkamp, J., Brenner, H., Bruno, G., Busch, M.A., Cabrera de León, A., Capuano, V., Casanueva, F.F., Casas, J.P., Caserta, C.A., Censi, L., Chen, F., Chen, S., Chirlaque, M.D., Cho, B., Cho, Y., Chudek, J., Claessens, F., Clarke, J., Clays, E., Cooper, C., Costanzo, S., Cottel, D., Cowell, C., Crujeiras, A.B., Cui, L., D'Arrigo, G., Dauchet, L., De Backer, G., De Bacquer, D., de Gaetano, G., De Henauw, S., De Smedt, D., Dennison, E., Deschamps, V., DiCastelnuovo, A., Dobson, A.J., Donfrancesco, C., Döring, A., Drygas, W., Du, Y., Dziankowska-Zaborszczyk, E., Eggertsen, R., Ekelund, U., Elosua, R., Eriksson, J.G., Evans, A., Faeh, D., Felix-Redondo, F.J., Fernández-Bergés, D., Ferrari, M., Ferrieres, J., Finn, J.D., Forslund, A.S., Forsner, M., Frontera, G., Fujita, Y., Gaciong, Z., Galvano, F., Gao, J., Garcia-de-la-Hera, M., Garnett, S.P., Gaspoz, J.M., Gasull, M., Gates, L., Gianfagna, F., Gill, T.K., Giovannelli, J., Goltzman, D., GonzalezGross, M., Gottrand, F., Graff-Iversen, S., Grafnetter, D., Gregor, R.D., Grodzicki, T., Grosso, G., Gruden, G., Gu, D., Guallar-Castillón, P., Gudmundsson, E.F., Guessous, I., Gunnlaugsdottir, J., Gutzwiller, F., Hardy, R., Hata, J., Haugsgjerd, T., Hayes, A.J., He, J., He, Y., Herrala, S., TapaniHihtaniemi, I., Hobbs, M., Hopman, W.M., MaríaHuerta, J., Huybrechts, I., Iacoviello, L., Iannone, A.G., Ikeda, N., Iwasaki, M., Jamrozik, K., Janszky, I., Jarvelin, M.R., Jasienska, G., Jennings, G., Jeong, S.L., QiangJiang, C., Joffres, M., Jokelainen, J.J., Jonas, J.B., Jóźwiak, J., Kajantie, E.O., Kauhanen, J., Keil, U., Keinänen-Kiukaanniemi, S., Kersting, M., Kiechl-Kohlendorfer, U., Kiechl, S., Kim, J., Kim, Y.Y., Klumbiene, J., Knoflach, M., Ko, S., Kolle, E., Korpelainen, R., Koskinen, S., Kouda, K., Kratzer, W., Kriemler, S., Krokstad, S., Kujala, U.M., Kurjata, P., HingLam, T., Lanska, V., Lappas, G., Laugsand, L.E., Lee, J., Lehtimäki, T., Li, Y., Lilly, C.L., Lin, X., Lind, L., Lissner, L., Liu, J., Lopez-Garcia, E., Lorbeer, R., EugenioLozano, J., Luksiene, D., Lundqvist, A., Lundqvist, R., Lytsy, P., Ma, G., Machi, S., Maggi, S., Magliano, D.J., Manzato, E., Mathiesen, E.B., McLachlan, S., McLean, R.M., McLean, S.B., Meirhaeghe, A., Meisinger, C., Metcalf, P., Mi, J., Miller, J.C., Moreno, L.A., Morin, S., Mossakowska, M., Muiesan, M.L., Mursu, J., Nakamura, H., Námešná, J., Nauck, M., MariaNavarrete-Muñoz, E., Neal, W.A., Nenko, I., Niiranen, T.J., Ning, G., Noale, M., Norie, S., Noto, D., O'Neill, T., O'Reilly, D., Oh, K., Olafsson, Ö., MichelPaccaud, F., Pajak, A., Palmieri, L., Panza, F., Parnell, W.R., Peltonen, M., Peters, A., Petersmann, A., Pigeot, I., Pilotto, L., Piwonska, A., Plans-Rubió, P., Porta, M., Price, J.F., Puder, J.J., Puhakka, S.E., Radisauskas, R., Raitakari, O., Ramos, R., Redon, J., Rigo, F., Rodriguez-Perez, M., Romaguera, D., Ronkainen, K., Rosengren, A., Ruidavets, J.B., Rutkowski, M., Salanave, B., Salmerón, D., Salomaa, V., Salonen, J.T., Salvetti, M., Sans, S., Saramies, J.L., Saum, K.U., Scheidt-Nave, C., Schienkiewitz, A., Schipf, S., Schmidt, C.O., Schöttker, B., Sebert, S., Sen, A., Shaw, J.E., Shibuya, K., WookShin, D., Shiri, R., Simons, J., Simons, L.A., Sjöström, M., Slowikowska-Hilczer, J., Slusarczyk, P., Solfrizzi, V., Sonestedt, E., Soumare, A., Staessen, J.A., Stathopoulou, M.G., Steene-Johannessen, J., Stehle, P., Stieber, J., Stöckl, D., Stokwiszewski, J., Sundström, J., Suriyawongpaisal, P., Tamosiunas, A., JooTan, E., Taylor, A., Tell, G., Thijs, L., Tolonen, H., Topór-Madry, R., JoséTormo, M., Torrent, M., Tsugane, S., Tuomainen, T.P., Tuomilehto, J., Tzourio, C., Van Herck, K., Vanderschueren, D., Vanuzzo, D., Vatten, L., Vega, T., Veronesi, G., Vioque, J., Virtanen, J., Visvikis-Siest, S., Vollenweider, P., Voutilainen, S., Vrijheid, M., Wagner, A., Wang, M.D., Wang, Q., XingWang, Y., Wannamethee, S.G., Wei, W., Whincup, P.H., Wiecek, A., Willeit, J., Willeit, P., Wojtyniak, B., Wong, A., Woodward, M., GiwercmanWu, A., Wu, F.C., Wu, S., Xu, H., Xu, L., Yan, W., Yang, X., Ye, X., Yoshihara, A., Zambon, S., Zhao, W., Universiteit Gent = Ghent University (UGENT), Istituto Superiore di Sanità (ISS), Helmholtz Zentrum München = German Research Center for Environmental Health, Kyushu University, The Arctic University of Norway [Tromsø, Norway] (UiT), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome] (UNIROMA)-University of Naples Federico II = Università degli studi di Napoli Federico II, Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Catania = University of Catania (Unict), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Innsbruck Medical University = Medizinische Universität Innsbruck (IMU), Università degli Studi di Padova = University of Padua (Unipd), Università degli Studi di Brescia = University of Brescia (UniBs), Service Epidémiologie clinique et santé publique [CHU Toulouse], Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Università degli studi di Bari Aldo Moro = University of Bari Aldo Moro (UNIBA), Laboratoire Chrono-environnement (UMR 6249) (LCE), Leopold Franzens Universität Innsbruck - University of Innsbruck, National Institute of Public Health - National Institute of Hygiene [Poland], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Medical University of Silesia, Katowice, University of Helsinki, National Institute for Health and Welfare, University of Helsinki, University of Helsinki, and University of Helsinki, Finnish Institute of Occupational Health
Subjects: Male, gupo de ascendencia continental asiática, Settore MED/09 - Medicina Interna, Total Cholesterol, Ldl Cholesterol, Hdl Cholesterol, Blood Lipids, Multi-country Study, Epidemiology, kolesteroli, humanos, Blood lipids, BLOOD-PRESSURE, 030204 cardiovascular system & hematology, triglicéridos, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, HDL cholesterol, Medicine and Health Sciences, CARDIOVASCULAR RISK-FACTORS, Medicine, 030212 general & internal medicine, mediana edad, lípidos, Public, Environmental & Occupational Health, 2. Zero hunger, anciano, education.field_of_study, Age Factors, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Middle Aged, colesterol, adulto, kansainvälinen vertailu, Lipids, 3142 Public health care science, environmental and occupational health, 3. Good health, Europe, Cholesterol, Population Surveillance, LDL cholesterol, SERUM-LIPIDS, Female, lipids (amino acids, peptides, and proteins), Life Sciences & Biomedicine, Adult, Asian Continental Ancestry Group, Canada, Total cholesterol, blood lipids, multi-country study, medicine.medical_specialty, Asia, Medicina, European Continental Ancestry Group, Population, Nursing, HDL-kolesteroli, White People, DIETARY-FAT, 03 medical and health sciences, Sex Factors, Asian People, kansanterveys, vigilancia de la población, Humans, CORONARY-HEART-DISEASE, ddc:610, LDL-kolesteroli, education, Triglycerides, METAANALYSIS, Aged, INDIVIDUAL DATA, Science & Technology, business.industry, Omvårdnad, blood lipid, Cholesterol, HDL, Ecological study, nutritional and metabolic diseases, Cholesterol, LDL, United States, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Cholesterol/blood, Lipids/blood, Population Surveillance/methods, Triglycerides/blood, chemistry, WORLDWIDE TRENDS, Multi-country study, grupo de ascendencia continental europea, business, HIGH-DENSITY-LIPOPROTEIN, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Demography, Lipoprotein
Abstract: Artículo con numerosos autores. Sólo quedan reflejados el primero, los pertenecientes a la UAM y el colectivo, Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol., This work was supported by the Wellcome Trust (grant numbers 101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z). R.C. acknowledges funding from the Ministry of Health of the Czech Republic (grant number 15-27109A)
Published: 2020
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9. Alemtuzumab as initial therapy for Sézary syndrome: A report of 2 cases

Author: Caitlin M. Brumfiel, Aarthi Shenoy, Sanna D. Ronkainen, and Karl M. Saardi
Subjects: medicine.medical_specialty, business.industry, medicine, lcsh:Dermatology, Alemtuzumab, Case Report, Dermatology, lcsh:RL1-803, business, Initial therapy, medicine.drug
Published: 2020

10. Assessment of ejection fraction and heart perfusion using myocardial perfusion single-photon emission computed tomography in Finland and Estonia: a multicenter phantom study

Author: Ari-Petteri Ronkainen, Jari O. Heikkinen, Pia H Linder, Chibuzor T M Eneh, and Eero Hippeläinen
Subjects: Estonia, Imaging chain, Single-photon emission computed tomography, Scintigraphy, Imaging phantom, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Heart perfusion, Coronary Circulation, medicine, Humans, Radiology, Nuclear Medicine and imaging, Finland, Tomography, Emission-Computed, Single-Photon, Reproducibility, Ejection fraction, medicine.diagnostic_test, Phantoms, Imaging, business.industry, Myocardial Perfusion Imaging, Stroke Volume, General Medicine, 3. Good health, 030220 oncology & carcinogenesis, Nuclear medicine, business, Perfusion
Abstract: OBJECTIVES Myocardial SPECT/CT imaging is frequently performed to assess myocardial perfusion and dynamic parameters of heart function, such as ejection fraction (EF). However, potential pitfalls exist in the imaging chain that can unfavorably affect diagnosis and treatment. We performed a national cardiac quality control study to investigate how much SPECT/CT protocols vary between different nuclear medicine units in Finland, and how this may affect the heart perfusion and EF values. METHODS Altogether, 21 nuclear medicine units participated with 27 traditional SPECT/CT systems and two cardiac-centered IQ-SPECT systems. The reproducibility of EF and the uniformity of perfusion were studied using a commercial dynamic heart phantom. SPECT/CT acquisitions were performed and processed at each participating unit using their own clinical protocol and with a standardized protocol. The effects of acquisition protocols and analysis routines on EF estimates and uniformity of perfusion were studied. RESULTS Considerable variation in EF estimates and in the uniformity of perfusion were observed between the units. Uniformity of perfusion was improved in some units after applying the higher count-statistic standard acquisition protocol. EF estimates varied more due to differences in analysis routines than as a result of different acquisition protocols. The results obtained with the two IQ-SPECT systems differed substantially from the traditional multipurpose cameras. CONCLUSION On average, the EF and heart perfusion were accurately estimated by SPECT/CT, but high errors could be produced if the acquisition and analysis routines were poorly optimized. Eight of the 21 participants altered their imaging protocol after this quality control tour.
Published: 2020
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11. Integrated access and backhaul a New Type of Wireless Backhaul in 5G

Author: Henrik Ronkainen, Anders Ericsson, Christer Östberg, and Jonas Edstam
Subjects: Flexibility (engineering), Computer science, business.industry, Wireless backhaul, IAB, 010401 analytical chemistry, Testbed, 020206 networking & telecommunications, 02 engineering and technology, 01 natural sciences, lcsh:P87-96, 0104 chemical sciences, lcsh:Communication. Mass media, Protocol stack, Backhaul (telecommunications), integrated access and backhaul, 0202 electrical engineering, electronic engineering, information engineering, wireless backhaul, Electrical and Electronic Engineering, Telecommunications, business, 5G, mm wave communication
Abstract: In this paper, we study the concept and the potentials of integrated access and backhaul (IAB) as one of the main innovative aspects of 5G networks. We study IAB networks from different perspectives. Particularly, we summarize the recent Rel-16 discussions on IAB, and highlight the main IAB-specific agreements on different protocol layers. Moreover, we present simulations and proof-of-concept testbed results to evaluate the performance of IAB networks in both urban and suburban areas. As show, for both suburban and urban scenarios, IAB is an attractive complement to fiber, with high flexibility and low time-to-market.
Published: 2020
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12. Are Rubber Gloves Marketed as Accelerator-Free Truly Free of Accelerators? [RETRACTED]

Author: Sanna D. Ronkainen, Sara A. Hylwa, Makenzie E. Pillsbury, and Molly C Goodier
Subjects: Accelerant, Chromatography, business.industry, Electrospray ionization, technology, industry, and agriculture, Dermatology, equipment and supplies, medicine.disease, Mass spectrometry, Tandem mass spectrometry, body regions, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Natural rubber, visual_art, visual_art.visual_art_medium, Immunology and Allergy, Medicine, Mercaptobenzothiazole, 030212 general & internal medicine, business, Allergic contact dermatitis, Contact dermatitis
Abstract: BACKGROUND Allergic contact dermatitis to rubber accelerators in gloves has been well described in the literature. In response to this, glove manufacturers have recently marketed "accelerator-free" gloves. Little research has been done, to confirm whether these gloves are truly free from the accelerators known to cause contact dermatitis. OBJECTIVE The aim of the study was to verify use of accelerators in reportedly accelerator-free/low-dermatitis-potential gloves. METHODS A total of 16 commercially available medical gloves touted as "accelerator-free," "sensitive," or "low dermatitis potential" were obtained and analyzed via mass spectrometry (liquid chromatography heated electrospray ionization tandem mass spectrometry and liquid chromatography heated electrospray high-resolution tandem mass spectrometry) to determine whether any of the 9 known rubber accelerators were present (thiurams, carbamates, mercaptobenzothiazole, and diphenylguanidine). RESULTS Despite marketing claims to the contrary, all tested gloves had at least 1 accelerant detected. Dipentamethylenethiuram disulfide, a thiuram, was found in all 16 gloves. Half of the gloves (8/16) contained more than 1 accelerator, with 1 glove having 5 rubber accelerators present. CONCLUSION Patients with allergic contact dermatitis to accelerators should be aware potentially sensitizing accelerators may be present in gloves that are reported to not contain them.
Published: 2020
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13. An overview of current safety requirements for autonomous machines – review of standards

Author: Ari Ronkainen, Timo Malm, and Risto Tiusanen
Subjects: Environmental Engineering, safety requirement, Computer science, business.industry, Mechanical Engineering, standard, Aerospace Engineering, Engineering (General). Civil engineering (General), Automation, safety concept, Systems engineering, General Materials Science, TA1-2040, Electrical and Electronic Engineering, Current (fluid), business, automation, autonomous work machine, Civil and Structural Engineering
Abstract: The development of automated work machine systems towards autonomous operation is proceeding rapidly in different industrial sectors. The aim of the study was to explore the current situation and possible differences in standardization supporting the development in different industrial sectors. The existing ISO and IEC standards and work items related to autonomous machinery were reviewed as well as activities in international industry groups regarding automation and autonomy of machinery. In general, the current standards are made mostly for machine manufacturers, but the views or responsibilities at worksite level are not considered. Three different approaches for safety concepts for different operating conditions were identified. One of them relies on onboard safety systems including sensor and perception systems for indoor applications. One guides to separate and isolate the autonomously operating machinery and to use access control to the autonomous operating zone. The third one is relying mainly on the machine operator’s ability to understand the situation and to react correctly according to the available information. From technology point of view there seems to be a gap between the safety requirements set in standards and the state of the art in currently available technology.
Published: 2020
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14. Trends and Indications in International Business: Topics for Future Research

Author: Czinkota, Michael R. and Ronkainen, Ilkka A.
Published: 2009

15. Does every Clavien-Dindo complication matter? A national multi-center study in kidney cancer surgery

Author: Ansa Kilponen, Erkkilä Kaisa, Margus Tramberg, Marjo Seppänen, Taina Isotalo, Heikki Seikkula, Sirkku Mustonen, Otto Ettala, Hanna Ronkainen, Thea Veitonmäki, Christian Palmberg, Pogodin-Hannolainen Dimitri, Timo K. Nykopp, and Harry Nisen
Subjects: Male, medicine.medical_specialty, Clavien-Dindo Classification, Urology, medicine.medical_treatment, 030232 urology & nephrology, Kidney, Nephrectomy, 03 medical and health sciences, Postoperative fever, 0302 clinical medicine, Postoperative Complications, Medicine, Humans, Complication rate, Retrospective Studies, business.industry, University hospital, medicine.disease, Kidney Neoplasms, 3. Good health, Surgery, Nephrology, 030220 oncology & carcinogenesis, Multi center study, business, Complication, Kidney cancer
Abstract: BACKGROUND There is huge variation in Clavien-Dindo (CD) complication rates in urology. We sought to optimize the use of the CD system in kidney tumor surgery. METHODS We retrospectively analyzed 1,286 patients undergoing kidney tumor operations in 12 Finnish hospitals during 2016-2017. Primary CD assignments were made by site urologists. Data were centrally reviewed by two authors in consensus meetings. Consistency of the primary assignments was assessed by the number of cases requiring correction. Complication load was compared as different outcome rates between five university hospital regions. RESULTS The overall complication rate in primary data was 40% (517/1286) and varied significantly from 32 to 62% (p
Published: 2021

16. ‘I was excited to train, so I didn’t have problems with the coach’: dual career athletes’ experiences of (dis)empowering motivational climates

Author: Harri Rintala, Kaisa Aunola, Noora J. Ronkainen, Milla Saarinen, and Tatiana V. Ryba
Subjects: dual careers, Cultural Studies, Secondary education, media_common.quotation_subject, Applied psychology, Coaching, empowering coaching, 03 medical and health sciences, 0302 clinical medicine, motivaatioilmasto, 0502 economics and business, Elite athletes, valmennus, Empowerment, Finland, media_common, youth athletes, motivaatio, biology, business.industry, Athletes, 05 social sciences, 030229 sport sciences, biology.organism_classification, urakehitys, Dual (category theory), koulutus, motivational climate, opiskelu, psyykkinen valmennus, business, Psychology, human activities, 050212 sport, leisure & tourism, kaksoisura, huippu-urheilijat, urheilijat
Abstract: In addition to investing in athletic development, adolescent elite athletes are expected to complete their secondary education. As a result of this expectation and the demands of sport and education, they may struggle to sustain high levels of motivation for both domains. Grounded in theoretical tenets of empowering coaching, this study sought to explore student–athletes’ perceptions of empowering and disempowering motivational climates and their possible implications for athletes’ dual career experiences. Semi-structured interviews were conducted with 17 Finnish student–athletes, and the data were thematically analysed. The analysis indicated that a majority of the athletes had experiences of disempowering coaching climates due to coaches’ exclusive emphasis on athletic performance. It is concluded that the perception that obtaining an education is less important than sport may potentially decrease athletes’ motivation to pursue an academic track and thus challenge their exploration of future vocations outside the sporting context. peerReviewed
Published: 2019
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17. Facial nerve function and hearing after microsurgical removal of sporadic vestibular schwannomas in a population-based cohort

Author: Antti Ronkainen, Heikki Löppönen, Tuomas Rauramaa, Arto Immonen, Ismail Taha, Esa Mervaala, Jukka Huttunen, Nils Danner, Antti Hyvärinen, Olli-Pekka Kämäräinen, Antti Ranta, and Juha E. Jääskeläinen
Subjects: Microsurgery, medicine.medical_specialty, medicine.medical_treatment, Population, Schwannoma, Facial nerve, Radiosurgery, 030218 nuclear medicine & medical imaging, Benign tumor, Vestibulocochlear nerve, 03 medical and health sciences, Vestibular schwannoma, 0302 clinical medicine, Hearing, medicine, education, Retrosigmoid approach, Intraoperative monitoring, education.field_of_study, business.industry, medicine.disease, Surgery, Original Article - Tumor - Schwannoma, Neurology (clinical), Neurosurgery, business, 030217 neurology & neurosurgery
Abstract: Background Vestibular schwannoma (VS) is a benign tumor originating from the vestibulocochlear nerve. The optimal treatment strategy is debated, since surgery may result in iatrogenic facial nerve injury. We report the results of VS surgery in a population-based unselected cohort in a center with access to Cyber Knife (CK) radiosurgery. Methods We reviewed 117 consecutive operations and found 95 patients who had their primary operation due to vestibular schwannoma between 2001 and 2017. Facial nerve function was evaluated with the House-Brackmann (HB) scale and hearing with the EU classification. Results The population consisted of 37 males and 58 females with a median age of 54 years (range 19–79). One year after surgery 67% of patients had a good outcome (HB 1–2). The rate of good outcome was 90% if no facial nerve damage was observed during intraoperative monitoring, the size of the tumor was under 30 mm and no hydrocephalus was present. During the study period, the treatment strategy changed from total to near-total resection after the introduction of CK radiosurgery, which could be used as a second-line treatment in case of residual tumor regrowth. This resulted in an improvement of outcomes (0% HB 5–6) despite the larger tumor sizes (25 ± 14 mm vs. 31 ± 9 mm, p
Published: 2019
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18. External Validation of the ELAPSS Score for Prediction of Unruptured Intracranial Aneurysm Growth Risk

Author: Amr Abdulazim, Satoshi Kuroda, Eva L. Leemans, René van den Berg, Antti Ronkainen, Johanna Kuhmonen, Yvo B.W.E.M. Roos, Walid Moudrous, Timo Koivisto, Jaakko Rinne, Juha Öhman, Edward J St George, Daina Kashiwazaki, Ido R. van den Wijngaard, Mayte Sánchez van Kammen, Mario Teo, Akio Morita, Antti E. Lindgren, Toshikazu Kimura, Mervyn D.I. Vergouwen, Laura Ten Hove, Yoshiaki Shiokawa, Melissa Rahi, Juha E. Jääskeläinen, Charles B. L. M. Majoie, Dagmar Verbaan, Liisa Pyysalo, Anne Christine Januel, Katharina A. M. Hackenberg, Christophe Cognard, Hieronymus D. Boogaarts, Nima Etminan, Gabriel J.E. Rinkel, W. Peter Vandertop, Jacoba P. Greving, Graduate School, Neurology, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, Radiology and Nuclear Medicine, Amsterdam Neuroscience - Systems & Network Neuroscience, Neurosurgery, Experimental Vascular Medicine, and Division 2
Subjects: medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, Subarachnoid hemorrhage, Neurology, Population, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Aneurysm, medicine, Journal Article, cardiovascular diseases, education, Unruptured intracranial aneurysm, education.field_of_study, business.industry, Model validation, Prevention, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Aneurysm growth, External validation, medicine.disease, Confidence interval, Risk factors, lcsh:RC666-701, Radiological weapon, Cohort, Original Article, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract: Contains fulltext : 215616.pdf (Publisher’s version ) (Open Access) Background and PURPOSE: Prediction of intracranial aneurysm growth risk can assist physicians in planning of follow-up imaging of conservatively managed unruptured intracranial aneurysms. We therefore aimed to externally validate the ELAPSS (Earlier subarachnoid hemorrhage, aneurysm Location, Age, Population, aneurysm Size and Shape) score for prediction of the risk of unruptured intracranial aneurysm growth. METHODS: From 11 international cohorts of patients >/=18 years with >/=1 unruptured intracranial aneurysm and >/=6 months of radiological follow-up, we collected data on the predictors of the ELAPSS score, and calculated 3- and 5-year absolute growth risks according to the score. Model performance was assessed in terms of calibration (predicted versus observed risk) and discrimination (c-statistic). RESULTS: We included 1,072 patients with a total of 1,452 aneurysms. During 4,268 aneurysm-years of follow-up, 199 (14%) aneurysms enlarged. Calibration was comparable to that of the development cohort with the overall observed risks within the range of the expected risks. The c-statistic was 0.69 (95% confidence interval [CI], 0.64 to 0.73) at 3 years, compared to 0.72 (95% CI, 0.68 to 0.76) in the development cohort. At 5 years, the c-statistic was 0.68 (95% CI, 0.64 to 0.72), compared to 0.72 (95% CI, 0.68 to 0.75) in the development cohort. CONCLUSION: s The ELAPSS score showed accurate calibration for 3- and 5-year risks of aneurysm growth and modest discrimination in our external validation cohort. This indicates that the score is externally valid and could assist patients and physicians in predicting growth of unruptured intracranial aneurysms and plan follow-up imaging accordingly.
Published: 2019
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19. Nephrectomy improves the survival of metastatic renal cell cancer patients with moderate to good performance status—results from a Finnish nation-wide population-based study from 2005 to 2010

Author: Pasi Ohtonen, Markku H. Vaarala, Lauri Laru, and Hanna Ronkainen
Subjects: medicine.medical_specialty, RD1-811, medicine.medical_treatment, Population, Metastatic renal cell carcinoma, 030232 urology & nephrology, Subgroup analysis, Population-based, Renal tumor, Nephrectomy, 03 medical and health sciences, 0302 clinical medicine, Surgical oncology, Cytoreductive nephrectomy, Internal medicine, medicine, Humans, Overall survival, education, Carcinoma, Renal Cell, RC254-282, Survival analysis, Finland, Retrospective Studies, education.field_of_study, Performance status, business.industry, Research, Metastasectomy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cytoreduction Surgical Procedures, Prognosis, Kidney Neoplasms, Cancer registry, Oncology, 030220 oncology & carcinogenesis, Surgery, business
Abstract: Background The purpose of this study was to evaluate the effects of cytoreductive nephrectomy (CN) and metastasectomies on the survival of patients with synchronous metastatic renal cell cancer (mRCC) using real-life, population-based national dataset. Methods Nationwide data, including all cases of synchronous mRCC in Finland diagnosed on a 6-year timeframe, based on the Finnish Cancer Registry and complemented with patient records from the treating hospitals, were analyzed. Patients with Eastern Cooperative Oncology Group (ECOG) performance status 3–4 were excluded. Univariate and adjusted multivariable survival analysis were performed, including subgroup analysis for patients with different medical therapies. Nephrectomy complications were also analyzed. Results A total of 732 patients were included in the analysis. CN was performed for 389 (53.1%) patients, whereas 68 (9.3%) patients underwent nephrectomy and metastasectomies of all lesions (surgery with curative intent). Median overall survival (OS) for patients who did not undergo nephrectomy was 5.9 (95% confidence interval [CI] = 4.6–7.2) months. Patients who had a CN had a median OS of 16.6 (95% CI = 14.2–19.1, p < 0.001) months, whereas patients who had surgery with curative intent had a median OS of 51.3 (95% CI = 36.0–66.6, p < 0.001) months. The survival benefit of CN and metastasectomies remained significant in all medical therapy subgroups and in both of the applied multivariable statistical models. Conclusions Surgical treatment of metastatic renal cell cancer is associated with a significant survival benefit in patients with good and moderate performance status, regardless of the chosen medical therapy.
Published: 2021

20. Duodenal eosinophilia and the link to anxiety: A population‐based endoscopic study

Author: Lars Agréus, Marjorie M. Walker, Jukka Ronkainen, Pertti Aro, Michael P. Jones, Nicholas J. Talley, and Anna Andreasson
Subjects: Male, medicine.medical_specialty, Physiology, Anxiety, Hospital Anxiety and Depression Scale, Endoscopy, Gastrointestinal, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Eosinophilia, medicine, Humans, Dyspepsia, medicine.diagnostic_test, Endocrine and Autonomic Systems, business.industry, Esophagogastroduodenoscopy, Gastroenterology, Odds ratio, Middle Aged, Confidence interval, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Duodenum, Population study, Female, 030211 gastroenterology & hepatology, medicine.symptom, business, Follow-Up Studies
Abstract: Introduction The concept of gut-to-brain communication via microbial or inflammatory pathways is gaining increased attention but genuine pathology directly linking gut perturbation to anxiety is lacking. We hypothesized that duodenal eosinophilia, as known to occur in functional dyspepsia (FD), may be an underlying cause of anxiety and may help explain the striking association between FD and anxiety. Methods Randomly selected subjects from the national population register of Sweden completed the validated Abdominal Symptom Questionnaire; 1000 completed esophagogastroduodenoscopy and the Hospital Anxiety and Depression Scale questionnaire. Duodenal biopsies were obtained from 1st (D1) and 2nd portion (D2). Eligible subjects who underwent endoscopy (n = 887) were invited to participate in a 10-year follow-up study with the same questionnaires. Among endoscopy normal subjects, FD was identified by Rome criteria, and controls were symptom free. Duodenal eosinophilia was based on pre-defined cut-offs. Finding are reported as odds ratios (ORs) with 95% confidence interval and p-value. Results The study population comprised 89 cases with FD and 124 healthy controls (mean age 62 years, SD 12, 34% male). Clinical anxiety at follow-up was elevated in those with D1 eosinophilia at baseline considering either new-onset anxiety (OR = 4.5, 95% CI 0.8, 23.8; p = 0.08) or follow-up anxiety adjusting for baseline anxiety (OR = 4.51 (95% CI 1.03, 19.81; p = 0.046). Conclusion Duodenal eosinophilia may potentially be a mechanism linked to anxiety independent of FD.
Published: 2021
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21. Toward Efficient Academia-Industry Collaboration: A Case Study of Joint VR System Development

Author: Tuuli Keskinen, Markku Turunen, Jaakko Hakulinen, Kimmo Ronkainen, Roope Raisamo, Viveka Opas, Hanna Heinonen, John Mäkelä, Sanni Siltanen, Alisa Burova, Paulina Becerril Palma, Tampere University, and Computing Sciences
Subjects: Knowledge management, Work (electrical), Process (engineering), business.industry, Computer science, 213 Electronic, automation and communications engineering, electronics, Context (language use), Joint (building), Action research, Virtual reality, business, Collaborative virtual environment, Pace
Abstract: Collaborative academia-industry development and evaluation of virtual reality (VR) systems is a mutually beneficial opportunity to investigate VR technology in a real context and conduct user studies with target users. However, such collaboration is rarely performed due to variations in project pace and work methods. In this article, we introduce the process of action research on joint design, development, and evaluation of a collaborative VR system to address industrial needs. The paper further presents employees’ subjective opinions and perceived value of industrial VR applica- tions and reflects on their involvement throughout the process. The article concludes with a process-oriented framework for remote academia-industry collaboration, supported with practical sugges- tions on how to support this collaboration. Our experiences reveal the methods and advantages of remote collaboration in all phases of the process and signify the efficiency of the remote framework for academia-industry collaboration, especially relevant in the light of the COVID-19 pandemia acceptedVersion
Published: 2021

22. Expected impact of MRI-related interreader variability on ProScreen prostate cancer screening trial: a pre-trial validation study

Author: Kari Natunen, Antti Rannikko, Johanna Ronkainen, Suvi Marjasuo, Anu Kenttämies, Outi Oksanen, Kati Lind, Ronja Hietikko, Tuomas Mirtti, Kimmo Taari, Teuvo L.J. Tammela, Juha Oksala, Tuomas Saarinen, Ritja Savolainen, Kirsty Ijäs, Tuomas P. Kilpeläinen, Anssi Auvinen, HUS Abdominal Center, Urologian yksikkö, University of Helsinki, Helsinki University Hospital Area, Research Program in Systems Oncology, Research Programs Unit, Faculty of Medicine, Department of Surgery, HUS Medical Imaging Center, Department of Diagnostics and Therapeutics, Clinicum, HUSLAB, Department of Pathology, Tampere University, Department of Radiology, and Health Sciences
Subjects: Male, medicine.medical_treatment, ACCURACY, GUIDELINES, 030218 nuclear medicine & medical imaging, PI-RADS version 2, Random Allocation, Prostate cancer, 0302 clinical medicine, Observer Variation, Clinical Trials as Topic, education.field_of_study, Radiological and Ultrasound Technology, medicine.diagnostic_test, Prostatectomy, General Medicine, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Prostate cancer screening, Oncology, 030220 oncology & carcinogenesis, Cohort, Screening, BIOPSY, Radiology, Pseudonymized, Research Article, Image-Guided Biopsy, lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_specialty, lcsh:R895-920, Population, 3122 Cancers, DIAGNOSIS, lcsh:RC254-282, Agreement, 03 medical and health sciences, Magnetic resonance imaging, Biopsy, medicine, Humans, Radiology, Nuclear Medicine and imaging, education, Aged, business.industry, Prostatic Neoplasms, 3126 Surgery, anesthesiology, intensive care, radiology, medicine.disease, 3141 Health care science, Neoplasm Grading, business
Abstract: Background The aim of this study is to investigate the potential impact of prostate magnetic resonance imaging (MRI) -related interreader variability on a population-based randomized prostate cancer screening trial (ProScreen). Methods From January 2014 to January 2018, 100 men aged 50–63 years with clinical suspicion of prostate cancer (PCa) in Helsinki University Hospital underwent MRI. Nine radiologists individually reviewed the pseudonymized MRI scans of all 100 men in two ProScreen trial centers. All 100 men were biopsied according to a histological composite variable comprising radical prostatectomy histology (N = 38) or biopsy result within 1 year from the imaging (N = 62). Fleiss’ kappa (κ) was used to estimate the combined agreement between all individual radiologists. Sample data were subsequently extrapolated to 1000-men subgroups of the ProScreen cohort. Results Altogether 89% men of the 100-men sample were diagnosed with PCa within a median of 2.4 years of follow-up. Clinically significant PCa (csPCa) was identified in 76% men. For all PCa, mean sensitivity was 79% (SD ±10%, range 62–96%), and mean specificity 60% (SD ±22%, range 27–82%). For csPCa (Gleason Grade 2–5) MRI was equally sensitive (mean 82%, SD ±9%, range 67–97%) but less specific (mean 47%, SD ±20%, range 21–75%). Interreader agreement for any lesion was fair (κ 0.40) and for PI-RADS 4–5 lesions it was moderate (κ 0.60). Upon extrapolating these data, the average sensitivity and specificity to a screening positive subgroup of 1000 men from ProScreen with a 30% prevalence of csPCa, 639 would be biopsied. Of these, 244 men would be true positive, and 395 false positive. Moreover, 361 men would not be referred to biopsy and among these, 56 csPCas would be missed. The variation among the radiologists was broad as the least sensitive radiologist would have twice as many men biopsied and almost three times more men would undergo unnecessary biopsies. Although the most sensitive radiologist would miss only 2.6% of csPCa (false negatives), the least sensitive radiologist would miss every third. Conclusions Interreader agreement was fair to moderate. The role of MRI in the ongoing ProScreen trial is crucial and has a substantial impact on the screening process.
Published: 2020

23. Prognostic value of the 2010 consensus definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

Author: Heikki Kiiski, Eija Junttila, Antti Ronkainen, Essi Raatikainen, Liisa Pyysalo, Anne Kuitunen, Annukka Vahtera, and Heini Huhtala
Subjects: Adult, medicine.medical_specialty, Subarachnoid hemorrhage, Consensus, Ischemia, law.invention, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, law, medicine, Humans, 030212 general & internal medicine, Functional ability, Retrospective Studies, business.industry, Glasgow Outcome Scale, Incidence (epidemiology), Subarachnoid Hemorrhage, medicine.disease, Prognosis, Intensive care unit, Neurology, Emergency medicine, Cohort, Observational study, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract: Background and purpose Delayed cerebral ischemia (DCI) complicates the recovery of approximately 30% of patients with aneurysmal subarachnoid hemorrhage (aSAH). The definition of DCI widely varies, even though a consensus definition has been recommended since 2010. This study aimed to evaluate the prognostic value of the 2010 consensus definition of DCI in a cohort of patients with aSAH. Methods We conducted a single-center, retrospective, observational study that included consecutive adult patients with aSAH who were admitted to the intensive care unit from January 2010 to December 2014. DCI was evaluated 48 h to 14 days after onset of aSAH symptoms using the 2010 consensus criteria and outcome was assessed by the Glasgow Outcome Scale (GOS) at discharge from hospital. Results A total of 340 patients were analyzed and the incidence of DCI was 37.1%. The median time from primary hemorrhage to the occurrence of DCI was 97 h. Neurological deterioration was observed in most (89.7%) of the patients who fulfilled the DCI criteria. The occurrence of DCI was strongly associated with an unfavorable outcome (GOS 1–3) at hospital discharge (OR 2.65, 95% CI 1.69–4.22, p Conclusions The incidence of DCI after aSAH is high and its occurrence is strongly associated with an unfavorable neurological outcome. This finding adds to the previous literature, which has shown that DCI appears to be a major contributor affecting the functional ability of survivors of aSAH. To further advance reliable knowledge of DCI, future studies should adhere to the consensus definition of DCI.
Published: 2020

24. Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case-control comparison with family members

Author: Mikko Kauppinen, Jaakko Rinne, Seppo Helisalmi, Cecilia Avellan, Anne M. Koivisto, Sami Kastinen, Mitja I. Kurki, Markus Perola, Joel Huovinen, Mikko Hiltunen, Anne M. Remes, Hilkka Soininen, Antti Ronkainen, Simo Komulainen, Antti Junkkari, Minna Oinas, Joel Rasanen, Ville E. Korhonen, Ville Leinonen, Kimmo Lönnrot, Juha E. Jääskeläinen, Janek Frantzén, Clinicum, HUS Neurocenter, Neurokirurgian yksikkö, University of Helsinki, and Helsinki University Hospital Area
Subjects: 0301 basic medicine, Male, SYMPTOMS, FEATURES, Comorbidity, Logistic regression, lcsh:RC346-429, 3124 Neurology and psychiatry, Comorbidities, MELLITUS, 0302 clinical medicine, Familial, Normal pressure hydrocephalus, Epidemiology, EPIDEMIOLOGY, Depression (differential diagnoses), Aged, 80 and over, Depression, Diabetes, Family aggregation, General Medicine, IMPAIRMENT, Middle Aged, Hydrocephalus, Normal Pressure, Exact test, Neurology, Hypertension, NPH, SFMBT1, Female, GLYMPHATIC SYSTEM, MRI, medicine.medical_specialty, Heart Diseases, 03 medical and health sciences, Cellular and Molecular Neuroscience, INPH, Developmental Neuroscience, Internal medicine, Diabetes mellitus, medicine, Genetics, Diabetes Mellitus, Humans, Family, Risk factor, VASCULAR RISK-FACTORS, lcsh:Neurology. Diseases of the nervous system, Aged, business.industry, Research, 3112 Neurosciences, medicine.disease, 030104 developmental biology, Case-Control Studies, business, 030217 neurology & neurosurgery
Abstract: Background The pathophysiological basis of idiopathic normal pressure hydrocephalus (iNPH) is still unclear. Previous studies have shown a familial aggregation and a potential heritability when it comes to iNPH. Our aim was to conduct a novel case-controlled comparison between familial iNPH (fNPH) patients and their elderly relatives, involving multiple different families. Methods Questionnaires and phone interviews were used for collecting the data and categorising the iNPH patients into the familial (fNPH) and the sporadic groups. Identical questionnaires were sent to the relatives of the potential fNPH patients. Venous blood samples were collected for genetic studies. The disease histories of the probable fNPH patients (n = 60) were compared with their ≥ 60-year-old relatives with no iNPH (n = 49). A modified Charlson Comorbidity Index (CCI) was used to measure the overall disease burden. Fisher’s exact test (two-tailed), the Mann–Whitney U test (two-tailed) and a multivariate binary logistic regression analysis were used to perform the statistical analyses. Results Diabetes (32% vs. 14%, p = 0.043), arterial hypertension (65.0% vs. 43%, p = 0.033), cardiac insufficiency (16% vs. 2%, p = 0.020) and depressive symptoms (32% vs. 8%, p = 0.004) were overrepresented among the probable fNPH patients compared to their non-iNPH relatives. In the age-adjusted multivariate logistic regression analysis, diabetes remained independently associated with fNPH (OR = 3.8, 95% CI 1.1–12.9, p = 0.030). Conclusions Diabetes is associated with fNPH and a possible risk factor for fNPH. Diabetes could contribute to the pathogenesis of iNPH/fNPH, which motivates to further prospective and gene-environmental studies to decipher the disease modelling of iNPH/fNPH.
Published: 2020

25. Does free public transit increase physical activity and independent mobility in children? Study protocol for comparing children’s activity between two Finnish towns with and without free public transit

Author: Jussi Ronkainen, Samira Ramezani, Arto J. Pesola, Pirjo Hakala, Tiina E. Laatikainen, Karen Villanueva, Sari Tuuva-Hongisto, Päivi Berg, South-Eastern Finland University of Applied Sciences, Department of Built Environment, Royal Melbourne Institute of Technology, Aalto-yliopisto, and Aalto University
Subjects: Male, Parents, Built environment, Ethnography, Transportation, Walking, Comprehensive school, Study Protocol, 0302 clinical medicine, Residence Characteristics, 030212 general & internal medicine, Moderate-to-vigorous physical activity, Everyday life, Child, Finland, Travel, Schools, lcsh:Public aspects of medicine, 05 social sciences, digestive, oral, and skin physiology, Public Assistance, Accessibility, Sedentary time, PPGIS, Evaluation Studies as Topic, Research Design, Public transport, Female, 050703 geography, medicine.medical_specialty, Public participation GIS, 0507 social and economic geography, SoftGIS, 03 medical and health sciences, Bus, medicine, Humans, Cities, Students, Socioeconomic status, Exercise, Commuting, business.industry, Physical activity, Public health, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Children’s independent mobility, Children's independent mobility, Accelerometer, Housing, Demographic economics, Residence, business
Abstract: Background Children’s habitual physical activity, including active travel and catching public transit (walking and cycling to and from destinations), and independent mobility (mobility without an adult) have decreased. Public transit trips are physically active and can provide access to hobbies independent of parents, but there is no device-measured data about children’s total physical activity time following the introduction of free public transit. Our aim is to compare physical activity and independent mobility between children living in two Finnish towns, one with a recently introduced free public transit system, and the other without free public transit. Methods The city of Mikkeli has provided free public transit for all comprehensive school children since 2017. Various districts from Mikkeli, and the reference town of Kouvola (towns from South-Eastern Finland with a comparative population size and geographical structure), are selected based on their accessibility and the availability of public transit services. Samples of 10–12-year-old children will be recruited through primary schools. We will compare moderate-to-vigorous physical activity time, sitting time (a thigh-worn Fibion® device) and independent mobility (a participatory mapping method, PPGIS) of children: 1) who live in towns with and without free public transit, 2) who live and go to school in districts with high vs. low perceived and objective access to free public transit, and 3) who report using vs. not using free public transit. In addition, ethnography will be used to get insights on the social and cultural effects of the free public transit on children’s and parent’s everyday life. Discussion There is a need for scalable solutions that can increase children’s physical activity independent of their socioeconomic background or place of residence. This project will give information on how a political action to provide free public transit for children is associated with their total physical activity time and independent mobility patterns, therefore providing highly relevant information for political decision-making and for promoting independent physical activity in children.
Published: 2020

26. 'I want to do well for myself as well!' : Constructing coaching careers in elite women’s football

Author: David M. Richardson, Noora J. Ronkainen, and Emily J. Sleeman
Subjects: narrative, naisurheilu, Football, Coaching, career development, Reflexive pronoun, ammatti-identiteetti, coaching, narratiivinen tutkimus, Narrative, identiteetti, Sociology, Business and International Management, business.industry, vignettes, Gender studies, urakehitys, Tourism, Leisure and Hospitality Management, Elite, sports, women’s sport, business, valmentajat, Social Sciences (miscellaneous), coach identity, Career development
Abstract: There is a limited understanding of career development of sport coaches, especially from the subjective perspective focused on personal meaning and evaluation of this life project in sport. We drew on career construction theory and narrative methodology to explore football coaches’ career development, adaptability resources, and the meanings they assigned to their journeys. Ten women’s football (soccer) coaches (2 women) aged 23-60 in England took part in narrative interviews which we analysed using thematic narrative analysis. Our analysis indicated that early immersion into the football narrative context most often resulted in low career exploration and a strong commitment to coaching as an attempt to keep the footballing identity narrative ‘going’. Whilst the majority of coaches had a full-time occupation elsewhere, they self-identified as professional coaches and approached coaching with a career orientation animated by a desire to progress to a full-time coaching position. The coaches were resourceful and active career agents in crafting their careers in football; however, most of them expressed little concern or curiosity for other careers aside professional coaching, leaving them vulnerable to psychological distress if unable to realise their career ambition. The findings illustrate the seductive nature of football with the narrative context providing coaches with a cherished sense of identity but also bringing a permanent sense of insecurity and costs to their lives outside of the game.
Published: 2020

27. Towards Social Enterprise with Internet of Office Desks

Author: Johanna Kallio, Jussi Ronkainen, Julia Kantorovitch, Pauli Räsänen, Vesa Kyllönen, and Elena Vildjiounaite
Subjects: Knowledge management, business.industry, Mental health, Profit (economics), Barometer, law.invention, Work (electrical), SDG 3 - Good Health and Well-being, Turnover, law, Presenteeism, The Internet, Business, Line management
Abstract: Social enterprises are organisations, combining profit making with support of their employees and environment. Employee stress is harmful for both society (due to increased risk of mental health disorders and cardiovascular diseases) and for enterprise performance (due to increased risk of presenteeism, employee turnover and early retirement). This work aims at helping enterprises to improve employee wellbeing. To this end, we introduce a concept of IoT-based privacy-aware “team barometer” and present a first study into using inexpensive PIR (passive infrared) motion detection sensors in such barometers. The study was conducted as follows: first, we deployed IoT system in real offices and collected employee data in the course of everyday work during several months. Second, we developed a machine learning method to classify human conditions on the basis of collected PIR data. In the tests, this method recognised employees’ stress with 80% accuracy and dissatisfaction with indoor environmental quality - with 75% accuracy. Third, we integrated stress detection results into a “team barometer” and conducted interviews of line managers. Interview results suggest that the proposed IoT-based team barometer can be beneficial for both employees and enterprises because of its potential to discover and mitigate workplace problems notably faster than with current practice to use periodic surveys.
Published: 2020
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28. An Exploration of the Experiences of Elite Youth Footballers: The Impact of Organizational Culture

Author: David Tod, Mark Nesti, Martin Littlewood, Francesca Mary Champ, and Noora J. Ronkainen
Subjects: business.industry, education, 05 social sciences, Professional development, Organizational culture, Identity (social science), 030229 sport sciences, Football, Public relations, Sport psychology, 050105 experimental psychology, Personal development, C813, 03 medical and health sciences, 0302 clinical medicine, Elite, 0501 psychology and cognitive sciences, Club, sports, business, Psychology, human activities, Applied Psychology
Abstract: The present study explored how the organizational cultural experiences of elite youth footballers shaped their identity development and behavior. The first author occupied the position of sport psychology practitioner-researcher within 1 professional football club over 3 years. Traditional ethnographic research methods were employed, including observations, field notes, reflections, and informal interviews. A cultural sport psychology perspective on identity as a social construction and research on the cultural characteristics of professional football were used as frameworks to make sense of the data. Despite the introduction of the Elite Player Performance Plan in 2012, the traditional masculine culture of professional football dominated the studied club. Creative nonfiction vignettes revealed that youth players were encouraged to develop their self-stories focused on a single-minded dedication to professional football. The limited identity-related resources offered at both club and cultural level are detrimental for players in terms of their well-being and long-term psychological development. From the results of this study, we suggest that future sports psychology practice within professional football may best be delivered at an organizational level. However, for sport psychologists to be effective in this role, they must develop an understanding of the subcultural features and characteristics of the organization. In line with this, there would be great value in introducing a focus on organizational culture within sport psychology professional training and education routes. Lay Summary: This paper explores the impact of the professional football culture on the psychological development of elite youth footballers. From the findings we suggest that sport psychology should be delivered at an organisational level.
Published: 2018
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29. Traumatic cervical spinal cord injury: recovery of penetration/aspiration and functional feeding outcome

Author: Teemu M. Luoto, Tiina Ihalainen, Antti Ronkainen, Anna-Maija Korpijaakko-Huuhka, and Irina Rinta-Kiikka
Subjects: Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Speech Therapy, Eating, 03 medical and health sciences, 0302 clinical medicine, Primary outcome, Swallowing, Laryngeal penetration, Internal medicine, medicine, Humans, In patient, Prospective Studies, Prospective cohort study, Spinal Cord Injuries, Aged, Aged, 80 and over, business.industry, Incidence (epidemiology), Cervical Cord, Videotape Recording, Recovery of Function, General Medicine, Middle Aged, University hospital, Treatment Outcome, Neurology, Fluoroscopy, Acute Disease, Cervical spinal cord injury, Female, Neurology (clinical), Larynx, Deglutition Disorders, 0305 other medical science, business, 030217 neurology & neurosurgery
Abstract: Prospective cohort study.This prospective cohort study aims to evaluate the recovery of penetration/aspiration and functional feeding outcome in patients with acute TCSCI.Tampere University Hospital, Tampere, Finland METHODS: Forty-six patients with TCSCI were enrolled. All the patients received speech therapeutic interventions based on their clinical needs and were examined with a videofluoroscopic swallowing study (VFSS) at enrollment. The incidence of VFSS-verified laryngeal penetration/aspiration according to Rosenbek's Penetration-Aspiration Scale (PAS) served as the primary outcome. The secondary outcome was the level of functional oral intake (as per the Functional Oral Intake Scale; FOIS). Based on the PAS results, the patients were divided into two groups: (i) penetrator/aspirators (PAS score ≥3) and (ii) non-penetrator/aspirators (PAS score ≤2). Follow-up VFS studies were primarily conducted on the patients with penetration/aspiration in prior VFS studies. The follow-up VFS studies were scheduled on the basis of clinical demand.Of the 46 patients, 48% had penetration/aspiration in the first VFSS. The second VFSS was conducted on 20 patients, of whom 6 patients (30%) had penetration/aspiration. The third VFSS was conducted on 9 patients. Of these, only two (22%) patients were still penetrator/aspirators. The majority (n = 37, 88%) of the patients presented a total oral intake without restrictions at the time of the final follow-up. Only one patient (2%) was still tube-dependent with consistent oral intake.Swallowing physiology in patients with TCSCI improved during the first months after injury, and the number of penetrator/aspirators decreased progressively.
Published: 2018
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30. Critical evaluation of the Clavien-Dindo classification for postoperative complications in renal tumor surgery, a national multi-center study from Finland

Author: H. Ronkainen, T. Veitonmäki, M. Tramberg, S. Mustonen, A. Kilponen, Harry Nisen, C. Palmberg Christian, K. Erkkilä, E. Ettala, H. Seikkula, D. Pogodin-Hannolainen, Timo K. Nykopp, Marjo Seppänen, and Taina Isotalo
Subjects: medicine.medical_specialty, Clavien-Dindo Classification, business.industry, Urology, Multi center study, medicine, Renal tumor, business, Surgery
Published: 2021
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31. Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk – Results from the PROG-IMT collaboration

Author: Sathanur R. Srinivasan, Christine Espinola-Klein, Albert Hofman, Jing Liu, Eric de Groot, Tomi-Pekka Tuomainen, Helmuth Steinmetz, Ta-Chen Su, Carmen Suárez, Maria Rosvall, Stela McLachlan, Raffaele Izzo, Marcus Dörr, Liliana Grigore, Gunnar Engström, Stein Harald Johnsen, David Yanez, Giel Nijpels, Giuseppe Danilo Norata, Fabrizio Veglia, Matthias W. Lorenz, Dong Zhao, Lu Gao, Wuxiang Xie, Damiano Baldassarre, Mauro Amato, Ellisiv B. Mathiesen, Michiel L. Bots, Dirk Sander, Joseph F. Polak, Matthieu Plichart, Holger Poppert, Matthias Sitzer, Ralph L. Sacco, Irene Schmidtmann, Heiko Uthoff, Manuel F. Landecho, Horst Bickel, Gerald S. Berenson, Oscar H. Franco, Bo Hedblad, Kazuo Kitagawa, Daniel Staub, Jackie F. Price, Caroline Schmidt, Alberico L. Catapano, Tatjana Rundek, Thapat Wannarong, M. Arfan Ikram, Kathrin Ziegelbauer, Alfonso Friera, Francesco Rozza, Kimmo Ronkainen, Jacqueline M. Dekker, Peter Willeit, Samuela Castelnuovo, Coen D.A. Stehouwer, Shuhei Okazaki, Pierre Ducimetière, Stefan Blankenberg, Johann Willeit, Oscar Beloqui, Maryam Kavousi, Henry Völzke, Kuo-Liong Chien, Grace Parraga, Bernhard Iglseder, Rafael Gabriel, Lena Bokemark, Stefan Kiechl, Cesare R. Sirtori, Göran Bergström, Jussi Kauhanen, Simon G. Thompson, Nicola De Luca, Lars Lind, Jean Philippe Empana, Moïse Desvarieux, Ulf Schminke, Hung-Ju Lin, Elena Tremoli, Lorenz, Matthias W, Gao, Lu, Ziegelbauer, Kathrin, Norata, Giuseppe Danilo, Empana, Jean Philippe, Schmidtmann, Irene, Lin, Hung-Ju, Mclachlan, Stela, Bokemark, Lena, Ronkainen, Kimmo, Amato, Mauro, Schminke, Ulf, Srinivasan, Sathanur R, Lind, Lar, Okazaki, Shuhei, Stehouwer, Coen D A, Willeit, Peter, Polak, Joseph F, Steinmetz, Helmuth, Sander, Dirk, Poppert, Holger, Desvarieux, Moise, Ikram, M Arfan, Johnsen, Stein Harald, Staub, Daniel, Sirtori, Cesare R, Iglseder, Bernhard, Beloqui, Oscar, Engström, Gunnar, Friera, Alfonso, Rozza, Francesco, Xie, Wuxiang, Parraga, Grace, Grigore, Liliana, Plichart, Matthieu, Blankenberg, Stefan, Su, Ta-Chen, Schmidt, Caroline, Tuomainen, Tomi-Pekka, Veglia, Fabrizio, Völzke, Henry, Nijpels, Giel, Willeit, Johann, Sacco, Ralph L, Franco, Oscar H, Uthoff, Heiko, Hedblad, Bo, Suarez, Carmen, Izzo, Raffaele, Zhao, Dong, Wannarong, Thapat, Catapano, Alberico, Ducimetiere, Pierre, Espinola-Klein, Christine, Chien, Kuo-Liong, Price, Jackie F, Bergström, Göran, Kauhanen, Jussi, Tremoli, Elena, Dörr, Marcu, Berenson, Gerald, Kitagawa, Kazuo, Dekker, Jacqueline M, Kiechl, Stefan, Sitzer, Matthia, Bickel, Horst, Rundek, Tatjana, Hofman, Albert, Mathiesen, Ellisiv B, Castelnuovo, Samuela, Landecho, Manuel F, Rosvall, Maria, Gabriel, Rafael, de Luca, Nicola, Liu, Jing, Baldassarre, Damiano, Kavousi, Maryam, de Groot, Eric, Bots, Michiel L, Yanez, David N, Thompson, Simon G, Lorenz, Matthias W [0000-0002-7565-1751], Apollo - University of Cambridge Repository, General practice, APH - Health Behaviors & Chronic Diseases, Epidemiology and Data Science, Interne Geneeskunde, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), Epidemiology, Neurology, Radiology & Nuclear Medicine, Pirro, Matteo, and PROG-IMT study group
Subjects: Male, Myocardial Infarction, lcsh:Medicine, PROGRESSION, Cardiovascular Medicine, 030204 cardiovascular system & hematology, Vascular Medicine, Biochemistry, Carotid Intima-Media Thickness, Geographical locations, DISEASE, 0302 clinical medicine, Risk Factors, Germany, Medicine and Health Sciences, Medicine, Cardiac and Cardiovascular Systems, Myocardial infarction, skin and connective tissue diseases, lcsh:Science, ARTERY INTIMA, Stroke, Intersectoral Collaboration, POPULATION, Cardiovascular Diseases/diagnosis, METABOLIC SYNDROME, education.field_of_study, Kardiologi, Multidisciplinary, Agricultural and Biological Sciences(all), VDP::Medical disciplines: 700::Clinical medical disciplines: 750, Hazard ratio, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750, Middle Aged, Prognosis, Predictive value, 3. Good health, Europe, Neurology, Italy, Cardiovascular Diseases, HYPERTENSIVE MEN, Cardiology, cardiovascular system, Female, Research Article, medicine.medical_specialty, High cardiovascular risk, Cerebrovascular Diseases, Science, Population, 030209 endocrinology & metabolism, ATHEROSCLEROSIS RISK, Arbetsmedicin och miljömedicin, 03 medical and health sciences, Carotid intima media thickness (CIMT), Internal medicine, Humans, European Union, ddc:610, cardiovascular diseases, education, Aged, Sweden, Biochemistry, Genetics and Molecular Biology(all), Proportional hazards model, business.industry, lcsh:R, Health Risk Analysis, Correction, Occupational Health and Environmental Health, Atherosclerosis, medicine.disease, Confidence interval, Health Care, Intima-media thickness, MYOCARDIAL-INFARCTION, Medical Biophysics, lcsh:Q, VASCULAR RISK, sense organs, Carotid intima media thickness , Cardiovascular risk, People and places, Metabolic syndrome, business, FOLLOW-UP, 030217 neurology & neurosurgery, Genetics and Molecular Biology(all)
Abstract: AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events. Cox regression models were fit to estimate the hazard ratio (HR) of the combined endpoint (myocardial infarction, stroke or vascular death) per standard deviation (SD) of CIMT change, adjusted for CVD risk factors. These HRs were pooled across studies. In groups A, B and C we observed 3483, 2845 and 1165 endpoint events, respectively. Average common CIMT was 0.79mm (SD 0.16mm), and annual common CIMT change was 0.01mm (SD 0.07mm), both in group A. The pooled HR per SD of annual common CIMT change (0.02 to 0.43mm) was 0.99 (95% confidence interval: 0.95-1.02) in group A, 0.98 (0.93-1.04) in group B, and 0.95 (0.89-1.04) in group C. The HR per SD of common CIMT (average of the first and the second CIMT scan, 0.09 to 0.75mm) was 1.15 (1.07-1.23) in group A, 1.13 (1.05-1.22) in group B, and 1.12 (1.05-1.20) in group C. CONCLUSIONS: We confirm that common CIMT is associated with future CVD events in individuals at high risk. CIMT change does not relate to future event risk in high-risk individuals. The PROG-IMT project, which includes this publication, has been funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, www.dfg.de) under the grants DFG Lo 1569/2-1 and DFG Lo 1569/2-3, received by MWL. The DFG had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Simon Thompson is supported by the British heart Foundation (CH/12/2/29428). Some of the contributing studies were funded by different parties, as listed in the acknowledgement section. Here, too, the funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Sí
Published: 2018
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32. 28158 Multiple cutaneous neoplasms and uveal melanoma in a patient with Muir-Torre syndrome

Author: Cameron Zachary, Emily L. Guo, Sanna Ronkainen, and Paige K. Dekker
Subjects: medicine.medical_specialty, Muir–Torre syndrome, business.industry, Melanoma, medicine, Dermatology, medicine.disease, business
Published: 2021
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33. Effect of hydrolyzed infant formula vs conventional formula on risk of type 1 diabetes the TRIGR randomized clinical trial

Author: Knip M., Akerblom H. K., Altaji E., Becker D., Bruining J., Castano L., Danne T., De Beaufort C., Dosch H. -M., Dupre J., Fraser W. D., Howard N., Ilonen J., Konrad D., Kordonouri O., Krischer J. P., Lawson M. L., Ludvigsson J., Madacsy L., Mahon J. L., Ormisson A., Palmer J. P., Pozzilli P., Savilahti E., Serrano-Rios M., Songini M., Taback S., Vaarala O., White N. H., Virtanen S. M., Wasikowa R., Mandrup-Poulsen T., Arjas E., Lernmark A., Laara E., Schmidt B., Hyytinen M., Koski K., Koski M., Merentie K., Pajakkala E., Reunanen A., Salonen M., Terhonen T., Virkkunen S., Cuthbertson D., Gainer B., Hadley D., Malloy J., Nallamshetty L., Shanker L., Bradley B., Lough G., Fraser W., Sermer M., Taback S. P., Franciscus M., Nucci A., Palmer J., Alahuhta K., Barlund S., Korhonen T., Kovanen L., Lehtonen E., Niinisto S., Pekkala M., Sorkio S., Toivanen L., Vahatalo L., Uusitalo U., Ohman T., Bongiorno R., Catteau J., Fraser G., Lloyd M., Crock P., Giles M., Siech K., See D. W., Brown C., Craig M., Johnston A., Bere L. J., Clarson C. L., Jenner M., McManus R., Renato N., Lovell M., Higo D., Kent N., Kwan J., Marshall C., Metzger D., Chanoine J. -P., Stewart L., Thompson D., Edwards A., Lange I., Mercer J., Pacaud D., Josephine H., Schwarz W., Stephure D. K., Boer J., Chatur T., Chick C., Couch B., Demianczuk N., Girgis R., Marks S., Ryan E., Thompson M., Dean H. J., Grant L., Hamelin K., LaForte J., Murphy L., Catte D., Schneider C., Sellers E. A. C., Woo V., Boland A., Clark H. D., Cooper T., Gruslin A., Karovitch A., Keely E., Malcolm J. C., Sauro V., Tawagi G. F., Andrighetti S., Arnold G., Barrett J., Blumer I., Daneman D., Donat D., Ehrlich R., Feig D., Gottesman I., Gysler M., Karkanis S., Kenshole A., Knight B., Lackie E., Lewis V., Martin M. J., Maxwell C., Oliver G., Panchum P., Shilletto N., Simone A., Skidmore M., Turrini T., Wong S., Allen C., Belanger L., Bouchard I., Ferland S., Frenette L., Garrido-Russo M., Leblanc M., Imbeault J., Morin V., Olivier G., Weisnagell J., Costain G., Dornan J., Heath K., MacSween M. -C., McGibbon A., Ramsay C., Sanderson F., Sanderson S., Benabdesselam L., Gonthier M., Huot C., Thibeault M., Laforte D., Legault L., Perron P., Armson A., Canning P., Cummings E. A., Ivanko V., McLeod L., Mokashi A., Scott K., Bridger T., Crane J., Crummell C., Curtis J. C., Dawson C., Joyce C., Newhook L. A., Newman S., Druken E., Begum-Hasan J., Breen A., Houlden R., Woods M., Carrson G., Kelly S., Martel M. J., Penner M., Sankaran K., Hardy-Brown K., King N., White R. A., Park M., Popkin J., Robson L., Coles K., Al Taji E., Cerna M., Cerny M., Francova H., Hainerova I., Kothankova H., Koukalova R., Krakorova V., Mendlova P., Sitova R., Stechova K., Vavrinec J., Vosahlo J., Zlatohlavkova B., Brazdova L., Faksova P., Gregorova D., Kantor L., Malkova K., Venhacova J., Venhacova P., Cipra A., Skvor J., Budejovice C., Tomsikova Z., Botkova-Krauseova H., Mockova A., Paterova P., Gogelova P., Kandrnalova J., Einberg U., Jakovlev U., Posiadlo S., Rannaste E., Raukas R., Riikjarv M. -A., Valla K., Astover V., Kirss A., Retpap J., Taht E., Tillmann V., Vahtra S., Heikkila M., Hirvasniemi M., Luopajarvi K., Johansson S., Kleemola P., Laukkanen E., Parkkola A., Pigg H. -M., Puttonen H., Renlund M., Salonen K., Suomalainen H., Tenkula T., Teramo K., Jarvenpaa A. -L., Hamalainen A. -M., Jussila R., Kiiveri S., Haavisto H., Holopainen S., Kupiainen H., Leeve T., Lumme K., Nironen T., Tenhola S., Tiilikainen T., Keinonen H., Lautala P., Salonen P., Vesanto M., Aspholm A. S., Asunta P., Ikavalko H., Jason E., Jaminki S., Kekki P., Koskinen M., Lehtimaki S., Lahde J., Makela M., Peltoniemi S., Poutiainen L., Ranta K., Salonsaari T., Sarviharju-Tujula S. -L., Selvenius J., Siljander H., Haanpaa P. -L., Holm C., Juutilainen A., Jarvelainen V., Kangaskolkka-Keskilohko A. -M., Laino E., Marjamaki L., Suominen E., Ylitalo S., Hokkanen M., Lounamaa R., Matikainen M., Nuuja A., Paalanen I., Puupponen A. R., Salo-Edwards H., Alanne S., Kultti T., Linjama H., Muhonen K., Vaaraniemi M., Talvitie T., Backman M., Hanhijarvi R., Koivula P., Lindstrom K., Martikainen A., Nurmi P., Bjork A., Huopio H., Komulainen J., Lehtomaki S., Muikku E., Pesola J., Sankilampi U., Arkkola T., Hekkala A., Jurvakainen S., Koivikko M. -L., Kahonen M., Leinonen E., Mykkanen T., Pohjola H., Riikonen K., Niittyvuopio A., Stenius A., Tapanainen P., Veijola R., Alar A., Jovio S., Korpela P., Makinen E., Hietanen L., Kivisto J., Kaar M. -L., Lehtimaki P., Mustila T., Popov E., Saatela S., Taittonen L., Ahtiainen K., Laaksonen N., Luoto M., Viitala J., Virransalo R., Nykanen P., Paajanen S., Parkkinen S., Pyrhonen H., Sarkka T., Aschemeier B., Bektas S., Biester T., Datz N., Deiss D., Fath M., Lupke K., Muller B., Nestoris C., Rothes S., Sadeghian E., Semler K., Arato A., Krikovszky D., Nobilis A., Szenasi J., Benevento D., Anguissola G. B., Biagioni M., Bizzarri C., Cherubini V., Ferrito L., Giordano C., Giorgetti C., Khazrai Y. M., Kyanvash S., Maddaloni E., Napoli A., Piergiovanni F., Pitocco D., Suraci T., Tabacco G., Valente L., Visalli N., Carboni M. B., Cavallo R., Cau V., Isola C., Ledda A., Loddo M., Mannu C., Pettinau M., Pisano S., Porceddu M., Putzu C., Rita A., Peters D., Schierloh U., Bisschoff M., Blonk L., Lappenschaar T., Manai B., Seesink M., Sperling-Conrad M., Verhagen M., Zoethout J. A., Basiak A., Chalas M., Chesiak M., Gramza A., Iwankiewicz J., Sieradzan E., Wikiera B., Ciechanowska M., Dziatkowiak H., Futona B., Gorska A., Glowacka-Wony M., Kaim I., Klich B., Starzyk J., Wolanin M., Tokarska L., Chucherco D., Deja G., Firek-Pedras M., Jarosz-Chobot P., Kalina M., Kutrowska-Adamusiak K., Minkina-Pedras M., Muchaka-Bianga M., Bodalski J., Mlynarski W., Szadkowska A., Cieslak A., Cypryk K., Dziatosz K., Jastzebowska J., Krysiak A., Szymanska U., Wilcznski J., Zawodniak-Szalapska M., Aguay A., Bilbao J. R., Chueca M., Cortazar A., Echarte G., Frutos T. G., Jimenez P., Martul P., Moreno A., Oyarzabal M., Rica I., Salgado Y., Martinez-Larrad M. T., Hawkins F. G., Hernandez R., Herranz L., Pallardo L. F., Deibarra L. S., Fernandez B. H., Luis J. L., Ortiz-Quintana L., Recarte P. P., Arnau D. R., Aronsson L., Boden S., Fredriksson J., Isacsson E., Johansson I., Karlsson E., Lock C., Sandstrom A. -M., Konefal M. S., Andreasson C., Dahlstrom U., Hanas R., Lundqvist K., Windell L., Jansson I., Karlsson A. -K., Lindbladh B., Odenman I., Pettersson C., Sundberg F., Sundqvist M., Aronsson S., Bellman I., Bengtsson A. -B., Lyden G. -B., Nilsson N. -O., Soderblom M., Unt C., Augustsson M., Bengtsson M., Fors H., Helmrich A., Johansson T. O., Andersson A. -C., Boiard-Stomlid A., Hellgren G., Kallsholm H., Lindqvist J., Nilsson M., Nordwall M., Stromstedt C., Ahsberg C., Lindh A., Lindhe C., Samuelsson C., Wiik A., Edenwall H., Ljumgcrantz M., Persson I. -B., Strigard E., Svensson B. -L., Aman J., Breivik G. -E., Detlofsson I. -L., Kroon M., Sarnblad S., Johansson C., Ilvered R., Lundberg A., Akesson K., Beccarelli A., Gadient M., Rappold-Amrein C., Schoenle E., Daftary A., Damagro-Elias M. E., Gilmour C., Klein M. B., Lain C., Salerno D., Smith M. E., Vats K., Pfaff D. J., Malone P., Mansfield P., Munns M., Nickel K., Pompilio K., Siemion W., Taculad R., Van Horn K., Zdanadewic M., Chambliss C., Jones J., Sadler M., Tanner-Blasiar M., Bell C., Camper N., Devaskar S., Devaskar U., Horowitz H., Rogers L., Shannahan R., Silk K., Bermudez Z., Colon R., Frazer T., Martinez-Nieves B., Torres J., Vega J., Chan M., Cook S., Goland R., Greenberg E., Jules N., Montes J., Nelson M., Parra-Valencia Z., Schachner H., Softness B., Kiviniemi M., Suomenin R., Alexander A., Hyrckowian E., Nichol L., Trucco M., Karjalainen E., Louhio T., Sarnesto A., Valtonen E., Davydova B., Helander S., Hamalainen J., Harkonen T., Joutsjoki L., Kararic M., Latva-Koivisto M., Lonn E., Nurmi T., Ollila I., Rinkinen J., Ronkainen M., Tukiainen H., Cederlof A., Kiikeri M., Tsupari S., Cheng R., Bryant K., Chan Y., Maezawa Y., Paltser G., Rasavi R., Tsui H., Winer S., Wu P., Yantha J., Pediatrics, Knip M., Akerblom H.K., Altaji E., Becker D., Bruining J., Castano L., Danne T., De Beaufort C., Dosch H.-M., Dupre J., Fraser W.D., Howard N., Ilonen J., Konrad D., Kordonouri O., Krischer J.P., Lawson M.L., Ludvigsson J., Madacsy L., Mahon J.L., Ormisson A., Palmer J.P., Pozzilli P., Savilahti E., Serrano-Rios M., Songini M., Taback S., Vaarala O., White N.H., Virtanen S.M., Wasikowa R., Mandrup-Poulsen T., Arjas E., Lernmark A., Laara E., Schmidt B., Hyytinen M., Koski K., Koski M., Merentie K., Pajakkala E., Reunanen A., Salonen M., Terhonen T., Virkkunen S., Cuthbertson D., Gainer B., Hadley D., Malloy J., Nallamshetty L., Shanker L., Bradley B., Lough G., Fraser W., Sermer M., Taback S.P., Franciscus M., Nucci A., Palmer J., Alahuhta K., Barlund S., Korhonen T., Kovanen L., Lehtonen E., Niinisto S., Pekkala M., Sorkio S., Toivanen L., Vahatalo L., Uusitalo U., Ohman T., Bongiorno R., Catteau J., Fraser G., Lloyd M., Crock P., Giles M., Siech K., See D.W., Brown C., Craig M., Johnston A., Bere L.J., Clarson C.L., Jenner M., McManus R., Renato N., Lovell M., Higo D., Kent N., Kwan J., Marshall C., Metzger D., Chanoine J.-P., Stewart L., Thompson D., Edwards A., Lange I., Mercer J., Pacaud D., Josephine H., Schwarz W., Stephure D.K., Boer J., Chatur T., Chick C., Couch B., Demianczuk N., Girgis R., Marks S., Ryan E., Thompson M., Dean H.J., Grant L., Hamelin K., LaForte J., Murphy L., Catte D., Schneider C., Sellers E.A.C., Woo V., Boland A., Clark H.D., Cooper T., Gruslin A., Karovitch A., Keely E., Malcolm J.C., Sauro V., Tawagi G.F., Andrighetti S., Arnold G., Barrett J., Blumer I., Daneman D., Donat D., Ehrlich R., Feig D., Gottesman I., Gysler M., Karkanis S., Kenshole A., Knight B., Lackie E., Lewis V., Martin M.J., Maxwell C., Oliver G., Panchum P., Shilletto N., Simone A., Skidmore M., Turrini T., Wong S., Allen C., Belanger L., Bouchard I., Ferland S., Frenette L., Garrido-Russo M., Leblanc M., Imbeault J., Morin V., Olivier G., Weisnagell J., Costain G., Dornan J., Heath K., MacSween M.-C., McGibbon A., Ramsay C., Sanderson F., Sanderson S., Benabdesselam L., Gonthier M., Huot C., Thibeault M., Laforte D., Legault L., Perron P., Armson A., Canning P., Cummings E.A., Ivanko V., McLeod L., Mokashi A., Scott K., Bridger T., Crane J., Crummell C., Curtis J.C., Dawson C., Joyce C., Newhook L.A., Newman S., Druken E., Begum-Hasan J., Breen A., Houlden R., Woods M., Carrson G., Kelly S., Martel M.J., Penner M., Sankaran K., Hardy-Brown K., King N., White R.A., Park M., Popkin J., Robson L., Coles K., Al Taji E., Cerna M., Cerny M., Francova H., Hainerova I., Kothankova H., Koukalova R., Krakorova V., Mendlova P., Sitova R., Stechova K., Vavrinec J., Vosahlo J., Zlatohlavkova B., Brazdova L., Faksova P., Gregorova D., Kantor L., Malkova K., Venhacova J., Venhacova P., Cipra A., Skvor J., Budejovice C., Tomsikova Z., Botkova-Krauseova H., Mockova A., Paterova P., Gogelova P., Kandrnalova J., Einberg U., Jakovlev U., Posiadlo S., Rannaste E., Raukas R., Riikjarv M.-A., Valla K., Astover V., Kirss A., Retpap J., Taht E., Tillmann V., Vahtra S., Heikkila M., Hirvasniemi M., Luopajarvi K., Johansson S., Kleemola P., Laukkanen E., Parkkola A., Pigg H.-M., Puttonen H., Renlund M., Salonen K., Suomalainen H., Tenkula T., Teramo K., Jarvenpaa A.-L., Hamalainen A.-M., Jussila R., Kiiveri S., Haavisto H., Holopainen S., Kupiainen H., Leeve T., Lumme K., Nironen T., Tenhola S., Tiilikainen T., Keinonen H., Lautala P., Salonen P., Vesanto M., Aspholm A.S., Asunta P., Ikavalko H., Jason E., Jaminki S., Kekki P., Koskinen M., Lehtimaki S., Lahde J., Makela M., Peltoniemi S., Poutiainen L., Ranta K., Salonsaari T., Sarviharju-Tujula S.-L., Selvenius J., Siljander H., Haanpaa P.-L., Holm C., Juutilainen A., Jarvelainen V., Kangaskolkka-Keskilohko A.-M., Laino E., Marjamaki L., Suominen E., Ylitalo S., Hokkanen M., Lounamaa R., Matikainen M., Nuuja A., Paalanen I., Puupponen A.R., Salo-Edwards H., Alanne S., Kultti T., Linjama H., Muhonen K., Vaaraniemi M., Talvitie T., Backman M., Hanhijarvi R., Koivula P., Lindstrom K., Martikainen A., Nurmi P., Bjork A., Huopio H., Komulainen J., Lehtomaki S., Muikku E., Pesola J., Sankilampi U., Arkkola T., Hekkala A., Jurvakainen S., Koivikko M.-L., Kahonen M., Leinonen E., Mykkanen T., Pohjola H., Riikonen K., Niittyvuopio A., Stenius A., Tapanainen P., Veijola R., Alar A., Jovio S., Korpela P., Makinen E., Hietanen L., Kivisto J., Kaar M.-L., Lehtimaki P., Mustila T., Popov E., Saatela S., Taittonen L., Ahtiainen K., Laaksonen N., Luoto M., Viitala J., Virransalo R., Nykanen P., Paajanen S., Parkkinen S., Pyrhonen H., Sarkka T., Aschemeier B., Bektas S., Biester T., Datz N., Deiss D., Fath M., Lupke K., Muller B., Nestoris C., Rothes S., Sadeghian E., Semler K., Arato A., Krikovszky D., Nobilis A., Szenasi J., Benevento D., Anguissola G.B., Biagioni M., Bizzarri C., Cherubini V., Ferrito L., Giordano C., Giorgetti C., Khazrai Y.M., Kyanvash S., Maddaloni E., Napoli A., Piergiovanni F., Pitocco D., Suraci T., Tabacco G., Valente L., Visalli N., Carboni M.B., Cavallo R., Cau V., Isola C., Ledda A., Loddo M., Mannu C., Pettinau M., Pisano S., Porceddu M., Putzu C., Rita A., Peters D., Schierloh U., Bisschoff M., Blonk L., Lappenschaar T., Manai B., Seesink M., Sperling-Conrad M., Verhagen M., Zoethout J.A., Basiak A., Chalas M., Chesiak M., Gramza A., Iwankiewicz J., Sieradzan E., Wikiera B., Ciechanowska M., Dziatkowiak H., Futona B., Gorska A., Glowacka-Wony M., Kaim I., Klich B., Starzyk J., Wolanin M., Tokarska L., Chucherco D., Deja G., Firek-Pedras M., Jarosz-Chobot P., Kalina M., Kutrowska-Adamusiak K., Minkina-Pedras M., Muchaka-Bianga M., Bodalski J., Mlynarski W., Szadkowska A., Cieslak A., Cypryk K., Dziatosz K., Jastzebowska J., Krysiak A., Szymanska U., Wilcznski J., Zawodniak-Szalapska M., Aguay A., Bilbao J.R., Chueca M., Cortazar A., Echarte G., Frutos T.G., Jimenez P., Martul P., Moreno A., Oyarzabal M., Rica I., Salgado Y., Martinez-Larrad M.T., Hawkins F.G., Hernandez R., Herranz L., Pallardo L.F., Deibarra L.S., Fernandez B.H., Luis J.L., Ortiz-Quintana L., Recarte P.P., Arnau D.R., Aronsson L., Boden S., Fredriksson J., Isacsson E., Johansson I., Karlsson E., Lock C., Sandstrom A.-M., Konefal M.S., Andreasson C., Dahlstrom U., Hanas R., Lundqvist K., Windell L., Jansson I., Karlsson A.-K., Lindbladh B., Odenman I., Pettersson C., Sundberg F., Sundqvist M., Aronsson S., Bellman I., Bengtsson A.-B., Lyden G.-B., Nilsson N.-O., Soderblom M., Unt C., Augustsson M., Bengtsson M., Fors H., Helmrich A., Johansson T.O., Andersson A.-C., Boiard-Stomlid A., Hellgren G., Kallsholm H., Lindqvist J., Nilsson M., Nordwall M., Stromstedt C., Ahsberg C., Lindh A., Lindhe C., Samuelsson C., Wiik A., Edenwall H., Ljumgcrantz M., Persson I.-B., Strigard E., Svensson B.-L., Aman J., Breivik G.-E., Detlofsson I.-L., Kroon M., Sarnblad S., Johansson C., Ilvered R., Lundberg A., Akesson K., Beccarelli A., Gadient M., Rappold-Amrein C., Schoenle E., Daftary A., Damagro-Elias M.E., Gilmour C., Klein M.B., Lain C., Salerno D., Smith M.E., Vats K., Pfaff D.J., Malone P., Mansfield P., Munns M., Nickel K., Pompilio K., Siemion W., Taculad R., Van Horn K., Zdanadewic M., Chambliss C., Jones J., Sadler M., Tanner-Blasiar M., Bell C., Camper N., Devaskar S., Devaskar U., Horowitz H., Rogers L., Shannahan R., Silk K., Bermudez Z., Colon R., Frazer T., Martinez-Nieves B., Torres J., Vega J., Chan M., Cook S., Goland R., Greenberg E., Jules N., Montes J., Nelson M., Parra-Valencia Z., Schachner H., Softness B., Kiviniemi M., Suomenin R., Alexander A., Hyrckowian E., Nichol L., Trucco M., Karjalainen E., Louhio T., Sarnesto A., Valtonen E., Davydova B., Helander S., Hamalainen J., Harkonen T., Joutsjoki L., Kararic M., Latva-Koivisto M., Lonn E., Nurmi T., Ollila I., Rinkinen J., Ronkainen M., Tukiainen H., Cederlof A., Kiikeri M., Tsupari S., Cheng R., Bryant K., Chan Y., Maezawa Y., Paltser G., Rasavi R., Tsui H., Winer S., Wu P., Yantha J., University of Zurich, and Knip, Mikael
Subjects: Male, Risk, medicine.medical_specialty, Casein, Breastfeeding, 030209 endocrinology & metabolism, 610 Medicine & health, 2700 General Medicine, Endocrinology and Diabetes, Disease-Free Survival, law.invention, Follow-Up Studie, Nutrition Policy, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, SDG 3 - Good Health and Well-being, law, Internal medicine, Diabetes mellitus, medicine, Humans, Cumulative incidence, 030212 general & internal medicine, Child, Infant Nutritional Physiological Phenomena, Original Investigation, 2. Zero hunger, Type 1 diabetes, business.industry, Hazard ratio, Absolute risk reduction, Infant, Newborn, Caseins, General Medicine, ta3121, medicine.disease, Infant Formula, 3. Good health, Diabetes Mellitus, Type 1, Infant formula, 10036 Medical Clinic, Endokrinologi och diabetes, Female, business, Human, Follow-Up Studies
Abstract: IMPORTANCE Early exposure to complex dietary proteins may increase the risk of type 1 diabetes in children with genetic disease susceptibility. There are no intact proteins in extensively hydrolyzed formulas. OBJECTIVE To test the hypothesis that weaning to an extensively hydrolyzed formula decreases the cumulative incidence of type 1 diabetes in young children. DESIGN, SETTING, AND PARTICIPANTS An international double-blind randomized clinical trial of 2159 infants with human leukocyte antigen-conferred disease susceptibility and a first-degree relative with type 1 diabetes recruited from May 2002 to January 2007 in 78 study centers in 15 countries; 1081 were randomized to be weaned to the extensively hydrolyzed casein formula and 1078 to a conventional formula. The follow-up of the participants ended on February 28, 2017. INTERVENTIONS The participants received either a casein hydrolysate or a conventional adapted cows milk formula supplemented with 20% of the casein hydrolysate. The minimum duration of study formula exposure was 60 days by 6 to 8 months of age. MAIN OUTCOMES AND MEASURES Primary outcome was type 1 diabetes diagnosed according to World Health Organization criteria. Secondary outcomes included age at diabetes diagnosis and safety (adverse events). RESULTS Among 2159 newborn infants (1021 female [47.3%]) who were randomized, 1744 (80.8%) completed the trial. The participants were observed for a median of 11.5 years (quartile [Q] 1-Q3, 10.2-12.8). The absolute risk of type 1 diabetes was 8.4% among those randomized to the casein hydrolysate (n = 91) vs 7.6% among those randomized to the conventional formula (n = 82) (difference, 0.8%[95% CI, -1.6% to 3.2%]). The hazard ratio for type 1 diabetes adjusted for human leukocyte antigen risk group, duration of breastfeeding, duration of study formula consumption, sex, and region while treating study center as a random effect was 1.1 (95% CI, 0.8 to 1.5; P = .46). The median age at diagnosis of type 1 diabetes was similar in the 2 groups (6.0 years [Q1-Q3, 3.1-8.9] vs 5.8 years [Q1-Q3, 2.6-9.1]; difference, 0.2 years [95% CI, -0.9 to 1.2]). Upper respiratory infections were the most common adverse event reported (frequency, 0.48 events/year in the hydrolysate group and 0.50 events/year in the control group). CONCLUSIONS AND RELEVANCE Among infants at risk for type 1 diabetes, weaning to a hydrolyzed formula compared with a conventional formula did not reduce the cumulative incidence of type 1 diabetes after median follow-up for 11.5 years. These findings do not support a need to revise the dietary recommendations for infants at risk for type 1 diabetes. Funding Agencies|Eunice Kennedy Shriver National Institute of Child Health and Development (NICHD); National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health [HD040364, HD042444, HD051997]; Canadian Institutes of Health Research; Commission of the European Communities [QLK1-2002-00372]; European Foundation for the Study of Diabates/JDRF/Novo Nordisk; Academy of Finland (Centre of Excellence in Molecular Systems Immunology and Physiology Research) [250114]; Dutch Diabetes Research Foundation; Finnish Diabetes Research Foundation; JDRF
Published: 2018

34. Structural Pulmonary Abnormalities Still Evident in Schoolchildren with New Bronchopulmonary Dysplasia

Author: Teija Dunder, Marja Perhomaa, Eveliina Ronkainen, Lauri Mattila, and Mikko Hallman
Subjects: Male, Spirometry, medicine.medical_specialty, High-resolution computed tomography, Adolescent, medicine.medical_treatment, Gestational Age, Air trapping, Severity of Illness Index, 03 medical and health sciences, 0302 clinical medicine, DLCO, Forced Expiratory Volume, 030225 pediatrics, Internal medicine, medicine, Humans, Child, Lung, Bronchopulmonary Dysplasia, Mechanical ventilation, medicine.diagnostic_test, business.industry, Infant, Newborn, respiratory system, medicine.disease, Respiration, Artificial, respiratory tract diseases, Peribronchial Thickening, medicine.anatomical_structure, 030228 respiratory system, Bronchopulmonary dysplasia, Pediatrics, Perinatology and Child Health, Linear Models, Cardiology, Female, medicine.symptom, Tomography, X-Ray Computed, business, Infant, Premature, Follow-Up Studies, Developmental Biology
Abstract: Background: A new pattern of bronchopulmonary dysplasia (BPD) has emerged with the improved survival of preterm children. Objectives: Our aim was to characterize structural abnormalities associated with new BPD and to evaluate whether the severity of high-resolution computed tomography (HRCT) changes is associated with lung function. Methods: HRCT scans were performed on 21 schoolchildren with a history of new BPD (mild, n = 9; moderate, n = 4; and severe, n = 8) with a mean age of 12.7 years (range: 8.7-16.7). Scans were interpreted by 2 radiologists using a structured scoring system. Spirometry (forced expiratory volume in 1 s [FEV1] and maximum mid-expiratory flow [MMEF]) and the diffusion capacity of the lung for carbon monoxide (DLCO) were measured. Results: At least 1 HRCT abnormality was evident in 17 children (81%), including linear-to-triangular subpleural opacities (71%), air trapping (29%), mosaic perfusion (24%), peribronchial thickening (14%), and emphysema (14%). The HRCT score was higher in the severe BPD group (11.50; 95% CI 2.86-20.14) than in the mild or moderate BPD group (1.39; 95% CI 0.24-2.54, and 2.75; 95% CI 0.28-5.22, respectively). HRCT scores were inversely related to FEV1 (β -4.23; 95% CI -6.97 to -1.49, p = 0.004) and MMEF (β -3.45; 95% CI -6.10 to -0.80, p = 0.013) but not to DLCO. The duration of the initial mechanical ventilation was associated with HRCT scores (p = 0.014). Conclusions: Structural lung abnormalities are common among schoolchildren with a history of new BPD, resembling abnormalities described in the presurfactant era. HRCT abnormalities are associated with the duration of early mechanical ventilation and the severity of BPD and they are correlated with spirometry.
Published: 2017
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35. Traumatic cervical spinal cord injury: a prospective clinical study of laryngeal penetration and aspiration

Author: Tiina Ihalainen, Irina Rinta-Kiikka, Anna-Maija Korpijaakko-Huuhka, Eerika Koskinen, Teemu M. Luoto, and Antti Ronkainen
Subjects: Adult, Male, 030506 rehabilitation, medicine.medical_specialty, Adolescent, Video Recording, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Swallowing, Humans, Medicine, Prospective Studies, Prospective cohort study, Spinal cord injury, Spinal Cord Injuries, Aged, Aged, 80 and over, business.industry, Incidence, Cervical Cord, General Medicine, Middle Aged, medicine.disease, Dysphagia, Deglutition, Surgery, Neurology, Fluoroscopy, Anesthesia, Cohort, Cervical Vertebrae, Female, Neurology (clinical), Larynx, medicine.symptom, Deglutition Disorders, 0305 other medical science, Airway, business, Complication, Paraplegia, 030217 neurology & neurosurgery
Abstract: Prospective cohort study. Dysphagia is a relatively common secondary complication in patients with traumatic cervical spinal cord injuries (TCSCI). The purpose of this study was to determine the incidence of aspiration and penetration in patients with acute TCSCI. Tampere University Hospital, Tampere, Finland. A total of 46 patients with TCSCI were evaluated with a videofluoroscopic swallowing study (VFSS). Rosenbek’s penetration-aspiration scale (PAS) was used to classify the degree of penetration or aspiration. The medical records of each patient were systematically reviewed. Of the 46 patients, 85% were male. The mean age at the time of the injury was 62.1 years. Most patients had an incomplete injury (78%), and most of them due to a fall (78%). In the VFSS 19 (41%) patients penetrated and 15 (33%) aspirated. Only 12 (26%) of the patients had a PAS score of 1 indicating that swallowed material did not enter the airway. Of the patients who aspirated, 73% had silent aspiration. The incidence of penetration or aspiration according to VFSS is high in this cohort of patients with TCSCI. Therefore, the swallowing function of patients with acute TCSCI should be routinely evaluated before initiating oral feeding. VFSS is highly recommended, particularly to rule out the possibility of silent aspiration and to achieve information on safe nutrition consistency.
Published: 2017
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36. Guidelines on eosinophilic esophagitis: evidence‐based statements and recommendations for diagnosis and management in children and adults

Author: Joaquín Rodríguez-Sánchez, Alex Straumann, Jukka Ronkainen, Alberto Ravelli, Stephen Attwood, Alain M. Schoepfer, Stephan Miehlke, Alfredo J. Lucendo, Jesús González-Cervera, Jorge Amil Dias, Javier Molina-Infante, Ulrike von Arnim, Christian Bussmann, Ingrid Terreehorst, Cecilio Santander, Helen Larsson, Ángel Arias, Mogens Bove, Alexandra Papadopoulou, Martin Storr, Albert J. Bredenoord, University of Zurich, and Lucendo, Alfredo J
Subjects: medicine.medical_specialty, Pediatrics, Evidence-based practice, Manometry, Food impaction, evidence-based practice, 610 Medicine & health, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, medicine, Humans, 2715 Gastroenterology, guidelines, Eosinophilic esophagitis, Grading (education), Review Articles, business.industry, Gastroenterology, Reference Standards, medicine.disease, Dysphagia, Esophageal Achalasia, 10219 Clinic for Gastroenterology and Hepatology, Oncology, 030220 oncology & carcinogenesis, Family medicine, 2730 Oncology, 030211 gastroenterology & hepatology, Esophagoscopy, Allergists, consensus development conferences, medicine.symptom, business, Esophagitis
Abstract: Eosinophilic esophagitis (EoE) is one of the most prevalent esophageal diseases and the leading cause of dysphagia and food impaction in children and young adults. This underlines the importance of optimizing diagnosys and treatment of the condition, especially after the increasing amount of knowledge on EoE recently published. Therefore, the UEG, EAACI ESPGHAN, and EUREOS deemed it necessary to update the current guidelines regarding conceptual and epidemiological aspects, diagnosis, and treatment of EoE. General methodology according to the Appraisal of Guidelines for Research and Evaluation (AGREE) II and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used in order to comply with current standards of evidence assessment in formulation of recommendations. An extensive literature search was conducted up to August 2015 and periodically updated. The working group consisted of gastroenterologists, allergists, pediatricians, otolaryngologists, pathologists, and epidemiologists. Systematic evidence-based reviews were performed based upon relevant clinical questions with respect to patient-important outcomes. The guidelines include updated concept of EoE, evaluated information on disease epidemiology, risk factors, associated conditions, and natural history of EoE in children and adults. Diagnostic conditions and criteria, the yield of diagnostic and disease monitoring procedures, and evidence-based statements and recommendation on the utility of the several treatment options for patients EoE are provided. Recommendations on how to choose and implement treatment and long-term management are provided based on expert opinion and best clinical practice. Evidence-based recommendations for EoE diagnosis, treatment modalities, and patients' follow up are proposed in the guideline
Published: 2017
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37. Prototype Environment for integrating and sharing Farm Things and associated data

Author: Antti Suokannas, Jussi Nikander, Raimo Linkolehto, Markus Jäger, Ari Ronkainen, and Liisa Pesonen
Subjects: Knowledge management, Computer science, computer.internet_protocol, business.industry, Environmental resource management, 04 agricultural and veterinary sciences, 02 engineering and technology, General Medicine, Service-oriented architecture, 040103 agronomy & agriculture, 0202 electrical engineering, electronic engineering, information engineering, 0401 agriculture, forestry, and fisheries, 020201 artificial intelligence & image processing, The Internet, Precision agriculture, business, Internet of Things, computer
Published: 2017
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38. Bilateral epidermal nevi in the external auditory canals treated with CO 2 laser

Author: Sanna Ronkainen, Keon M. Parsa, Ashley Dilorenzo, Michael Hoa, and Neha Rajpal
Subjects: Adnexal structures, Co2 laser, integumentary system, business.industry, medicine.medical_treatment, Dermatology, Anatomy, Ablation, External Auditory Canals, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Epidermis (zoology), 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, otorhinolaryngologic diseases, medicine, AUDITORY/EAR, skin and connective tissue diseases, business, neoplasms
Abstract: Epidermal nevi are benign hamartomas of the epidermis and adnexal structures of the skin. We present the case of epidermal nevi in the bilateral external auditory ear canals of an otherwise healthy 23-year-old woman treated with CO2 laser ablation.
Published: 2020
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39. Cropinfra research data collection platform for ISO 11783 compatible and retrofit farm equipment

Author: Raimo Linkolehto, Jere Kaivosoja, Ari Ronkainen, Pasi Suomi, Juha Backman, Jussi Nikander, Markku Koistinen, Liisa Pesonen, Luke Natural Resources Institute Finland, Natural Resources Institute Finland, Geoinformatics, Department of Built Environment, Aalto-yliopisto, and Aalto University
Subjects: 0106 biological sciences, Computer science, Cloud computing, Horticulture, Asset (computer security), 01 natural sciences, Data capture, Documentation, Development platform, Data collection, Agricultural machinery, business.industry, Forestry, 04 agricultural and veterinary sciences, Automation, Manufacturing engineering, Computer Science Applications, Data transfer, Document database, New product development, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Precision agriculture, ISOBUS, business, Agronomy and Crop Science, 010606 plant biology & botany
Abstract: The agricultural machinery produces an increasing number of measurements during operations. The primary use of these measurements is to control agricultural operations on the farm. Data that describes the in-field variation in plant growth potential and growing conditions is the basis for precision farming. The secondary use for the gathered information is documentation of work and work performance for business purposes. Researcher also benefits from the increasing measurement capabilities. Biologists and agronomists can model the crops and agronomic phenomena. Work scientists can analyse the agricultural work processes. And finally, machines with additional accurate sensors can be used for agricultural machine product development and technological research purposes. This paper concentrates on an independent research data collection platform (Cropinfra) which can be used to collect data for all above mentioned purposes. Data can be collected both from ISOBUS (ISO 11783) compliant machines as well as older and proprietary systems and stored to database for further analysis. The farm machines in Cropinfra are supplemented with extra sensors that are more accurate than existing in commercial machines. Therefore, the Cropinfra can be used as a reference measurement system to verify the correct operation of the machines as well as to produce data for biological research purposes. This paper will also present how the cloud connection of the data collection system can be realized. The solution was designed to be compatible with the existing ISO 11783-10 standard. The examples presented in this paper verify that the solution works in real farming environment. The data has been used in numerous research projects already, and in the future the data will be an important asset when machine learning and other artificial intelligence methods will be studied and utilized.
Published: 2019

40. Trisk 95 as a novel skin mirror for normal and diabetic systemic glucose level

Author: Sufyan Suleman, Walid Mahfouf, Seppo Vainio, Nsrein Ali, Diana Motei, Hamid Reza Rezvani, Isabelle Marty, Veli-Pekka Ronkainen, University of Oulu, Biothérapies des maladies génétiques et cancers, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Référence pour les Maladies Rares de la Peau [Bordeaux], CHU Bordeaux [Bordeaux], [GIN] Grenoble Institut des Neurosciences (GIN), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA), Oulu University Hospital [Oulu], This work was supported Academy of Finland Grants (251314, 315030, 307533, 206038, 121647), Finnish Cultural, Sigrid Jusélius and Finnish Cancer Research Foundations, the European Community’s Seventh Framework Programme Health (FP7/2007-2013) under Grant Agreement FP7-HEALTH-F5-2012-INNOVATION-1 EURenOmics 305608, and H2020-FETOPEN-2018-019-2020-01 projects MindGap GA 829040 and Gladiator (GA 828837)., European Project: 305608,EC:FP7:HEALTH,FP7-HEALTH-2012-INNOVATION-1,EURENOMICS(2012), Bodescot, Myriam, and European Consortium for High-Throughput Research in Rare Kidney Diseases - EURENOMICS - - EC:FP7:HEALTH2012-10-01 - 2017-09-30 - 305608 - VALID
Subjects: Blood Glucose, Keratinocytes, Proteomics, Transcription, Genetic, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], lcsh:Medicine, Mitochondrion, Calcium in biology, Mice, 0302 clinical medicine, Transcription (biology), Insulin, lcsh:Science, Cells, Cultured, Skin, 0303 health sciences, Multidisciplinary, Phenotype, Cell biology, Mitochondria, 030220 oncology & carcinogenesis, Biomarker (medicine), Cell signalling, medicine.medical_specialty, chemistry.chemical_element, Carbohydrate metabolism, Calcium, Article, 03 medical and health sciences, In vivo, Internal medicine, Diabetes mellitus, Calcium flux, medicine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Diabetes Mellitus, Animals, Calcium Signaling, 030304 developmental biology, business.industry, Blood Glucose Self-Monitoring, lcsh:R, medicine.disease, Mice, Inbred C57BL, Endocrinology, Increased risk, Glucose, chemistry, lcsh:Q, business, Carrier Proteins, Biomarkers
Abstract: Coping with diabetes requires frequent and even today mostly invasive blood glucose-based monitoring. Partly due to this invasive nature and the associated reduced skin wound healing and increased risk of infection, non-invasive glucose monitoring technologies would represent considerable progress. Edited keratinocytes may enable such a function.To address this hypothesis, we conducted a proteomic screen in the skin by making use of the experimental in vivo mouse model of type I diabetes alongside controls. We identified Trisk 95 as the only protein whose expression is induced in response to high blood glucose. A luciferase reporter assay demonstrated that induction of Trisk 95 expression occurs not only at the protein level but also transcriptionally. This induction was associated with a marked elevation in the Fluo-4 signal, suggesting a role for intracellular calcium changes in the signalling cascade. Strikingly, these changes lead concurrently to fragmentation of the mitochondria. As judged from the knockout findings, both the calcium flux and the mitochondrial phenotype were dependent on Trisk 95 function, since the phenotypes in question were abolished.The data demonstrate that the skin represents an organ that reacts robustly and thus mirrors changes in systemic blood glucose levels. The findings are also consistent with a channelling model of Trisk 95 that serves as an insulin-independent but glucose-responsive biomarker taking part in releasing calcium from the cellular stores in the skin. The skin cells may thus provide a novel mean for glucose monitoring when analysing changes in labelled Trisk 95 and calcium. By that, this study is the first proof of the concept of our registered patent (No. PCT FI2016/050917), which proposes the use of cells as biosensors for developing personalized health-monitoring devices.
Published: 2019
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41. Maternal hemoglobin associates with preterm delivery and small for gestational age in two Finnish birth cohorts

Author: Justiina Ronkainen, Anni Heiskala, Peppi Koivunen, Estelle Lowry, Iida Uusitalo, Marjo-Riitta Järvelin, Marja Vääräsmäki, Eero Kajantie, Sylvain Sebert, HUS Children and Adolescents, University Management, Lastentautien yksikkö, Children's Hospital, and University of Helsinki
Subjects: Male, Intrauterine growth restriction, Cohort Studies, Hemoglobins, 0302 clinical medicine, 3123 Gynaecology and paediatrics, 030212 general & internal medicine, Finland, 2. Zero hunger, education.field_of_study, OUTCOMES, 030219 obstetrics & reproductive medicine, Obstetrics, Obstetrics and Gynecology, Gestational age, Small for gestational age, 3. Good health, PREGNANCY, Infant, Small for Gestational Age, Premature Birth, GROWTH, Female, Developed country, Infant, Premature, Adult, medicine.medical_specialty, Offspring, Population, Young Adult, 03 medical and health sciences, RISK-FACTOR, medicine, Humans, Preterm delivery, ANEMIA, education, Pregnancy, business.industry, Infant, Newborn, Maternal hemoglobin, medicine.disease, Reproductive Medicine, Large for gestational age, MODERATE, Hemoglobin, WEIGHT, business
Abstract: Objective: To test whether maternal hemoglobin during pregnancy associates with offspring perinatal outcomes in a developed country. Changes in maternal hemoglobin concentration during pregnancy are partly physiological phenomena reflecting alterations of maternal blood volume. Especially hemoglobin measures outside the physiological range may influence maternal health and fetal growth with long-lasting consequences. Study design: We studied an unselected sample drawn from two regional birth cohorts born 20 years apart: The Northern Finland Birth Cohorts 1966 and 1986. These are two mother-and-child population-based birth cohorts together comprising 21,710 mothers and their children. After exclusions, the sample size of the current study was 20,554. Concentrations of maternal hemoglobin at first and last antenatal visits were categorized as low (lowest 10%), medium (reference) or high (highest 10%). Multinomial logistic regression analyses for categories of maternal hemoglobin and perinatal outcomes such as preterm delivery and full-term small and large for gestational age were conducted with adjustments for maternal cofactors. Results: Low maternal hemoglobin at early pregnancy associated with decreased risk of full-term small for gestational age (adjusted OR 0.73, 95% CI [0.58, 0.93], p = 0.010). At late pregnancy, low maternal hemoglobin associated with increased risk of preterm delivery (adjusted OR 1.60, 95% CI [1.26, 2.02], p
Published: 2019

42. The Effect of Camera Height, Actor Behavior, and Viewer Position on the User Experience of 360° Videos

Author: Tuuli Keskinen, Jaakko Hakulinen, John Mäkelä, Ville Mäkelä, Kimmo Ronkainen, Markku Turunen, Jussi Karhu, Pekka Kallionierni, Informaatioteknologian ja viestinnän tiedekunta - Faculty of Information Technology and Communication Sciences, and Tampere University
Subjects: business.industry, Computer science, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, camera height, viewer height, Virtual reality, 360° videos, Position (obstetrics), viewer position, User experience design, virtual environments, head-mounted displays, user experience, Immersion (virtual reality), virtual reality, Computer vision, Artificial intelligence, Tietojenkäsittely ja informaatiotieteet - Computer and information sciences, business, omnidirectional videos
Abstract: 360° videos can be viewed in an immersive manner with a head-mounted display (HMD). However, it is unclear how the viewing experience is affected by basic properties of 360° videos, such as how high they are recorded from, and whether there are people close to the camera. We conducted a 24-participant user study where we explored whether the viewing experience is affected by A) camera height, B) the proximity and actions of people appearing in the videos, and C) viewer position (standing/sitting). The results, surprisingly, suggest that the viewer's own height has little to no effect on the preferred camera height and the experience. The most optimal camera height situates at around 150 centimeters, which hits the comfortable height range for both sitting and standing viewers. Moreover, in some cases, people being close to the camera, or the camera being very low, has a negative effect on the experience. Our work contributes to understanding and designing immersive 360° experiences.
Published: 2019

43. Spanning the globe

Author: Dimofte, Claudiu V., Johansson, John K., and Ronkainen, Ilka A.
Subjects: Brand name products -- International marketing, Brand name products -- Public opinion, Advertising, marketing and public relations, Business, Business, general
Abstract: A survey on the perception of consumers on global brands showed that the pro-global and anti-global respondents agreed that global brands have competitive dominance. Anti-globals also think that global brands have positive benefits such as convenience, recognition, and availability. The automatic associations of consumers to global brands are also studied.
Published: 2008

44. Sa150 EOSINOPHILS, NEUTROLPHILS AND LYMPHOCYTES IN THE SQUAMOUS ESOPHAGEAL MUCOSA- HOW MANY ARE TOO MANY?

Author: Jukka Ronkainen, Pertti Aro, Nicholas J. Talley, Marjorie M. Walker, Mudar Zand Irani, Anna Andreasson, Lars Agréus, and Michael P. Jones
Subjects: Pathology, medicine.medical_specialty, Esophageal mucosa, Hepatology, business.industry, Gastroenterology, Medicine, business
Published: 2021
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45. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants

Author: Cesare, Mariachiara Di, Bentham, James, Stevens, Gretchen A., Zhou, Bin, Danaei, Goodarz, Lu, Yuan, Bixby, Honor, Cowan, Melanie J., Riley, Leanne M., Hajifathalian, Kaveh, Fortunato, Lea, Taddei, C., Bennett, James E., Ikeda, Nayu, Khang, Young-Ho, Kyobutungi, Catherine, Laxmaiah, Avula, Li, Yanping, Lin, Hsien-Ho, Miranda, J. Jaime, Mostafa, Aya, Turley, Maria L., Paciorek, Christopher J., Gunter, Marc, Ezzati, Majid, Abdeen, Ziad A., Hamid, Zargar Abdul, Abu-Rmeileh, Niveen M., Acosta-Cazares, Benjamin, Adams, Robert, Aekplakorn, Wichai, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahrens, Wolfgang, Ali, Farhan, Alkerwi, Ala'a, Alvarez-Pedrerol, Mar, Aly, Eman, Amouyel, Philippe, Amuzu, Antoinette, Andersen, Lars Bo, Anderssen, Sigmund A., Andrade, Dolores S., Anjana, Ranjit Mohan, Aounallah-Skhiri, Hajer, Ariansen, Inger, Aris, Tahir, Arlappa, Nimmathota, Arveiler, Dominique, Assah, Felix K., Avdicova, Maria, Azizi, Fereidoun, Babu, Bontha V., Balakrishna, Nagalla, Bandosz, Piotr, Banegas, Jose R., Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Mauro V., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Baur, Louise A., Beaglehole, Robert, Romdhane, H. B., Benet, Mikhail, Bernabe-Ortiz, Antonio, Bernotine, Gailute, Bettiol, Heloisa, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhatti, Zaid, Bhutta, Zulfiqar A., Bi, HongSheng, Bi, Yufang, Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Blake, Margaret, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boissonnet, Carlos P., Bongard, Vanina, Bovet, Pascal, Bradbury, Mark, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Bruno, Graziella, Bueno-de-Mesquita, H. B., Bugge, Anna, Burns, C., Leon, Antonio Cabrera de, Cacciottolo, Joseph, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C., Capuano, Vincenzo, Cardoso, Viviane C., Carvalho, Maria J., Casanueva, Felipe F., Casas, Juan-Pablo, Caserta, Carmelo A., Castetbon, Katia, Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nishi, Chen, Chien-Jen, Chen, Fangfang, Chen, Shuohua, Chen, Y. Z., Cheng, Ching-Yu, Chetrit, Angela, Chiolero, Arnaud, Chiou, Shu-Ti, Chirita-Emandi, Adela, Cho, Yumi, Christensen, Kaare, Chudek, Jerzy, Cifkova, Renata, Claessens, Frank, Clays, Els, Concin, Hans, Cooper, Cyrus, Cooper, Rachel, Coppinger, Tara C., Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crujeiras, Ana B., D'Arrigo, Graziella, d'Orsi, Eleonora, Dallongeville, Jean, Damasceno, Albertino, Damsgaard, Camilla T., Dankner, Rachel, Dauchet, Luc, Backer, Guy De, Bacquer, Dirk De, Gaetano, Giovanni de, Hanauw, Stefaan De, Smedt, Delphine De, Deepa, Mohan, Deev, Alexander D., Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Dhana, Klodian, Castelnuovo, Augusto F. Di, Dias-da-Costa, Juvenal Soares, Diaz, Alejandro, Djalalinia, Shirin, Do, Ha T. P., Dobson, Annette J., Donfrancesco, Chiara, Döring, A., Doua, Kouamelan, Drygas, Wojciech, Egbagbe, Eruke E., Eggertsen, Robert, Ekelund, Ulf, Ati, Jalila El, Elliott, Paul, Engle-Stone, Reina, Erasmus, Rajiv T., Erem, Cihangir, Eriksen, Louise, Peña, J. E. De La, Evans, Alun, Faeh, David, Fall, Caroline H., Farzadfar, Farshad, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrari, Marika, Ferreccio, Catterina, Ferrieres, Jean, Finn, Joseph D., Fischer, Krista, Flores, E. M., Foeger, Bernhard, Foo, Leng Huat, Forslund, Ann-Sofie, Fortmann, Stephen P., Fouad, Heba M., Francis, Damian K., Franco, M. Do Carmo, Franco, Oscar H., Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujita, Yuki, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Gates, Louise, Geleijnse, Johanna M., Ghasemian, Anoosheh, Giampaoli, Simona, Gianfagna, Francesco, Giovannelli, Jonathan, Giwercman, Aleksander, Goldsmith, Rebecca A., Gross, M. G., Rivas, J. P. G., Gorbea, M. B., Gottrand, Frederic, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Grontved, Anders, Gruden, Grabriella, Grujic, Vera, Gu, Dongfeng, Guan, Ong Peng, Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Guo, Xiu H., Guo, Yin, Gupta, Prakash C., Gureje, Oye, Gurzkowska, Beata, Gutierrez, Laura, Gutzwiller, Felix, Halkjaer, Jytte, Hardy, Rebecca, Kumar, Rachakulla Hari, Hayes, Alison J., He, Jiang, Hendriks, Marleen Elisabeth, Cadena, L. H., Heshmat, Ramin, Hihtaniemi, Ilpo Tapani, Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Hofman, Albert, Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Htay, Thein Thein, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Hussieni, Abdullatif S., Huu, C. N., Huybrechts, Inge, Hwalla, Nahla, Iacoviello, Licia, Iannone, Anna G., Ibrahim, Mohsen M., Ikram, M. Arfan, Irazola, Vilma E., Islam, Muhammad, Iwasaki, Masanori, Jackson, Rod T., Jacobs, Jeremy M., Jafar, Tazeen, Jamil, Kazi M., Jamrozik, Konrad, Jasienska, Grazyna, Jiang, Chao Qiang, Joffres, Michel, Johansson, Mattias, Jonas, Jost B., Jorgensen, Torben, Joshi, Pradeep, Juolevi, Anne, Jurak, Gregor, Juresa, Vesna, Kaaks, Rudolf, Kafatos, Anthony, Kalter-Leibovici, Ofra, Kapantais, Efthymios, Kasaeian, Amir, Katz, Joanne, Kaur, Prabhdeep, Kavousi, Maryam, Keil, Ulrich, Boker, Lital Keinan, Kelishadi, Roya, Kemper, Han C. G., Kengne, Andre Pascal, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khaw, Kay-Tee H., Khouw, Ilse M. S. L., Kiechl, Stefan, Killewo, Japhet, Kim, Jeongseon, Kiyohara, Yutaka, Klimont, Jeannette, Kolle, Elin, Kolsteren, Patrick, Korrovits, Paul, Koskinen, Seppo, Kouda, Katsuyasu, Koziel, Slawomir, Kratzer, Wolfgang, Krokstad, Steinar, Kromhout, Daan, Kruger, Herculina S., Kula, Krzysztof, Kulaga, Zbigniew, Kumar, R. Krishna, Kusuma, Yadlapalli S., Kuulasmaa, Kari, Laamiri, Fatima Zahra, Laatikainen, Tiina, Lachat, Carl, Laid, Youcef, Lam, Tai Hing, Landrove, Orlando, Lanska, Vera, Lappas, Georg, Laugsand, Lars E., Bao, K. Le Nguyen, Le, Tuyen D., Leclercq, Catherine, Lee, Jeannette, Lehtimaki, Terho, Lekhraj, Rampal, Leon-Munoz, Luz M., Lim, Wei-Yen, Lima-Costa, M. F., Lin, Xu, Linneberg, Allan, Lissner, Lauren, Litwin, Mieczyslaw, Liu, Jing, Lorbeer, Roberto, Lotufo, Paulo A., Lozano, J. E., Luksiene, Dalia, Lundqvist, Annamari, Lunet, Nuno, Lytsy, Per, Ma, Guansheng, Machi, Suka, Maggi, Stefania, Magliano, Dianna J., Makdisse, Marcia, Malekzadeh, Reza, Malhotra, Rahul, Rao, Kodavanti Mallikharjuna, Manios, Yannis, Mann, Jim I., Manzato, Enzo, Margozzini, Paula, Markey, Oonagh, Marques-Vidal, Pedro, Marrugat, Jaume, Martin-Prevel, Yves, Martorell, Reynaldo, Masoodi, Shariq R., Matsha, Tandi E., Mazur, Artur, Mbanya, Jean Claude N., McFarlane, Shelly R., McGarvey, Stephen T., McKee, Martin, McLachlan, Stela, McLean, Rachael M., McNulty, Breige A., Yusof, S. Md, Mediene-Benchekor, Sounnia, Meirhaeghe, Aline, Meisinger, Christa, Mendes, Larissa L., Menezes, Ana Maria B., Mensink, Gert B. M., Meshram, Indrapal I., Metspalu, Andres, Mi, Jie, Michaelsen, Kim F., Mikkel, Kairit, Miller, Jody C., Miquel, J. F., Misigoj-Durakovic, Marjeta, Mohamed, Mostafa K., Mohammad, Kazem, Mohammadifard, Noushin, Mohan, Viswanathan, Yusoff, Muhammad Fadhli Mohd, Molbo, Drude, Moller, Niels C., Molnar, Denes, Mondo, Charles K., Monterrubio, Eric A., Monyeki, Kotsedi Daniel K., Moreira, Leila B., Morejon, Alain, Moreno, Luis A., Morgan, Karen, Mortensen, Erik Lykke, Moschonis, George, Mossakowska, Malgorzata, Mota, Jorge, Motlagh, Mohammad Esmaeel, Motta, Jorge, Mu, Thet Thet, Muiesan, Maria Lorenza, Mueller-Nurasyid, Martina, Murphy, Neil, Mursu, Jaakko, Murtagh, Elaine M., Musa, Kamarul Imran, Musil, Vera, Nagel, Gabriele, Nakamura, Harunobu, Namesna, Jana, Nang, E. E. K., Nangia, Vinay B., Nankap, Martin, Narake, Sameer, Navarrete-Muñoz, E. 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Yusoff, A.F., Zainuddin, A., Zambon, S., Zdrojewski, T., Zeng, Y., Zhao, D., Zhao, W., Zheng, Y., Zhou, M., Zhu, D., Zimmermann, E., Zuñiga Cisneros, J., Erasmus MC other, Epidemiology, Medical Oncology, Cardiology, Repositório Científico do Instituto Politécnico do Porto, University Medical Center Utrecht, Imperial College Trust, Yiallouros, Panayiotis K. [0000-0002-8339-9285], NCD Risk Factor Collaboration (ukupan broj autora: 754), Repositório da Universidade de Lisboa, Di Cesare M, Bentham J, Stevens GA, Zhou B, Danaei G, Lu Y, Bixby H, Cowan MJ, Riley LM, Hajifathalian K, Fortunato L, Taddei C, Bennett JE, Ikeda N, Khang Y-O, Kyobutungi C, Laxmaiah A, Li Y, Lin H-O, Miranda JJ, Mostafa A, Turley ML, Gunter M, Ezzati M, Abdeen ZA, Hamid ZA, Abu-Rmeileh NM, Acosta-Cazares B, Adams R, Aekplakorn W, Aguilar-Salinas CA, Ahmadvand A, Ahrens W, Ali MM, Ala'a Alkerwi A, Alvarez-Pedrerol M, Aly E, Amouyel P, Antoinette Amuzu A, Andersen LB, Anderssen SA, Andrade DS, Anjana RM, Aounallah-Skhiri H, Ariansen I, Aris T, Arlappa N, Arveiler D, Assah FK, Avdicová M, Azizi F, Babu BV, Balakrishna N, Bandosz P, Banegas. JR, Barbagallo CM, Barceló A, Barkat A, Barros MV, Bata I, Batieha AM, Batista RL, Baur LA, Beaglehole R, Romdhane HB, Benet M, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava SH, Bhatti Z, Bhutta ZA, Bi HS, Bi Y, Bjerregaard P, Bjertness E, Bjertness MB, Björkelund C, Blake M, Blokstra A, Bo S, Bobak M, Boddy LM, Boehm BO, Boeing H, Boissonnet CP, Bongard V, Bovet P, Braeckman L, Bragt MCE, Brajkovich I, Branca F, Breckenkamp J, Brenner H, Brewster LM, Brian GR, Bruno G, Bueno-de-Mesquita HB, Bugge A, Burns C, de León CA, Cacciottolo J, Cama T, Cameron C, Camolas J, Can G, Cândido APC, Capuano V, Cardoso VC, Carvalho MJ, Casanueva FF, Casas J-P, Caserta CA, Castetbon K, Chamukuttan S, Chan AW, Chan Q, Chaturvedi HK, Nishi Chaturvedi N, Chen C-J, Chen F, Chen H, Chen S, Chen Z, Cheng C-Y, Chetrit A, Chiolero A, Chiou S-T, Chirita-Emandi A, Cho Y, Kaare Christensen K, Chudek J, Renata Cifkova R, Claessens F, Clays E, Concin H, Cooper C, Cooper R, Coppinger TC, Costanzo C, Cottel D, Cowell C, Craig CL, Crujeiras AB, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Damsgaard CT, Dankner R, Luc Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Deev AD, Dehghan A, Delisle H, Delpeuch F, Dhana K, Di Castelnuovo AF, Dias-da-Costa JS, Diaz A, Djalalinia S, Do HTP, Dobson AJ, Donfrancesco C, Döring A, Doua K, Drygas W, Egbagbe EE, Eggertsen R, Ekelund U, El Ati J, Elliott P, Engle-Stone R, Erasmus RT, Erem C, Eriksen L, Escobedo-de la Peña J, Evans A, Faeh D, Fall CH, Farshad Farzadfar F, Felix-Redondo FJ, Ferguson TS, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn JD, Fischer K, Monterubio Flores E, Föger B, Foo LH, Forslund A-S, Fortmann SP, Fouad HM, Francis DK, Franco MdC, Franco OH, Guillermo Frontera G, Fuchs FH, Fuchs SC, Fujita Y, Furusawa T, Gaciong Z, Gafencu M, Gareta D, Garnett SP, Gaspoz J-M, GasulL M, Gates L, Geleijnse JM, Ghasemian A, Giampaoli S, GianfagnA F, Giovannelli J, Giwercman A, Goldsmith RA, Gonzalez Gross M, González Rivas JP, Gorbea MB, Gottrand F, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou MG, Gregor RD, Grodzicki T, Grøntved A, Gruden G, Grujic V, Gu D, Guan OP, Gudnason V, Guerrero R, Guessous I, Guimaraes AL, Gulliford MC, Gunnlaugsdottir J, Guo XK, Guo Y, Gupta PC, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Halkjær J, Hardy R, Kumar RH, Hayes AJ, He J, Hendriks ME, Hernandez Cadena L, Heshmat R, Hihtaniemi IP, Sai SY, Ho SC, Hobbs M, Hofman A, Hormiga CM, Horta BH, Houti L, Htay TT, Htet AS, Htike MMT, Hu Y, Hussieni HS, Huu CN, Huybrechts I, Hwalla N, Iacoviello L, Iannone AG, Ibrahim MM, Ikram MA, Irazola VE, Islam M, Iwasaki M, Jackson RT, Jacobs JM, Tazeen Jafar T, Jamil KM, Jamrozi K, Jasienska G, Jiang CQ, Joffres M, Johansson M, Jonas JB, Jørgensen T, Joshi P, Juolevi A, Jurak G, Vesna Jureša V, Kaaks R, Kafatos A, Kalter-Leibovici O, Kapantais E, Kasaeian A, Katz J, Kaur P, Kavousi M, Keil U, Keinan Boker L, Kelishadi R, Kemper HHCG, Kengne AP, Kersting M, Key T, Khader YS, Khalili D, Khang Y-H, Kay-Tee H Khaw K-TH, Khouw LMSL, Kiechl S, Killewo J, Kim J, Kiyohara Y, Klimont J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kratzer W, Krokstad S, Kromhout D, Kruger HS, Kula K, Kulaga Z, Kumar RK, Kusuma YS, Kuulasmaa K, Laamiri FZ, Laatikainen T, Lachat C, Laid Y, Lam TH, Landrove O, Lanska V, Lappas G, Laugsand LE, Nguyen Bao KL, Le TD, Leclercq C, Lee J, Jeonghee Lee J, Lehtimäki T, Lekhraj R, León-Muñoz LM, Lim W-Y, M Fernanda Lima-Costa MF, Lin H-H, Lin X, Linneberg A, Lissner L, Litwin M, Liu J, Lorbeer R, Lotufo PA, Lozano JE, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Machi S, Maggi S, Magliano DJ, Makdisse M, Malekzadeh R, Malhotra R, Mallikharjuna Rao K, Manios Y, Mann JI, Manzato E, Margozzini P, Markey O, Marques-Vidal P, Marrugat P, Martin-Prevel Y, Martorell R, Masoodi SR, Matsha TE, Mazur A, Mbanya JCN, McFarlane SR, McGarvey ST, McKee M, McLachlan S, McLean RM, McNulty BA, Md Yusof S, Mediene-Benchekor S, Meirhaeghe A, Meisinger A, Mendes LL, Menezes AMB, Mensink GBM, Meshram II, Metspalu A, Mi JM, Michaelsen KF, Miller JC, Miquel JF, Mišigoj-Duraković M, Mohamed MK, Mohammad K, Mohammadifard N, Mohan V, Mohd Yusoff MF, Molbo D, Møller NC, Molnár D, Mondo CK, Monterrubio EA, Monyeki KDK, Leila B Moreira LB, Morejon A, Moreno LA, Morgan K, Mortensen EL, Moschonis G, Mossakowska M, Mota J, Motlagh ME, Motta J, Mu TT, Muiesan ML, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh EM, Musa KI, Musil V, Nagel G, Nakamura H, Námešná J, Nang EEK, Nangia VB, Nankap M, Narake S, Navarrete-Muñoz EM, Nenko I, Neovius M, Nervi F, Neuhauser HK, Nguyen ND, Ngoc Nguyen Q, Nieto-Martínez RE, Ning G, Ninomiya T, Nishtar S, Noale M, Norat T, Noto D, Al Nsour M, O'Reilly D, Ochoa-Avilés AM, Oh K, Olayan IH, Olinto MTA, Oltarzewski M, Omar MA, Onat A, Ordunez P, Ortiz AP, Osler M, Osmond C, Ostojic AM, Otero JA, Overvad K, Paccaud F, Padez C, Pajak A, Palli D, Palloni A, Palmieri L, Panda-Jonas S, Panza F, Parnell WR, Parsaeian M, Pednekar MS, Peeters PH, Peixoto SV, Pereira AC, Pérez CM, Peters A, Peykari N, Pham ST, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Piwonski J, Pedro Plans-Rubió P, Poh BK, Porta M, Portegies MLP, Poulimeneas D, Pradeepa R, Prashant M, Price JF, Puiu M, Punab M, Qasrawi RF, Qorbani M, Quoc Bao T, Radic I, Ricardas Radisauskas R, Rahman M, Raitakari O, Raj M, Ramachandra Rao S, Ramachandran A, Ramke J, Ramos R, Rampal S, Rasmussen F, Redon J, Reganit PFM, Robespierre Ribeiro R, Riboli E, Rigo F, Rinke de Wit TF, Ritti-Dias RM, Juan A Rivera JA, Robinson SM, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez MdC, Rodríguez-Villamizar LA, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Rubinstein A, Rühli FJ, Rui O, Ruiz-Betancourt BS, Russo Horimoto ARV, Rutkowski M, Sabanayagam C, Sachdev HS, Saidi O, Salanave B, Salazar Martinez E, Salomaa V, Salonen JT, Salvetti M, Sánchez-Abanto J, Sandjaja A, Sans S, Santos DA, Santos O, dos Santos RN, Santos R, Sardinha LB, Sarrafzadegan N, Saum K-U, Savva SC, Scazufca M, Schaffrath Rosario A, Schargrodsky H, Schienkiewitz A, Schmidt IM, Schneider IJ, Schultsz C, Schutte AE, Sein AA, Sen A, Senbanjo IO, Sepanlou SG, Shalnova SA, Shaw JE, Shibuya K, Shin Y, Shiri R, Siantar R, Sibai AM, Silva AM, Simon M, Simons J, Simons LA, Sjostrom M, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith MC, Snijder MB, So H-K, Sobngwi E, Söderberg S, Soekatri MYE, Solfrizzi V, Sonestedt E, Sørensen TIA, Sorić M, Sossa Jérome C, Soumare A, Staessen JA, Starc G, Stathopoulou MG, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein AD, Stergiou GS, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Strufaldi MW, Chien-An Sun C-A, Sundström J, Sung Y-T, Sunyer J, Suriyawongpaisal P, Swinburn BA, Sy RG, Szponar L, E Shyong Tai E, Tammesoo M-L, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Jakob Tarp J, Tarqui-Mamani CB, Taylor A, Félicité Tchibindat F, Thijs L, Thuesen BH, Tjonneland A, Tolonen HK, Janne S Tolstrup JS, Topbas M, Topór-Madry R, Torrent M, Traissac P, Trichopoulos D, Trinh OTH, Trivedi A, Tshepo L, Tulloch-Reid MK, Tuomainen T-P, Tuomilehto J, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ukoli FAM, Ulmer H, Unal B, Valdivia G, Susana Va S, Valvi D, van der Schouw YT, Van Herck K, Van Minh H, van Valkengoed IGM, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren WMM, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque P, Virtanen JK, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrijheid M, Wade AN, Wagner A, Walton J, Wan Mohamud WN, Wang M-D, Wang Q, Wang YX, Wannamethee SG, Wareham N, Deepa Weerasekera D, Whincup PH, Widhalm K, Widyahening IS, Wiecek A, Wilks RJ, Willeit J, Wojtyniak B, Wong, Wong TY, Woo J, Woodward M, Wu FC, JianFeng Wu JF, Wu SL, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros PK, Yoshihara A, Qi Sheng You QS, Younger-Coleman NO, Yusoff AF, Ahmad A Zainuddin AA, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhou M, Zhu D, Zimmermann E, Zuñiga Cisneros J, General Internal Medicine, AII - Amsterdam institute for Infection and Immunity, Public and occupational health, Global Health, and APH - Amsterdam Public Health
Subjects: Male, Obesidad, CHILDREN, Salud, Review, países desarrollados, Global Health, Body Mass Index, Body mass index, population study, 0302 clinical medicine, Models, Factores de riesgo cardiovascular, Medicine, body mass index, underweight, overweight, obesity, Young adult, Human Nutrition & Health, education.field_of_study, Humane Voeding & Gezondheid, General Medicine, ASSOCIATION, 11 Medical And Health Sciences, adulto, predicción, adulto joven, CARDIOVASCULAR-DISEASE, thinness/epidemiology, NONCOMMUNICABLE DISEASES, NCD Risk Factor Collaboration (NCD-RisC), Enfermedades cardiovasculares, Developed country, teorema de Bayes, Medical sciences, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Thinness, Humans, education, Developing Countries, obesidad, VLAG, Science & Technology, Models, Statistical, CAUSE-SPECIFIC MORTALITY, Bayes Theorem, medicine.disease, QP, Obesity, adult body-mass, Indice de masa corporal (IMC), RISK-FACTORS, Adolescent, Adult, Developed Countries, Female, Forecasting, Obesity/epidemiology, Prevalence, Thinness/epidemiology, Young Adult, RA, Body mass index, Demography, Meta-Analysis, Gerontology, Settore MED/09 - Medicina Interna, Nutrition and Disease, humanos, adolescente, Overweight, países en desarrollo, Voeding en Ziekte, Medicine and Health Sciences, Global health, 030212 general & internal medicine, Non-U.S. Gov't, Medicine (all), Research Support, Non-U.S. Gov't, prevalencia, Public Health, Global Health, Social Medicine and Epidemiology, Statistical, Underweight, medicine.symptom, pooled analysis, Life Sciences & Biomedicine, obesity/*epidemiology, Population, 030209 endocrinology & metabolism, Research Support, Medicine, General & Internal, EPIDEMIC, General & Internal Medicine, Journal Article, Life Science, ddc:610, Obesidad morbida, OBESITY PREVENTION, OVERWEIGHT, business.industry, índice de masa corporal, COHORTS, purl.org/pe-repo/ocde/ford#3.02.00 [https], Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Ciencias socio biomédicas, business, delgadez
Abstract: Copyright © NCD Risk Factor Collaboration. Open Access article distributed under the terms of CC BY., Background: Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods: We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical model to these data to estimate trends from 1975 to 2014 in mean BMI and in the prevalences of BMI categories (, Wellcome Trust, Grand Challenges Canada
Published: 2016
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46. A forecast of globalization, internal business and trade: report from Delphi study

Author: Czinkota, Michael R. and Ronkainen, Ilkka A.
Subjects: International trade -- Forecasts and trends, Globalization -- Analysis, Delphi technique -- Usage, International trade, Market trend/market analysis, Business, Business, international
Abstract: The impact of globalization on business environments is discussed. The details of a Delphi study on on the various emerging, developing and megamarkets in the world are presented.
Published: 2005

47. A forecast of globalization, international business and trade: report from a Delphi study

Author: Czinkota, Michael R. and Ronkainen, Ilkka A.
Subjects: Globalization -- Analysis, Automobile equipment and supplies industry -- Analysis, Business, Business, international
Published: 2005

48. Effects of coaching style on prosocial and antisocial behavior among Chinese athletes

Author: Dong Wang, Zuosong Chen, Noora J. Ronkainen, Kun Wang, and Tao Huang
Subjects: Mediation (statistics), Social Psychology, biology, Athletes, business.industry, 05 social sciences, Psychological intervention, 050301 education, 030229 sport sciences, biology.organism_classification, Coaching, Structural equation modeling, 03 medical and health sciences, 0302 clinical medicine, Prosocial behavior, Psychology, business, 0503 education, Social psychology, Self-determination theory, Moral disengagement
Abstract: We examined the effects of coaching style, motivation style, and moral disengagement on prosocial and antisocial behavior among Chinese athletes. Participants were 203 athletes (36.9% women; Mage = 19.0, SD = 2.6 years) from the Fujian Provincial Sports Team. Structural equation modeling analysis results revealed that the autonomy-supportive coaching style had an indirect and positive effect on prosocial behavior through the mediation of autonomous motivation. Further, the controlling coaching style had an indirect and positive effect on antisocial behavior through the mediation of controlled motivation and moral disengagement. The findings indicate that as coaching style influences prosocial and antisocial behavior among Chinese athletes, it should be targeted when interventions aimed at reducing their immoral behavior are developed.
Published: 2016
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49. Exercise cardiac power and the risk of coronary heart disease and cardiovascular mortality in men

Author: Sae Young Jae, Kimmo Ronkainen, Sudhir Kurl, Jari A. Laukkanen, and Timo H. Mäkikallio
Subjects: Adult, Male, medicine.medical_specialty, Population, Coronary Disease, 030204 cardiovascular system & hematology, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Risk of mortality, medicine, Humans, 030212 general & internal medicine, education, Finland, Cardiovascular mortality, education.field_of_study, Exercise Tolerance, business.industry, VO2 max, General Medicine, Middle Aged, Prognosis, Survival Analysis, Coronary heart disease, Blood pressure, Quartile, Cardiovascular Diseases, Exercise Test, Cardiology, business, Follow-Up Studies, Cohort study
Abstract: The aim of this study was to examine the relationship of exercise cardiac power (ECP), defined as a ratio of directly measured maximal oxygen uptake with peak systolic blood pressure during exercise, with the risk of mortality from coronary heart diseases (CHD) and cardiovascular diseases (CVD).Population-based cohort study with an average follow-up of 25 years from eastern Finland. About 2358 men at baseline participated in exercise stress test and 182 CHD and 302 CVD deaths occurred.Men with low ECP ( 8.7 mL/mmHg, lowest quartile) had a 3.5-fold (95% CI 2.1-5.8, p 0.0001) risk of CHD mortality as compared with men with high ECP (16.4 mL/mmHg, highest quartile) after adjusting for age and examination year. Low ECP was associated with a 2.8-fold risk of CHD and 2.4-fold for CVD mortality after additional adjustment for conventional risk factors. After further adjustment for leisure time physical activity, the results hardly changed (HR 2.5, 95% CI 1.71-3.67, p 0.001).ECP provides non-invasive and easily available measure for the prediction of CHD and CVD mortality. One of the most potential explanation for the association between ECP and the risk of CHD and CVD mortality is an elevated afterload and peripheral resistance indicated by hypertension. Key messages Index of exercise cardiac power defined as the ratio of directly measured maximal oxygen uptake (VO
Published: 2016
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50. Reduced kidney function is a risk factor for atrial fibrillation

Author: Jari A. Laukkanen, Jouni Karppi, Francesco Zaccardi, Sudhir Kurl, and Kimmo Ronkainen
Subjects: medicine.medical_specialty, Renal function, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, Medicine, 030212 general & internal medicine, Risk factor, Creatinine, biology, business.industry, Hazard ratio, Atrial fibrillation, General Medicine, medicine.disease, Confidence interval, Cystatin C, chemistry, Nephrology, biology.protein, Cardiology, Albuminuria, medicine.symptom, business
Abstract: There is limited knowledge on the relationship between kidney function and incidence of atrial fibrillation. Thus, this prospective study was designed to evaluate whether various biomarkers of kidney function are associated to the risk of atrial fibrillation. The study population consisted of 1840 subjects (615 women and 1225 men) aged 61-82 years. Cystatin C- and creatinine-based estimation of glomerular filtration rate (eGFRcys and eGRFcreat , respectively) and urinary albumin/creatinine ratio (ACR) were assessed to investigate their relationship with the risk of atrial fibrillation. During a median follow-up of 3.7 years, a total of 159 incident atrial fibrillation cases occurred. After adjustment for potential confounders, the risk of atrial fibrillation was increased (hazard ratio 2.74, 95% confidence interval (CI) 1.56-4.81, P
Published: 2016
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