86 results on '"Sun Young Shin"'
Search Results
2. Peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children
- Author
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Yoo Yeon Park, Ye Jin Ahn, and Sun Young Shin
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medicine.medical_specialty ,Adolescent ,genetic structures ,Optic Disk ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,Macula Lutea ,Child ,Optic Disk Drusen ,business.industry ,Retinal ,Foveal avascular zone ,Inner plexiform layer ,medicine.disease ,Optic disc drusen ,eye diseases ,Ganglion ,medicine.anatomical_structure ,chemistry ,030221 ophthalmology & optometry ,Optic nerve ,Ovoid ,sense organs ,business ,Sclera ,Tomography, Optical Coherence ,030217 neurology & neurosurgery ,Optic disc - Abstract
Background To analyse structural characteristics and perifoveal/peripapillary vasculature by OCT in children with peripapillary hyperreflective ovoid mass-like structures (PHOMS) and compare the results with those of normal subjects. Methods Forty-five patients (84 eyes) under 18 years old with blurry disc margin were evaluated with spectral domain-OCT and swept course-OCT. Patients were divided into four groups, according to presence of PHOMS and then the size of the existing PHOMS. Eyes with visible optic disc drusen (ODD) were not included. Foveal avascular zone (FAZ) and vessel densities from macula and optic disc area were assessed and potential associations between vessel density and structural parameters, such as peripapillary retinal nerve fibre layer (pRNFL), and macular ganglion cell and inner plexiform layer (mGCIPL) thickness, were analysed. Results Among 45 patients (eighty-four eyes), coexisting buried ODD were found only in eyes with PHOMS. The scleral canal diameter was significantly smaller in PHOMS positive eyes compared to control eyes. Vessel density measurements from the papillary, peripapillary and optic nerve head (ONH) regions in the large PHOMS group were significantly lower compared to the control group (papillary; P = 0.014, peripapillary; P = 0.001, ONH; P = 0.046). FAZ area and macular vessel densities showed no difference compared to normal eyes in all three PHOMS groups. pRNFL and mGCIPL thickness did not differ among four groups and correlations were also not significant. Conclusions Children with PHOMS have smaller scleral canal and can entail buried ODD. Vessel densities of optic disc area in large PHOMS eyes are significantly lower than in normal eyes.
- Published
- 2021
3. Clinical Characteristics of Rhinogenic Optic Neuropathy Associated with Paranasal Sinus Disease
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Sun Young Shin, Yooyeon Park, Miyoung Chu, and Shin Hae Park
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Optic neuropathy ,Ophthalmology ,medicine.medical_specialty ,business.industry ,Sinus disease ,medicine ,Radiology ,business ,medicine.disease ,Visual field - Published
- 2020
4. Interocular difference associated with myopic progression following unilateral lateral rectus recession in early school-aged children
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Yooyeon Park, Ye Jin Ahn, Shin Hae Park, and Sun Young Shin
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Male ,medicine.medical_specialty ,Eye Movements ,genetic structures ,Spherical equivalent ,Ophthalmologic Surgical Procedures ,Post surgery ,Refraction, Ocular ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,Ophthalmology ,Myopia ,Humans ,Medicine ,Child ,Dioptre ,Retrospective Studies ,Lateral rectus recession ,School age child ,business.industry ,Korean population ,Large series ,General Medicine ,Prognosis ,eye diseases ,Oculomotor Muscles ,Case-Control Studies ,Child, Preschool ,Disease Progression ,030221 ophthalmology & optometry ,Exotropia ,Female ,sense organs ,business ,Intermittent exotropia ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
To compare refractive changes in operated eyes and fellow unoperated eyes following unilateral lateral rectus recession in early school-aged children. A retrospective case control study. The medical records of children under ten years of age with intermittent exotropia who underwent unilateral lateral recession surgery were reviewed. The operated eyes were reviewed and the fellow unoperated eyes were used as control. The rate of myopic progression was calculated by spherical equivalent (SE) changes per year, and by the rate of refractive growth (RRG) equation. SE showed a myopic shift one week after surgery and in the following months, from -1.43 ± 1.84 diopters (D) at 1 week post operation to -1.57 ± 2.22 D at one year and, finally -2.95 ± 2.97 D at the average 4.62 years following surgery. However, the SE shift was not significantly different from the unoperated eye. The low myopia group (under -3.0 D) showed a significantly higher myopic change in the operated eye until one year post operation (p = 0.022). The average myopic shift ratio was -0.53 ± 0.46 D yearly in the operated eye. This study presents data of a large series of refractive changes secondary to lateral rectus recession, and of long-term myopia progression in Korean population.
- Published
- 2019
5. Examining English Test Practicality among Different Stakeholders in Thailand
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Arnon Chaisuriya and Sun-Young Shin
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Linguistics and Language ,Medical education ,business.industry ,media_common.quotation_subject ,Demographic data ,Delivery mode ,TOEIC ,Education ,Test (assessment) ,International communication ,Perception ,The Internet ,Psychology ,business ,Female students ,media_common - Abstract
This study investigated perceptions of university students from various areas in Thailand regarding aspects of English test practicality including affordability, convenience, resources, contents, and delivery modes. 210 students filled out a questionnaire consisting of three sections: demographic data, perceptions of test practicality, and views on content and delivery. The data was further analyzed to see whether any differences in the perceptions of test practicality existed between students from universities in Bangkok and those from other regional universities. An additional analysis was conducted to examine relationship between their perceptions and other variables, such as socio-economic status (SES) and gender. The results revealed that Thai university students viewed the test of English for international communication as important for their future careers despite their unfamiliarity with it. Several aspects of practicality can be enhanced by taking extra steps, such as organizing orientations for high-school students or college freshmen, offering scholarships and fee waivers, and creating a level-based test. Stakeholders from middle-income families and those outside the metropolis had acquaintance with and an encouraging attitude toward the test and the opportunity to achieve a higher score. Regarding gender’s effects on test practicality, while male students embraced computer and the Internet as the new delivery mode, female students, on the other hand, seemed reluctant to do so.
- Published
- 2019
6. 4.8 An Area and Energy Efficient 0.12nJ/Pixel 8K 30fps AV1 Video Decoder in 5nm CMOS Process
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Seung-Yong Lee, Sun-Young Shin, YongMi Lee, Homin Kang, Kyungah Jeong, Kyung-Koo Lee, Eikyung Moon, Lee Seokhyun, Yohan Lim, SukHwan Lim, Seung-Sick Jun, Chang-hyun Yim, Inyup Kang, and Taesung Kim
- Subjects
Pixel ,Gate count ,Computer science ,business.industry ,Logic gate ,Video decoder ,Clock rate ,Static random-access memory ,business ,Decoding methods ,Computer hardware ,Coding (social sciences) - Abstract
Major content providers such as YouTube and Netflix use AV1, a state-of-art video coding standard that was finalized in 2018. This paper presents a video processor that supports the AV1 standard via a Multi-Format video Decoder (MFD). An MFD can decode various video coding standards, such as H.264/AVC, HEVC and AV1. The video decoder can decode up to 8K Ultra HD (8K-UHD) video at 30fps at 468MHz core clock frequency. The MFD is fabricated using a state-of-the-art 5nm CMOS process with a 5,835k NAND2 equivalent gate count and 518kB SRAM. For AV1, MFD dissipates 116mW for decoding AV1 $7680 \times4320p$ video at 30fps (0.12nJ/pixel) with core operating voltage at 0.7V.
- Published
- 2021
7. Influence of coronavirus disease 2019 on myopic progression in children treated with low-concentration atropine
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Shin Hae Park, Hae Ri Yum, and Sun Young Shin
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Atropine ,Viral Diseases ,Pediatrics ,Epidemiology ,Medical Conditions ,Risk Factors ,Myopia ,Medicine and Health Sciences ,Public and Occupational Health ,Child ,Volume concentration ,Visual Impairments ,Quarantines ,Eye Lens ,Multidisciplinary ,Chemistry ,Infectious Diseases ,Physical Sciences ,Engineering and Technology ,Medicine ,Smartphone ,Anatomy ,Research Article ,medicine.drug ,medicine.medical_specialty ,Adolescent ,Coronavirus disease 2019 (COVID-19) ,Ocular Anatomy ,Science ,Equipment ,Alkaloids ,Environmental risk ,Ocular System ,Republic of Korea ,medicine ,Humans ,Near work ,Eye lens ,Pandemics ,Retrospective Studies ,Communication Equipment ,Computers ,business.industry ,Chemical Compounds ,COVID-19 ,Biology and Life Sciences ,Covid 19 ,Retrospective cohort study ,Physical Activity ,Axial elongation ,Ophthalmology ,Communicable Disease Control ,Eyes ,Ophthalmic Solutions ,Cell Phones ,business ,Head - Abstract
Purpose The outbreak of coronavirus disease 2019 (COVID-19) has caused many children to stay indoors. Increased near work and insufficient outdoor activities are considered important risk factors for myopic progression. This study aimed to compare the changes in myopic progression before and after COVID-19 in children treated with low-concentration atropine. Methods The records of 103 eyes of 103 children who were treated with low-concentration atropine eye drops were retrospectively reviewed. We classified children according to the concentration of atropine eye drops and children’s age. The beginning of the pre-COVID-19 period was set from January 2019 to May 2019, and the endpoint was set in March 2020. The beginning of the post-COVID-19 period was set in March 2020, and the endpoint was set from January 2021 to March 2021. We evaluated the questionnaires administered to children’s parents. Results A significant myopic progression was observed in the post-COVID-19 period compared to the pre-COVID-19 period in the 0.05% and 0.025% atropine groups (P < 0.001 and P = 0.020, respectively). For children aged 5 to 7 and 8 to 10 years, the axial elongations were significantly faster in the post-COVID-19 period than in the pre-COVID-19 period (P = 0.022 and P = 0.005, respectively). However, the rates of axial elongation and myopic progression were not significantly different between pre- and post-COVID-19 in children aged 11 to 15 years (P = 0.065 and P = 0.792, respectively). The average time spent using computers and smartphones and reading time were significantly increased, and the times of physical and outdoor activity were significantly decreased in the post-COVID-19 period compared to the pre-COVID-19 period. Conclusions The rates of myopic progression have increased substantially after the spread of COVID-19 with an increase in the home confinement of children. Therefore, it is necessary to control the environmental risk factors for myopia, even in children undergoing treatment for the inhibition of myopic progression.
- Published
- 2021
8. Change of ocular parameters in children with large cup-to-disc ratio and interocular cup-to-disc ratio asymmetry
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Hae Ri Yum, Shin Hae Park, and Sun Young Shin
- Subjects
Retinal Ganglion Cells ,medicine.medical_specialty ,Refractive error ,genetic structures ,media_common.quotation_subject ,Optic Disk ,Nerve fiber layer ,Glaucoma ,chemical and pharmacologic phenomena ,Cup-to-disc ratio ,Asymmetry ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Nerve Fibers ,Ophthalmology ,mental disorders ,Medicine ,Humans ,Child ,media_common ,business.industry ,Retinal ,medicine.disease ,eye diseases ,Sensory Systems ,medicine.anatomical_structure ,chemistry ,Child, Preschool ,030221 ophthalmology & optometry ,Optic nerve ,sense organs ,business ,030217 neurology & neurosurgery ,Tomography, Optical Coherence ,Optic disc - Abstract
Enlarged optic disc cupping and interocular cup-to-disc ratio (CDR) asymmetry are often important indicators of glaucoma. Clinically, we occasionally encounter children with large CDR and interocular CDR asymmetry during vision screening. This study aimed to report longitudinal change of ocular parameters in children with large cup-to-disc ratio (CDR) and interocular CDR asymmetry. This was a retrospective, observational case series of 160 eyes of 160 children with large CDR who visited a tertiary eye center from January 2010 to June 2016. Average CDR ≥ 0.6 were considered large CDR values, and CDR asymmetry was defined as an interocular difference ratio value greater than 0.2. All included patients showed interocular pressure (IOP)
- Published
- 2020
9. Oculocardiac reflex and oculorespiratory reflex during strabismus surgery under general anesthesia using the laryngeal mask airway with maintenance of spontaneous respiration: A retrospective study
- Author
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Sun Young Shin, Min Ju Kim, and Jin Joo
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oculorespiratory reflex ,Adult ,Medicine (General) ,Anesthesia, General ,Biochemistry ,Laryngeal Masks ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Laryngeal mask airway ,030202 anesthesiology ,Reflex ,Humans ,Medicine ,Spontaneous respiration ,Child ,Surgical treatment ,Retrospective Studies ,business.industry ,Strabismus surgery ,Respiration ,Biochemistry (medical) ,Retrospective cohort study ,oculocardiac reflex ,Cell Biology ,General Medicine ,Oculocardiac reflex ,Strabismus ,depth of anesthesia ,Reflex, Oculocardiac ,Anesthesia ,spontaneous respiration ,030221 ophthalmology & optometry ,laryngeal mask airway ,business ,Depth of anesthesia ,Retrospective Clinical Research Report - Abstract
ObjectiveTo determine (1) how the specific muscle undergoing surgical treatment affects the occurrence of the oculocardiac reflex (OCR) and oculorespiratory reflex (ORR) and (2) whether the depth of anesthesia influences the occurrence of the OCR and ORR in patients undergoing strabismus surgery with a laryngeal mask airway with maintenance of spontaneous respiration.MethodsThe medical records of patients who underwent strabismus surgery on the lateral rectus (LR) and medial rectus (MR) muscles from January 2017 to December 2017 were retrospectively reviewed.ResultsThe incidence of the OCR was not significantly different between LR and MR operations in either pediatric or adult patients. The incidence of the ORR as indexed by the tidal volume (TV) was significantly higher during MR than LR surgery in pediatric patients (29.3% vs. 10.1%, respectively). The change in TV during muscle traction and the bispectral index were significantly correlated in both pediatric and adult patients (r2 = 0.034 and 0.058, respectively).ConclusionsThe OCR was not influenced by the specific muscle undergoing surgery or the depth of anesthesia. The incidence of the ORR as indexed by the TV was higher during MR surgery in pediatric patients and was positively correlated with the depth of anesthesia.
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- 2020
10. Revitalizing Local Economies through the Sharing Economy : Focusing on the Cases of North America, Europe, and China
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Tae-Seok Jang, Sun-Young Shin, Sehwan Oh, and Sungho Rho
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Sharing economy ,Community currency ,business.industry ,General Medicine ,Business ,International trade ,China - Published
- 2018
11. 'A Case of Management for Advanced Hepatocellular Carcinoma with Extrahepatic Metastasis by Autologous Natural Killer Cells Combined with Immune Checkpoint Inhibitor'
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Hong Jae Jeon, Eunju Kim, Seong Gyu Hwang, Yun Bin Lee, Young Eun Chon, Ara Woo, Kyu Sung Rim, Hana Park, Sun Young Shin, and Joo Ho Lee
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biology ,business.industry ,medicine.medical_treatment ,Programmed cell death 1 ,Hepatocellular carcinoma ,Immune checkpoint inhibitors ,biology.protein ,Cancer research ,Extrahepatic metastasis ,Medicine ,Immunotherapy ,business ,medicine.disease - Published
- 2018
12. Detailed anatomy of the abducens nerve in the lateral rectus muscle
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Yong Seok Nam, In-Beom Kim, and Sun Young Shin
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Histology ,Palsy ,business.industry ,Lateral rectus muscle ,General Medicine ,Anatomy ,Trunk ,03 medical and health sciences ,Oculomotor Muscle ,Dissection ,0302 clinical medicine ,Cadaver ,030221 ophthalmology & optometry ,Medicine ,business ,Free nerve ending ,Abducens nerve ,030217 neurology & neurosurgery - Abstract
The aims of this study were to elucidate the detailed anatomy of the abducens nerve in the lateral rectus muscle (LRM) and the intramuscular innervation pattern using Sihler staining. In this cohort study, 32 eyes of 16 cadavers were assessed. Dissection was performed from the LRM origin to its insertion. The following distances were measured: from LRM insertion to the bifurcation point of the abducens nerve, from LRM insertion to the entry site of the superior branch or inferior branch, from the upper border of the LRM to the entry site of the superior branch, from the lower border of LRM to the entry site of inferior branch, and the widths of the main trunk and superior and inferior branches. The single trunk of the abducens nerve divided into two branches 37 mm from insertion of the LRM, and 22 of 32 (68.8%) orbits showed only two superior and inferior branches with no subdivision. The superior branch entered the LRM more anteriorly (P = 0.037) and the superior branch was thinner than the inferior branch (P = 0.040). The most distally located intramuscular nerve ending was observed at 52.9 ± 3.5% of the length of each muscle. Non-overlap between the superior and inferior intramuscular arborization of the nerve was detected in 27 of 32 cases (84.4%). Five cases (15.6%) showed definite overlap of the superior and inferior zones. This study revealed the detailed anatomy of the abducens nerve in the LRM and provides helpful information to understand abducens nerve palsy. Clin. Anat. 30:873-877, 2017. © 2017 Wiley Periodicals, Inc.
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- 2017
13. Distant stereoacuity in children with anisometropic amblyopia
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Yeon Woong Chung, Sun Young Shin, and Shin Hae Park
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Male ,Visual acuity ,genetic structures ,Visual Acuity ,Amblyopia ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Vision test ,Child ,Dioptre ,Retrospective Studies ,Depth Perception ,business.industry ,Distance Perception ,Vision Tests ,Follow up studies ,General Medicine ,eye diseases ,Stereoscopic acuity ,Ophthalmology ,Child, Preschool ,Stereotests ,030221 ophthalmology & optometry ,Optometry ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
To characterize changes in distant stereoacuity using Frisby–Davis Distance test (FD2) and Distant Randot test (DR) during treatment for anisometropic amblyopia, to determine factors that influence posttreatment stereoacuity and to compare the two distant stereotests. Fifty-eight anisometropic amblyopic patients with an interocular difference of ≥1.00 diopter who achieved the visual acuity 20/20 following amblyopia treatment were retrospectively included. Stereoacuity using FD2 and DR for distant and Titmus test for near measurement were assessed and compared at the initial, intermediate, and final visit. Multivariate regression models were used to identify factors associated with initial and final stereoacuity. The two distant stereotests revealed a significant improvement in distant stereoacuity after successful amblyopia treatment. Distant stereoacuity using FD2 showed the greatest improvement during the follow up period. The number of nil scores was higher in DR than FD2 at each period. In multivariate analysis, better final stereoacuity was associated with better initial amblyopic eye acuity in both distant stereotests, but not in the Titmus test. Comparing the two distant stereotests, final stereoacuity using FD2 was associated with initial stereoacuity and was moderately related with the Titmus test at each period, but final stereoacuity using DR was not. Distant stereoacuity measured with both FD2 and DR showed significant improvement when the visual acuity of the amblyopic eye achieved 20/20. Changes in distant stereoacuity by FD2 and DR during the amblyopia treatment were somewhat different.
- Published
- 2017
14. Clinical Features in Children with Posterior Polymorphous Corneal Dystrophy
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Sun Young Shin, Soon Il Choi, Ye Jin Ahn, Hae Ri Yum, and Shin Hae Park
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Male ,0301 basic medicine ,medicine.medical_specialty ,Refractive error ,Corneal endothelium ,Intraocular pressure ,Visual acuity ,Adolescent ,genetic structures ,Visual Acuity ,Cell Count ,Fundus (eye) ,Astigmatism ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,Vision test ,Child ,Intraocular Pressure ,Retrospective Studies ,Corneal Dystrophies, Hereditary ,Slit Lamp ,business.industry ,Vision Tests ,Endothelium, Corneal ,medicine.disease ,eye diseases ,Posterior polymorphous corneal dystrophy ,030104 developmental biology ,Child, Preschool ,030221 ophthalmology & optometry ,Female ,sense organs ,medicine.symptom ,business ,Optometry - Abstract
PURPOSE To describe clinical features in children diagnosed with posterior polymorphous corneal dystrophy (PPCD) in their first or second decade of life. METHODS A retrospective study was performed with the medical records of seven unrelated Korean pediatric patients who were diagnosed with PPCD and were followed up for a minimum of 3 years. Thorough ocular examinations were performed, including best-corrected visual acuity, intraocular pressure, refractive and keratometric measurements, slit-lamp biomicroscopy, and specular microscopy at all visits. RESULTS Slit-lamp examinations revealed vesicular lesions in one patient and horizontally parallel band-like endothelial lesions in six patients. Unilateral corneal involvement was displayed in 4 patients, yielding 10 eyes with deep corneal features characteristic of PPCD. Other corneal, iris, or fundus pathologic findings were not detected in all cases. Among four children who were examined in their visual development (approximately under 8 years of age), two cases demonstrated unilateral amblyopia at initial examination and exhibited improved visual acuity after refractive correction and occlusion therapy. Astigmatism more than 1.5D, which is generally considered amblyogenic, was found in 8 among 10 PPCD-affected eyes. A final visual acuity of more than 20/32 was achieved with appropriate refractive correction in all PPCD-affected eyes. There was a negative correlation between the corneal astigmatism and the mean endothelial cell density (ECD) (r = -0.655, P = .011). Initial specular microscopic examinations revealed reduced ECD (1733.0 ± 543.9 cells/mm) composed of enlarged cells (average cell area, 624.8 ± 182.1 μm/cell) in PPCD-affected eyes, compared with those in PPCD-unaffected eyes from our study subjects (P < .001 and P = .005, respectively). A statistically significant percent loss in ECD from initial to 3 years was noted in the PPCD-affected eyes (P = .03). CONCLUSIONS The awareness and treatment of refractive error are important, especially in children with early-onset PPCD during the reversible period of amblyopia. Long-term monitoring of corneal endothelium is required in pediatric patients with early-onset PPCD based on a significant endothelial loss over 3 years in PPCD-affected eyes.
- Published
- 2017
15. A Study on Success Model of Broadband convergence Network for rural area
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Chang-Kyo Suh and Sun-Young Shin
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Computer science ,business.industry ,Broadband ,Is success model ,Convergence (relationship) ,Rural area ,Digital divide ,Telecommunications ,business ,Computer network - Published
- 2017
16. Clinical features of posterior microphthalmos associated with papillomacular fold and high hyperopia
- Author
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Sun Young Shin, Ye Jin Ahn, Shin Hae Park, and Young Chun Lee
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Optic Disk ,Optic disk ,Audiology ,03 medical and health sciences ,0302 clinical medicine ,Retinal Diseases ,Macula Lutea ,Ophthalmology ,medicine ,Humans ,Microphthalmos ,Retrospective Studies ,business.industry ,Eye Diseases, Hereditary ,medicine.disease ,Hyperopia ,030104 developmental biology ,Child, Preschool ,030221 ophthalmology & optometry ,Female ,business ,Esotropia ,Tomography, Optical Coherence ,Optometry - Abstract
The aim was to evaluate the characteristic clinical features of posterior microphthalmos.Medical records of four patients (eight eyes) between the ages of three and 31 years with posterior microphthalmos were reviewed retrospectively. Thorough ocular examinations were performed, including visual acuity, intraocular pressure, ocular alignment, axial length, cycloplegic refraction, slitlamp biomicroscopy of the anterior segment and fundus and spectral-domain optical coherent tomography (SD-OCT).All subjects had presented with high hyperopia (+11.0 to +15.75 D) and retinal papillomacular folds in both eyes. They also had reduced bilateral axial length (15.55-18.61 mm), with foreshortening of the posterior segment and a relatively normal anterior segment. Papillomacular retinal folds involving the inner retinal layers and sparing the outer retinal layers, along with the absence of foveal depression, were confirmed by macular SD-OCT. In three patients, we found esodeviations associated with posterior microphthalmos and one of these required strabismic surgery. Concomitant optic nerve hypoplasia and a newly-developed neurosensory retinal detachment were found in one patient.Posterior microphthalmos is a developmental arrest of ocular growth. In addition to high hyperopia and retinal papillomacular folds, various types of esotropia, optic disc hypoplasia and neurosensory retinal detachment may accompany posterior microphthalmos. In particular, children with posterior microphthalmos require early appropriate management of the high refractive error and resultant esotropia.
- Published
- 2016
17. Genotypic and phenotypic characteristics of Korean children with childhood-onset Leber's hereditary optic neuropathy
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Shin Hae Park, Yooyeon Park, Ye Jin Ahn, Myungshin Kim, Sun Young Shin, and Hyojin Chae
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medicine.medical_specialty ,Visual acuity ,genetic structures ,Visual Acuity ,Optic Atrophy, Hereditary, Leber ,DNA, Mitochondrial ,Optic neuropathy ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Atrophy ,Interquartile range ,Ophthalmology ,Republic of Korea ,medicine ,Humans ,Subclinical infection ,medicine.diagnostic_test ,business.industry ,Fundus photography ,Leber's hereditary optic neuropathy ,medicine.disease ,eye diseases ,Sensory Systems ,Mutation ,030221 ophthalmology & optometry ,Optic nerve ,medicine.symptom ,Visual Fields ,business ,030217 neurology & neurosurgery - Abstract
We sought to identify the phenotypic and genotypic characteristics of Korean children with genetically confirmed Leber’s hereditary optic neuropathy (LHON). The medical records of 64 genetically confirmed LHON patients were reviewed. Seventeen patients aged 13 years or younger with optic atrophy with positive mitochondrial DNA (mtDNA) mutations were considered to demonstrate childhood-onset LHON. The non-childhood-onset group included 47 patients with genetically confirmed LHON who experienced disease onset later than 13 years of age. The type of mtDNA mutation, visual acuity (VA), color vision, fundus photography, retinal nerve fiber layer (RNFL) thickness, and visual field were investigated. Sequence analysis of the mitochondrial genome revealed five different kinds of LHON-associated mtDNA mutations among our childhood-onset patients, including m.11778G>A (58.8%), m.3496G>T (11.8%), m.3497C>T (5.9%), m.11696G>A (5.9%), and m.14502T>C (5.9%). The mean final best-corrected VA in the childhood-onset group was better than that in the non-childhood-onset group with the value of logMAR 0.29 (0.09–0.75) vs. 0.55 (0.27–1.29) (expressed as median (interquartile range); p = 0.05). Spontaneous visual recovery was observed in 35.3% of the childhood-onset group but in only 12.8% of the non-childhood-onset group (p = 0.04). Eight patients (47.1%) showed interocular asymmetry of the disease, with two presenting true unilateral involvement of the optic nerve and the other six patients demonstrating unilateral subclinical manifestations with bilateral optic atrophy. Involvement of secondary mitochondrial mutations was confirmed in patients with childhood-onset LHON. Characteristic clinical features of childhood-onset LHON included a higher proportion of subacute or insidious onset of symptoms, better VA, higher spontaneous recovery, and asymmetrical ocular involvement.
- Published
- 2019
18. Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients
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Ji-Sun Moon and Sun Young Shin
- Subjects
Adenoma ,Male ,Retinal Ganglion Cells ,medicine.medical_specialty ,genetic structures ,Nerve fiber layer ,Outer plexiform layer ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,Ophthalmology ,Optic Nerve Diseases ,medicine ,Humans ,Pituitary Neoplasms ,Outer nuclear layer ,Ganglion cell layer ,Retrospective Studies ,Retinal pigment epithelium ,business.industry ,Retinal ,Optic Nerve ,Middle Aged ,Inner plexiform layer ,eye diseases ,Sensory Systems ,medicine.anatomical_structure ,chemistry ,Optic Chiasm ,Inner nuclear layer ,030221 ophthalmology & optometry ,Female ,sense organs ,business ,030217 neurology & neurosurgery ,Tomography, Optical Coherence ,Follow-Up Studies - Abstract
To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function. A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer. The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004
- Published
- 2019
19. Surgical and sensory outcomes in patients with intermittent exotropia according to preoperative refractive error
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Shin Hae Park, Yeon Woong Chung, Yoo Yeon Park, Sun Young Shin, and Ye Jin Ahn
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Male ,Refractive error ,medicine.medical_specialty ,Visual acuity ,genetic structures ,Eye Movements ,Visual Acuity ,Emmetropia ,Sensory system ,Ophthalmologic Surgical Procedures ,Article ,03 medical and health sciences ,0302 clinical medicine ,Ophthalmology ,medicine ,Humans ,In patient ,Child ,Retrospective Studies ,Depth Perception ,business.industry ,Retrospective cohort study ,medicine.disease ,Refractive Errors ,eye diseases ,Stereoscopic acuity ,Oculomotor Muscles ,Child, Preschool ,Preoperative Period ,030221 ophthalmology & optometry ,Exotropia ,Female ,medicine.symptom ,business ,Intermittent exotropia ,030217 neurology & neurosurgery - Abstract
BACKGROUND/OBJECTIVES: To analyze the surgical and sensory outcomes of intermittent exotropia according to refractive errors and the factors associated with surgical success. SUBJECTS/METHODS: A total of 326 children were divided into three groups according to preoperative refractive error; hyperopic eyes with SE ≥+2D (hyperopic group), eyes with SE between −1D and +2D (emmetropic group), and myopic eyes with SE ≤−1D (myopic group). The surgical outcomes and the sensory outcomes measured by near and distant stereoacuity were compared among the three groups. RESULTS: The surgical success rate in hyperopic group was significantly lower compared to myopic group at last follow-up (P = 0.012). Preoperative near stereopsis was not different among three groups, however, the distance stereopsis was significantly deteriorated in the hyperopic group compared to the other two groups (Titmus; P = 0.168, FD2; P
- Published
- 2019
20. Detailed Anatomy of the Lateral Rectus Muscle-Superior Rectus Muscle Band
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Yooyeon Park, In-Beom Kim, Sun Young Shin, and Yong Seok Nam
- Subjects
genetic structures ,Article Subject ,Attachment site ,Lacrimal gland ,01 natural sciences ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Cadaver ,medicine ,0101 mathematics ,business.industry ,010102 general mathematics ,Rectus muscle ,Lateral rectus muscle ,Anatomy ,eye diseases ,Ophthalmology ,medicine.anatomical_structure ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,Ligament ,sense organs ,business ,Research Article ,Superior rectus muscle - Abstract
Background. To elucidate the detailed anatomy of the lateral rectus muscle-superior rectus muscle (LR-SR) band by cadaver eye investigation. Methods. In total, 48 eyes of 24 cadavers were observed macroscopically. The lateral rectus muscle (LRM) and superior rectus muscle (SRM) were dissected from their origins to their insertions under the dissecting microscope, and the location, width, length, and tensile strength of the LR-SR bands were measured. Results. The LR-SR band is the thick ligament interconnecting LRM pulleys with SRM pulleys. The LR-SR band was covered by the orbital part of the lacrimal gland superiorly, and the intermuscular septum between the LRM and SRM was shown anterior to the LR-SR band. The length of the attachment site between the LR-SR band and the SRM was less at 8.64 ± 1.52 mm (p=0.040), its thickness was thinner at 0.74 ± 0.16 mm (p=0.002), and its tensile strength was weaker at 7.64 ± 1.82 N (p=0.028) compared to the attachment site between the LR-SR band and the LRM. Conclusions. This study revealed the detailed anatomy of the LR-SR band and provided helpful information to understand heavy eye syndrome and sagging eye syndrome.
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- 2019
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21. Long term change of the optic disc and OCT parameters during myopic shift in children with large cup to disc ratio
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Sun Young Shin, Yoo Yeon Park, Ye Jin Ahn, and Shin Hae Park
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Male ,0301 basic medicine ,Refractive error ,Time Factors ,Eye Diseases ,genetic structures ,Nerve fiber layer ,Glaucoma ,Cup-to-disc ratio ,Pathology and Laboratory Medicine ,Diagnostic Radiology ,chemistry.chemical_compound ,Nerve Fibers ,0302 clinical medicine ,Animal Cells ,Medicine and Health Sciences ,Myopia ,Peripapillary atrophy ,Child ,Tomography ,Neurons ,Visual Impairments ,Multidisciplinary ,Radiology and Imaging ,Organ Size ,medicine.anatomical_structure ,Medicine ,Female ,Anatomy ,Cellular Types ,Tomography, Optical Coherence ,Research Article ,Optic disc ,medicine.medical_specialty ,Ganglion Cells ,Imaging Techniques ,Ocular Anatomy ,Science ,Optic Disk ,Research and Analysis Methods ,Optic Disc ,03 medical and health sciences ,Signs and Symptoms ,Ocular System ,Diagnostic Medicine ,Ophthalmology ,medicine ,Humans ,business.industry ,Significant difference ,Biology and Life Sciences ,Retinal ,Cell Biology ,medicine.disease ,eye diseases ,030104 developmental biology ,chemistry ,Cellular Neuroscience ,Case-Control Studies ,030221 ophthalmology & optometry ,Eyes ,sense organs ,Atrophy ,business ,Head ,Neuroscience - Abstract
PurposeThis observational case series was to determine long term optic disc changes in eyes with large cup to disc ratio (CDR) and compare the changes induced by myopic shift during childhood with normal control eyes.MethodsChildren under 15 years of age who developed myopia with serial optic disc photographs and spectral domain (SD)-optical coherence tomography (OCT) images with a minimal interval of three years were evaluated. Children with average CDR ≥ 0.6 on SD-OCT were classified as having large CDR. The ratios of vertical disc diameter (VDD), horizontal disc diameter (HDD), and maximum peripapillary atrophy (PPA) width (PPW) were measured to quantify morphologic changes of optic discs and SD-OCT parameters, such as peripapillary retinal nerve fiber layer (RNFL) thickness and macular ganglion cell and inner plexiform layer (GCIPL) thickness were measured.ResultsOf the 82 eyes (82 patients) analyzed, 42 eyes had large CDR and 40 eyes were normal controls. The mean age and refractive error at initial examination were not different between groups (P = 0.33, P = 0.76, respectively). The changes in HDD/VDD and PPW/VDD ratios during follow-up showed no significant difference among the groups (P = 0.45, P = 0.62, respectively). No statistical significance was found in changes in RNFL and GCIPL thickness between the two groups (P = 0.74, P = 0.79, respectively).ConclusionsChildren with enlarged CDR showed changes in optic disc morphology and RNFL/GCIPL thickness similar to normal children during myopic shift.
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- 2020
22. The diluted atropine for inhibition of myopia progression in Korean children
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Sun Young Shin and Ji-Sun Moon
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medicine.medical_specialty ,Photophobia ,genetic structures ,atropine ,Logistic regression ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Korean children ,lcsh:Ophthalmology ,Clinical Research ,Internal medicine ,medicine ,myopia ,Adverse effect ,Dioptre ,business.industry ,Incidence (epidemiology) ,Odds ratio ,Confidence interval ,eye diseases ,Ophthalmology ,Atropine ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,progression ,medicine.symptom ,business ,030217 neurology & neurosurgery ,medicine.drug - Abstract
AIM: To evaluate the efficacy and safety of three different concentrations of diluted atropine for the control of myopia in Korean children, and to assess the risk factors associated with rapid myopia progression. METHODS: A total of 285 children, with refractive errors within the range of -6 diopters (D) between 5 and 14 years of age were included. After using 0.01%, or 0.025%, or 0.05% atropine, for about 1y, changes in refraction, axial lengths and frequency of adverse events were analyzed. Logistic regression analyses were performed to evaluate the risk factors associated with rapid myopia progression. RESULTS: The changes in the mean spherical equivalent values were -0.134 D/mo in the before atropine group, -0.070 D/mo in the 0.01% atropine group, -0.047 D/mo in the 0.025% atropine group, and -0.019 D/mo in the 0.05% atropine group, with significant differences between the groups (P
- Published
- 2018
23. Expression of MyoD, insulin like growth factor binding protein, thioredoxin and p27 in secondarily overacting inferior oblique muscles with superior oblique palsy
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Sun Young Shin, Jun Sub Choi, and Yeon Woong Chung
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,Extraocular muscles ,MyoD ,medicine.disease_cause ,Insulin-like growth factor-binding protein ,Superior oblique palsy ,03 medical and health sciences ,Ocular Motility Disorders ,Thioredoxins ,lcsh:Ophthalmology ,Western blot ,Internal medicine ,medicine ,Humans ,Thioredoxin ,Inferior oblique muscle overaction ,Aged ,MyoD Protein ,Palsy ,medicine.diagnostic_test ,biology ,business.industry ,p27 ,General Medicine ,Middle Aged ,Immunohistochemistry ,Trochlear Nerve Diseases ,Ophthalmology ,030104 developmental biology ,Endocrinology ,medicine.anatomical_structure ,lcsh:RE1-994 ,Oxidative stress ,Oculomotor Muscles ,Case-Control Studies ,biology.protein ,Female ,business ,Cell activation ,Insulin-Like Growth Factor Binding Protein 5 ,Cyclin-Dependent Kinase Inhibitor p27 ,Research Article - Abstract
Backgound To identify and compare specific protein levels between overacting inferior oblique (IO) muscles in superior oblique (SO) palsy patients and normal IO muscles. Methods We obtained 20 IO muscle samples from SO palsy patients with IO overaction ≥ + 3 who underwent IO myectomies (IOOA group), and 20 IO samples from brain death donors whose IO had functioned normally, according to their ophthalmological chart review (control group). We used MyoD for identifying satellite cell activation, insulin-like growth factor binding protein 5 (IGFBP5) for IGF effects, thioredoxin for oxidative stress, and p27 for satellite cell activation or oxidative stress in both groups. Using immunohistochemistry and Western blot, we compared expression levels of the four proteins (MyoD, IGFBP5, thioredoxin, and p27). Results Levels of thioredoxin and p27 were decreased significantly in the IOOA group. MyoD and IGFBP5 levels showed no significant difference between the groups. Conclusions Based on these findings, the overacting IOs of patients with SO palsy had been under oxidative stress status versus normal IOs. Pathologically overacting extraocular muscles may have an increased risk of oxidative stress compared with normal extraocular muscles.
- Published
- 2018
24. The effect of parental factors in children with large cup-to-disc ratios
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Min Ji Ha, Hae-Young Lopilly Park, and Sun Young Shin
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Male ,Intraocular pressure ,Eye Diseases ,Optic disk ,lcsh:Medicine ,Glaucoma ,Spherical equivalent ,Diagnostic Radiology ,Families ,0302 clinical medicine ,Nerve Fibers ,Animal Cells ,Medicine and Health Sciences ,030212 general & internal medicine ,lcsh:Science ,Child ,Children ,Tomography ,Neurons ,Multidisciplinary ,Radiology and Imaging ,Pedigree ,medicine.anatomical_structure ,Child, Preschool ,Female ,Anatomy ,Cellular Types ,Optic disc ,Research Article ,medicine.medical_specialty ,Imaging Techniques ,Ocular Anatomy ,Optic Disk ,chemical and pharmacologic phenomena ,Research and Analysis Methods ,Optic Disc ,03 medical and health sciences ,Ocular System ,Diagnostic Medicine ,Ophthalmology ,mental disorders ,medicine ,Genetics ,Humans ,Intraocular Pressure ,business.industry ,lcsh:R ,Biology and Life Sciences ,Human Genetics ,Cell Biology ,medicine.disease ,Cross-Sectional Studies ,Age Groups ,Cellular Neuroscience ,Case-Control Studies ,People and Places ,030221 ophthalmology & optometry ,Eyes ,lcsh:Q ,Population Groupings ,business ,Head ,Neuroscience - Abstract
Background To investigate large cup-to-disc ratios (CDR) in children and to determine the relationship between parental CDR and clinical characteristics associated with glaucoma. Methods Two hundred thirty six children aged 6 to 12 years with CDR ≥ 0.6 were enrolled in this study. Subjects were classified into two groups based on parental CDR: disc suspect children with disc suspect (CDR ≥0.6) parents and disc suspect children without disc suspect parents. Ocular variables were compared between the two groups. Results Of the 236 disc suspect children, 100 (42.4%) had at least one disc suspect parent. Intraocular pressure (IOP) was higher in disc suspect children with disc suspect parents (16.52±2.66 mmHg) than in disc suspect children without disc suspect parents (14.38±2.30 mmHg, p = 0.023). In the group with disc suspect parents, vertical CDR significantly correlated with IOP (R = -0.325, p = 0.001), average retinal nerve fiber layer (RNFL) thickness (R = -0.319, p = 0.001), rim area (R = -0.740, p = 0.001), and cup volume (R = 0.499, p = 0.001). However, spherical equivalent (R = 0.333, p = 0.001), AL (R = -0.223, p = 0.009), and disc area (R = 0.325, p = 0.001) significantly correlated with vertical CDR in disc suspect children without disc suspect parents, in contrast to those with disc suspect parents. Larger vertical CDR was associated with the presence of disc suspect parents (p = 0.001), larger disc area (p = 0.001), thinner rim area (p = 0.001), larger average CDR (p = 0.001), and larger cup volume (p = 0.021). Conclusions and relevance Family history of large CDR was a significant factor associated with large vertical CDR in children. In children with disc suspect parents, there were significant correlations between IOP and average RNFL thickness and vertical CDR.
- Published
- 2017
25. Effects of the Rho-Kinase Inhibitor Y-27632 on Extraocular Muscle Surgery in Rabbits
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Sun Young Shin, Ji-Sun Moon, and Hyun Kyung Kim
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Conjunctiva ,Article Subject ,medicine.medical_treatment ,Adhesion (medicine) ,Inflammation ,Extraocular muscles ,03 medical and health sciences ,lcsh:Ophthalmology ,Fibrosis ,medicine ,Saline ,business.industry ,medicine.disease ,eye diseases ,Surgery ,Ophthalmology ,030104 developmental biology ,medicine.anatomical_structure ,Rho kinase inhibitor ,lcsh:RE1-994 ,Anesthesia ,sense organs ,medicine.symptom ,business ,Superior rectus muscle ,Research Article - Abstract
Purpose. To evaluate the effect of the Rho-kinase inhibitor Y-27632 on postoperative inflammation and adhesion following extraocular muscle surgery in rabbits.Methods. The superior rectus muscle reinsertion was performed on both eyes of 8 New Zealand white rabbits. After reinsertion, the rabbits received subconjunctival injections of the Rho-kinase inhibitor and saline on each eye. To assess acute and late inflammatory changes, Ki-67, CD11β+, and F4/80 were evaluated and the sites of muscle reattachment were evaluated for a postoperative adhesion score and histopathologically for collagen formation.Results. F4/80 antibody expression was significantly different in the Rho-kinase inhibitor-injected group at both postoperative day 3 and week 4 (p=0.038, 0.031). However, Ki-67 and CD11β+ were not different the between two groups. The difference in the SRM/conjunctiva adhesion score between the two groups was also significant (p=0.034). Conclusion. Intraoperative subconjunctival injection of the Rho-kinase inhibitor may be effective for adjunctive management of inflammation and fibrosis in rabbit eyes following extraocular muscle surgery.
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- 2017
26. Pathogenic Mitochondrial DNA Mutations and Associated Clinical Features in Korean Patients With Leber's Hereditary Optic Neuropathy
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Shin Hae Park, Myungshin Kim, Hae Ri Yum, Sun Young Shin, Hyojin Chae, and Yonggoo Kim
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Male ,medicine.medical_specialty ,Mitochondrial DNA ,Visual acuity ,genetic structures ,Visual Acuity ,Optic Atrophy, Hereditary, Leber ,medicine.disease_cause ,DNA, Mitochondrial ,Gastroenterology ,Optic neuropathy ,Cellular and Molecular Neuroscience ,Nerve Fibers ,Atrophy ,Asian People ,Internal medicine ,Republic of Korea ,Humans ,Medicine ,Genetic Predisposition to Disease ,Aged ,Mutation ,Homoplasmy ,business.industry ,Leber's hereditary optic neuropathy ,Sequence Analysis, DNA ,Middle Aged ,medicine.disease ,eye diseases ,Sensory Systems ,Heteroplasmy ,Ophthalmology ,Female ,Visual Fields ,medicine.symptom ,business ,Color Perception - Abstract
Purpose To identify the spectrum of pathogenic mitochondrial DNA (mtDNA) mutations and clinical features in Korean patients with genetically confirmed Leber's hereditary optic neuropathy (LHON). Methods The medical records of 34 unrelated, genetically confirmed LHON patients were reviewed. Total genomic DNA was isolated from the peripheral blood leukocytes of the patients with suspected LHON, and primary or secondary mtDNA mutations were identified by direct sequencing. We analyzed the visual acuity (VA), color vision, RNFL thickness, and visual field (VF) at the final visit from 20 patients who were followed-up for more than 6 months after the onset of LHON. Results Among 34 patients, 21 (61.8%) had the homoplasmic primary mutation, 11 (32.4%) had the homoplasmic secondary mutation, and 2 (5.9%) had the heteroplasmic primary mutation along with the homoplasmic secondary mutation. Analysis of mtDNA sequences revealed six different types of LHON-associated mutations: two primary LHON-associated primary mutations, m.11778G>A (20 patients, 58.8%) and m.14484T>C (3 patients, 8.8%), and four secondary LHON-associated mutations, which were m.3394T>C (3 patients, 8.8%), m.3497C>T (4 patients, 11.8%), m.11696G>A (4 patients, 11.8%), and m.14502T>C (2 patients, 5.9%). Secondary mutation-carrying patients demonstrated a decreased in RNFL thickness, similar to those in primary mutation-carrying LHON patients. These patients had a higher female ratio (P = 0.019), better VA (P = 0.043) and color vision (P = 0.005), as well as better VF. Conclusions In addition to common primary LHON-associated mutations, our study identified secondary mtDNA mutations, which should be considered when evaluating patients with optic atrophy.
- Published
- 2014
27. Change in the antioxidative capacity of extraocular muscles in patients with exotropia
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Su Kyung Jung, Jun Sob Choi, and Sun Young Shin
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,genetic structures ,Blotting, Western ,SOD1 ,Nitric Oxide Synthase Type I ,Extraocular muscles ,medicine.disease_cause ,Antioxidants ,Lipofuscin ,Superoxide dismutase ,Cellular and Molecular Neuroscience ,Superoxide Dismutase-1 ,Internal medicine ,medicine ,Humans ,Strabismus ,biology ,Superoxide Dismutase ,business.industry ,Middle Aged ,Catalase ,medicine.disease ,Tissue Donors ,eye diseases ,Sensory Systems ,Oxidative Stress ,Ophthalmology ,medicine.anatomical_structure ,Endocrinology ,Oculomotor Muscles ,biology.protein ,Exotropia ,Female ,sense organs ,business ,Oxidative stress - Abstract
We compared the oxidative stress and antioxidant capacities of the medial rectus muscles (MRMs) between the patients with constant exotropia and control subjects. A total of 40 MRMs from patients with constant exotropia and 40 MRMs from normal donor eyes (controls) were assessed. Neuronal nitric oxide synthase (nNOS), superoxide dismutase (SOD), and catalase levels were compared between the two groups using western blot analysis. In addition, the lipofuscin accumulation level was compared between the exotropic and control groups. According to western blot analysis, the nNOS level was significantly higher in the exotropic group than in the control group (P
- Published
- 2014
28. Life-Threatening Acute Fulminant Myocarditis Following a Coffee Diet Program
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Hee Kyung Kim, Jung-Hyun Kim, Kyu Hyun Han, Eunkyung Kim, Hye Cheol Jeong, Sun Young Shin, Bo Hye Kim, Hak Su Kim, and Ji Hyun Lee
- Subjects
toxoids ,medicine.medical_specialty ,Myocarditis ,Medical treatment ,business.industry ,Fulminant ,medicine.medical_treatment ,coffee ,lcsh:Medical emergencies. Critical care. Intensive care. First aid ,Disease ,lcsh:RC86-88.9 ,extracorporeal membrane oxygenation ,medicine.disease ,Internal medicine ,medicine ,Extracorporeal membrane oxygenation ,Cardiology ,Hemodynamic stability ,myocarditis ,Intensive care medicine ,business - Abstract
Myocarditis is an inflammatory disease of the myocardium caused by various infectious or noninfectious triggers. Although viral infections are important causes of myocarditis, some drugs or toxins can also cause myocarditis. We report a case of life-threatening fulminant myocarditis which followed an extensive coffee diet program. Despite medical treatment, the patient was not able to maintain hemodynamic stability. She was supported by extracorporeal membrane oxygenation and completely recovered 3 months later.
- Published
- 2014
29. Changes in axial length in accommodative esotropia patients with minimal hyperopic correction
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Ye Jin Ahn, Shin Hae Park, and Sun Young Shin
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Male ,Refractive error ,Visual acuity ,genetic structures ,Vision ,Visual Acuity ,Social Sciences ,Spherical equivalent ,Pediatrics ,Severity of Illness Index ,Cornea ,Families ,Negative shift ,Ocular physiology ,Child Development ,Medicine and Health Sciences ,Psychology ,Case Series ,Child ,Children ,Eye Lens ,Esotropia ,Multidisciplinary ,Accommodation, Ocular ,Axial length ,Axial Length, Eye ,Eyeglasses ,Hyperopia ,Optical Equipment ,Research Design ,Child, Preschool ,Engineering and Technology ,Medicine ,Sensory Perception ,Female ,Anatomy ,medicine.symptom ,Research Article ,medicine.medical_specialty ,Clinical Research Design ,Ocular Anatomy ,Science ,Equipment ,Accommodative esotropia ,Research and Analysis Methods ,Refraction, Ocular ,Ocular System ,Ophthalmology ,medicine ,Humans ,Retrospective Studies ,business.industry ,Biology and Life Sciences ,Prisms ,medicine.disease ,eye diseases ,Age Groups ,People and Places ,Eyes ,Population Groupings ,sense organs ,business ,Head ,Neuroscience ,Follow-Up Studies - Abstract
Purpose To compare the changes of spherical equivalent refractive error (SER) and axial length (AL) for three years in hyperopic children with minimal undercorrection according to the presence of accommodative esotropia (AE). Methods A total of 67 hyperopic children were enrolled. The patients were divided into 3 groups and matched by initial age upon examination; esotropic eyes with AE (AE group), fellow eyes with AE (FE group), and right eyes without esotropia (HE group). Changes of SER and AL were serially measured every six months for three years and collected data were compared among the groups. Results All three groups underwent significant myopic shift and AL elongation during the follow-up period. However, the least amount of change was found in the AE group. The AE group (-0.96 ± 1.38D) exhibited significantly less change in SER compared to the HE group (-1.76 ± 1.11D) and the FE group (-1.57 ± 1.33D) (both p
- Published
- 2019
30. Rathke cleft cyst presenting as unilateral progressive oculomotor nerve palsy
- Author
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Jinhee Jang, Hae Ri Yum, Sun Young Shin, and Shin Hae Park
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Ophthalmology ,business.industry ,medicine ,General Medicine ,Anatomy ,Rathke cleft cyst ,Oculomotor nerve palsy ,medicine.disease ,business - Published
- 2015
31. Developing a framework for using E-portfolios as a research and assessment tool
- Author
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Sun-Young Shin
- Subjects
Linguistics and Language ,Context effect ,Computer science ,business.industry ,Comprehension approach ,computer.software_genre ,Second-language acquisition ,Language and Linguistics ,Computer Science Applications ,Education ,Interlanguage ,Language assessment ,Written language ,Language proficiency ,Artificial intelligence ,business ,Language industry ,computer ,Natural language processing ,Cognitive psychology - Abstract
As Tarone (1998) stated, an understanding of interlanguage variation in relation to contextual changes has been a key issue in both second language acquisition (SLA) and language assessment (LA) research. Research on interlanguage variation has shown that systematic variation is often evidenced when different phonological and syntactic forms are examined across contexts. Such systematic variation has raised important questions about the distinction between competence and performance, and generalizability of results beyond the research elicitation tasks or test tasks in SLA and LA research. However, most previous studies that have examined this issue are based on cross-sectional data with a focus on between-group differences rather than within-individual differences across different contexts. Such limited data often make it difficult for researchers to understand individual developmental trends in interlanguage as well as to interpret context effects on the learner's spoken and written language data. Electronic (E)-portfolios may address this limitation by serving as a valuable research and assessment tool for collecting and storing an individual learner's language samples obtained across different tasks over time. The technology may also enhance the situational and interactional authenticity of tasks by including multi-media input and constructed response tasks. However, it is not clear how tasks in E-portfolios can be constructed to represent various linguistic and situational contexts, and how they could be systematically evaluated and scored. In that vein, this article addresses a number of limitations of existing E-portfolios as a research and assessment tool, and offers recommendations and suggestions for future research.
- Published
- 2013
32. Unilateral lateral rectus advancement with medial rectus recession vs bilateral medial rectus recession for consecutive esotropia
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Shin Hae Park, Sun Young Shin, Hyun Kyung Kim, and Youn Hea Jung
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,Bilateral medial rectus recession ,Visual Acuity ,Ophthalmologic Surgical Procedures ,Lateral rectus advancement ,Medial rectus recession ,Cellular and Molecular Neuroscience ,Esophoria ,medicine ,Humans ,Child ,Retrospective Studies ,Vision, Binocular ,Exophoria ,Esotropia ,business.industry ,medicine.disease ,eye diseases ,Sensory Systems ,Surgery ,Ophthalmology ,Treatment Outcome ,Consecutive esotropia ,Oculomotor Muscles ,Female ,sense organs ,business ,Exotropia ,Strabismus surgery - Abstract
To compare unilateral lateral rectus (LR) advancement with medial rectus (MR) recession with bilateral MR recession for patients with consecutive esotropia (ET) Twenty-nine patients who developed consecutive ET of 30–35 PD following bilateral LR recession for intermittent exotropia were retrospectively reviewed. LR advancement into the original insertion site with 4.5 mm (30 PD ET) and 5.0 mm (35 PD ET) MR recession in the chiefly deviating eye was performed in 14 patients (A&R group). For 15 patients (BMR group), 4.5 and 5.0 mm bilateral MR recession was performed for 30 and 35 PD esodeviation respectively. As the primary outcome measure, postoperative ocular alignment between 5 PD of esophoria and 10 PD exophoria was considered a success. At 12 months postoperatively, successful surgical outcome was noticed in 12 patients (85.7 %) in the A&R group and 11 patients (73.3 %) in the BMR group. There was no statistically significant difference of final success rate between the A&R group and BMR group (p = 0.411). At 12 months after surgery for consecutive ET, seven (50 %) and eight patients (53.3 %) acquired binocular fine stereopsis ≤100 s of arc in the A&R and BMR groups respectively Advancement of the previously recessed LR with recession of the MR in the chiefly deviating eye has a high success rate comparable to that of bilateral MR recession, with the advantage of preserving one MR muscle for potential future intervention.
- Published
- 2012
33. EVALUATION OF BROADBAND INTERNET SERVICE FOR RURAL AREAS IN KOREA
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Chang-Kyo Suh and Sun-Young Shin
- Subjects
Service (business) ,Service quality ,business.product_category ,business.industry ,Broadband ,Internet access ,The Internet ,Rural area ,Service provider ,business ,Telecommunications ,Digital divide - Abstract
Although according to the 2015 OECD survey South Korea ranks number one in broadband internet service in the world, the rural areas in South Korea still lack the enough internet infrastructure to access the national backbone network effectively. Because of the economic feasibility the internet service providers are reluctant to install the broadband internet for the rural areas where less than 50 households live. Recently South Korea has invested lots of efforts to provide broadband access to the rural areas to overcome the digital divide. In this research, to evaluate the performance of broadband internet service for rural areas in South Korea we develop the empirical model based on the information systems success model. Then, we collect the questionnaires from the subscribers who have used the broadband internet service since 2013. Finally, the structural equation model validates the causal relationship between system and/or service quality and performance. The major findings and suggestion for further research will be discussed in the conference in details.
- Published
- 2016
34. Effects of an Anti-transforming Growth Factor-β Agent (Pirfenidone) on Strabismus Surgery in Rabbits
- Author
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Jun-Sub Choi, Hyun Kyung Kim, Sun Young Shin, and Kyoung In Jung
- Subjects
medicine.medical_specialty ,Pathology ,Pyridones ,medicine.medical_treatment ,Masson's trichrome stain ,Cellular and Molecular Neuroscience ,Postoperative Complications ,Transforming Growth Factor beta ,Fibrosis ,Ophthalmology ,medicine ,Animals ,Inflammation ,Wound Healing ,business.industry ,Growth factor ,Anti-Inflammatory Agents, Non-Steroidal ,Pirfenidone ,medicine.disease ,Sensory Systems ,Strabismus ,Disease Models, Animal ,Oculomotor Muscles ,Toxicity ,Rabbits ,Wound healing ,business ,Follow-Up Studies ,Superior rectus muscle ,medicine.drug ,Strabismus surgery - Abstract
To evaluate the usefulness of an anti-transforming growth factor-β (TGF-β) agent, pirfenidone (PFD) on postoperative inflammation and fibrosis following strabismus surgery in rabbits.Both eyes of 16 New Zealand white rabbits underwent reinsertion of the superior rectus muscle (SRM). After reinsertion of the SRM, PFD-loaded liposomes (0.5 mg/ml) were injected into the right eye (PFD group) and normal saline-loaded liposomes was injected into the left eye (control group), subconjunctivally (0.4 ml). To assess the postoperative inflammatory changes and fibrosis of the SRM, immunofluorescence staining with anti-CD11b antibody was performed at 3 days postoperatively, and Masson's trichrome staining was performed at 4 weeks postoperatively. To evaluate the toxicity of PFD on muscle fibers, the integrity of the muscle fibers was examined by transmission electron microscopy (TEM) at 3 days and 4 weeks postoperatively.CD11b protein expression was significantly reduced in the PFD group compared with the control group at 3 days postoperatively (p = 0.012). Masson trichrome staining, which stains collagen, was diminished in the PFD group at 4 weeks postoperatively. TEM revealed disorganized muscle fibers and vacuoles in both groups, but this was less prominent in the PFD group.Intraoperative injection of PFD may be effective as an adjunctive treatment to decrease inflammation and fibrosis resulting from strabismus surgery.
- Published
- 2012
35. Detailed anatomy of the capsulopalpebral fascia
- Author
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Yong Seok Nam, Seung-Ho Han, and Sun Young Shin
- Subjects
Histology ,business.industry ,Eyelids ,General Medicine ,Anatomy ,Fascia ,Middle Aged ,Inferior rectus muscle ,medicine.anatomical_structure ,Inferior oblique muscle ,Oculomotor Muscles ,Cadaver ,medicine ,Lower border ,Humans ,business ,Aged - Abstract
This study was designed to elucidate the detailed anatomy of the capsulopalpebral fascia (CPF) and capsulopalpebral head (CPH), and their relationships to the inferior rectus muscle (IRM). In this cohort study, 40 eyes from 20 cadavers were observed macroscopically. Dissection was carried out from the CPF origin to its insertion, and the CPF origin pattern was photographed in each specimen. The width, length, and tensile strength of the CPF were measured. The CPF originated 25.07 ± 1.07 mm laterally and 24.86 ± 1.10 mm medially from the origin of the IRM and extended to the lower border of the inferior oblique muscle, and it firmly adhered to the IRM surface and formed into the CPH. The CPH was 4.31 ± 0.86 mm laterally and 6.18 ± 1.94 mm medially in length and 7.47 ± 0.81 mm in width. The CPF originated from the total width or 3/4 temporal part of the IRM in 32 (80%) of 40 faces. There was asymmetry in the pattern of the CPF origin between the left and right eyes in 4 of 20 paired specimens (20%). The tensile strength of the posterior layer was 19.12 ± 11.22 N, which was significantly higher than that of the anterior layer (8.59 ± 3.88 N) (P = 0.001). This study provided a good understanding of the CPF structures conducive to performing IRM surgery. Clin. Anat. 25:709–713, 2012. © 2011 Wiley Periodicals, Inc.
- Published
- 2011
36. Strabismus following bilateral cataract surgery in childhood
- Author
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Shin Hae Park, Jung Hwa Na, and Sun Young Shin
- Subjects
Male ,medicine.medical_specialty ,genetic structures ,medicine.medical_treatment ,Visual Acuity ,Cataract Extraction ,Cataract ,Functional Laterality ,Postoperative Complications ,Lens Implantation, Intraocular ,Ophthalmology ,medicine ,Humans ,Strabismus ,Retrospective Studies ,business.industry ,Infant ,General Medicine ,Cataract surgery ,eye diseases ,Child, Preschool ,Female ,sense organs ,business - Abstract
To evaluate the clinical characteristics of strabismus in children undergoing bilateral cataract surgery.We retrospectively reviewed the medical records of 56 children undergoing bilateral cataract surgery who had no evidence of strabismus before the surgery and a difference of less than two Snellen lines in postoperative best-corrected visual acuity between the two eyes.Strabismus developed in 31 (55.4%) patients after cataract extraction. Age at the time of cataract diagnosis (P = 0.006) and extraction (P = 0.025) was significantly lower in the strabismus group than in the no-strabismus group. Exotropia (45.2%) was the prevalent type of strabismus, followed by esotropia (35.5%). Patients with cataracts extracted within the first 12 months of life comprised 51.6% of the strabismus group and 20% of the no-strabismus group (P = 0.026). Strabismus surgery was performed in 11 patients. In five aphakic patients with strabismus, the angle of deviation decreased significantly after secondary intraocular lens implantation, and strabismus surgery was not required.Strabismus is a frequent complication following bilateral cataract surgery in childhood. Children undergoing bilateral cataract surgery, especially at an early age, should be followed carefully for the development of strabismus.
- Published
- 2010
37. Is the Insertional Anatomy of Rectus Extraocular Muscles Binocularly Symmetrical?
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Hyun Kyung Cho and Sun Young Shin
- Subjects
Male ,Vision, Binocular ,genetic structures ,business.industry ,General Medicine ,Anatomy ,Middle Aged ,Extraocular muscles ,eye diseases ,Sensory Systems ,Cellular and Molecular Neuroscience ,Ophthalmology ,medicine.anatomical_structure ,Oculomotor Muscles ,Cadaver ,Humans ,Medicine ,Female ,sense organs ,business ,Orbit - Abstract
Purpose: This study was performed to examine the location, width, and insertional shape of rectus extraocular muscles (EOMs), and to elucidate the symmetry of the insertional anatomy of rectus EOMs in the left and right eyes. Methods: EOMs were dissected from their origin to the insertion point in 100 intact orbits of 50 cadavers. The width, location, and shape of 4 rectus EOMs insertions were measured. The insertional shapes were classified into 6 categories: straight, oblique, convex, oblique-convex, concave, and nonspecific types. Results: The most common types of insertional shapes were superior rectus muscle, oblique type (34%); inferior rectus muscle, oblique type (7%); lateral rectus muscle, concave type (41%); and medial rectus muscle, straight type (37%). The distance from the limbus to insertion and the width of rectus EOMs were almost symmetrical between the left and right eyes of the paired specimens. However, the insertional shapes were different in 46% of the superior rectus, 56% of the inferior rectus, 58% of the lateral rectus, and 46% of the medial rectus muscles. In a given individual, 49 individuals demonstrated asymmetric insertional shapes in at least 1 rectus EOM in both eyes. Conclusions: Ocular surgeons should consider the possibility of differences in the insertional shape of rectus EOMs between the left and right eyes, especially when performing rectus EOM recession.
- Published
- 2009
38. Structural equation model for effective CRM of information infrastructure industry in Korea
- Author
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Sun Young Shin, Tae Hee Moon, and So Young Sohn
- Subjects
Customer retention ,Service quality ,Knowledge management ,business.industry ,General Engineering ,Customer relationship management ,Computer Science Applications ,Customer advocacy ,Artificial Intelligence ,Customer equity ,Customer satisfaction ,Business ,Information infrastructure ,Customer intelligence - Abstract
In Korea, information infrastructure industry has been expanding its business. However, service level of information infrastructure has not reached the expected level of customers in the context of CRM (Customer Relationship Management) yet. In this paper, we develop a structural equation model for Customer Satisfaction Index (CSI) to measure the quality level of information infrastructure reflecting the aspects of information infrastructure industry. Then, we compare the KII (Korea Information Infrastructure) satisfaction Indices from various customer groups using the structural equation model (SEM). It is expected that the results of our study suggest helpful strategies to increase the satisfaction level of KII customers.
- Published
- 2009
39. A Study on Development and Validation of DIP to Application of Aircraft Database in Rea- Time Simulator Environment
- Author
-
Sun Young Shin, Jong-Min Ahn, Chong-Sup Kim, Im-Ju Kang, Gi-Beom Lee, Sung-Jun Ahn, and In-Je Cho
- Subjects
Structure (mathematical logic) ,Engineering ,Database ,business.industry ,media_common.quotation_subject ,computer.software_genre ,Trim ,Development (topology) ,Software ,Quality (business) ,Function (engineering) ,business ,computer ,Reliability (statistics) ,Simulation ,media_common ,Interpolation - Abstract
In this paper, design, development and evaluation of DIP(Database Interface Program) are presented. The main purpose of this study is to improve the simulation quality to get more realistic response of target system. The designed and developed major function is composed of flexible memory structure, efficient arithmetic database language and high speed interpolation/extrapolation algorithm. To evaluate the operation speed and accuracy of returned data, trim simulation is performed based on in-house software and, DIP is applied to existing real-time simulator such as engineering HQS(Handling Quality Simulator) to evaluate reliability and performance. The result of evlaution reveals that calculation speed and data accuracy are satisfied, and flight performance is satisfied in the real-time simulator environments.
- Published
- 2008
40. Ocular Manifestations in Korean Patients with Multiple Sclerosis
- Author
-
Jung Eun Cheon, Ji Soo Kim, Jeong Min Hwang, and Sun Young Shin
- Subjects
medicine.medical_specialty ,Oligoclonal band ,genetic structures ,business.industry ,Multiple sclerosis ,Medical record ,Internuclear ophthalmoplegia ,medicine.disease ,eye diseases ,Surgery ,Visual field ,Ophthalmology ,Normal brain MRI ,Edema ,medicine ,Optic neuritis ,sense organs ,Neurology (clinical) ,medicine.symptom ,business - Abstract
Objective: The overall influence of race on ocular manifestations in multiple sclerosis (MS) is unknown. Methods: This study reviewed ocular manifestations in Korean MS patients from 1996 to 2004. Results: Of the 121 patients, 62 (51%) showed ocular manifestations that comprised optic neuritis (ON) in 52 (42.9%), ocular motor deficits in 11 (9.1%), and visual field defects in 2 (1.7%). Of the 27 patients (45 eyes) with ON whose medical records were available for results of the ophthalmologic tests, 19 patients (70%) experienced painless visual loss and 8 eyes (17.8%) showed severe disc edema. Twenty-nine of 37 patients (78.4%) with isolated ON as an initial manifestation showed normal brain MRI and twenty-seven (73%) negative oligoclonal band (OCB). Of the ocular motor findings, unilateral internuclear ophthalmoplegia (6 patients) was the most common. Conclusions: Korean MS patients showed lower frequencies of ON and ocular motor deficits than Caucasian and Japanese patients. The known risk factors associ...
- Published
- 2008
41. Ramosetron versus ondansetron for postoperative nausea and vomiting in strabismus surgery patients
- Author
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Hue Jung Park, Sun Young Shin, Jin Joo, and Shinhye Park
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,Nausea ,medicine.drug_class ,Anesthesia, General ,Ramosetron ,Ondansetron ,03 medical and health sciences ,chemistry.chemical_compound ,Young Adult ,0302 clinical medicine ,Double-Blind Method ,030202 anesthesiology ,medicine ,Antiemetic ,Humans ,Prospective Studies ,Strabismus ,Postoperative nausea ,business.industry ,Incidence ,Strabismus surgery ,Middle Aged ,Surgery ,Anesthesiology and Pain Medicine ,Treatment Outcome ,chemistry ,Patient Satisfaction ,Anesthesia ,Postoperative Nausea and Vomiting ,Vomiting ,Antiemetics ,Benzimidazoles ,Female ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Postoperative nausea and vomiting ,medicine.drug ,Research Article - Abstract
Postoperative nausea and vomiting (PONV) is one of the most common adverse outcomes after strabismus surgery. The primary outcome of this prospective, randomized, double-blind study was to compare the incidences of nausea or vomiting, and patient satisfaction of ondansetron and ramosetron after strabismus surgery under general anesthesia. The secondary outcome was to investigate whether the number of involved extraocular muscles (EOMs) in strabismus surgery was related to PONV. One hundred and five patients (aged 18–60 years) undergoing strabismus surgery were allocated randomly to one of the three groups: placebo, ondansetron, or ramosetron. Patients received 2 ml placebo, 4 mg ondansetron, or 0.3 mg ramosetron at the end of surgery. Each of the three groups was subdivided into two subgroups according to the number of EOMs involved in the surgery: subgroup S, single-muscle correction; subgroup M, multiple-muscle correction. The incidences of nausea or vomiting, and patient satisfaction at 2, 24 and 48 h after surgery were analyzed as primary outcome. With regard to subgroups S and M in the placebo, ondansetron and ramosetron groups, incidences of nausea or vomiting, and patient satisfaction at 2, 24 and 48 h after surgery were analyzed as seconadary outcome. The incidence of nausea was significantly lower in the ramosetron group at 2 h (9.4 %) than in the placebo (45.2 %) and ondansetron (34.7 %) groups (P
- Published
- 2015
42. Risk factors of persistent diplopia following secondary intraocular lens implantation in patients with sensory strabismus from uncorrected monocular aphakia
- Author
-
Sun Young Shin, Shin Hae Park, and Ye Jin Ahn
- Subjects
Adult ,Male ,medicine.medical_specialty ,Visual acuity ,Time Factors ,endocrine system diseases ,genetic structures ,medicine.medical_treatment ,Visual Acuity ,Intraocular lens ,Aphakia, Postcataract ,Aphakia ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Lens Implantation, Intraocular ,Risk Factors ,Vision, Monocular ,Ophthalmology ,medicine ,Diplopia ,Humans ,Strabismus ,Retrospective Studies ,business.industry ,Retrospective cohort study ,Middle Aged ,medicine.disease ,eye diseases ,Sensory Systems ,Oculomotor Muscle ,Oculomotor Muscles ,030221 ophthalmology & optometry ,Female ,sense organs ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Strabismus surgery - Abstract
We aimed to compare clinical characteristics between diplopia-free and diplopia-persistent patients after successful strabismus surgery, when patients complained of diplopia following secondary intraocular lens (IOL) implantation after prolonged aphakia accompanied by sensory strabismus. Retrospective review of medical records of patients who complained of diplopia following secondary IOL placement with sensory strabismus after prolonged uncorrected monocular aphakia from isolated ocular trauma was done. We classified patients into two groups according to persistency of diplopia, 6 months after successful strabismus surgery. Clinical characteristics were compared between groups. A total of 31 patients were included. The diplopia-persistent group showed longer duration of uncorrected aphakia (p = 0.02), less severe corneal astigmatism (p = 0.04), a smaller exodeviation angle (p = 0.02), and more frequent vertical deviation (p = 0.015), extorsion (p = 0.022) and monocular nystagmus (p = 0.028) than the diplopia-free group. In all patients in the diplopia-free group, diplopia could be eliminated prior to strabismus surgery using loose prisms in free space, whereas seven patients in the diplopia-persistent group prior to surgery could not resolve diplopia. Our data will be helpful for ocular surgeons in determining whether to insert secondary IOL in prolonged aphakia with sensory strabismus, or whether strabismus surgery will eliminate diplopia that develops following secondary IOL placement in this situation.
- Published
- 2015
43. Optimal Methods for the Management of Iatrogenic Colonoscopic Perforation
- Author
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Sun Mi Jin, Won Hee Kim, Jong Woo Kim, Sung Pyo Hong, Chang Il Kwon, Sun Young Shin, Chi Young Park, Dae Kyu Shin, Yang Hyun Cho, Pil Won Park, Ki Baik Hahm, and Kwang Hyun Ko
- Subjects
Laparoscopic surgery ,lcsh:Internal medicine ,medicine.medical_specialty ,Exploratory laparotomy ,medicine.medical_treatment ,Perforation (oil well) ,Medicine (miscellaneous) ,Peritonitis ,Colonoscopy ,030230 surgery ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Radiology, Nuclear Medicine and imaging ,lcsh:RC799-869 ,lcsh:RC31-1245 ,medicine.diagnostic_test ,business.industry ,General surgery ,Gastroenterology ,Colonoscopic perforation ,medicine.disease ,Surgery ,lcsh:Diseases of the digestive system. Gastroenterology ,030211 gastroenterology & hepatology ,Original Article ,business ,Optimal methods - Abstract
Background/Aims: Colonoscopic perforations have been managed with exploratory laparotomy, and have resulted in some morbidity and mortality. Recently, laparoscopic surgery is commonly performed for this purpose. The aim of this study was to compare the outcomes of several management strategies for iatrogenic colonoscopic perforations. Methods: We retrospectively reviewed the medical records of patients who had been treated for colonoscopic perforation between January 2004 and April 2013 at CHA Bundang Medical Center in Korea. Results: A total of 41 patients with colonoscopic perforation were enrolled. Twenty patients underwent conservative management with a success rate of 90%. Surgical management was performed in 23 patients including two patients who were converted to surgical management after the failure of the initial conservative management. Among 14 patients who underwent surgery at 8 hours after the perforation, there was no considerable difference in adverse outcomes between the laparotomy group and the laparoscopic surgery group. The medical costs and claim rate were 1.45 and 1.87 times greater in the exploratory laparotomy group, respectively. Conclusions: Conservative management of colonoscopic perforation could be an option for patients without overt symptoms of peritonitis or with a small defect size. If surgical management is required, laparoscopic surgery may be considered as the initial procedure even with a delayed diagnosis.
- Published
- 2015
44. A case of nodular regenerative hyperplasia of the liver combined with toxic hepatitis
- Author
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Hana Park, Dae Kyu Shin, Sun Mi Jin, Yang Hyun Cho, Sang Hee Song, Sun Young Shin, Gwang Il Kim, and Kyu Sung Rim
- Subjects
Toxic hepatitis ,medicine.medical_specialty ,Pathology ,Asymptomatic ,Gastroenterology ,Fibrosis ,Internal medicine ,medicine ,Humans ,Aspartate Aminotransferases ,Endoscopy, Digestive System ,medicine.diagnostic_test ,business.industry ,Alanine Transaminase ,Bilirubin ,General Medicine ,Hyperplasia ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Endoscopy ,Liver ,Focal Nodular Hyperplasia ,Liver biopsy ,Duodenal Ulcer ,Portal hypertension ,Female ,medicine.symptom ,Chemical and Drug Induced Liver Injury ,business ,Tomography, X-Ray Computed ,Nodular regenerative hyperplasia - Abstract
Nodular regenerative hyperplasia (NRH) is an uncommon liver condition characterized by diffuse transformation of the hepatic parenchyma into regenerative nodules without fibrosis. Portal vasculopathy caused by abnormal hepatic venous flow may induce hepatocyte hyperplasia, which forms regenerative nodules. Underlying diseases or certain drugs may also be the cause of NRH. This condition is often underdiagnosed as the patients remain asymptomatic until development of portal hypertension, and histopathologic confirmation by liver biopsy is the only way of making a definite diagnosis. The management mainly involves prevention and treatment of the complications of portal hypertension. The frequency of diagnosis of NRH has increased rapidly in recent years, however, only a few cases have been reported in Korea. Here, we report on a case of NRH of the liver combined with toxic hepatitis.
- Published
- 2015
45. Location and Gaze-Dependent Shift of Inferior Oblique Muscle Position: Anatomic Contributors to Vertical Strabismus Following Lower Lid Blepharoplasty?
- Author
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Joseph L. Demer and Sun Young Shin
- Subjects
Adult ,Blepharoplasty ,Male ,business.product_category ,genetic structures ,Eye Movements ,medicine.medical_treatment ,Pulley ,Inferior rectus muscle ,Young Adult ,Inferior oblique muscle ,medicine ,Humans ,Strabismus ,Aged ,Vision, Binocular ,Eye Movements, Strabismus, Amblyopia and Neuro-Ophthalmology ,business.industry ,Anatomy ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,eye diseases ,Oculomotor Muscle ,medicine.anatomical_structure ,Hypertropia ,Hyperopia ,Oculomotor Muscles ,Female ,Eyelid ,sense organs ,business ,Follow-Up Studies - Abstract
Lower lid blepharoplasty is widely performed aesthetic surgery that corrects involutional changes.1 This surgery involves the region of the lower eyelid retractors, connective tissue bands extending from the region of the conjoined inferior rectus muscle (IR), and inferior oblique muscle (IO) pulleys. This region also includes Lockwood's ligament, a connective tissue structure that supports the globe. Complications of blepharoplasty have been reported, including diplopia due to strabismus.2–8 While vertical strabismus is relatively infrequent, it is one of the most bothersome complications. The mechanism of this diplopia is not well understood. The lower eyelid has an intimate anatomic relationship with the IO and orbital bones.9,10 The IO pulley is partly coupled to the mobile IR pulley by elastic tissues. The lower eyelid normally moves in coordination with vertical eye position by roughly the same amount, as does the globe surface. However, while the IO pulley is shifted by the IR's orbital layer, the IO pulley moves only half as far at the IO pulley and lower lid.11 This means that in infraduction, the IO pulley more closely approximates the lower lid skin surface than in other gaze positions. Elasticity of lower lid tissues contributes to the coordinated shifts of the lower lid, IO pulley, and eye. Fibrous adhesions of the IO-IR pulley to the orbital floor may produce restrictive hypertropia by hindering normal posterior pulley shift during infraduction.12 It is therefore plausible that milder changes in elastic mechanical forces in the eyelids following blepharoplasty might be transmitted to IR and IO so as to contribute to strabismus following blepharoplasty. Such a putative effect would probably be related to individual variations in lid and bony orbital anatomy. We hypothesized that the lower lid blepharoplasty could affect IO position, since the lower lid is intimately coupled to the IO-IR pulley system. If such an effect were to occur, it should be most pronounced in patients who have shallow orbits or other anatomic features bringing the IO-IR pulley assembly into proximity with the skin. This could cause vertical strabismus following lower lid blepharoplasty. Therefore, this study sought to investigate, using high-resolution magnetic resonance imaging (MRI), the position of IO relative to the adnexa in subjects with vertical strabismus following lower lid blepharoplasty, comparing these with controls.
- Published
- 2014
46. Clinical Features of Patients over the Age of 60 Years Who Have Undergone Strabismus Surgery
- Author
-
Shin Hae Park, Rowoon Yi, and Sun Young Shin
- Subjects
03 medical and health sciences ,Ophthalmology ,medicine.medical_specialty ,0302 clinical medicine ,business.industry ,030221 ophthalmology & optometry ,medicine ,030206 dentistry ,business ,Strabismus ,Surgery ,Strabismus surgery - Published
- 2017
47. Serial Photographic Monitoring of Spontaneous Clearance of Corneal Blood Stain in a Child with Traumatic Hyphema
- Author
-
Bo Een Hwang, Sun Young Shin, Ye Jin Ahn, and Shin Hae Park
- Subjects
medicine.medical_specialty ,business.industry ,Corneal Diseases ,Spontaneous remission ,General Medicine ,medicine.disease ,Stain ,Traumatic hyphema ,Wounds nonpenetrating ,Eye injuries ,Surgery ,medicine.anatomical_structure ,Cornea ,Correspondence ,medicine ,business ,Hyphema - Published
- 2017
48. Changes in ocular parameters depending on the motion-in-depth of a three-dimensional display
- Author
-
Shin Hae Park, Hae Ri Yum, Hang-Bong Kang, and Sun Young Shin
- Subjects
Adult ,Male ,Motion Perception ,Near point ,Stereo display ,Motion (physics) ,Cellular and Molecular Neuroscience ,Young Adult ,Imaging, Three-Dimensional ,Medicine ,Humans ,Motion perception ,Depth Perception ,Vision, Binocular ,business.industry ,Three dimensional display ,Accommodation, Ocular ,Convergence, Ocular ,Middle Aged ,Sensory Systems ,Healthy Volunteers ,Ophthalmology ,Tears ,Optometry ,Female ,Depth perception ,business ,Binocular vision ,Accommodation - Abstract
To compare changes in ocular parameters after watching a display of three-dimensional (3D) images, with reference to motion-in-depth and viewer age.A total of 30 healthy subjects were enrolled (of whom 17 were aged 20-30 years and 13, 40-50 years). All subjects watched 3D displays with binocular disparities of 1° or 3° run towards the viewer (who wore polarised glasses) at two defined velocities (slow, 105 mm/s; fast, 257 mm/s) for 15 min at intervals of 1 week. The viewing distance was 1.020 m. The near point of accommodation (NPA) and near point of convergence (NPC), and the tear break-up time (tBUT) of each subject, were measured before and after watching the 3D display. All parameters were repeatedly measured at intervals of 10 min after watching until baseline values became re-established.NPA and NPC deteriorated more, and tBUT decreased more, after watching a 3D display with fast rather than slow motion-in-depth (all p values0.05). NPA deteriorated more in those aged 40-50 years as compared in those aged 20-30 years after watching a display of binocular disparity of 3° at fast motion-in-depth (p=0.028). NPC deteriorated more in those aged 40-50 years as compared in those aged 20-30 years after watching a display of binocular disparity of 3° at slow and fast motion-in-depth (p=0.001). The NPA and NPC recovery times were longer after watching at fast motion-in-depth than slow motion-in-depth (p0.05). The decrease of tBUT was greater after watching at fast rather than slow motion-in-depth but only when the binocular disparity was 1°. All parameters returned to baseline values within 80 min.Motion-in-depth has an important influence on ocular parameters when a 3D display is watched, and our information would provide some basis in manufacturing 3D equipment.
- Published
- 2014
49. A case of invasive pulmonary aspergillosis with direct invasion of the mediastinum and the left atrium in an immunocompetent patient
- Author
-
Hye Yun Jeong, Minjung Shim, Kyu-Hyun Han, Hak Su Kim, Ji Min Chu, Sun Young Shin, Eunkyung Kim, Sang Ho Cho, Jung-Hyun Kim, and Daejin Kim
- Subjects
Pulmonary and Respiratory Medicine ,Invasive Pulmonary Aspergillosis ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Left atrium ,Mediastinum ,Case Report ,Invasive pulmonary aspergillosis ,medicine.disease ,Grocott's methenamine silver stain ,Mediastinal Neoplasms ,Mediastinal Neoplasm ,Surgery ,Lesion ,Heart Neoplasms ,Infectious Diseases ,medicine.anatomical_structure ,Cardiac tamponade ,Biopsy ,medicine ,medicine.symptom ,business ,Immunocompetence - Abstract
We report a case of invasive pulmonary aspergillosis invading the mediastinum and the left atrium. A 70-year-old woman was hospitalized for dyspnea. She had been well controlled for her diabetes mellitus and hypertension. The chest X-ray disclosed mediastinal widening, and the computed tomography scan of the chest showed that there was a large mediastinal mass and this lesion extended into the left atrium and right bronchus. The cardiac echocardiography showed that a huge mediastinal cystic mass compressed in the right atrium and a hyperechoic polypoid lesion in the left. The pathology from the bronchoscopic biopsy observed abundant fungal hyphae which was stained with periodic acid-Schiff and Gomori's methenamine silver. Despite the treatment with antifungal agents, she died from cardiac tamponade after three months. Invasive pulmonary aspergillosis, which involves the mediastinum and the heart, is very rare in immunocompetent patients.
- Published
- 2014
50. Changes in ocular factors according to depth variation and viewer age after watching a three-dimensional display
- Author
-
Sun Young Shin, Hae Ri Yum, Hang-Bong Kang, and Shin Hae Park
- Subjects
Adult ,Male ,Visual perception ,Vision Disparity ,education ,Near point ,Stereo display ,Cellular and Molecular Neuroscience ,Young Adult ,Imaging, Three-Dimensional ,Reference Values ,Tear meniscus height ,Diplopia ,Medicine ,Humans ,Depth Perception ,business.industry ,Age Factors ,Three dimensional display ,Accommodation, Ocular ,Convergence, Ocular ,Middle Aged ,Tear osmolarity ,eye diseases ,Sensory Systems ,Healthy Volunteers ,Ophthalmology ,Tears ,Binocular disparity ,Optometry ,Female ,Asthenopia ,business ,Accommodation ,Photic Stimulation - Abstract
To investigate changes in ocular factors according to the binocular disparity in three-dimensional (3D) images and age after watching 3D display.A total of 38 volunteers were enrolled, and they watched a 3D display with a 1° or 3° disparity for 30 min at an interval of 1 week. The near point of accommodation (NPA), near point of convergence (NPC) and tear break-up time (tBUT) of each subject were measured before and after watching the 3D display. In addition, the tear meniscus height and depth were measured using Visante optical coherence tomography and tear osmolarity was measured using TearLab osmometer. A survey of subjective symptoms was also conducted.NPA and NPC increased after watching the 3D display (p0.05). NPC and NPA increased more in the 40s-50s group (i.e., subjects aged in their 40s and 50s) than in the 20s-30s group (ie, subjects aged in their 20s and 30s) after watching 3D content with a 3° disparity (p0.05). tBUT and tear meniscus height and depth decreased after watching 3D content (p0.05). They decreased more in the 40s-50s group than in the 20s-30s group after watching 3D content with a 3° disparity (p0.05). Recovery times of NPA and NPC were significantly greater after watching 3D content with a 3° disparity and in the 40s-50s group (p0.05).Watching a 3D display affects accommodation and convergence abilities and tear dynamics in a transient fashion, especially in the case of 3D images with a large binocular disparity, and in older subjects. These results provide helpful information for establishment of guidelines for 3D equipment manufacturers.
- Published
- 2014
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