49,797 results on '"YOSHIDA"'
Search Results
2. Efficacy and safety of preoperative chemoradiotherapy with S-1 for advanced rectal cancer: a phase II study
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Akiharu Kurihara, Takamaru Koda, Satoru Kagami, Kimihiko Yoshida, Atsuro Terahara, Kimihiko Funahashi, Tomoaki Kaneko, Mitsunori Ushigome, Yasuo Nagashima, and Yasuyuki Miura
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medicine.medical_specialty ,Preoperative chemoradiotherapy ,Text mining ,Oncology ,business.industry ,Colorectal cancer ,Medicine ,Phases of clinical research ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,medicine.disease - Abstract
Background: Preoperative chemoradiotherapy (CRT) for patients with rectal cancer has not yet been established in Japan. We conducted a non-randomized phase II study to evaluate the efficacy and safety of preoperative CRT with S-1, a fixed-dose combination of tegafur, gimeracil, and oteracil potassium. Methods: We conducted a prospective, interventional, single-center study. Radiotherapy was administered at a total dose of 45 Gy (1.8 Gy in 25 fractions) for five weeks. S-1 was administered orally for a total of nine weeks (five weeks during and four weeks after radiotherapy) at a dose of 80 mg/m2/day. The endpoint was the pathological complete response (pCR) rate. The required sample size was calculated to be 30 individuals. The characteristics of the 28 patients included were as follows: cStage (II:12/ III:16), median age of 66 years (range 40–77 years), male/female (20/8), and lesion site (Ra-Rb:3/Rb:23/Rb-P:2). Results: Preoperative treatment was completed in 27 patients (96%). Treatment abandon was because of diarrhea. Grade 3 or higher adverse events were observed in only two patients (7%). Clinical downstaging was performed in eight patients (29%). Radical resection was achieved in 27 patients (96%), including 19 (68%) who underwent sphincter-preserving surgery. The pCR rate was 11% (three patients). The three-year disease-free survival rate was 79%, and the overall survival was 89%. No local recurrence occurred three years after surgery. Conclusions: Preoperative CRT with S-1 has an acceptable safety profile, and can potentially contribute to preserving anal function in patients with rectal cancer.Trial registration: UMIN Clinical Trial Registry: UMIN000013598. Registered 1 April 2014, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000015887
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- 2023
3. Delayed neuromonitoring alarm after scoliosis correction in Lenke type 4 adolescent idiopathic scoliosis
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Yu Yamato, Go Yoshida, Yukihiro Matsuyama, and Tomohiko Hasegawa
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medicine.medical_specialty ,Adolescent ,business.industry ,Scoliosis correction ,Idiopathic scoliosis ,General Medicine ,Spinal cord ,Evoked Potentials, Motor ,Neurosurgical Procedures ,ALARM ,Blood pressure ,medicine.anatomical_structure ,Scoliosis ,Spinal cord ischaemia ,Anesthesia ,Orthopedic surgery ,medicine ,Humans ,Female ,Orthopedic Procedures ,Kyphosis ,business ,Child - Abstract
A 12-year-old girl underwent surgery for Lenke type 4 adolescent idiopathic scoliosis. After scoliosis correction, the transcranial motor-evoked potential (Tc-MEP) showed no alarm. However, the Tc-MEP amplitude had declined ~10 min after correction, with a normal blood pressure (BP) and body temperature and without any technical monitoring errors. Therefore, we suspected indirect spinal cord ischaemia because of the delayed true-positive Tc-MEP alarm. All the strong corrections made loss of Tc-MEP and all the correction releases made recovers of waveform. Finally, a weak correction was performed, and the Tc-MEP amplitude was recovered. Because transient spinal cord ischaemia due to correction of triple curves may cause a delayed monitoring alarm, the monitoring team should frequently check Tc-MEP after these manoeuvres. This patient had no neurological deficits and was considered to be a rescue case.
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- 2023
4. Peripheral Retinal Leakage after Intravenous Administration of a Gadolinium-based Contrast Agent: Age Dependence, Temporal and Inferior Predominance and Potential Implications for Eye Homeostasis
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Michihiko Sone, Toshiaki Taoka, Rintaro Ito, Mariko Kawamura, Tadao Yoshida, and Shinji Naganawa
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medicine.medical_specialty ,Retina ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Retinal ,Fluid-attenuated inversion recovery ,medicine.disease ,Fluorescein angiography ,Contrast medium ,chemistry.chemical_compound ,medicine.anatomical_structure ,chemistry ,Ophthalmology ,medicine ,Radiology, Nuclear Medicine and imaging ,Endolymphatic hydrops ,Ora serrata ,business - Abstract
Purpose Peripheral retinal leakage (PRL) of contrast medium from the ora serrata (i.e., the peripheral part of the retina) was recently reported in normal eyes using ultra-widefield fluorescein angiography. We occasionally see PRL of gadolinium-based contrast agents (GBCAs) in the vitreous from the temporal and inferior sides of the ora serrata on MR images of subjects without ophthalmic disease. In this study, we retrospectively evaluated these MR images to determine if PRL was associated with aging. We also evaluated whether the initial leakage appeared in the temporal and inferior sides, and whether there was uniform distribution within the vitreous after 24 hours. Methods In 127 subjects (9 volunteers, 85 patients with sudden deafness, and 33 patients with a suspicion of endolymphatic hydrops), pre- and post-contrast-enhanced heavily T2-weighted 3D-fluid attenuated inversion recovery (FLAIR) images were obtained. The presence or absence of PRL was subjectively evaluated. For patients with a suspicion of endolymphatic hydrops, 3D-real inversion recovery (IR) images were also obtained at pre-, 10 mins, 4 hours, and 24 hours after intravenous administration (IV) of GBCA. Four circular ROIs were placed in the vitreous humor and the signal intensity was measured. Results In the cases with PRL (n = 88) and without PRL (n = 47), the median age was 59 and 47 years, respectively (P = 0.001). At 4 hours after IV-GBCA, the mean signal increase in the inferior temporal ROI was greater than all the other ROIs. At 24 hours after IV-GBCA, no significant difference in signal intensity was observed for the four ROIs. Conclusion PRL of GBCA is age-dependent and occurs mainly from the inferior temporal side of the ora serrata. The contrast effect was uniformly distributed at 24 hours after IV-GBCA. Future observations in a variety of diseases will determine the clinical significance of these findings.
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- 2023
5. Useful Preoperative Simulation of Laparoscopic Surgery for Rectal Cancer in Patients with Kyphosis
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Hiromichi Sonoda, Kohki Takeda, Ryo Ohta, Hiroshi Yoshida, Takeshi Yamada, Akihisa Matsuda, Seiichi Shinji, Sho Kuriyama, Takuma Iwai, Toshimitsu Miyasaka, and Koji Ueda
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Laparoscopic surgery ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Kyphosis ,General Medicine ,medicine.disease ,Inferior mesenteric artery ,Surgery ,Retractor ,Pneumoperitoneum ,Lower anterior resection ,medicine.artery ,Medicine ,Respiratory function ,business ,Abdominal surgery - Abstract
Kyphosis makes abdominal surgery difficult. Here, we report a case of rectal cancer in a patient with kyphosis on whom laparoscopic surgery was adequately performed owing to preoperative simulation. An 81-year-old woman with rectal cancer was admitted to our department, and laparoscopic surgery was planned. On physical examination, the patient showed severe kyphosis. To adequately perform laparoscopic surgery, a detailed and thorough preoperative simulation was conducted. 1) Simulations of port arrangement and anatomy with 3-D CT, 2) body position simulation, 3) selection of surgical instruments, 4) preoperative discussion with the anesthesiologist were conducted. We planned to insert the first port from the umbilical region for pneumoperitoneum and the camera port from the ventral region under pneumoperitoneum. We planned to insert the ports on the right side of the patient's body from caudal regions, considering the location of the inferior mesenteric artery and the limited degrees and space due to the costal arch and the promontorium. Beach chair position was planned. We used a fan-shaped retractor and a sponge-made retractor to remove the small intestine from the surgical view. We discussed with the anesthesiologist preoperatively, and decided to keep the pneumoperitoneum pressure under 8 mmHg during the operation considering the respiratory function. Lower anterior resection with D2 lymph node dissection was performed without any intraoperative complications, and at 2 years post-surgery, the patient was healthy with no signs of recurrence. Laparoscopic surgery may be a good choice in patients with kyphosis, and we believe that preoperative simulation will result in an uneventful surgery.
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- 2022
6. Salvage Surgery Compared to Surgery After Induction Chemoradiation Therapy for Advanced Lung Cancer
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Shinsuke Uchida, Shun-ichi Watanabe, Yukihiro Yoshida, Kazuo Nakagawa, Keisuke Asakura, Yuko Nakayama, Aki K. Kobayashi, Yuichiro Ohe, and Masaya Yotsukura
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Lung Neoplasms ,genetic structures ,Locally advanced ,Carcinoma, Non-Small-Cell Lung ,medicine ,Humans ,cardiovascular diseases ,Lung cancer ,Neoplasm Staging ,Retrospective Studies ,Salvage Therapy ,business.industry ,Medical record ,Chemoradiotherapy ,Perioperative ,Surgical procedures ,medicine.disease ,Surgery ,Treatment Outcome ,cardiovascular system ,Salvage surgery ,Non small cell ,Neoplasm Recurrence, Local ,Pulmonary resection ,Cardiology and Cardiovascular Medicine ,business ,circulatory and respiratory physiology - Abstract
Background Salvage surgery is performed for selected patients with relapses of locally advanced lung cancer after definitive chemoradiation therapy (CRT), and seems to be effective. To date, the feasibility of such salvage surgery, particularly anatomical pulmonary resection, has not been fully evaluated. To assess the feasibility of salvage surgery after definitive CRT, we compared clinical outcomes of surgery after definitive CRT to those of surgery after induction CRT. Methods Medical records of patients who underwent surgery from January 2000 to January 2018 were reviewed. We compared patients with salvage anatomical pulmonary resection after definitive CRT to patients with surgery after induction CRT in terms of perioperative and long-term outcomes. Results Twenty-three patients underwent salvage surgery after definitive CRT for locally advanced lung cancer (salvage group) and 36 underwent surgery after induction CRT for cN2-stage III non-small cell lung cancer (induction CRT group). The surgical procedures in the salvage group were 2 segmentectomies, 13 lobectomies, 1 bi-lobectomy and 7 pneumonectomies, and those in the induction CRT group were 34 lobectomies and 2 bi-lobectomies. There was no 30-day or 90-day mortality in either group. The 5-year overall survival was 44.7% for the salvage group and 58.6% for the induction CRT group. The 5-year progression-free interval was 42.2% for the salvage group and 47.7% for the induction CRT group. Conclusions Salvage anatomical pulmonary resection after definitive CRT for locally advanced lung cancer is feasible with acceptable morbidity and prognosis in highly selected patients.
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- 2022
7. Decreased CFTR/PPARγ and increased transglutaminase 2 in nasal polyps
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Jun-ichi Ohkubo, Thi Nga Nguyen, Hideaki Suzuki, Yasuhiro Yoshida, Takuro Kitamura, and Tetsuro Wakasugi
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Tissue transglutaminase ,Cystic Fibrosis Transmembrane Conductance Regulator ,Peroxisome proliferator-activated receptor ,Cystic fibrosis ,Nasal Polyps ,Western blot ,otorhinolaryngologic diseases ,medicine ,Humans ,Protein Glutamine gamma Glutamyltransferase 2 ,Nasal polyps ,RNA, Messenger ,chemistry.chemical_classification ,Isopeptide bond ,biology ,medicine.diagnostic_test ,business.industry ,General Medicine ,respiratory system ,medicine.disease ,Molecular biology ,digestive system diseases ,Cystic fibrosis transmembrane conductance regulator ,PPAR gamma ,Nasal Mucosa ,Otorhinolaryngology ,chemistry ,biology.protein ,Immunohistochemistry ,Surgery ,business - Abstract
Objective Transglutaminase (TGM)2 and peroxisome proliferator-activated receptor (PPAR)γ are thought to participate in the pathogenesis of nasal polyp formation in cystic fibrosis (CF). We herein investigated expressions of cystic fibrosis transmembrane conductance regulator (CFTR), TGM2, PPARγ and isopeptide bonds, a reaction product of TGM, in non-CF nasal polyps. Methods Nasal polyps and inferior turbinates were collected from chronic rhinosinusitis patients without CF during transnasal endoscopic sinonasal surgery. Expressions of CFTR, TGM2, isopeptide bonds and PPARγ were examined by fluorescence immunohistochemistry and quantitative RT-PCR. Expression of CFTR was also analyzed by Western blot. Results Immunohistochemical fluorescence of the nasal polyp was significantly lower for CFTR and PPARγ, and significantly higher for TGM2 and isopeptide bonds than that of the turbinate mucosa. Lower expression of CFTR in the nasal polyp than in the turbinate mucosa was also observed in Western blot. Expression of PPARG mRNA was significantly lower in the nasal polyp than in the turbinate mucosa, whereas expressions of CFTR mRNA or TGM2 mRNA did not differ between the two tissues. Immunohistochemical fluorescence for CFTR showed significant negative correlation with that for TGM2 and isopeptide bonds, and significant positive correlation with that for PPARγ. The fluorescence for TGM2 was positively correlated with that for isopeptide bonds and negatively correlated with that for PPARγ. The fluorescence for isopeptide bonds tended to be negatively correlated with that for PPARγ. Conclusions These results suggest a possible role of the CFTR-TGM2-PPARγ cascade in the pathogenesis of nasal polyp formation in non-CF patients as in CF patients.
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- 2022
8. Prognostic impact of IDH mutations in chondrosarcoma
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Eisuke Kobayashi, Suguru Fukushima, Shintaro Iwata, Fumihiko Nakatani, Makoto Nakagawa, Issay Kitabayashi, Masaya Sekimizu, Makoto Endo, Akira Kawai, Hitoshi Ichikawa, and Akihiko Yoshida
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musculoskeletal diseases ,animal structures ,IDH1 ,Chondrosarcoma ,Bone Neoplasms ,IDH2 ,Metastasis ,Biopsy ,medicine ,Humans ,Orthopedics and Sports Medicine ,Enzyme Inhibitors ,medicine.diagnostic_test ,business.industry ,Prognosis ,musculoskeletal system ,medicine.disease ,Isocitrate Dehydrogenase ,Idh mutation ,Clinical trial ,Isocitrate dehydrogenase ,Mutation ,Cancer research ,Surgery ,business - Abstract
Mutant isocitrate dehydrogenase (IDH) in chondrosarcoma produces the oncometabolite 2-hydroxyglutarate (2-HG) and contributes to malignant progression, and is therefore a potential therapeutic target for chondrosarcoma. Robust historical control data are important in clinical trials of rare cancers such as chondrosarcoma in order to show a clear benefit of new drugs. However, it remains controversial whether IDH mutation status is associated with the clinical outcome of chondrosarcoma, and this hinders the development of mutant IDH inhibitors in clinical trials.background METHODS: We investigated the relationship between IDH gene status and clinicopathological data in 38 chondrosarcoma patients from whom frozen tumor samples were obtained at the time of biopsy or surgery. Targeted next-generation sequencing was also performed to compare genetic alterations between patients with and without IDH mutations.The results revealed 15 cases (40%) of heterozygous IDH1 mutations and five cases (13%) of IDH2 mutations. IDH-mutant chondrosarcoma was associated with worse overall survival than IDH-wild-type chondrosarcoma (IDH1/2 Mut vs. IDH Wt, P = 0.006; IDH1 Mut vs. IDH Wt, P = 0.030; IDH2 Mut vs. IDH Wt, P 0.0001). IDH mutation was also a significant poor prognostic factor both in univariate (P = 0.026) and multivariate (P = 0.048) analyses. Targeted next-generation sequencing revealed that characteristic mutations in chondrosarcoma, including TP53 and COL2A1, were more common in the IDH-mutant group than in the IDH-wild-type group.results CONCLUSION: This study is the first to report in detail the characteristics and clinical courses of IDH-mutant chondrosarcoma patients in Japan. Our data suggested that IDH-mutant chondrosarcomas might have a worse prognosis than that of IDH-wild-type chondrosarcoma, possibly through the more aggressive characters after metastasis. This information will be useful for designing clinical trials of mutant IDH inhibitors for treatment of advanced chondrosarcoma.
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- 2022
9. Diagnosis of medial meniscal ramp lesion is difficult by pre-operative magnetic resonance imaging evaluation and needs a methodical arthroscopic exploration
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Yuko Nagaya, M. Kobayashi, Sanshiro Yasuma, Jiro Kato, Hideki Murakami, Masahito Yoshida, Tetsuya Takenaga, Yohei Kawaguchi, Hiroaki Fukushima, Yusuke Kawanishi, Masahiro Nozaki, and Gen Kuroyanagi
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medicine.diagnostic_test ,business.industry ,Anterior Cruciate Ligament Injuries ,Anterior cruciate ligament ,Reproducibility of Results ,Magnetic resonance imaging ,Menisci, Tibial ,Magnetic Resonance Imaging ,Sagittal plane ,Pre operative ,Tibial Meniscus Injuries ,Lesion ,Arthroscopy ,medicine.anatomical_structure ,medicine ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Ramp lesion ,medicine.symptom ,business ,Nuclear medicine ,Medial meniscus - Abstract
Background Meniscal ramp lesion (RL) is the peripheral lesion of the posterior horn of the medial meniscus (PHMM) associated with anterior cruciate ligament (ACL) tear. The purpose of this study was to evaluate the accuracy of pre-operative magnetic resonance imaging (MRI) evaluation in diagnosing RL and to identify whether the difficulty in diagnosis differs depending on the location of RL. Methods ACL-injured patients undergoing ACL reconstruction from January 2017 to January 2019 were enrolled. A methodical arthroscopic exploration to identify RL was conducted intra-operatively using three steps, namely, the anterior visualization step, the inter-condylar visualization step, and the posteromedial step. The location of the RLs was evaluated and classified into two types as follows: Red-red zone (RR) - a meniscal tear of the red-red zone of the PHMM. Menisco-capsular junction (MCJ) - a lesion at the menisco-capsular junction of the PHMM, which is more peripheral than RR. Furthermore, the accuracy of 1.5-T MRI evaluation to diagnose RL by two testers using sagittal proton-density fat-saturated images was calculated. Results Of the 81 patients enrolled, 11 had RL: 5 cases each were at the MCJ and RR, and 1 case was at both locations. The sensitivity of MRI for detecting RL was 27.3–45.5%, whereas the specificity was 84.3–95.7% in total. The sensitivity of MRI in detecting RL at the RR and MCJ was 40.0–80.0%, 0–20.0%, respectively. The intra-observer reliability of the MRI evaluation was moderate (κ coefficient: 0.40–0.46), while the inter-observer reliability was fair to moderate (κ coefficient: 0.27–0.41). Conclusions A low sensitivity of the MRI in detecting RL at the MCJ was observed, and the reliability of the MRI evaluation for diagnosis of RL was not high. Therefore, methodical arthroscopic exploration is essential to diagnose RL even when it is not suspected on pre-operative MRI.
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- 2022
10. Massive digital gene expression analysis reveals different predictive profiles for immune checkpoint inhibitor therapy between adenocarcinoma and squamous cell carcinoma of advanced lung cancer
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Tomoko Yoshida, Kazuhiko Takeda, Toshihiko Kaneda, Hiroaki Yanagimoto, Takao Yoshida, Kayoko Kibata, Koji Tsuta, Takayasu Kurata, and Hiroshige Yoshioka
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Adult ,Male ,Cancer Research ,Lung Neoplasms ,Immune checkpoint inhibitors ,Programmed Cell Death 1 Receptor ,Gene Expression ,Adenocarcinoma ,GPI-Linked Proteins ,Antigens, CD ,Antigens, Neoplasm ,Predictive Value of Tests ,Carcinoma, Non-Small-Cell Lung ,Proto-Oncogene Proteins ,Gene expression ,medicine ,Biomarkers, Tumor ,Genetics ,Humans ,Basal cell ,RNA, Messenger ,Anti PD-1 antibody ,Lung cancer ,Immune Checkpoint Inhibitors ,HLA-DP beta-Chains ,RC254-282 ,Adaptor Proteins, Signal Transducing ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Middle Aged ,medicine.disease ,Cadherins ,Neoplasm Proteins ,Treatment Outcome ,Nivolumab ,Oncology ,Drug Resistance, Neoplasm ,Cancer research ,Carcinoma, Squamous Cell ,Female ,Advanced non-small cell lung cancer ,business ,Apoptosis Regulatory Proteins ,Transcriptome - Abstract
Background Immune checkpoint inhibitors prolong the survival of non-small cell lung cancer (NSCLC) patients. Although it has been acknowledged that there is some correlation between the efficacy of anti-programmed cell death-1 (PD-1) antibody therapy and immunohistochemical analysis, this technique is not yet considered foolproof for predicting a favorable outcome of PD-1 antibody therapy. We aimed to predict the efficacy of nivolumab based on a comprehensive analysis of RNA expression at the gene level in advanced NSCLC. Methods This was a retrospective study on patients with NSCLC who were administered nivolumab at the Kansai Medical University Hospital. To identify genes associated with response to anti-PD-1 antibodies, we grouped patients into responders (complete and partial response) and non-responders (stable and progressive disease) to nivolumab therapy. Significant genes were then identified for these groups using Welch’s t-test. Results Among 42 analyzed cases (20 adenocarcinomas and 22 squamous cell carcinomas), enhanced expression of MAGE-A4, BBC3, and OTOA genes was observed in responders with adenocarcinoma, and enhanced expression of DAB2, HLA-DPB,1 and CDH2 genes was observed in responders with squamous cell carcinoma. Conclusions This study predicted the efficacy of nivolumab based on a comprehensive analysis of mRNA expression at the gene level in advanced NSCLC. We also revealed different gene expression patterns as predictors of the effectiveness of anti PD-1 antibody therapy in adenocarcinoma and squamous cell carcinoma.
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- 2022
11. A Rapidly Growing Small-Intestinal Metastasis from Lung Cancer
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Masahiro Hotta, Goro Takahashi, Katsuyoshi Ankoh, Yoshinobu Shioda, Ryuji Ohashi, Koji Ueda, Kazuhide Yonaga, Takuma Iwai, Toshimitsu Miyasaka, Yohei Kaneya, Ryo Ohta, Akihisa Matsuda, Seiichi Shinji, Hiromichi Sonoda, Sho Kuriyama, Hiroshi Yoshida, Takeshi Yamada, and Kohki Takeda
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Intestinal metastasis ,medicine.medical_specialty ,Gastrointestinal bleeding ,Lung Neoplasms ,business.industry ,General Medicine ,medicine.disease ,Gastroenterology ,Primary tumor ,Small intestine ,Metastasis ,medicine.anatomical_structure ,Intestinal Perforation ,Gastrointestinal perforation ,Internal medicine ,Atypia ,Humans ,Medicine ,Gastrointestinal Hemorrhage ,business ,Lung cancer - Abstract
Small intestinal metastasis from lung cancer is a relatively rare occurrence, and often causes intestinal obstruction, gastrointestinal perforation, and/or gastrointestinal bleeding making it is an oncological emergency. Many patients have been reported to undergo emergency surgery owing to the rapid progression of the intestinal metastatic lesion; however, information regarding the changes that occur in such metastases over time remains lacking. Therefore, we analyzed 4 patients who had small intestinal metastases arising from lung cancer, who were treated during a 10-year period (January 2011 to December 2020), and whose tumor diameter changes were recorded. The average tumor volume growth rate was 1.48 (1.31-1.78) -fold, and the median observation period was 22 (4-39) days, showing a rapid increase. Histopathologically, in patients with a high degree of primary tumor atypia, rapid tumor growth caused by intratumoral hemorrhage may occur. This was considered to be one of the factors responsible for the rapid increase in tumor volume.
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- 2022
12. Confirming Prior and Identifying Novel Correlates of Acute Calcium Pyrophosphate Crystal Arthritis
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Kazuki Yoshida, Daniel H. Solomon, Weixing Huang, and Sara K. Tedeschi
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medicine.medical_specialty ,business.industry ,Calcium pyrophosphate ,Osteoarthritis ,Odds ratio ,medicine.disease ,Confidence interval ,Odds ,Gout ,Crystal arthritis ,chemistry.chemical_compound ,Rheumatology ,chemistry ,Rheumatoid arthritis ,Internal medicine ,medicine ,business - Abstract
To investigate previously identified and novel correlates of acute calcium pyrophosphate (CPP) crystal arthritis among well-characterized cases.In this case-control study, we identified cases of acute CPP crystal arthritis using a validated algorithm (positive predictive value 81%) applied in the Partners HealthCare electronic health record (EHR). Cases were matched to general patient controls on the year of first EHR encounter and index date. Prespecified potential correlates included sex, race, and comorbidities and medications previously associated with CPP deposition/acute CPP crystal arthritis in the literature. We estimated odds ratios (ORs) and 95% confidence intervals using conditional logistic regression models adjusted for demographic characteristics, comorbidities, medications prescribed in the past 90 days, health care utilization, and multimorbidity score.We identified 1,697 cases matched to 6,503 controls. Mean ± SD age was 73.7 ± 11.8 years, 56.7% were female, 80.8% were White, and 10.3% were Black. All prespecified covariates were more common in cases than controls. Osteoarthritis (OR 3.08), male sex (OR 1.35), rheumatoid arthritis (OR 2.09), gout (OR 2.83), proton pump inhibitors (OR 1.94), loop diuretics (OR 1.60), and thiazides (OR 1.46) were significantly associated with acute CPP crystal arthritis after full adjustment. Black race was associated with lower odds for acute CPP crystal arthritis compared to White race (OR 0.47).Using a validated algorithm to identify nearly 1,700 patients with acute CPP crystal arthritis, we confirmed important correlates of this acute manifestation of CPP deposition. This is the first study to report higher odds for acute CPP crystal arthritis among males.
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- 2022
13. Development of a Two-Layer Staggered GAGG Scatter Detector for Whole Gamma Imaging
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Sodai Takyu, Hideaki Tashima, Taiga Yamaya, Fujino Obata, Kei Kamada, Eiji Yoshida, Akira Yoshikawa, and Fumihiko Nishikido
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Physics ,Gamma imaging ,Optics ,business.industry ,Detector ,Two layer ,Radiology, Nuclear Medicine and imaging ,Development (differential geometry) ,business ,Instrumentation ,Atomic and Molecular Physics, and Optics - Published
- 2022
14. Prescribing Patterns of Hydroxychloroquine and Glucocorticoids Among Lupus Patients After New‐Onset End‐Stage Renal Disease
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Anna Broder, Mimi Y. Kim, Candace H. Feldman, Ana Valle, Karen H. Costenbader, Wenzhu B. Mowrey, and Kazuki Yoshida
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medicine.medical_specialty ,Systemic lupus erythematosus ,business.industry ,medicine.medical_treatment ,Lupus nephritis ,Hydroxychloroquine ,Disease ,urologic and male genital diseases ,medicine.disease ,End stage renal disease ,New onset ,Rheumatology ,Internal medicine ,medicine ,Medicare Part D ,business ,Dialysis ,medicine.drug - Abstract
Optimal strategies for managing lupus medications after end-stage renal disease (ESRD) have not been addressed. The objective was to identify the current US-wide prescribing patterns of hydroxychloroquine (HCQ) and oral glucocorticoids (GS) among systemic lupus erythematosus (SLE) patients with incident ESRD enrolled in the US Renal Data System (USRDS) registry.We identified incident ESRD patients age ≥18 years with SLE as a primary cause of ESRD between January 2006 and June 2013. Patients who were started on dialysis at ESRD onset and enrolled in Medicare Part D within 93 days as required by Medicare were included.Among the 2,654 new-onset ESRD patients with Part D, the median duration of follow-up was 761 days (interquartile range [IQR] 374-1,375). At baseline, 1,076 patients (41%) were not receiving HCQ or GS, 220 (8%) were prescribed HCQ alone, 509 (19%) were prescribed both HCQ and GS, and 849 (32%) were prescribed GS alone. Of the 1,983 patients who either never received or discontinued HCQ after ESRD onset, 667 (34%) continued GS to the end of the follow-up period. The median GS dose was lower for patients taking HCQ (14 mg [IQR 9-21]) compared to patients who were never prescribed HCQ (15 mg [IQR 9-27]) or patients who discontinued HCQ after ESRD (17 mg [IQR 10-27]; P = 0.001).Approximately one-third of patients with lupus nephritis and new-onset ESRD received GS monotherapy at high doses. As GS-related complications contribute to hospitalizations and deaths in SLE ESRD, changing these prescribing practices may improve morbidity and mortality outcomes.
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- 2022
15. Backdoor Attack on Deep Neural Networks Triggered by Fault Injection Attack on Image Sensor Interface
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Takeshi Fujino, Tatsuya Oyama, Shunsuke Okura, and Kota Yoshida
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Computer science ,business.industry ,Interface (computing) ,image sensor interface ,backdoor attack ,fault injection attack ,mobile industry processor interface (MIPI) ,Biochemistry ,Atomic and Molecular Physics, and Optics ,Image (mathematics) ,Analytical Chemistry ,Adversarial system ,Benchmark (computing) ,Traffic sign recognition ,Computer vision ,Artificial intelligence ,Image sensor ,Electrical and Electronic Engineering ,business ,Instrumentation ,MNIST database ,Backdoor - Abstract
Recent automobiles use image sensors to take in the physical world information, and deep neural networks (DNNs) are used to recognize the surroundings to control the vehicles. Adversarial examples and backdoor attacks that induce misclassification by tampering with input images to DNN have been proposed as methods of attacking DNNs. As an example of attacks on DNNs equipped in automobiles, a method has been reported in which an adversarial mark is added to input images by physically putting a sticker on a road sign. However, the method reduces reproducibility due to the influence of the shooting environment. The tampering area needs to be increased to improve reproducibility. However, these large marks are easily seen by people. We propose a method of adding an adversarial mark for triggering backdoor attacks by a fault injection attack on the Mobile Industry Processor Interface (MIPI), which is the popular CMOS image sensor interface. This method can increase the reproducibility of attacks. We attack the MIPI to add adversarial marks to the input image. Two attack drivers are electrically connected to the MIPI data lane in our attack system. Most image signals are transferred from the sensor to the processor by canceling the attack signal. Then, the adversarial mark is added by activating the attack signal. An adversary aiming to carry out backdoor attacks mixes poison data, which consists of images tampered with adversarial marks at specific locations and of adversarial target classes, into a training dataset. The backdoor model classifies images with adversarial marks into an adversarial target class and other images into the correct classes. We conducted backdoor attack experiments with the MNIST dataset for handwritten digit recognition and the German Traffic Sign Recognition Benchmark (GTSRB) dataset for traffic sign recognition. Attacks on MNIST had a 91% success rate with 1% poison data, and attacks on GTSRB had a 92% success rate with 5.1% poison data.
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- 2023
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16. Formulation of Japanese Orthopaedic Association (JOA) clinical practice guideline for the management of low back pain- the revised 2019 edition
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Osamu Shirado, Yoshiyasu Arai, Tetsuhiro Iguchi, Shiro Imagama, Mamoru Kawakami, Takuya Nikaido, Tadanori Ogata, Sumihisa Orita, Daisuke Sakai, Kimiaki Sato, Masahiko Takahata, Katsushi Takeshita, Takashi Tsuji, Kei Ando, Teruaki Endo, Hironari Fukuda, Masafumi Goto, Hiroshi Hashidume, Masayuki Hino, Yohei Ide, Hirokazu Inoue, Taro Inoue, Yuyu Ishimoto, Kenyu Ito, Sadayuki Ito, Masumi Iwabuchi, Shoji Iwahashi, Hiroshi Iwasaki, Ryohei Kagotani, Shunsuke Kanbara, Kinshi Kato, Atsushi Kimura, Tomoko Kitagawa, Hiroshi Kobayashi, Kazuyoshi Kobayashi, Jun Komatsu, Hiroyuki Koshimizu, Masaaki Machino, Tsunemasa Matsubara, Yu Matsukura, Akihito Minamide, Masakazu Minetama, Kenji Mizokami, Tadao Morino, Masayoshi Morozumi, Keiji Nagata, Ichiro Nakae, Masafumi Nakagawa, Yukihiro Nakagawa, Kyotaro Ota, Kenichiro Sakai, Rikiya Saruwatari, Shinichi Sasaki, Takahiro Shimazaki, Yasuyuki Shiraishi, Masanari Takami, Satoshi Tanaka, Masatoshi Teraguchi, Ryoji Tominaga, Masaki Tomori, Ichiro Torigoe, Mikito Tsushima, Shunji Tsutsui, Kazuyuki Watanabe, Hiroshi Yamada, Kei Yamada, Hidetoshi Yamaguchi, Kimiaki Yokosuka, Takanori Yoshida, Tatsuhiro Yoshida, Masato Yuasa, and Yasutsugu Yugawa
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medicine.medical_specialty ,Evidence-Based Medicine ,business.industry ,MEDLINE ,Medical information ,Guideline ,Low back pain ,Clinical Practice ,Orthopedics ,Japan ,Clinical question ,Family medicine ,Practice Guidelines as Topic ,medicine ,Humans ,Orthopedics and Sports Medicine ,Surgery ,Guideline development ,medicine.symptom ,business ,Low Back Pain ,Societies, Medical - Abstract
Background The latest clinical guidelines are mandatory for physicians to follow when practicing evidence-based medicine in the treatment of low back pain. Those guidelines should target not only Japanese board-certified orthopaedic surgeons, but also primary physicians, and they should be prepared based entirely on evidence-based medicine. The Japanese Orthopaedic Association Low Back Pain guideline committee decided to update the guideline and launched the formulation committee. The purpose of this study was to describe the formulation we implemented for the revision of the guideline with the latest data of evidence-based medicine. Methods The Japanese Orthopaedic Association Low Back Pain guideline formulation committee revised the previous guideline based on a method for preparing clinical guidelines in Japan proposed by Medical Information Network Distribution Service Handbook for Clinical Practice Guideline Development 2014. Two key phrases, "body of evidence" and "benefit and harm balance" were focused on in the revised version. Background and clinical questions were determined, followed by literature search related to each question. Appropriate articles were selected from all the searched literature. Structured abstracts were prepared, and then meta-analyses were performed. The strength of both the body of evidence and the recommendation was decided by the committee members. Results Nine background and nine clinical qvuestions were determined. For each clinical question, outcomes from the literature were collected and meta-analysis was performed. Answers and explanations were described for each clinical question, and the strength of the recommendation was decided. For background questions, the recommendations were described based on previous literature. Conclusions The 2019 clinical practice guideline for the management of low back pain was completed according to the latest evidence-based medicine. We strongly hope that this guideline serves as a benchmark for all physicians, as well as patients, in the management of low back pain.
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- 2022
17. Physical Compatibility of Nafamostat with Analgesics, Sedatives, and Muscle Relaxants for Treatment of Coronavirus Disease 2019
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Masayoshi, Kondo, Makihiko, Nagano, Mariko, Yoshida, Naoki, Yoshida, Naoya, Tagui, Masato, Yoshida, Kazutoshi, Sugaya, Hisamitsu, Takase, Kondo, Masayoshi, Nagano, Makihiko, Yoshida, Mariko, Yoshida, Naoki, Tagui, Naoya, Yoshida, Masato, Sugaya, Kazutoshi, and Takase, Hisamitsu
- Subjects
Drug ,Coronavirus disease 2019 (COVID-19) ,media_common.quotation_subject ,Guanidines ,Fentanyl ,Drug Incompatibility ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Hypnotics and Sedatives ,Dexmedetomidine ,Rocuronium ,media_common ,Analgesics ,Muscle Relaxants, Central ,SARS-CoV-2 ,business.industry ,General Medicine ,Benzamidines ,COVID-19 Drug Treatment ,Nafamostat ,Treatment Outcome ,030220 oncology & carcinogenesis ,Anesthesia ,Morphine ,Midazolam ,030211 gastroenterology & hepatology ,business ,medicine.drug - Abstract
BACKGROUND: Severe coronavirus disease (COVID-19) may require continuous administration of analgesics, sedatives, and muscle relaxants. Nafamostat has recently been reported as a therapeutic agent for COVID-19. However, there is a lack of information on the compatibility of nafamostat with the aforementioned drug classes. This study evaluated the physical compatibility of nafamostat with these drug classes. METHODS: Nafamostat was combined with 1-3 target drugs (fentanyl, morphine, midazolam, dexmedetomidine, and rocuronium). Fifteen physical compatibility tests were conducted. Nafamostat was dissolved in 5% glucose solution; the final concentration was 10 mg/mL. All other medications were diluted in 0.9% sodium chloride to obtain clinically relevant concentrations. The power of hydrogen (pH) of all medications was measured during each test. Compatibility tests were conducted with four test solutions wherein nafamostat and the target drugs were compounded at equal volume ratios (1:1, 1:1:1, or 1:1:1:1). Visual appearance, turbidity, and pH were evaluated immediately after mixing and at 1 and 3 hours. Physical incompatibilities were defined as gross precipitation, cloudiness, appearance of the Tyndall effect, or a turbidity change of ≥0.5 nephelometric turbidity unit (NTU) based on nafamostat. RESULTS: The mean pH of nafamostat was 3.13 ± 0.03. The combination of nafamostat, fentanyl, and dexmedetomidine had the highest pH (3.39 ± 0.01; 3 hours after mixing). All drugs were compatible with nafamostat until 3 hours after admixture, with a mean turbidity value of
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- 2021
18. Usefulness of a Colonic Stent for Colonic Obstruction Caused by Lung Cancer Metastasis
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Mikito, Suzuki, Katsuji, Okada, Nobuatsu, Koyama, Naoyuki, Yamashita, Aya, Yamagishi, Takeshi, Yamada, Hiroshi, Yoshida, Suzuki, Mikito, Okada, Katsuji, Koyama, Nobuatsu, Yamashita, Naoyuki, Yamagishi, Aya, Yamada, Takeshi, and Yoshida, Hiroshi
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Male ,medicine.medical_specialty ,Abdominal pain ,Lung Neoplasms ,medicine.medical_treatment ,Self Expandable Metallic Stents ,Malignancy ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Carcinoma, Non-Small-Cell Lung ,Colostomy ,Biopsy ,medicine ,Humans ,Endoscopic stenting ,Lung cancer ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,General Medicine ,Perioperative ,Middle Aged ,medicine.disease ,Abdominal Pain ,Surgery ,Survival Rate ,Treatment Outcome ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Stents ,030211 gastroenterology & hepatology ,medicine.symptom ,Tomography, X-Ray Computed ,business ,Intestinal Obstruction - Abstract
The gastrointestinal tract is not a common site for metastasis from lung cancer, and colonic metastases are especially rare. Although surgical intervention can improve colonic obstruction, perioperative mortality is high in patients with advanced malignancy, and these patients experience a significant deterioration in quality of life postoperatively. This report describes an uncommon case of colonic metastasis from non-small cell lung cancer (NSCLC), in which colonic obstruction was improved with a self-expanding metallic stent. A 62-year-old man was admitted to our hospital for progressively worsening abdominal pain. He had been treated with immunotherapy and chemotherapy after being diagnosed with NSCLC (T4N2M1) 1.5 years earlier. Enhanced computed tomography showed intestinal obstruction and a mass in the colon at the hepatic flexure. Histopathological analysis of a biopsy specimen confirmed NSCLC metastasis. Considering his general condition, endoscopic stenting was chosen as an urgent decompression procedure. He was discharged 45 days after stenting and was able to resume immunotherapy. Emergency stenting could be offered at experienced centers when operative intervention is not part of the treatment plan, as it is safe and improves the efficiency of care along with the quality of life.
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- 2021
19. Development of an Outer Tube That Reduces Nasal Pain and Epistaxis during Transnasal Endoscopy
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Hiroshi, Makino, Satoshi, Nomura, Tadashi, Teramoto, Takashi, Tajiri, Hiroshi, Yoshida, Makino, Hiroshi, Nomura, Satoshi, Teramoto, Tadashi, Tajiri, Takashi, and Yoshida, Hiroshi
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Adult ,Male ,medicine.medical_specialty ,Endoscope ,Pain ,03 medical and health sciences ,0302 clinical medicine ,Japan ,otorhinolaryngologic diseases ,medicine ,Humans ,Transnasal endoscopy ,Tube (container) ,Nasal Turbinate ,Nose ,Aged ,Nasal endoscopy ,business.industry ,Endoscopy ,Mean age ,General Medicine ,Middle Aged ,respiratory system ,Surgery ,Epistaxis ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,business ,Nasal concha - Abstract
BackgroundRecently, transnasal endoscopy has become common in Japan. While transnasal endoscopy has many advantages, nasal pain and epistaxis are typical complaints. Consequently, we developed a new tube sheath system for transnasal endoscopy to reduce nasal pain and epistaxis. This new tube sheath system (outer sheath and inner tube) has been named Nasal Slider® and is produced by TOP Corporation, Japan.MethodsA tube sheath longer than the nasal concha is inserted to reduce pain along the nasal turbinate. Since the sheath is left in place, tubes can be passed through the nose multiple times without causing additional pain.A total of 34 consecutive patients (mean age 68.1 years, 22 males and 12 females) who had experienced transnasal endoscopy in the past, would undergo transnasal endoscopy with Nasal Slider® again. After the transnasal endoscopy was completed, patients who gave consent for use of the nasal slider® were interviewed using 3 questionnaires about nasal discomfort, nasal pain and epistaxis.ResultsSince the transnasal endoscope passes inside the sheath, epistaxis can be prevented. Thirty patients for whom trans nasal endoscopy using Nasal Slider® could be carried out. Twenty-seven and 28 patients of all patients used Nasal Slider® expressed feeling less nasal discomfort and pain compared to an examination without Nasal Slider®. No epistaxis was detected in all patients using Nasal Slider®.ConclusionsTo reduce nasal pain and epistaxis, Nasal Slider® for transnasal endoscopy was considerably available. It is currently in use at many hospitals in Japan.
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- 2021
20. The Growth Potential and Patency of Free Right Internal Thoracic Arteries Verified by Computed Tomography Angiography
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Kohei Sumi, Minoru Yoshida, Tadashi Isomura, Shunsuke Yamagishi, Masanori Hirota, and Shigehiko Yoshida
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Male ,Pulmonary and Respiratory Medicine ,Time Factors ,Computed Tomography Angiography ,Saphenous vein graft ,Coronary Artery Disease ,Internal thoracic artery ,Anastomosis ,Coronary Angiography ,medicine.artery ,medicine ,Humans ,Thoracic artery ,Coronary Artery Bypass ,Mammary Arteries ,Radial artery ,Internal Mammary-Coronary Artery Anastomosis ,Vascular Patency ,Retrospective Studies ,Computed tomography angiography ,medicine.diagnostic_test ,business.industry ,Middle Aged ,Left internal thoracic artery ,Treatment Outcome ,medicine.anatomical_structure ,Female ,Surgery ,Cardiology and Cardiovascular Medicine ,Nuclear medicine ,business ,Follow-Up Studies ,Artery - Abstract
BACKGROUND The use of the left internal thoracic artery (LITA) is the gold standard in coronary artery bypass graft surgery (CABG). Multiarterial grafting for CABG is being increasingly emphasized. This study aimed to resolve the utility of the right internal thoracic artery (RITA) for multiple CABG as "free" RITA and described new evidence. METHODS One hundred sixty-three patients received solo CABG with bilateral internal thoracic arteries between 2005 and 2018. The RITA was used as in situ RITA, group A (n = 62), and the composite graft created with saphenous vein graft (SVG), group B (n = 101). The patency rate and graft size of the composite free RITA and SVG were examined by coronary computed tomography angiography. RESULTS The average number of distal anastomoses per patient was 3.4 ± 1.0 in group A, and 4.2 ± 1.1 in group B (P < .001). The sequential grafting with free RITA was in 86 patients. The patency rate of both LITA and RITA was similar in both groups. In group B, 40 patients received late computed tomography angiography at a mean of 46 months (range, 17 to 175). The late patency rate was 95.1% in LITA and 96.9% in free RITA. The diameter of free RITA increased from 2.06 ± 0.34 mm to 2.37 ± 0.23 mm (P = .036); that of in situ LITA increased from 2.08 ± 0.51 mm to 2.44 ± 0.49 mm (P = .047); and that of composite SVG decreased from 4.1 ± 0.9 mm to 2.6 ± 0.7 mm (P < .001). CONCLUSIONS Multiple bypass grafting can be sufficiently achieved with LITA and free RITA. The growth potential of free RITA and in situ LITA might play the important role of expected long-term patency.
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- 2021
21. A Case of Stanford Type A Aortic Dissection as a Complication of TAVI ; TA-TAVI Conversion as a Troubleshooting
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Yuto Narumiya, Shohei Yokoyama, Hideo Yoshida, Atsushi Tateishi, Kenji Yoshida, Yu Oshima, Munehiro Saiki, Kunikazu Hisamochi, Keiji Yunoki, and Naoki Yamane
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Aortic dissection ,medicine.medical_specialty ,business.industry ,Medicine ,Troubleshooting ,business ,medicine.disease ,Complication ,Surgery - Published
- 2021
22. Surface roughness characteristics of corroded steel pipe piles exposed to marine environment
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Gathimba, Naftary, Kitane, Yasuo, Yoshida, Takeshi, and Itoh, Yoshito
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Marine corrosion -- Analysis ,Steel pipes -- Research -- Environmental aspects -- Chemical properties ,Surface roughness -- Analysis ,Steel products ,Water levels ,Business ,Construction and materials industries - Abstract
ABSTRACT In determining the residual capacity of corroded steel structures, many studies have focussed solely on the section's remaining thickness and its strength. However, it is anticipated that the condition [...]
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- 2019
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23. COOPETITION WHERE BANKS FINTECH COMPANIES ARE STRONGER TOGETHER
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Yoshida, Gene
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Securities analysis ,High technology industry ,Banks (Finance) ,Retail trade ,Technology ,Banking, finance and accounting industries ,Business - Abstract
A TECHNOLOGICAL RENAISSANCE of the banking industry is underway. More banking products and services are available online while brick-and-mortar branches are going the way of Blockbuster. Data aggregators and price [...]
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- 2019
24. A THEORETICAL DISCUSSION CONCERNING THE FACTORS THAT INFLUENCE THE SURVIVAL OF BUSINESS CLUSTERS/UMA DISCUSSAO TEORICA ACERCA DOS FATORES QUE INFLUENCIAM A SOBREVIVENCIA DOS CLUSTERS DE NEGOCIOS/UNA DISCUSION TEORICA ACERCA DE LOS FACTORES QUE INFLUENCIO LA SUPERVIVENCIA DE LOS CLUSTERS DE NEGOCIOS
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Ferreira, Gleriani Torres Carbone, Vicente, Simone Cesar da Silva, Ferreira, Nelson Yoshida, and Guedes, Luis Fernando Ascencao
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- 2018
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25. Disc degeneration could be recovered after chemonucleolysis with condoliase.-1 year clinical outcome of condoliase therapy
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Yuh Watanabe, Keiichi Nakai, Tomohiro Yamada, Yukihiro Matsuyama, Tomohiko Hasegawa, Tomohiro Banno, Koichiro Ide, Shin Oe, Go Yoshida, Kenta Kurosu, Yu Yamato, Hideyuki Arima, and Yuki Mihara
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Adult ,Male ,medicine.medical_specialty ,Visual analogue scale ,Radiography ,Intervertebral Disc Degeneration ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Back pain ,Humans ,Orthopedics and Sports Medicine ,Adverse effect ,030222 orthopedics ,Lumbar Vertebrae ,medicine.diagnostic_test ,business.industry ,Intervertebral Disc Chemolysis ,Magnetic resonance imaging ,Middle Aged ,Oswestry Disability Index ,Surgery ,Treatment Outcome ,Back Pain ,Disc degeneration ,CONDOLIASE ,Female ,medicine.symptom ,business ,Intervertebral Disc Displacement ,030217 neurology & neurosurgery - Abstract
Background Condoliase-induced chemonucleolysis is a less-invasive alternative treatment for lumbar disc herniation (LDH); however, its long-term clinical outcome is still unclear. This study aimed to investigate 1-year clinical outcomes and assess radiographs after chemonucleolysis with condoliase. Methods We enrolled patients with LDH who received condoliase injection with a follow-up period of >1 year. Sixty patients (37 men, 23 women; mean age, 44.5 ± 18.9 years; mean follow-up period, 22.0 ± 6.0 months) were analyzed. Changes in disc height and degeneration were evaluated using magnetic resonance imaging. Visual analog scale (VAS) scores for leg and back pain and the Oswestry disability index (ODI) were obtained. All data were assessed at baseline, 1-month, 3-month, and 1-year follow-up. Results Surgical treatment was subsequently required in 8 patients (12.5%) after condoliase therapy. Their ODI and VAS scores for leg pain and back pain significantly improved at 1 year, as in those who received condoliase therapy only. On MRI, progression of Pfirrmann grade was observed in 23 patients (44.2%) at 3 months; however, 8 patients recovered to baseline at 1 year. The mean disc height decreased at 3 months; however, it recovered at 1 year. Disc height recovery (disc recovery rate >50%) was observed in 30.8% of the patients. Patients with disc height recovery were significantly younger than those without. Patients with longer symptom duration (≥1 year) showed significantly lower rates of effectiveness compared with those with shorter symptom durations ( Conclusions Chemonucleolysis with condoliase is a safe and minimally invasive treatment. Disc degeneration induced by chemonucleolysis could be recovered, particularly in younger patients. Prolonged symptom duration had adverse effects on outcome; thus, therapeutic intervention at the optimal time is needed.
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- 2022
26. Constrictive Pericarditis with Cardiac Ascites Caused Spontaneous Bacterial Peritonitis
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Yusuke Kashiwagi, Takashi Kunihara, Satoshi Hoshino, Michihiro Yoshimura, Tomohisa Nagoshi, Jun Yoshida, Michio Yoshitake, and Kenichi Hongo
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Liver Cirrhosis ,Constrictive pericarditis ,medicine.medical_specialty ,Cirrhosis ,medicine.medical_treatment ,Hemodynamics ,Peritonitis ,Gastroenterology ,Spontaneous bacterial peritonitis ,Internal medicine ,Ascites ,Internal Medicine ,Humans ,Medicine ,Pericardiectomy ,Chylous Ascites ,Heart Failure ,business.industry ,Pericarditis, Constrictive ,General Medicine ,medicine.disease ,Heart failure ,medicine.symptom ,Differential diagnosis ,business ,circulatory and respiratory physiology - Abstract
Patients with constrictive pericarditis (CP) typically present with symptoms related to right-sided heart failure, such as cardiac ascites. Spontaneous bacterial peritonitis (SBP) usually arises in association with ascites secondary to hepatic cirrhosis. We herein report a rare case of CP in which SBP developed due to cardiac ascites, even in the absence of cirrhosis. In this case, pericardiectomy improved both the hemodynamics and the ascites, while therapy with diuretics alone was insufficient. It is important to consider SBP in the differential diagnosis when any abdominal symptoms or an inflammatory response is found in patients with heart failure and cardiac ascites.
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- 2022
27. Trisomy 8-positive Polycythemia Vera Complicated with Intestinal Behçet's-like Disease: A New Perspective for a Clinical Approach
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Tetsuo Kondo, Keita Kirito, Fumihiko Iwamoto, Toru Kuno, Nobuyuki Enomoto, Shoji Kobayashi, Shinichi Takano, Takashi Yoshida, Tatsuya Yamaguchi, and Yuki Mori
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medicine.medical_specialty ,Myeloid ,Trisomy ,Disease ,Behcet's disease ,Trisomy 8 ,Gastroenterology ,Polycythemia vera ,hemic and lymphatic diseases ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Myelofibrosis ,Polycythemia Vera ,Aged ,business.industry ,Behcet Syndrome ,General Medicine ,medicine.disease ,Bloody ,medicine.anatomical_structure ,Myelodysplastic Syndromes ,Female ,business ,Complication ,Chromosomes, Human, Pair 8 - Abstract
Behçet's disease (BD) is a multisystem inflammatory disease of unknown origin. It rarely but occasionally occurs together with myelodysplastic syndrome and primary myelofibrosis. Trisomy 8 is one of the most common cytogenetic abnormalities in myeloid neoplasms; however, the association of BD with polycythemia vera (PV) and trisomy 8 has not been reported. A 70-year-old woman, diagnosed with PV and treated with hydroxyurea, had bloody stool due to multiple ulcers in the ileocecal region. Considering the lack of a response to treatment and other features, we suspected complication with intestinal Behçet's-like disease. Our case suggests relationships among BD, trisomy 8, and PV.
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- 2022
28. Development and validation of a vascularity-based architectural classification for clear cell renal cell carcinoma: correlation with conventional pathological prognostic factors, gene expression patterns, and clinical outcomes
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Riuko Ohashi, Junichi Ikeda, Takashi Yoshida, Naho Atsumi, Chisato Ohe, Hidefumi Kinoshita, Mahul B Amin, Koji Tsuta, Kazuho Saiga, Yuri Noda, Koichiro Higasa, Yoshiki Yasukochi, and Haruyuki Ohsugi
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Univariate analysis ,Pathology ,medicine.medical_specialty ,business.industry ,H&E stain ,Gene signature ,medicine.disease ,Pathology and Forensic Medicine ,Clear cell renal cell carcinoma ,Vascularity ,Architectural pattern ,medicine ,medicine.symptom ,Stage (cooking) ,business ,Pathological - Abstract
The prognostic significance of an architectural grading system for clear cell renal cell carcinoma (ccRCC) has recently been demonstrated. The present study aimed to establish a vascularity-based architectural classification using the cohort of 436 patients with localized ccRCC who underwent extirpative surgery and correlated the findings with conventional pathologic factors, gene expression, and prognosis. First, we assessed architectural patterns in the highest-grade area on hematoxylin and eosin-stained slides, then separately evaluated our surrogate score for vascularity. We grouped nine architectural patterns into three categories based on the vascular network score. "Vascularity-based architectural classification" was defined: category 1: characterized by enrichment of the vascular network, including compact/small nested, macrocyst/microcystic, and tubular/acinar patterns; category 2: characterized by a widely spaced-out vascular network, including alveolar/large nested, thick trabecular/insular, papillary/pseudopapillary patterns; category 3: characterized by scattered vascularity without a vascular network, including solid sheets, rhabdoid and sarcomatoid patterns. Adverse pathological prognostic factors such as TNM stage, WHO/ISUP grade, and necrosis were significantly associated with category 3, followed by category 2 (all p < 0.001). We successfully validated the classification using The Cancer Genome Atlas (TCGA) cohort (n = 162), and RNA-sequencing data available from TCGA showed that the angiogenesis gene signature was significantly enriched in category 1 compared to categories 2 and 3, whereas the immune gene signature was significantly enriched in category 3 compared to categories 1 and 2. In univariate analysis, vascularity-based architectural classification showed the best accuracy in pathological prognostic factors for predicting recurrence-free survival (c-index = 0.786). The predictive accuracy of our model which integrated WHO/ISUP grade, necrosis, TNM stage, and vascularity-based architectural classification was greater than conventional risk models (c-index = 0.871 vs. 0.755-0.843). Our findings suggest that the vascularity-based architectural classification is prognostically useful and may help stratify patients appropriately for management based on their likelihood of post-surgical recurrence.
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- 2022
29. Nodal marginal zone lymphoma arising in the submental region: A case report and review of literature
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Takahiro Asano, Wataru Muraoka, Shunichi Yoshida, Seiji Asoda, Tatsuya Sakaguchi, Shunsuke Ochiai, Manabu Yamada, Kenichiro Suga, Taneaki Nakagawa, Daisuke Araki, Shosuke Yajima, and Takeshi Karube
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medicine.medical_specialty ,Ann Arbor staging ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Magnetic resonance imaging ,Marginal zone ,medicine.disease ,Pathology and Forensic Medicine ,Lymphoma ,Otorhinolaryngology ,B symptoms ,medicine ,Surgery ,Lymphadenectomy ,Radiology ,Oral Surgery ,Stage (cooking) ,medicine.symptom ,business ,Rare disease - Abstract
Nodal marginal zone lymphoma (NMZL) is a type of low-grade B-cell lymphoma arising in the follicular marginal zone of the lymph nodes. It is an extremely rare disease that accounts for 1.5 %–1.8 % of all malignant lymphomas. We herein report a case of nodal marginal zone lymphoma arising in the submental region. A 45-year-old woman was referred to our hospital because of swelling of the submental region. Contrast-enhanced computed tomography revealed 2 masses measuring 25 and 10 mm in diameter in the submental region, and the inside of the masses showed uniform enhancement. Magnetic resonance imaging revealed a low signal intensity on T1-weighted imaging and high signal intensity on T2-weighted images. Given these findings, the clinical diagnosis was submental tumor. We performed lymphadenectomy under general anesthesia. The histopathological diagnosis was NMZL. Subsequently, the patient was referred to the Department of Hematology, and a general examination was performed. There were no B symptoms, such as a fever or weight loss, and no lesions were found at other sites. The patient was ultimately diagnosed with Stage IA disease by Ann Arbor staging. At present, 26 months have passed, and the postoperative course has been uneventful.
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- 2022
30. An Autopsy Confirmed Neuromyelitis Optica Spectrum Disorder with Extensive Brain White Matter Lesion and Optic Neuritis but Intact Spinal Cord, Clinically Mimicking a Secondary Progressive Multiple Sclerosis-like Course
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Shinsui Tatsumi, Tetsuharu Kako, Kazuya Nokura, Mari Yoshida, and Fumika Azuma
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Pathology ,medicine.medical_specialty ,Multiple Sclerosis ,Optic Neuritis ,Autopsy ,Lesion ,Internal Medicine ,medicine ,Humans ,Spectrum disorder ,Optic neuritis ,Autoantibodies ,Aquaporin 4 ,Neuromyelitis optica ,business.industry ,Neuromyelitis Optica ,General Medicine ,Middle Aged ,Multiple Sclerosis, Chronic Progressive ,medicine.disease ,Spinal cord ,White Matter ,medicine.anatomical_structure ,Spinal Cord ,Etiology ,Secondary progressive multiple sclerosis ,Female ,medicine.symptom ,business - Abstract
A 57-year-old woman presented with optic neuritis with repeated clinical symptoms of focal demyelination of the cerebral white matter and brain stem for 14 years. At the end of the patient's course, the clinical signs mimicked secondary progressive multiple sclerosis, but whether it was caused by interferon administration or neuromyelitis optica spectrum disorders (NMOSD) - or a combination of both or others - was unclear. Histopathological findings indicated the etiology to be NMOSD, with no apparent plaque in spinal cord specimens. This case suggests that an accurate clinical diagnosis requires serum anti-aquaporin 4 antibody measurements as well as an autopsy examination.
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- 2022
31. Effect of hyperdry amniotic membrane in preventing tendon adhesion in a rabbit model
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Mineyuki Zukawa, Yoshiharu Kawaguchi, Hiroto Makino, Toshiko Yoshida, Ryusuke Osada, Motonori Okabe, Tomoatsu Kimura, Makiko Nogami, and Shoji Seki
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musculoskeletal diseases ,medicine.medical_specialty ,Adhesion (medicine) ,Tissue Adhesions ,Tendons ,03 medical and health sciences ,0302 clinical medicine ,Tendon Injuries ,medicine ,Animals ,Orthopedics and Sports Medicine ,Amnion ,Tendon healing ,Wound Healing ,030222 orthopedics ,business.industry ,Significant difference ,musculoskeletal system ,medicine.disease ,Tendon ,Surgery ,Transplantation ,medicine.anatomical_structure ,Orthopedic surgery ,Rabbit model ,Rabbits ,Range of motion ,business ,030217 neurology & neurosurgery - Abstract
Background No anti-adhesive materials are currently in clinical use for orthopaedic surgery. We developed a hyperdry amniotic membrane (HD-AM) for easy storage and transplantation as amniotic membrane. The purpose of this study was to examine the application of HD-AM to reduce peritendinous adhesions without impairing tendon healing. Methods We randomly divided 3 digits (2nd, 3rd, and 4th digits) from each rabbit into three groups: a tendon repair group; a tendon repair with HD-AM group (HD-AM group); and a control group (cast only). The effects of HD-AM on peritendinous adhesions and tendon healing were examined using microscopic, histological, and mechanical analyses in a rabbit flexor digitorum profundus tendon model. Results Adhesions on macroscopic evaluation of the tendon repair site were significantly smaller in the HD-AM group than in the tendon repair group. Little adhesion formation or foreign body reactions were seen by on histologic evaluation in the HD-AM group. Range of motion following tendon repair was significantly better in the HD-AM group than in the tendon repair group. Maximal tensile strength required to pull the tendon from the site of adhesion was significantly smaller in the HD-AM group than in the tendon repair group. As for tendon repair site, no significant difference was seen between the tendon repair and HD-AM groups. Conclusions HD-AM prevented peritendinous adhesion macroscopically, pathologically, and mechanically without impairing the sutured tendon. HD-AM has already been clinically applied in neurosurgery, ophthalmology, and otolaryngology, and clinical application as an anti-adhesive materials may be achieved in the future.
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- 2022
32. Increased Serum Alkaline Phosphatase and Functional Outcome in Patients with Acute Ischemic Stroke Presenting a Low Ankle–Brachial Index
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Hiroyuki Morino, Teppei Kamimura, Hiroki Ueno, Hirofumi Maruyama, Naohisa Hosomi, Tomohisa Nezu, Naoto Kinoshita, Daisuke Kuzume, Shiro Aoki, Takeshi Yoshida, Yuji Shiga, Hiroyuki Naito, and Yuko Morimoto
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medicine.medical_specialty ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Predictive Value of Tests ,Risk Factors ,Modified Rankin Scale ,Internal medicine ,Internal Medicine ,Humans ,Medicine ,Ankle Brachial Index ,cardiovascular diseases ,Acute ischemic stroke ,Stroke ,Ischemic Stroke ,business.industry ,Biochemistry (medical) ,Odds ratio ,Alkaline Phosphatase ,medicine.disease ,Confidence interval ,medicine.anatomical_structure ,Quartile ,Cohort ,Ankle ,Cardiology and Cardiovascular Medicine ,business ,human activities ,030217 neurology & neurosurgery - Abstract
Aims Elevated serum alkaline phosphatase (ALP) levels are associated with an increased risk of cerebrocardiovascular diseases. However, the associations of ALP with peripheral arterial disease (PAD) and outcomes in patients with acute ischemic stroke (AIS) are not well-known. Methods We examined the association between ALP levels and the ankle-brachial index (ABI) in 2111 consecutive patients with AIS. A poor functional outcome was defined as a modified Rankin Scale (mRS) score of 3-6 at 3 months after stroke. A low ABI was defined as a value of ≤ 0.9. Results Of the total cohort, 482 patients (22.8%) had a low ABI. ALP levels were higher in patients with a low ABI than in those without (p<0.001). The multivariable logistic analysis revealed that quartiles of ALP levels were significantly associated with a low ABI (odds ratio [OR]: 1.20, 95% confidence interval [CI]: 1.08-1.33). Of the 1322 patients with a premorbid mRS score of 0-2, 434 patients (32.8%) had a poor outcome. The multivariable analysis revealed that elevated serum ALP levels and a low ABI were independently associated with poor stroke outcomes after adjustment for baseline characteristics (OR: 1.21, 95% CI: 1.07-1.38, and OR: 2.00, 95% CI: 1.40-2.84, respectively). Conclusions Increased serum ALP levels are significantly associated with a low ABI. These indicators are independent prognostic factors for poor stroke outcomes at 3 months.
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- 2022
33. Prediction of the trabecular iris angle after posterior chamber phakic intraocular lens implantation
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Yoko Yoshida, Naoki Isogai, Takashi Kojima, Takahiro Kataoka, Tomoya Nishida, and Tomoaki Nakamura
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Systematic error ,Phakic Intraocular Lenses ,medicine.medical_specialty ,genetic structures ,Mean squared prediction error ,Iris ,Lens Implantation, Intraocular ,Optical coherence tomography ,Ophthalmology ,Linear regression ,Myopia ,medicine ,Humans ,cardiovascular diseases ,Iris (anatomy) ,Retrospective Studies ,Implantable collamer lens ,medicine.diagnostic_test ,business.industry ,Sensory Systems ,Posterior chamber phakic intraocular lens ,medicine.anatomical_structure ,Surgery ,Stepwise multiple regression analysis ,business ,Tomography, Optical Coherence - Abstract
Purpose To create an equation for predicting the trabecular iris angle (TIA) and to verify its accuracy after implantable collamer lens (ICL) implantation. Setting Nagoya Eye Clinic, Nagoya, Japan. Design Retrospective evaluation of a screening approach. Methods The subjects included 174 eyes (174 patients) that underwent ICL implantation. Patients were randomly assigned to the prediction equation group (116 eyes) or verification group (58 eyes). Anterior segment optical coherence tomography (AS-OCT; CASIA2 TOMEY) was performed before and 3 months after ICL surgery. For the prediction group, a prediction equation was created with the preoperative AS-OCT parameters and ICL size as independent variables and the postoperative anterior chamber depth (ACD) as dependent variables. Then, by applying the predicted post-ACD and preoperative AS-OCT parameters as independent variables and TIA after ICL surgery as the dependent variable, a prediction equation was created to predict the postoperative TIA (post-TIA) after ICL surgery. Each prediction equation was created using stepwise multiple regression analysis, and its accuracy was verified by a Bland-Altman plot in the verification group. Results The explanatory variables (standardized partial regression coefficient) selected in the post-TIA prediction equation were post-ACD (0.629), TIA750 (0.563), iris curvature (0.353), pupil diameter (-0.281), iris area (-0.249), and trabecular iris space area 250 (-0.171) (R2 = 0.646). There were no clinically significant systematic errors between measured and predictive post-TIA values in the verification group. The average absolute prediction error was 3.43° ± 2.22°. Conclusions Post-TIA can be accurately predicted from the predicted post-ACD and other preoperative AS-OCT parameters.
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- 2022
34. Chopstick operation training with the left non-dominant hand
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Susumu Yoshida, Daisuke Sawamura, Kazuki Yoshida, Yumi Suzuki, Satoshi Sakuraba, Naoya Hasegawa, Shinya Sakai, and Toshihiro Honke
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medicine.medical_specialty ,business.industry ,General Neuroscience ,education ,fnirs ,movement smoothness ,Neurosciences. Biological psychiatry. Neuropsychiatry ,medicine.disease_cause ,law.invention ,tool use ,Randomized controlled trial ,law ,motor skill acquisition ,Motor skill acquisition ,Physical therapy ,Medicine ,Psychological stress ,business ,Training program ,asymmetry ,Research Article ,RC321-571 - Abstract
Background Training a non-dominant hand is important for rehabilitating people who are required to change handedness. However, improving the dexterity in using chopsticks with a non-dominant hand through training remains unclear. This study is aimed to measure whether chopstick training improves non-dominant hand chopstick operation skills and leads to acquisition of skill levels similar to those of the dominant hand. Methods This single-blinded randomized controlled trial enrolled 34 healthy young right-handed subjects who scored >70 points on the Edinburgh Handedness Questionnaire Inventory. They were randomly allocated to training or control groups. The training group participated in a 6-week chopstick training program with the non-dominant left hand, while the control group did not. Asymmetry of chopstick operation skill, perceived psychological stress, and oxygen-hemoglobin concentration as a brain activity measure in each hemisphere were measured before and after training. Results Participants in the training group had significantly lower asymmetry than those in the control group during the post-training assessment (F[1,30] ≥ 5.54, p ≤ 0.03, partial η 2 ≥ 0.156). Only perceived psychological stress had a significantly higher asymmetry during the post-training assessment (t[15] = 3.81, p < 0.01). Conclusion Six weeks of chopstick training improved non-dominant chopstick operation skills, and a performance level similar to that of the dominant hand was acquired.
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- 2021
35. Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort
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Itaru Naitoh, Terumi Kamisawa, Atsushi Tanaka, Takahiro Nakazawa, Kensuke Kubota, Hajime Takikawa, Michiaki Unno, Atsushi Masamune, Shigeyuki Kawa, Seiji Nakamura, Kazuichi Okazaki, Keisuke Furumatsu, Shigeaki Sawai, Takuma Goto, Toshikatsu Okumura, Daisuke Suzuki, Masayuki Otsuka, Ikuhiro Kobori, Masaya Tamano, Mitsuhito Koizumi, Yoichi Hiasa, Naoto Kawabe, Yoshiki Hirooka, Satoshi Yamamoto, Yukio Asano, Kazuo Inui, Akihiko Horiguchi, Hiroyuki Watanabe, Daishu Toya, Katsuko Hatayama, Toshiharu Ueki, Norikatsu Kinoshita, Mitsuru Sugimoto, Hiromasa Ohira, Tsuyoshi Mukai, Eiichi Tomita, Keisuke Iwata, Shogo Shimizu, Jun Suetsugu, Masahito Shimizu, Keiji Tsuji, Ryoko Ishida, Masanori Ito, Ryutaro Furukawa, Naoya Sakamoto, Masahiro Araki, Satoshi Tanno, Yasunari Sakamoto, Tetsuhide Ito, Satoshi Takai, Shinichi Ikeya, Takanori Yamada, Norihiko Kudara, Akinori Shimizu, Keiji Hanada, Yasunori Ichiki, Hideki Kitada, Michio Hifumi, Hiroyuki Kimura, Masayuki Kurosaki, Namiki Izumi, Hajime Sumi, Jun-ichi Haruta, Katsumi Hayashi, Ryo Harada, Masafumi Inoue, Shinichiro Nakamura, Tetsuya Ito, Ko Tomishima, Hiroyuki Isayama, Kyoko Oura, Tsutomu Masaki, Naoto Shimokawahara, Shirou Tanoue, Kousei Maemura, Akio Ido, Ichiro Mizushima, Mitsuhiro Kawano, Katsunori Yoshida, Makoto Naganuma, Miki Murata, Akiyoshi Nishio, Yuji Fujita, Takuma Teratani, Shohei Matsubara, Hironao Tamai, Yuu Yoshida, Ryousaku Azemoto, Ken Kamata, Tomohiro Watanabe, Takahiro Kurosu, Wasaburou Koizumi, Jun Fujita, Hideyuki Seki, Yasuhiro Ueda, Takumi Fukumoto, Takuhiro Kousaki, Kazushige Uchida, Toshimasa Ochiai, Takeshi Kawasaki, Motohiko Tanaka, Etsuji Ishida, Kenji Notohara, Hideaki Mori, Toshiyuki Mori, Hideaki Kawabata, Masatoshi Miyata, Junichi Sakagami, Yoshito Itoh, Masahiro Shiokawa, Hiroshi Seno, Noriko Watanabe, Hiromi Kataoka, Toshinori Aoki, Mitsuhiro Fujishiro, Toru Niihara, Hiroto Nishimata, Akira Mitoro, Hitoshi Yoshiji, Motoyuki Yoshida, Masafumi Ikeda, Kengo Tomita, Ryota Hokari, Kenji Hayasaka, Yuji Amano, Kazuhiko Shioji, Kazunao Hayashi, Shuji Terai, Michiko Nakajima, Junya Yamahana, Ryusuke Matsumoto, Hideaki Kikuchi, Akira Kanamori, Seiki Kiriyama, Shinichi Iwatsu, Yuji Kato, Shigeru Horiguchi, Takahito Yagi, Hiroyuki Okada, Kazuyoshi Ohkawa, Motohiro Hirao, Naoki Hiramatsu, Noriko Oza, Haruo Imamura, Takeshi Baba, Shigeru Nakano, Tetsuya Shinobi, Shomei Ryozawa, Masayo Motoya, Hiroshi Nakase, Noboru Kinoshita, Kei Ito, Tatsuya Miyake, Naruaki Kohge, Hiroshi Tobita, Satoru Joshita, Takeji Umemura, Shinya Kawaguchi, Kazuya Ohno, Koichi Sonobe, Akihiko Satoh, Tooru Shimosegawa, Fumihiko Miura, Minami Yagi, Keiji Sano, Toshifumi Kin, Akio Katanuma, Kazuhiko Koike, Shin Miura, Youhei Kawashima, Tatehiro Kagawa, Seishin Azuma, Mamoru Watanabe, Mitsuyoshi Honjyo, Takao Itoi, Akira Honda, Katsumasa Kobayashi, Toru Asano, Suguru Mizuno, Takayoshi Nishino, Hideaki Taniguchi, Kazuto Tajiri, Ichiro Yasuda, Yoshiya Tanaka, Shinji Oe, Masaru Harada, Masanao Kurata, Mituharu Fukasawa, Nobuyuki Enomoto, Yuki Kawaji, Masayuki Kitano, Yuko Nishise, Hidetoshi Hirakawa, Tetsuya Ishizawa, Yoshiyuki Ueno, Miyuki Kaino, Yuko Fujimoto, and Isao Sakaida
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Male ,medicine.medical_specialty ,Autoimmune Pancreatitis ,Cholangitis, Sclerosing ,Gastroenterology ,Primary sclerosing cholangitis ,Serology ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Surveys and Questionnaires ,Internal medicine ,Humans ,Medicine ,Retrospective Studies ,Autoimmune pancreatitis ,Hepatology ,medicine.diagnostic_test ,business.industry ,Bile duct ,Ultrasound ,Magnetic resonance imaging ,Histology ,medicine.disease ,medicine.anatomical_structure ,Immunoglobulin G ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,IgG4-related disease ,Bile Ducts ,Immunoglobulin G4-Related Disease ,business ,Cholangiography - Abstract
Background The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort. Aims To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP. Methods We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a Japanese nationwide survey in 2019, and compared these items between IgG4-SC with and without AIP. Results AIP was present in 83.7% (730/872) of IgG4-SC. In IgG4-SC, bile duct wall thickening was observed on ultrasound (528/650; 81.2%), computed tomography (375/525; 71.4%) and magnetic resonance imaging or cholangiopancreatography (290/440; 65.9%). An elevated serum IgG4 level (≥ 135 mg/dL) was found in 88.0% (322/366). IgG4-related OOI other than AIP was observed in 25.2% (211/836). The proportion of females was significantly higher in IgG4-SC without AIP (28.9% vs. 20.1%; p = 0.025). Hilar stricture was the most common cholangiographic type in IgG4-SC without AIP (39/107; 36.4%).There were no significant differences between IgG4-SC with and without AIP in the rates of bile duct wall thickening, elevated serum IgG4 level, or IgG4-related OOI. Conclusions The clinical characteristics of IgG4-SC was similar between IgG4-SC with and without AIP in a large cohort.
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- 2021
36. Hotspot mutation profiles of AKT1 in Asian women with breast and endometrial cancers
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Kenji Tamura, Kazuki Sudo, Hiroshi Yoshida, Takayuki Kinoshita, Tatsunori Shimoi, Kan Yonemori, Jun Hashimoto, Takahiro Fukuda, Yasuhiro Fujiwara, Masayuki Yoshida, Mayu Yunokawa, Chikako Shimizu, Akihiko Shimomura, Emi Noguchi, and Tomoyasu Kato
- Subjects
Adult ,Cancer Research ,Receptor, ErbB-2 ,AKT1 ,Breast Neoplasms ,medicine.disease_cause ,Young Adult ,Breast cancer ,Asian People ,Endometrial cancer ,Surgical oncology ,HER2 ,Genetics ,medicine ,Humans ,Point Mutation ,RC254-282 ,Aged ,Aged, 80 and over ,Mutation ,business.industry ,Research ,Point mutation ,Cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Middle Aged ,medicine.disease ,Endometrial Neoplasms ,Oncology ,Cancer cell ,embryonic structures ,Cancer research ,AKT1 mutation ,Endometrioid histology ,Female ,business ,Proto-Oncogene Proteins c-akt - Abstract
Background The V-Akt murine thymoma viral oncogene (AKT) 1 (E17K) is a subfamily of serine/threonine protein kinases that affects the survival, proliferation, and invasion of cancer cells. The clinicopathological features and frequencies in Asian populations with AKT1 mutations in breast and endometrial cancers are unclear. Hence, we aimed to determine the frequencies and relationships between clinicopathological features and AKT1 mutations in Asian women with cancer. Methods We extracted DNA from 311 and 143 samples derived from patients with breast and endometrial cancers to detect the AKT1 point mutation (hotspot), E17K. We examined correlations between clinicopathological features and AKT1 mutation status. Results The frequency of AKT1 mutations in breast cancer was 7.4%, and they were found more frequently in human epidermal growth factor receptor 2 (HER2)-negative breast cancer subtypes, although this was not statistically significant (P = 0.08). The frequency of AKT1 mutations in endometrial cancer was 4.1%, and the mutations were histologically detected only in endometrioid types. However, AKT1 mutations did not correlate with relapse-free or overall survival of patients with breast or endometrial cancer. Conclusions AKT1 mutations are associated with HER2-negative subtype in breast cancer and in endometrial cancer with endometrioid histology. The frequencies of AKT1 mutations in breast and endometrial cancers were similar between Asian and other regional women. The frequency of mutations is too low in both tumor types to talk about predictive significance.
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- 2021
37. Recombinant Antithrombin Attenuates Acute Respiratory Distress Syndrome in Experimental Endotoxemia
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Yoshinori Kakino, Maho Matsuo, Yuki Kawasaki, Chihiro Takada, Yuto Tamaoki, Ryu Yasuda, Shinji Ogura, Isamu Muraki, Toshiaki Taniguchi, Hirotsugu Fukuda, Shozo Yoshida, Takahito Miyake, Akio Suzuki, Hiroyuki Tomita, Ayumi Kuroda, Hideshi Okada, Ayane Nishio, Nagisa Miyazaki, Shigeo Takashima, Risa Inagawa, Yuichiro Kitagawa, Tomoaki Doi, Haruka Okamoto, Tetsuya Fukuta, Keiko Suzuki, Yugo Wakayama, Kodai Suzuki, and Takahiro Yoshida
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Male ,0301 basic medicine ,medicine.medical_specialty ,Lipopolysaccharide ,Microarray ,DNA repair ,Ciliary plasm ,Inflammation ,030204 cardiovascular system & hematology ,Glycocalyx ,Antithrombins ,Pathology and Forensic Medicine ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Animals ,Endothelial dysfunction ,Lung ,Respiratory Distress Syndrome ,business.industry ,Antithrombin ,Regular Article ,medicine.disease ,Endotoxemia ,Recombinant Proteins ,Mice, Inbred C57BL ,Disease Models, Animal ,030104 developmental biology ,Endocrinology ,chemistry ,Endothelium, Vascular ,medicine.symptom ,business ,medicine.drug - Abstract
Sepsis-induced endothelial acute respiratory distress syndrome is related to microvascular endothelial dysfunction caused by endothelial glycocalyx disruption. Recently, recombinant antithrombin (rAT) was reported to protect the endothelial glycocalyx from septic vasculitis; however, the underlying mechanism remains unknown. Here, we investigated the effect of rAT administration on vascular endothelial injury under endotoxemia. Lipopolysaccharide (LPS; 20 mg/kg) was injected intraperitoneally into 10-week-old male C57BL/6 mice, and saline or rAT was administered intraperitoneally at 3 and 24 hours after LPS administration. Subsequently, serum and/or pulmonary tissues were examined for inflammation and cell proliferation and differentiation by histologic, ultrastructural, and microarray analyses. The survival rate was significantly higher in rAT-treated mice than in control mice 48 hours after LPS injection (75% versus 20%; P
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- 2021
38. Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study
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Fuminori Yamaji, Genki Yoshimura, Sho Nachi, Masato Shiba, Tomomi Shiga, Masahito Tachi, Ryo Kamidani, Norihide Kanda, Ryuichi Shimaoka, Yuichiro Kitagawa, Hideaki Oiwa, Shozo Yoshida, Haruka Okamoto, Yosuke Mizuno, Shinji Ogura, Takahiro Yoshida, Tomoaki Doi, Keigo Kusuzawa, Tetsuya Fukuta, Ryu Yasuda, Takahito Miyake, Takuma Ishihara, Hideshi Okada, Tomotaka Miura, and Kenichiro Morishige
- Subjects
Adult ,medicine.medical_specialty ,Science ,Article ,Medical research ,Transfusion requirement ,medicine ,Humans ,In patient ,Blood Transfusion ,Multivariable model ,Multidisciplinary ,Factor VIII ,business.industry ,Confounding ,Postpartum Hemorrhage ,Statistics ,Fibrinogen ,Retrospective cohort study ,University hospital ,Surgery ,Cryoprecipitate ,Medicine ,Transfusion therapy ,Female ,business - Abstract
To evaluate the effect of cryoprecipitate (CRYO) transfusion in women referred for postpartum hemorrhage (PPH). This retrospective cohort study included patients with primary PPH referred to Gifu University Hospital between April 2013 and March 2020. We analyzed the effect of CRYO transfusion on fluid balance 24 h after the initial examination using a multivariable linear regression model adjusted for several confounding variables. To evaluate whether outcomes were modified by active bleeding, an interaction term of CRYO*active bleeding was incorporated into the multivariable model. We identified 157 women: 38 in the CRYO group (cases) and 119 in the control group. Fluid balance in the aforementioned period tended to decrease in the CRYO group compared with that in the control group (coefficient − 398.91; 95% CI − 1298.08 to + 500.26; p = 0.382). Active bleeding on contrast-enhanced computed tomography affected the relationship between CRYO transfusion and fluid balance (p = 0.016). Other outcomes, except for the overall transfusion requirement, were not significantly different; however, the interaction effect of active bleeding was significant (p = 0.016). CRYO transfusion may decrease the fluid balance in the first 24 h in PPH patients, especially in those without active bleeding.
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- 2021
39. Segmental Hypoganglionosis of the Colon: A Case Report
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Aya, Yamagishi, Nobuatsu, Koyama, Naoyuki Yamashita, Mikito, Suzuki, Takeshi, Yamada, Manpei, Kawashima, Hiroshi, Yoshida, Yamagishi, Aya, Koyama, Nobuatsu, Suzuki, Mikito, Yamada, Takeshi, Kawashima, Manpei, and Yoshida, Hiroshi
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Abdominal pain ,medicine.medical_specialty ,Ileus ,Colon ,medicine.medical_treatment ,Myenteric Plexus ,Colonoscopy ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Colectomy ,Barium enema ,Ganglion Cysts ,medicine.diagnostic_test ,business.industry ,Transverse colon ,Fecal impaction ,Submucous Plexus ,General Medicine ,Middle Aged ,Hypoganglionosis ,medicine.disease ,digestive system diseases ,Abdominal Pain ,Surgery ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,medicine.symptom ,business ,Intestinal Obstruction - Abstract
A 64-year-old woman was admitted to hospital with persistent abdominal pain. She had been hospitalized with similar symptoms on five occasions during a period of 2 years. Computed tomography revealed dilatation and fecal impaction from the ileum to the transverse colon. A barium enema and simultaneous ileus tube radiography showed a narrow segment of descending-sigmoid colon. Colonoscopy showed no mucosal change. Her symptoms did not improve with conservative therapy, so descending and sigmoid colectomy was performed. Histologic examination showed disappearance of ganglion cells; axon of Meissner's plexuses was present, and the number of Auerbach's plexuses was decreased. The definitive diagnosis was segmental hypoganglionosis (SH) of the colon. The postoperative course was uneventful, and the functional result was positive at 1 year postoperatively. SH is extremely rare; however, surgical intervention is expected to be of benefit. Therefore, it is important to keep SH in mind when treating patients with chronic obstruction of the left side of the colon.
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- 2021
40. Experimental Evaluation of 1 kW-class Prototype REBCO Fully Superconducting Synchronous Motor Cooled by Subcooled Liquid Nitrogen for E-Aircraft
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Akira Tomioka, Yuichiro Sasamori, Takashi Yoshida, Hiromasa Sasa, S. Sato, Masayuki Konno, Shun Miura, Masataka Iwakuma, Miyuki Nakamura, Y. Aoki, Teruyoshi Sasayama, Sergey Lee, Kaoru Yamamoto, Teruo Izumi, Takahiro Umeno, Shinya Hasuo, Koichi Yoshida, Akifumi Kawagoe, Masao Syutoh, Takayo Hasegawa, Y. Hase, and Hirokazu Honda
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Materials science ,Rotor (electric) ,Superconducting electric machine ,business.industry ,Nuclear engineering ,Condensed Matter Physics ,01 natural sciences ,Electronic, Optical and Magnetic Materials ,law.invention ,Coolant ,Electrically powered spacecraft propulsion ,law ,Electromagnetic coil ,Thermal insulation ,0103 physical sciences ,Electrical and Electronic Engineering ,010306 general physics ,Synchronous motor ,business ,Armature (electrical engineering) - Abstract
For the development of electric propulsion aircrafts with light weight, low emission and high efficiency, MW-class fully superconducting synchronous machines operating at liquid nitrogen temperature were conceptually designed with REBa2Cu3O7- δ (REBCO) superconducting tapes in our previous studies. To verify the actualization of the structure and cooling method, a 1 kW-class prototype fully superconducting synchronous motor was designed and constructed in this study. The fixed armature was cooled with subcooled liquid nitrogen at 65 K. The rotor was cooled with helium gas. The pole number was two for the future high speed operation. The applicability of the complicated casing structure with three chambers into fully superconducting motor was also investigated from the viewpoint of thermal insulation. The operations as a motor up to 500 rpm and a generator demonstrated that the designed structure and cooling method were reasonable and effective for cooling the fixed armature and rotating field windings.
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- 2021
41. Stepwise improvement in limb shaking achieved by staged angioplasty for severe carotid stenosis
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Masahiro Toda, Yuki Kuranari, Takenori Akiyama, Keisuke Yoshida, Hiroki Yamada, Masahiro Katsumata, Yumiko Oishi, and Kento Takahara
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medicine.medical_specialty ,medicine.medical_treatment ,Hemodynamics ,Carotid endarterectomy ,Case Reports ,Angioplasty ,Internal medicine ,Occlusion ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Carotid Stenosis ,Aged ,medicine.diagnostic_test ,Cerebral infarction ,business.industry ,Stent ,General Medicine ,medicine.disease ,Stenosis ,Angiography ,Cardiology ,Female ,Stents ,Neurology (clinical) ,business ,Carotid Artery, Internal - Abstract
Cerebral hyperperfusion syndrome is a rare but severe complication of carotid artery stenting or carotid endarterectomy. Staged angioplasty is reportedly an effective strategy to avoid cerebral hyperperfusion syndrome. We encountered a case of internal carotid artery stenosis with a rare clinical presentation of limb shaking that was successfully improved by staged angioplasty. To our knowledge, there are no reported cases of limb shaking treated with staged angioplasty. A 76-year-old woman presented with continuous chorea in her left lower limb and shoulder. Medical examination revealed a tiny cerebral infarction in the right corona radiata and severe right internal carotid artery stenosis. Angiography showed near occlusion of the right internal carotid artery. Staged angioplasty was performed to avoid the risk of cerebral hyperperfusion syndrome. The first angioplasty resulted in an expanded diameter of 2.5 mm and was followed by definitive carotid artery stenting using a closed-cell stent 3.5 weeks later. Limb shaking improved in a stepwise manner along with an improvement in internal carotid artery stenosis and distal flow state with no signs of cerebral hyperperfusion syndrome. Patients with internal carotid artery stenosis or occlusion presenting with limb shaking have been suggested to have impaired cerebrovascular reactivity, which is also thought to be a risk factor for cerebral hyperperfusion syndrome. The stepwise improvement in limb shaking observed in this case supports the idea that the pathophysiology of limb shaking is related to cerebral haemodynamic impairment. Measures to prevent cerebral hyperperfusion syndrome, including staged angioplasty, should be actively considered in patients with limb shaking because the symptoms themselves suggest severe hypoperfusion.
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- 2023
42. Tuning of morphological, crystallographic, and optoelectronic properties of CuSCN by electrodeposition
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Tsukasa Yoshida, Yoshiyuki Suzuri, Kyota Uda, Tensho Nakamura, Yuki Tsuda, and Lina Sun
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Materials science ,business.industry ,Optoelectronics ,business - Abstract
Copper(I) thiocyanate (CuSCN) is known as a wide bandgap p-type semiconductor and recently demonstrated its high ability as a hole-transporting material in thin film devices such as dye-sensitized and perovskite solar cells [1]. However, in fact little is known for its intrinsic physical properties such as bandgap, band positions, optical transparency, carrier density and mobility. We have established methods to electrodeposit well-crystallized CuSCN thin films in various forms. Although the electrochemistry is fairly simple as limited by diffusion of 1 : 1 complex between Cu2+ and SCN- ions ([Cu(SCN)]+), the [Cu2+] : [SCN-] ratio, its absolute concentration and solvent can significantly alter the morphology and crystal orientation of resulting CuSCN [2]. Hybridization with various cationic organic dyes has also been achieved to furnish nanostructures and even transition from rhombohedral β to orthorhombic α form [3]. These unique features of the electrodeposition technique let us anticipate possibilities to tailor-tune physical properties of CuSCN to match the demands for the device applications. Moreover, electrodeposited CuSCN doesn’t hinder its use in flexible electronics unlike many other inorganic materials, since the process is done at room temperature. In this study, we have carried out electrodeposition of CuSCN to vary its morphology and crystal orientation by tuning the bath composition and studied their band structure to explore the room for tuning its physical properties. Morphologies of CuSCN thin films electrodeposited from stoichiometric (REF), Cu-rich and SCN-rich baths are compared in Figs. 1 a-c. While the REF sample has an open structure made of relatively large bulky particles, the Cu-rich sample is dense, made of tiny grains. XRD patterns have found almost random crystal orientation for the former and a high degree of preference of the latter to orient the c-axis of β-CuSCN perpendicular to the substrate. On the other hand, the one from the SCN-rich bath is made of elongated platelets (Fig. 1 b) and strongly oriented to lay down the c-axis in parallel with the substrate. As expected from the morphology, the Cu-rich film is highly transparent, whereas the other two are opaque due to light scattering (Table 1). Tauc plot for indirect transition indicated a systematic increase of bandgap from 3.58 to 3.64 eV on increasing the Cu2+ content. More significant difference was found for their work function (WF) measured by photoelectron yield spectroscopy (PYS). The threshold energy moved downwards from 5.31 to 5.66 eV vs. VAC from Cu-rich to SCN-rich film. The result indicates a high level of p-type doping in the presence of excess SCN-, probably due to increased concentration of Cu2+ as stabilized by SCN- bound to it. Enhanced photoluminescence has also been found for the electrodeposited CuSCN thin film especially for the SCN-rich sample, as compared to commercial CuSCN powder. Thus, electrodeposition has turned out to allow fine-tuning of physical properties of CuSCN for device applications. [1] Vinod E. Madhavan et al., ACS Energy Lett. 2016, 1, 1112−1117. [2] Lina Sun et al., Physics Procedia, 2011, 14, 12-24. [3] Yuki Tsuda et al., Chem., 2017, 148, 845-854. Figure 1
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- 2023
43. The Incidence of Iliac Screw-Related Complications After Long Fusion Surgery in Patients with Adult Spinal Deformity
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Keiichi Nakai, Shin Oe, Tomohiro Banno, Yukihiro Matsuyama, Tomohiko Hasegawa, Yu Yamato, Hideyuki Arima, Yuki Mihara, Koichiro Ide, Kenta Kurosu, Go Yoshida, and Yuh Watanabe
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Adult ,Male ,Pelvic tilt ,medicine.medical_specialty ,pelvic tilt ,Bone Screws ,complication ,Scoliosis ,surgery ,Quality of life ,rod breakage ,medicine ,Humans ,Orthopedics and Sports Medicine ,iliac screw ,Aged ,Retrospective Studies ,Fixation (histology) ,sagittal alignment ,loosening ,business.industry ,Incidence ,Incidence (epidemiology) ,adult spinal deformity ,incidence rate ,interbody fusion ,Retrospective cohort study ,musculoskeletal system ,medicine.disease ,Surgery ,Oswestry Disability Index ,Spinal Fusion ,Treatment Outcome ,Quality of Life ,Female ,Neurology (clinical) ,business ,osteotomy ,Lumbosacral joint - Abstract
Study Design: Retrospective study.Objective: To investigate the long-term clinical outcome and incidence of iliac screw-related complications in patients with adult spinal deformity (ASD).Summary of Background Data: Rigid lumbosacral fixation is crucial to achieve optimal global alignment and successful long-term clinical outcomes.Methods: The data of eligible patients with ASD who underwent spinopelvic fixation using bilateral iliac screws with at least 5-year follow-up periods were retrospectively analyzed. Iliac screw loosening and rod breakage between the S1 and iliac (S1/IL) screws were defined as distal instability (DI). Demographic data, health-related quality of life scores, and spinopelvic parameters in the DI group were compared with those in the non-DI group. Sub-group analyses were performed between the cases with and without alignment change after rod fracture at S1/IL.Results: Of the 159 patients, the data of 110 patients (15 men, 95 women; mean age, 67.8 years) were analyzed. The follow-up rate was 69%. Forty-five (41%) patients showed DI (29 cases [26%] in screw loosening, 16 cases [15%] in rod breakage). Eight patients (7.3%) required revision surgery because of iliac screw-related complications. No significant differences were observed in the Oswestry Disability Index and Scoliosis Research Society questionnaire (revised) scores between the DI and non-DI groups. The patients with iliac screw loosening showed significantly greater values of preoperative pelvic incidence, pelvic tilt (PT) and postoperative PT, and T1-pelvic angle. In patients with rod breakage at S1/IL, five patients (31%) who had associated mechanical complications showed an alignment change between pre and post rod breakage. They showed significantly higher and lower rates of high-grade osteotomies and L5/S interbody fusion, respectively.Conclusion: The incidence rate of iliac screw-related complications was relatively high. However, they had a little effect on sagittal alignment deterioration and there were few cases that required revision surgery., Mini abstract:Long fusion surgery with pelvic fixation using iliac screw resulted in higher incidence rates of iliac screw-related complications; however, the cases that required revision surgery were limited (7.3%). Iliac screw loosening and rod breakage at S1/IL had little effect on sagittal alignment deterioration.
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- 2022
44. Machine-learning model derived gene signature predictive of paclitaxel survival benefit in gastric cancer: results from the randomised phase III SAMIT trial
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Jia Guan, Takaki Yoshikawa, Shiro Tanaka, Heike I. Grabsch, Yohei Miyagi, Yasushi Rino, Jeeyun Lee, Junichi Sakamoto, Nesaretnam Barr Kumarakulasinghe, Yiong Huak Chan, Takashi Oshima, Michal Marek Hoppe, Anand D. Jeyasekharan, Mark De Simone, Munetaka Masuda, Akira Tsuburaya, Kazuhiro Yoshida, Cedric Chuan Young Ng, Raghav Sundar, Angie Lay-Keng Tan, Patrick Tan, RS: GROW - R2 - Basic and Translational Cancer Biology, and Pathologie
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Oncology ,medicine.medical_specialty ,Paclitaxel ,medicine.medical_treatment ,adjuvant treatment ,Adenocarcinoma ,THERAPY ,Disease-Free Survival ,Ramucirumab ,Machine Learning ,chemistry.chemical_compound ,CISPLATIN ,Stomach Neoplasms ,Internal medicine ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,Stomach cancer ,UFT ,DOCETAXEL ,Chemotherapy ,business.industry ,gastric cancer ,Gastroenterology ,Cancer ,Gene signature ,CHEMOTHERAPY ,medicine.disease ,COMPREHENSIVE MOLECULAR CHARACTERIZATION ,TUMORS ,FAMILY ,Clinical trial ,chemistry ,Cohort ,5-FLUOROURACIL ,SENSITIVITY ,business - Abstract
ObjectiveTo date, there are no predictive biomarkers to guide selection of patients with gastric cancer (GC) who benefit from paclitaxel. Stomach cancer Adjuvant Multi-Institutional group Trial (SAMIT) was a 2×2 factorial randomised phase III study in which patients with GC were randomised to Pac-S-1 (paclitaxel +S-1), Pac-UFT (paclitaxel +UFT), S-1 alone or UFT alone after curative surgery.DesignThe primary objective of this study was to identify a gene signature that predicts survival benefit from paclitaxel chemotherapy in GC patients. SAMIT GC samples were profiled using a customised 476 gene NanoString panel. A random forest machine-learning model was applied on the NanoString profiles to develop a gene signature. An independent cohort of metastatic patients with GC treated with paclitaxel and ramucirumab (Pac-Ram) served as an external validation cohort.ResultsFrom the SAMIT trial 499 samples were analysed in this study. From the Pac-S-1 training cohort, the random forest model generated a 19-gene signature assigning patients to two groups: Pac-Sensitive and Pac-Resistant. In the Pac-UFT validation cohort, Pac-Sensitive patients exhibited a significant improvement in disease free survival (DFS): 3-year DFS 66% vs 40% (HR 0.44, p=0.0029). There was no survival difference between Pac-Sensitive and Pac-Resistant in the UFT or S-1 alone arms, test of interaction pConclusionUsing machine-learning techniques on one of the largest GC trials (SAMIT), we identify a gene signature representing the first predictive biomarker for paclitaxel benefit.Trial registration numberUMIN Clinical Trials Registry: C000000082 (SAMIT); ClinicalTrials.gov identifier, 02628951 (South Korean trial)
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- 2022
45. Combined Lymphovenous Anastomosis and Great Saphenous Vein Stripping for Comorbid Lymphedema and Varicose Veins
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Shuhei Yoshida, Ayano Sasaki, Mitsunobu Harima, Toshio Uchiki, Shuji Yamashita, Kazunori Yokota, Hirofumi Imai, Shogo Nagamatsu, Isao Koshima, and Yumio Fujioka
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medicine.medical_specialty ,business.industry ,Anastomosis, Surgical ,Great saphenous vein ,medicine.disease ,Stripping (fiber) ,Surgery ,Lymphovenous anastomosis ,Varicose Veins ,body regions ,Lymphedema ,hemic and lymphatic diseases ,Varicose veins ,Humans ,Medicine ,Saphenous Vein ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Lymphatic Vessels - Abstract
Introduction: Treatment for patients with comorbid lymphedema and varicose veins is controversial. Surgical options for these patients are limited. The study was aimed to investigate the validity o...
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- 2022
46. Study on Cloud-Based GNSS Positioning Architecture with Satellite Selection Algorithm and Report of Field Experiments
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Seiji Yoshida
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Field (physics) ,Computer Networks and Communications ,GNSS applications ,Computer science ,business.industry ,Satellite ,Cloud computing ,Electrical and Electronic Engineering ,Architecture ,business ,Selection algorithm ,Software ,Remote sensing - Published
- 2022
47. Nodular Pulmonary Amyloidosis Associated with Sjögren's Syndrome
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Hiroshi Ishii, Yusuke Ueda, Takuto Miyamura, Yuji Yoshida, Hisako Kushima, Mitsuharu Ueda, Takato Ikeda, Seiji Haraoka, and Yoshiaki Kinoshita
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Lung Diseases ,Pathology ,medicine.medical_specialty ,business.industry ,Radiography ,Amyloidosis ,Pulmonary amyloidosis ,General Medicine ,medicine.disease ,Sjogren's Syndrome ,Internal Medicine ,Etiology ,Humans ,Medicine ,Female ,Cyst ,Differential diagnosis ,Sjogren s ,business ,Amyloidosis, Familial ,Lung ,Aged ,Rare disease - Abstract
Amyloidosis is a rare disease characterized by the deposition of abnormal proteins in extracellular tissues. We herein report a case with instructive radiologic features of nodular pulmonary amyloidosis associated with Sjögren's syndrome. A 67-year-old woman was referred to our department because of an abnormal chest radiograph. Chest computed tomography revealed multiple round cysts accompanied by calcified nodules. The patient was clinically diagnosed with primary Sjögren's syndrome and pathologically diagnosed with nodular pulmonary amyloidosis (light chain, kappa). Although multiple lung cysts have many etiologies, the presence of calcified nodules associated with multiple lung cysts is useful for narrowing down the differential diagnosis.
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- 2022
48. Development and Validation of a Risk Prediction Model for Atherosclerotic Cardiovascular Disease in Japanese Adults: The Hisayama Study
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Takanori Honda, Satoko Sakata, Mao Shibata, Yoshihiko Furuta, Yoichiro Hirakawa, Toshiharu Ninomiya, Sanmei Chen, Daigo Yoshida, Takanari Kitazono, and Jun Hata
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Adult ,Male ,medicine.medical_specialty ,Specific risk ,Blood Pressure ,Disease ,030204 cardiovascular system & hematology ,Overfitting ,Risk Assessment ,03 medical and health sciences ,0302 clinical medicine ,Japan ,Risk Factors ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Prospective Studies ,Exercise ,Proteinuria ,Proportional hazards model ,Atherosclerotic cardiovascular disease ,business.industry ,Biochemistry (medical) ,Middle Aged ,Atherosclerosis ,medicine.disease ,Blood pressure ,Cardiovascular Diseases ,Cardiology ,Female ,Morbidity ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,Follow-Up Studies ,Forecasting - Abstract
Aim To develop and validate a new risk prediction model for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) in Japanese adults. Methods A total of 2,454 participants aged 40-84 years without a history of cardiovascular disease (CVD) were prospectively followed up for 24 years. An incident ASCVD event was defined as the first occurrence of coronary heart disease or atherothrombotic brain infarction. A Cox proportional hazards regression model was used to construct the prediction model. In addition, a simplified scoring system was translated from the developed prediction model. The model performance was evaluated using Harrell's C statistics, a calibration plot with the Greenwood-Nam-D'Agostino test, and a bootstrap validation procedure. Results During a median of a 24-year follow-up, 270 participants experienced the first ASCVD event. The predictors of the ASCVD events in the multivariable Cox model included age, sex, systolic blood pressure, diabetes, serum high-density lipoprotein cholesterol, serum low-density lipoprotein cholesterol, proteinuria, smoking habits, and regular exercise. The developed models exhibited good discrimination with negligible evidence of overfitting (Harrell's C statistics: 0.786 for the multivariable model and 0.789 for the simplified score) and good calibrations (the Greenwood-Nam-D'Agostino test: P=0.29 for the multivariable model, 0.52 for the simplified score). Conclusion We constructed a risk prediction model for the development of ASCVD in Japanese adults. This prediction model exhibits great potential as a tool for predicting the risk of ASCVD in clinical practice by enabling the identification of specific risk factors for ASCVD in individual patients.
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- 2022
49. Adversarial Scan Attack against Scan Matching Algorithm for Pose Estimation in LiDAR-Based SLAM
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Masaya Hojo, Kota Yoshida, and Takeshi Fujino
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Adversarial system ,Lidar ,business.industry ,Computer science ,Applied Mathematics ,Signal Processing ,Computer vision ,Artificial intelligence ,Electrical and Electronic Engineering ,business ,Computer Graphics and Computer-Aided Design ,Pose ,Blossom algorithm - Published
- 2022
50. Fault Injection Attacks Utilizing Waveform Pattern Matching against Neural Networks Processing on Microcontroller
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Takeshi Fujino, Yuta Fukuda, and Kota Yoshida
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Microcontroller ,Artificial neural network ,Computer science ,business.industry ,Applied Mathematics ,Signal Processing ,Waveform ,Fault injection ,Pattern matching ,Electrical and Electronic Engineering ,business ,Computer Graphics and Computer-Aided Design ,Computer hardware - Published
- 2022
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