1. Ivabradine, coronary artery disease, and heart failure: beyond rhythm control
- Author
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Domenico Scrutinio, Gabriella Ricci, Michele Gesualdo, Francesca Cortese, Marco Matteo Ciccone, Graziano Riccioni, Annapaola Zito, Massimo Iacoviello, Pasquale Caldarola, Annagrazia Cecere, Pietro Scicchitano, Rocco Lagioia, Santa Carbonara, and Michele Moncelli
- Subjects
medicine.medical_specialty ,Population ,Diastole ,Pharmaceutical Science ,Rhythm control ,Coronary Artery Disease ,Review ,Coronary artery disease ,Heart Rate ,Internal medicine ,Drug Discovery ,Heart rate ,medicine ,Animals ,Humans ,Ivabradine ,funny current ,education ,heart-rate lowering drugs ,Pharmacology ,Heart Failure ,education.field_of_study ,business.industry ,lcsh:RM1-950 ,Benzazepines ,medicine.disease ,chronic heart failure ,lcsh:Therapeutics. Pharmacology ,heart rate reduction ,Heart failure ,Cardiology ,cardiac ischemic disease ,Artery diseases ,business ,Cardiac ischemic disease ,Chronic heart failure ,Funny current ,Heart rate reduction ,Heart-rate lowering drugs ,medicine.drug - Abstract
Pietro Scicchitano,1 Francesca Cortese,1 Gabriella Ricci,1 Santa Carbonara,1 Michele Moncelli,1 Massimo Iacoviello,1 Annagrazia Cecere,1 Michele Gesualdo,1 Annapaola Zito,1 Pasquale Caldarola,2 Domenico Scrutinio,3 Rocco Lagioia,3 Graziano Riccioni,4 Marco Matteo Ciccone1 1Section of Cardiovascular Diseases, Department of Emergency and Organ Transplantation, University of Bari, School of Medicine, Policlinico, Bari, Italy; 2Section of Cardiovascular Diseases, Policlinic, San Paolo Hospital, Bari, Italy; 3Section of Cardiovascular Diseases, Fondazione Maugeri, Cassano Murge, Italy; 4Intensive Cardiology Care Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy Abstract: Elevated heart rate could negatively influence cardiovascular risk in the general population. It can induce and promote the atherosclerotic process by means of several mechanisms involving endothelial shear stress and biochemical activities. Furthermore, elevated heart rate can directly increase heart ischemic conditions because of its skill in unbalancing demand/supply of oxygen and decreasing the diastolic period. Thus, many pharmacological treatments have been proposed in order to reduce heart rate and ameliorate the cardiovascular risk profile of individuals, especially those suffering from coronary artery diseases (CAD) and chronic heart failure (CHF). Ivabradine is the first pure heart rate reductive drug approved and currently used in humans, created in order to selectively reduce sinus node function and to overcome the many side effects of similar pharmacological tools (ie, β-blockers or calcium channel antagonists). The aim of our review is to evaluate the role and the safety of this molecule on CAD and CHF therapeutic strategies. Keywords: chronic heart failure, heart rate reduction, cardiac ischemic disease, heart-rate lowering drugs, funny current
- Published
- 2014