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Environmental and genetic factors play important roles in the development of schizophrenia (SCZ), bipolar disorder (BPD) or major depressive disorder (MDD). Some risk loci are identified with shared genetic effects on major psychiatric disorders. To investigate whetherWe focussed on 11 single-nucleotide polymorphisms (SNPs) harbouringWe found that rs3743592 was significantly associated with MDD and rs6498263 with BPD in both allele and genotype distributions. Before correction, rs3743592 showed allelic and genotypic significance with SCZ, rs6498263 showed allelic significance with SCZ. WGCNA identified top 10 modules of co-expressed genes. Gene Ontology (GO) and pathway analysis were used to examine the functions of SNX29, which revealed that SNX29 was involved in the regulation of a number of biological processes, such as TGF-beta, ErbB, and Wnt signalling pathway, etc.Our results supported common risk factors in

Background: Patients with chronic schizophrenia present cognitive impairment, which affects their social function and prevents them from reintegrating into society. Yijinjing is a traditional Chinese aerobic exercise that has a putative psychosomatic effect on improving cognitive function.Methods: From January to May 2021, 40 patients with chronic schizophrenia were recruited and randomly divided into a control group and a Yijinjing group. In the 12-week intervention, the patients in the control group received conventional treatment, whereas patients in the Yijinjing group performed Yijinjing exercise (40 min/session, twice a week) in addition to receiving conventional treatment. The Positive and Negative Syndrome Scale (PANSS), the Insight and Treatment Attitude Questionnaire (ITAQ), the Rosenberg Self-esteem Scale (SES), and the Mini Mental State Examination (MMSE) were used to measure clinical symptoms and cognitive function at 0, 6, and 12 weeks.Results: The demographic information was not significantly different between groups. At baseline, the scores of all the scales were not statistically different between groups. After 12 weeks of intervention, compared to those at baseline, the scores of the negative scale (t = 19.00, p < 0.0001), general psychopathology scale (t = 15.98, p < 0.0001), and total score (t = 15.47, p < 0.0001) of the PANSS and SES (t = 5.378, p < 0.0001) had significantly decreased, and the scores of the ITAQ (t = 7.984, p < 0.0001) and MMSE (t = 6.750, p < 0.0001) had significantly increased in Yijinjing group; the score of the MMSE increased in the control group as well (t = 2.491, p = 0.0222). Compared to the respective scores in the control group, the negative scale score (t = 2.953, p = 0.0054) significantly decreased, and the ITAQ (t = 3.043, p = 0.0042) and MMSE (t = 2.2.68, p = 0.0291) scores significantly increased in the Yijinjing group after 12 weeks of intervention.Conclusion: These results provide a preliminary indication that Yijinjing exercise had the potential to improve cognitive function and negative symptoms in patients with chronic schizophrenia. A larger-scale study to determine the trajectory of change in the longer term should be undertaken.

Pulmonary fibrosis is a chronic and progressive interstitial lung disease of known and unknown etiology. Over the past decades, macrophages have been recognized to play a significant role in IPF pathogenesis. According to their anatomical loci, macrophages can be divided to alveolar macrophages (AMs) subtypes and interstitial macrophages subtypes (IMs) with different responsibility in the damage defense response. Depending on diverse chemokines and cytokines in local microenvironments, macrophages can be induced and polarized to either classically activated (M1) or alternatively activated (M2) phenotypes in different stages of immunity. Therefore, we hypothesize that there is a “phagocytosis-secretion-immunization” network regulation of pulmonary macrophages related to a number of chemokines and cytokines. In this paper, we summarize and discuss the role of chemokines and cytokines involved in the “phagocytosis-secretion-immunization” network regulation mechanism of pulmonary macrophages, pointing toward novel therapeutic approaches based on the network target regulation in the field. Therapeutic strategies focused on modifying the chemokines, cytokines and the network are promising for the pharmacotherapy of IPF. Some Traditional Chinese medicines may have more superiorities in delaying the progression of pulmonary fibrosis for their multi-target activities of this network regulation.

In terms of fault diagnosis of liquid-propellant rocket engine, the fault diagnosis accuracy of the traditional method is low the characteristics of engine fault data are small sample and nonlinear variation. In order to improve the accuracy of sensor fault diagnosis and overcome the scarcity of related samples, the particle swarm optimization (PSO) with strong global searching ability is used to optimize the LS-SVM parameters, and the LSSVM optimal parameter values are obtained by iteration to improve the model fitting accuracy and generalization ability. At the same time, the traditional support vector machine and BP neural network model are used for the detection. The simulation results show that the least squares support vector machine (SVM) detection method based on particle swarm optimization has the advantages of high precision and high speed. It has certain effect and positive significance for improving the safety of liquid-propellant rocket engine test and engine failure loss.

Introduction Although HIV antibody tests have been widely accepted in clinical diagnosis of HIV infection, they may not be sufficient to diagnose all subjects with HIV infection. Except negative result of antibody test in the well-known" acute window phase", in rare cases, patients do not develop HIV antibodies despite demonstrable infection. Primary pulmonary Kaposi sarcoma (KS) without mucocutaneous involvement accounts for only 0-15% of all AIDS-related KS. KS is rare among Chinese subjects, especially in persons of Han descent. Methods A case of seronegative AIDS with primary pulmonary Kaposi sarcoma (KS) was reported. It's a 46-year-old Chinese man presented with sore throat, hemoptysis, fever, dyspnea and multiple lung nodules. The lung lesions grew over a 5-month period so as the symptoms worsened. The possibility of AIDS was discounted by his physicians because of the repeatedly negative HIV antibodies tests despite the ELISA tests or Western blot tests. Histopathologic diagnosis of fine needle lung biopsy in local hospital was undetermined. After admission, HIV infection was eventually confirmed by plasma HIV RNA testing. Histopathologic diagnosis of Lung Kaposi sarcoma was made through repeated fine needle aspiration biopsy as well as the review of former one. Multiple antibiotics and chemotherapy were administrated with no clinical effect due to advanced stage and the patient passed away soon after diagnosis. Results This is the first case of seronegative HIV-1 infection with presentation of primary pulmonary KS. Conclusion This case underscores the importance of plasma RNA test in conjunction with HIV antibody test for some rare patients with HIV infection who present with severe immunodeficiency and opportunistic infections or malignancy.

Background Recently, a nickel–titanium (NiTi) memory-shape device has been successfully used in gastrointestinal anastomosis. The aim of this study was to investigate the feasibility and safety of the device. Methods Four databases, reference lists, and the World Health Organization International Clinical Trials Registry Platform were systematically searched for randomized controlled trials assessing the clinical efficacy of a NiTi memory-shape device compared with that of a stapler in gastrointestinal or colorectal anastomosis. Results Seven randomized controlled trials regarding the use of compression anastomosis clips (CACs) were enrolled for meta-analysis. The use of CACs was associated with a significant reduction in hospital duration (mean = −0.88 d; 95% confidence interval [CI], −1.38 to −0.38), the time to flatus (mean = −0.36 d; 95% CI, −0.08 to −0.04), and the start of oral intake (mean = −0.45 d; 95% CI, −0.83 to −0.06), as well as a nonsignificant change in postoperative complications and mortality. These clinical outcomes did not significantly change with the use of compression anastomosis rings. Conclusions Colonic anastomosis with a CAC is likely to reduce hospital duration, time to flatus, and the start of oral intake without influencing mortality or postoperative complications and may be a safe and preferable choice in colonic anastomosis. Further well-designed trials should be performed to determine the safety and efficacy of the newly developed compression anastomosis ring in both ileocolic and colorectal anastomosis.

With the continuous improvement in technology, campus life and learning applications are becoming increasingly modernization, and the popularity of mobile networks makes mobile terminals (especially smart phones) work as the most important information form for college students. Taking advantages of Android platform’s features to achieve efficient and intelligent campus applications, not only can implement synchronization of information dissemination, as well as in-time, learning and life convenience, but also reduce the students’ dependence on computers, which makes interpersonal communication everywhere. This paper takes the campus dining application for example, to explore campus applications based on Android, thereby promoting the construction of campus information technology, and further enrich the local campus life and learning.

Summary Background and objective X-ray repair cross-complementing group 3 (XRCC3) is responsible for maintaining the integrity of the genome, playing a critical role in protecting it against mutations which lead to cancer. Polymorphisms at exons 7 of the XRCC3 gene may alter the XRCC3 repair efficiency. The aim of this study is to derive a precise estimation of the relationship between XRCC3 Thr241Met polymorphism and gastric cancer (GC) risk. Methods Two investigators independently searched the databases of Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) up to May 15, 2013. Odds ratio (OR) and 95% confidence intervals (CI) for XRCC3 Thr241Met polymorphism and GC were calculated in a fixed- or random- effects model depending on statistical heterogeneity. Results This meta-analysis included 9 case-control studies, which included 2209 cases and 3269 controls. Overall, the combined results based on all studies indicated that there was no association between XRCC3 Thr241Met polymorphism and GC susceptibility for all genetic models. When stratifying for race, we found the 241Met/Met genotype carriers might be at high risk of GC among Asians, but not among Caucasians. When stratifying by the location of gastric cancer, the combined results showed that Met/Met genotype carriers might have an increased risk of GC in non-cardiac gastric cancer, but not in cardiac cancer. Conclusion This meta-analysis confirmed that the XRCC3 Thr241Met gene polymorphism might be a risk factor for GC among Asians, and that differences in genotype distribution may be related to the location of gastric cancer. More well-designed studies based on larger population are needed to confirm our results.

A novel topology structure of supercapacitor energy storage converter (ESC) is presented with two cascaded bidirectional DC/DC converters connected to a bidirectional DC/AC converter. It can promote the energy utilization rate of supercapacitor and improve the ability of powering unbalanced and nonlinear loads. The effect of the midpoint voltage fluctuation of the cascaded connected DC bus capacitors on output voltage is analyzed, followed by the influence mechanism unbalanced and nonlinear loads. The control strategy to restrain the unbalance and zero sequence harmonic is proposed. The theoretical analysis and the proposed method are verified through simulations and experiments on a 100kVA supercapacitor ESC prototype.

Primary cardiac synovial sarcoma is an extremely rare entity. The clinical and pathologic characteristics are still poorly understood, and prognostic factors influencing overall survival are still unknown. In the present study, all characteristics of reported patients, including sex, age, clinical presentations, laboratory tests, electrocardiogram, imaging findings, pathology, location, therapy, and follow-up were carefully reviewed and survival analysis was performed. The present study has summarized some key features and may provide an effective consultation for the diagnosis and treatment of the tumor.

At present, our nation attaches more and more importance to development of LNG industry, and LNG terminal is an important part of LNG industry chain. Aiming at current problem of being no basis for LNG terminal fire prevention system design, this article puts forward the primary solution on fire prevention design for such sites by combining fire risk of LNG terminal, requirements of relevant regulations both at home and abroad and practical experience. In this article, LNG terminal fire prevention system consists of detection unit, execution system and extinguishing and alarm unit system. This article introduces the composition and function of each part.

Transanal tubes (TTs) have been used to prevent and reduce anastomotic leakage after rectal cancer surgery. The aim of this review was to investigate the efficacy and safety of the TT. A systematic literature search was performed to identify randomized controlled trials and controlled clinical trials assessing the clinical efficacy and safety of TTs in rectal cancer surgery. Seven trials with 1609 participants were included. The TT group had a lower anastomotic leakage rate than the non-transanal tube group [RR 0.38; 95 % confidence interval (CI) 0.25–0.58; P

For the problem that manual adjustment of the parameters of controller in sensorless control system costs too much time, manpower and always can not get a good result, a new method based on improved particle swarm optimization algorithm is proposed to optimize the parameters. The improved algorithm is based on the standard particle swarm optimization with the simulated annealing algorithm and chaotic search brought in. The speed of motor is estimated by the extend Kalman filter. The error between measured speed and estimated speed of the permanent magnet synchronous motor rotor is used as the fitness function in order that the parameters in the covariance matrix is adjusted.The result of simulation indicates that high estimation precision can be got and the motor represents steadily with few of ripple of the actual speed.With this method, the time of adjustment is reduced and manpower is saved. In addition, the validity of the method is proved in experiment with dSPACE.

Summary Background and aims Supplementation of fish oil (FO) containing lipid emulsions has been associated with a reduction in the length of hospital stay, infections and liver dysfunction in patients undergoing major surgery. We carried out a meta-analysis and subgroup analysis to examine randomised clinical trial (RCT)-based evidence of the aforementioned effects. Methods Four databases, reference lists and the WHO ICTRP were systematically searched for RCTs to access the clinical efficacy of fish oil-enriched total parenteral nutrition in post-surgery patients. Methodological quality assessment was based on the Cochrane Handbook and GRADE. Results Twenty-one RCTs were enrolled for meta-analysis. FO was associated with a significant reduction in the length of hospital stay (mean = −2.14 d, 95% CI = −3.02 to −1.27), infections (OR = 0.53, 95% CI = 0.35–0.81), ALT (mean = −6.35 U/L, 95% CI = −11.75 to −0.94), GGT (mean = −11.01 U/L, 95% CI = −20.77 to −1.25) and total bilirubin (mean = −2.06 μmol/L, 95% CI = −3.6 to −0.52), as well as a non-significant change in mortality and postoperative medical cost. The quality of evidence of each clinical outcome was accessed as high. Conclusion FO-enriched lipid emulsions are likely to reduce infections, the length of hospital stay and liver dysfunction without influencing mortality and may be a safe and preferable choice in post-surgery patients. Further well-designed trials should be performed to determine whether FO lipid emulsions reduce mortality in patients undergoing hepatic surgery, especially liver transplantation, and the cost effectiveness of such treatment.

Summary Background and objective The association between glutathione S-transferase T1 (GSTT1) gene polymorphisms and colorectal cancer (CRC) susceptibility is still controversial. In order to clarify the effect of GSTT1 genotype on the CRC risk, we carried out an updated meta-analysis of published case-control studies to provide more precise evidence. Methods Two investigators independently searched the databases of Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) up to October 15, 2012. Crude odds ratios (OR) and 95% confidence intervals (CI) were calculated to investigate the strength of the association in a fixed- or random-effects model depending on statistical heterogeneity. Results Forty-six case-control studies with 15,373 colorectal cancer cases and 21,238 controls were included. Overall, the pooled results indicated that GSTT1 null genotype was significantly associated with increased CRC risk (OR = 1.21, 95% CI = 1.10–1.33). When stratifying for ethnicity and control sources, we also observed positive association between GSTT1 null genotype and increased risk of CRC. When stratifying by the location, we found there was a statistically significant association in the rectal cancer (OR = 1.28, 95% CI = 1.01–1.64), but not in colon cancer (OR = 1.27, 95% CI = 0.94–1.73). Subgroup analyses for Dukes stage, histological differentiation of CRC and smoking habit did not reveal any significant differences in genotype distribution. In addition, we observed a strong correlation between increased CRC risk and the combined GSTM1 and GSTT1 null genotype. Conclusions This meta-analysis suggests that the GSTT1 null genotype may contribute to increased risk of colorectal cancer. More well-designed studies based on larger population are needed to confirm our results.

Time series forecasting is one of the important problems in the time series analysis. As one of the most powerful analysis tools for time series forecasting, neural network (NN) has been receiving considerable attention since many years ago and a large number of improvements of NN-based forecasting on time series have appeared in the relevant literature. This paper reviews the structure improvement of NN and the main combination of NN and other pop technologies in the improvement of algorithms.

Dear Editor, We have read the study entitled “Patellar resurfacing versus nonresurfacing in total knee arthroplasty: A meta-analysis of randomised controlled trials” by Chen et al. [1] with interest. In this updated meta-analysis, the authors compared clinical effectiveness of patellar resurfacing in total knee arthroplasty (TKA) with nonresurfacing. However, we have several questions regarding this study. Firstly, the authors used three electronic databases to search eligible studies. However, they did not provide the search strategy and flow diagram of the study selection. Therefore, we suggest that the authors should follow PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Statement criteria [2] when reporting a meta-analysis. Secondly, the previous meta-analysis reported by He et al. [3] ultimately recruited 16 randomised controlled trials (RCTs), while this updated study had only 14 eligible RCTs. We would like to know the possible reason for this difference. This updated meta-analysis indicated that patellar surfacing can reduce the reoperation rate. We agree with the authors that different surgeons and different prosthetic design may affect the outcomes. Therefore, as the authors have indicated, more RCTs are needed to reduce the bias.