Search

Traditional fluorescent materials used in anti-counterfeiting field usually exhibit monochromatic luminescence at a single-wavelength excitation, which is easily be forged by sophisticated counterfeiters. In this work, Zn2GeO4:Mn, x%Li (x=0 and 20), Zn2GeO4­NaLiGe4O9:Mn, x%Li (x=50 and 70) and NaLiGe4O9:Mn micro-phosphors with the multi-chromatic and multi-mode luminescence have been successfully synthesized via a hydrothermal approach followed by an annealing treatment. As expected that these Li+ doped Zn2GeO4:Mn and NaLiGe4O9:Mn phosphors exhibit a double peak emission including a long green afterglow (~540 nm) and a red photoluminescence (∼668 nm). By tuning Li+ doping concentrations, a gradual colour output and a tuneable afterglow duration are achieved. Particularly, the Zn2GeO4:Mn,Li and NaLiGe4O9:Mn phosphors exhibit excellent performance as security inks for printing luminescent numbers and anti-counterfeiting patterns, which shows an afterglow time-dependent or excitation wavelength-dependent luminescence colour evolution. This work proves the feasibility of Li+ doping strategy in emission tuning, which can stimulate further studies on multi-mode luminescent materials in anti-counterfeiting applications.

Cloud segmentation is fundamental in obtaining many parameters of clouds. However, traditional cloud segmentation performs far from satisfactory, due to the fuzzy boundaries and complex textures of clouds. Although deep learning methods have shown superior performance in cloud segmentation, they are constrained by limited labels in ground-based cloud image data sets. This letter established a new Ground-Based Cloud Segmentation (GBCS) data set with 1742 accurately labeled images. Then to evaluate how well deep learning models perform in cloud segmentation, 12 state-of-the-art semantic segmentation networks are selected, among which DeepLabV3+ outperformed all others. Since 1742 images are not enormous, a novel Transfer learning (TL)-DeepLabV3+ model was developed by TL: DeepLabV3+ network was trained with the PASCAL VOC 2012 data set, then retrained in GBCS. TL-DeepLabV3+ showed a high ability of cloud segmentation, scoring the Mean Intersection-over-Union (MIoU) of 91.05% in GBCS and further verified in the UTILITY data set and the Cirrus Cumulus Stratus Nimbus (CCSN) data set.

We examine the effect of investment restrictions on mutual fund performance. Utilizing a unique panel of mutual fund contract changes, we explore several ways these changes affect a fund, including: performance, funding risk, and managerial contracting. We find that the general shift towards fewer restrictions over the period 1996–2011 has provided little benefit to mutual funds. Specifically, neither performance nor flow increased and we observe no changes in risk on average. We do find, however, an increased likelihood of management turnover when restrictions are removed. We conclude that contract restrictions do not explain the general underperformance of mutual funds, and that these investment restrictions are not binding.

Background Circular RNAs (CircRNAs) have been found to possess vital functions in tumorigenesis of various cancer types, including non-small cell lung cancer (NSCLC). The aim of this study was to identify and explore the diagnostic values of the newly found Toll interacting protein (TOLLIP)-derived circRNA (circTOLLIP) for liquid biopsy in NSCLC. Methods RNase R and actinomycin D assays were conducted to confirm the existence and stability of circTOLLIP. RT-qPCR was performed to identify the expression levels of circTOLLIP in NSCLC tumor tissues, whole blood, and cell lines. The diagnostic values were evaluated by receiver operating characteristic (ROC) curve analysis. Results CircTOLLIP was screened as a candidate biomarker and was found to be significantly down-regulated in both NSCLC tissues and cell lines. Interestingly, circulating circTOLLIP was also lower-expressed in the whole blood of patients with NSCLC compared to that of patients with benign lung disease and healthy controls. Importantly, the circulating circTOLLIP represented better diagnostic values in comparison to the traditional tumor markers (NSE, CYFR21-1, and CA72-4), and showed higher stability even though the whole blood was exposed to various tough conditions. Conclusions Our findings indicate that circTOLLIP can be used as a non-invasive biomarker to distinguish early-stage NSCLC from benign lung diseases and from healthy controls, suggesting the potential application of circTOLLIP for liquid biopsy in NSCLC.

This paper examines the effect of rapid expansion of the hedge fund industry on mutual fund managerial turnovers. Deuskar et al. (2011) find that mutual funds retain skilled managers by offering side-by-side arrangements. We find that talented fund managers tend to leave mutual funds and establish their own hedge funds when side-by-side arrangements are not feasible. Mutual fund returns and flows decrease if their managers leave mutual funds to establish hedge funds, especially when the hedge fund industry is growing rapidly and performing well. Both institutional and retail investors react to this managerial turnover by reducing net flows.

In this paper, we propose an ultra-high speed random bit generator without the time-delay signature based on an ytterbium-doped random fiber laser (YRFL) with Rayleigh scattering feedback. The spectrum of the YRFL has a relatively broad bandwidth (0.35 nm) and the lasing temporal intensity shows random fluctuations without cavity induced time-delay signatures (TDS), which are essential for ultra-high speed random bit generation. The chaotic signal and its time-delayed signal sampling at 40 Giga samples per second (GS/s) are converted to digital 8-bit signals. By selecting 5 least significant bits from each 8-bit digital signal and using bitwise exclusive-OR operation, we experimentally achieve 200 Gbps physical random bit generation based on ytterbium-doped random fiber laser with the verified randomness. The combination of broadband emission and free of TDS makes random fiber lasers new promising sources for high performance random bit generation in a simple and compact configuration, which has a great potential in cryptography and secure communication applications.

We propose and experimentally demonstrate a centralized PON monitoring scheme using the reflection spectrum of a single fiber Bragg grating. Each fiber Bragg grating used in the scheme adopts different central reflection wavelength or 3-dB reflection bandwidth. The unique reflection spectrum is generated after each fiber Bragg grating used is interrogated by a broadband probe source. These generated reflection spectra are used to identify and distinguish the drop fiber links. The similarity analysis model is established to solve the problem of waveform superposition identification for different 3-dB reflection bandwidths with the same central reflection wavelength, which can further improve the network monitoring capacity. The proposed scheme provides a simple and effective monitoring solution for large-capacity network, especially for high-density network with small end-user distance difference.

Background Liberal oxygen therapy might increase the mortality rate of patients. Non-rebreathing masks (NRM) are a high-flow, non-invasive oxygen device that can provide oxygen concentration up to 95%. This study aimed to determine the impact of using NRM in patients with respiratory failure. Methods This retrospective cohort study was conducted in four medical institutions in Taiwan from January 2010 to December 2016. The association between mortality and NRM use before receiving ventilator support in patients with respiratory failure in the emergency department was analyzed. Patients were divided into the NRM treatment and no NRM treatment groups. A 1:4 propensity score matching was conducted. Regarding the duration of NRM use, treatments were grouped as 0 h, 0–1 h, 1–2 h, and >2 h. Results A total of 18,749 patients were included, with 1074 using NRM. After propensity score matching, 1028 patients using NRM (0–1 h: 508, 1–2 h: 193, and >2 h: 327) and 4112 patients not using NRM were analyzed. The 30-day mortality rates were 29.1%, 28.5%, 27.5%, and 35.5% in the 0 h, 0–1 h, 1–2 h, and >2 h treatment groups, respectively. Patients with respiratory failure due to pulmonary disease using NRM over 2 h had a higher mortality rate than patients not using NRM (hazard ratio: 1.3, 95% CI: 1.01–1.66). Conclusions Prolonged use of NRM in patients with respiratory failure due to pulmonary disease possibly increases mortality.

We theoretically explore dwell time for electrons in a semiconductor microstructure, which is constructed on the surface of the InAs/Al x In1- x As heterostructure by patterning a ferromagnetic (FM) stripe and a Schottky-metal (SM) stripe in a parallel configuration. Dwell time is found to be dependent on electron spins. Spin-polarized dwell time can be controlled by changing an applied voltage to SM stripe. Thus, electron spins can be separated in time dimension, and such a semiconductor microstructure can be used as an electrically tunable temporal spin splitter for spintronics device applications.

Background Pedicle screw insertion has been known to have several complications even in the most skilled surgical hands. However, injury to the thoracic aorta during pedicle screw insertion is rare, delayed presentation secondary to pseudoaneurysm is even rarer, the pseudoaneurysm formation caused by a series of malpositioned pedicle screws has perhaps not been reported so far. Case presentation In this paper, we report here a case in which inadvertent injury to the thoracic aorta resulted in pseudoaneurysm, its manifestation was initially vague, resulting in a delayed diagnosis. Delayed aortic pseudoaneurysm or injury can be asymptomatic for a long time. Patients with renewed or continued back pain should alert orthopaedic surgeons regarding the possibility of pseudoaneurysms, regardless of the period that has elapsed after pedicle screw implantation., Delayed aortic pseudoaneurysm or injury can be asymptomatic for a long time. Patients with renewed or continued back pain should alert orthopaedic surgeons regarding the possibility of pseudoaneurysms, regardless of the period that has elapsed after pedicle screw implantation.

Photoredox-mediated hydrogen atom transfer (HAT) catalysis has reshaped the synthetic strategy of C–H bond functionalization. The rationalization and prediction of HAT reactivity are crucial for the reaction design of photoredox-mediated C–H functionalization. In this work, we report the development of a machine learning model that can predict the HAT barrier of photoredox-mediated HAT catalysis using the physical organic descriptors of the ground state substrate and radical. Based on 2926 DFT-computed HAT barriers of the designed chemical space, the trained AdaBoost model is able to predict the HAT barrier with a mean absolute error of 0.60 kcal mol−1 in the out-of-sample test set. The applicability of the machine learning model is further validated by comparing the prediction against the DFT-computed reactivities on scaffolds and substituents that are not present in the designed chemical space, as well as experimental kinetics data of HAT reaction with the cumyloxyl radical. This work provides a machine learning approach for reactivity prediction from physical organic descriptors and DFT-computed statistics, offering a useful technique that can be directly applied in the experimental designs of photoredox-mediated HAT catalysis.

Lin He,1 Xin Hong,2 Rajaraman Suryakumar,2 Ramesh Sarangapani2 1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Alcon Research LLC, Fort Worth, TX, USACorrespondence: Lin HeDepartment of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USATel +1-817-302-5666Email retinoblastoma13q14@gmail.comPurpose: To predict clinical defocus curve performance of the PanOptix intraocular lens (IOL) model TFNT00, a population-based image quality metric was applied to a pseudophakic eye model.Methods: Visual acuity (VA) was simulated using a 2-surface reduced eye model. For each virtual eye, the derived corneal surface was combined with scaled IOL surface. Corneal power and aberration, anterior chamber depth, and pupil size were iterated using a Monte-Carlo approach. Image quality of the IOLs was assessed using the total aberration map to compute the amplitude point spread function. A diffraction-normalized light-in-the-bucket metric was calculated for each virtual eye for defocuses from − 3.5 D to +1.0 D (step size 0.25 D) and transformed to VAs and defocus curves. Simulated VA for the ReSTOR +3.0 D lens was used to generate a calibration function by linear regression correlation of simulated data with clinical VA data. Simulated TFNT00 VA was then validated by comparing defocus curves to clinical TFNT00 data.Results: From − 3.5 D to +1.0 D, the simulated defocus curve was generally consistent with the defocus curve from the TFNT00 clinical trial. The mean absolute difference was 0.022 logMAR (∼ 1 letter) for simulated VA versus clinical trial VA.Conclusion: IOL image quality can be assessed using a population-based virtual eye model to simulate VA and predict clinical performance. Computational modeling and simulation can be applied to future IOL development before clinical trials are conducted.Keywords: light-in-the-bucket, modulation transfer function, pseudophakic eye model

Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are still unknown. We show that acute administration of EPA impairs learning and memory and hippocampal LTP in adult and prepubescent mice. Similar deficits are duplicated by endogenously elevating EPA in the hippocampus in the transgenic fat-1 mouse. Furthermore, the damaging effects of EPA are mediated through enhancing GABAergic transmission via the 5-HT6R. Interestingly, DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR. We conclude that EPA exhibits an unexpected detrimental impact on cognitive functions, suggesting that caution must be exercised in omega-3 fatty acid supplementation and the combination of EPA and DHA at a natural ratio is critical for learning and memory and synaptic plasticity., Acute administration of EPA impairs learning and memory and hippocampal LTP in mice that was mediated through enhancing GABAergic transmission via the 5-HT6R. DHA can prevent EPA-induced impairments at a ratio of EPA to DHA similar to that in marine fish oil via the 5-HT2CR.

Purpose The human eye exhibits large amounts (2.5 diopters) of longitudinal chromatic aberration (LCA). Its impact on polychromatic image quality, however, has been shown experimentally and by computer modeling to be small or absent. We hypothesized that modest changes in pseudophakic LCA created by higher and lower Abbe number materials will have little or no impact on polychromatic image quality in pseudophakic eyes. Materials and Methods Using published chromatic and monochromatic aberration data from pseudophakic eyes and higher and lower Abbe number materials (37 and 55), we computed monochromatic point spread functions for 21 wavelengths across the visible spectrum. After weighting by either the RGB spectra of a liquid crystal display or by a flat white spectrum, they were weighted by the human spectral sensitivity function (Vλ) before being added to generate polychromatic PSFs. Results In the absence of monochromatic aberrations, the reduced LCA due to higher Abbe number intraocular lens (IOL) materials resulted in a reduction of 0.08 diopters in the mean defocus generated by LCA. At the retinal plane, the higher Abbe number pseudophakic model produced improvements in polychromatic modulation transfer functions (MTFs) similar to those generated by a 0.05 diopter reduction in spherical defocus. When monochromatic aberrations were added to make the model more representative of actual pseudophakic eyes, the differences in image quality became sub-threshold for human vision or disappeared completely. Conclusion The anticipated gains in polychromatic image quality from employing higher Abbe number IOL materials with reduced LCA do not materialize in plausible aberrated models of pseudophakic eyes.

Traditional silicon-based photodetectors are limited by the band gap of silicon, which results in a limited working wavelength range. In this report, due to the excellent properties of Indium Antimonide, the InSb/Si heterojunction photodetectors are fabricated. Under ambient temperature of 280K, as-prepared photodetectors show a specific detectivity of 9.31011 cm Hz1/2/W, responsivity of 54 mA/W, on/off ratio of 5104 under the laser irradiation of 635 nm. In order to explore the influence of working temperature on device performance, the photoresponse at different temperatures was tested. This report proved that as the working temperature increases, the responsivity and specific detectivity of the device decrease, and the performance of the device becomes worse.

The hole-transport-material (HTM) free perovskite solar cells (PSCs) have drawn great attentions due to the simple structure, low fabrication cost and long term stability. However, the photoelectric conversion efficiency (PCE) of the HTM-free PCSs are still low comparing with the traditional sandwich type PSCs. In this work, a new HTM-free PSC is proposed with CH3NH3PbI3/CsSnI3 all-perovskite heterojunction as light-harvester and carbon as back electrode through simulation using the wxAMPS tools. The results are analyzed and compared with the traditional HTM-free perovskite solar cells. It reveals that the narrow band gap CsSnI3 broadens the absorption spectrum to near-infrared region and the high hole mobility favors efficient hole transfer. The optimal performance is achieved as Voc = 1.08 eV, Jsc = 25.33 mA/cm2, FF = 79.27%, PCE = 21.64%. Comparing to the bare CH3NH3PbI3 absorbing layer, the device efficiency of CH3NH3PbI3/CsSnI3 heterojunction is improved from 18.29% to 21.64%. This indicates that the proposed HTM-free PSC is promising for future photovoltaic and optoelectronics applications.

OBJECTIVE: To provide clinical management guidelines for novel coronavirus (COVID-19) in pregnancy. METHODS: On February 5, 2020, a multidisciplinary teleconference comprising Chinese physicians and researchers was held and medical management strategies of COVID-19 infection in pregnancy were discussed. RESULTS: Ten key recommendations were provided for the management of COVID-19 infections in pregnancy. CONCLUSION: Currently, there is no clear evidence regarding optimal delivery timing, the safety of vaginal delivery, or whether cesarean delivery prevents vertical transmission at the time of delivery; therefore, route of delivery and delivery timing should be individualized based on obstetrical indications and maternal-fetal status.

Travel physical energy expenditure for travellers has impact on travel mode choice behaviour. However, quantitative study on travel physical energy expenditure is rare. In this paper, the concept of travel physical energy expenditure coefficient has been presented. A case study has been carried out of young travellers in Beijing to get the value of physical energy expenditure per unit time under three transport modes, walking, car and public transportation. A series of experiments have been designed and conducted, which consider influence factors including age, gender, travel mode, riding posture, luggage level and crowded level. By analysing the travel data of money, travel time and physical energy expenditure, we determined that the value of travel physical energy expenditure coefficient δ is 0.058 RMB/KJ, which means that travellers can pay 0.058 RMB to reduce 1 KJ physical energy expenditure. Next, a travel mode choice model has been proposed using a multinomial logit model (MNL), considering economic cost, time cost and physical energy cost. Finally, the case study based on OD from Xizhimen to Tiantongyuan in Beijing was conducted. It is verified that it will be in better agreement with the actual travel behaviour when we take the physical energy expenditure for different types of travellers into account.

Background Circulating tumour cells (CTCs) can be assessed through a minimally invasive blood sample with potential utility as a predictive, prognostic and pharmacodynamic biomarker. The large heterogeneity of melanoma CTCs has hindered their detection and clinical application. Methods Here we compared two microfluidic devices for the recovery of circulating melanoma cells. The presence of CTCs in 43 blood samples from patients with metastatic melanoma was evaluated using a combination of immunocytochemistry and transcript analyses of five genes by RT-PCR and 19 genes by droplet digital PCR (ddPCR), whereby a CTC score was calculated. Circulating tumour DNA (ctDNA) from the same patient blood sample, was assessed by ddPCR targeting tumour-specific mutations. Results Our analysis revealed an extraordinary heterogeneity amongst melanoma CTCs, with multiple non-overlapping subpopulations. CTC detection using our multimarker approach was associated with shorter overall and progression-free survival. Finally, we found that CTC scores correlated with plasma ctDNA concentrations and had similar pharmacodynamic changes upon treatment initiation. Conclusions Despite the high phenotypic and molecular heterogeneity of melanoma CTCs, multimarker derived CTC scores could serve as viable tools for prognostication and treatment response monitoring in patients with metastatic melanoma.

Alzheimer’s Disease (AD) is a form of dementia which causes memory, thinking, and behavior disorders in humans. Effective early diagnosis and treatment of AD is of fundamental importance as it can reduce disease progression, allow more effective management of symptoms, facilitate timely patient access to advice and support, and lower associated costs of health care. Given that Alzheimer’s typically progresses in stages over an extended period of time, we propose that automated analysis of time sequential data may enhance disease prediction. We present a novel time-series Alzheimer’s Disease Prediction Model (ADPM) comprising Random Forest (RF) region of \ud interest (ROI) selection and Gated Recurrent Units (GRU) prediction. Experiments show that our methodology achieves higher classification accuracy in comparison to existing algorithms, and can facilitate prediction of early onset AD. Furthermore, testing demonstrates that random forest ROI selection can identify disease-relative brain regions across different image modalities (MRI, PET, DTI).

Diabetes mellitus is considered to be a major risk factor for cardiovascular disease, the most common cause of death in diabetes. However, therapeutic strategies for myocardial protection in patients with diabetes are still limited. Cordycepin is a traditional Tibetan medicine with a long history of widespread use, and exerts a wide range of anti-tumor, anti-inflammatory, and anti-oxidative effects. In recent years, although the therapeutic potential of cordycepin has attracted the attention of researchers, it remains unknown whether cordycepin plays a protective role in myocardial ischemia/reperfusion (MI/R) injury in diabetic patients. Here, using a diabetic mouse model, we found that cordycepin protected diabetic hearts from MI/R injury by promoting mitochondrial fusion and Mfn2 expression. Our in vitro results showed that cordycepin enhanced Mfn2-medicated mitochondrial fusion, improved mitochondrial function, and reduced cardiomyocyte apoptosis in high-glucose/high-fat cultured simulated ischemia/reperfusion cardiomyocytes. Furthermore, we found that knockout of Mfn2 significantly blocked the cardioprotective effects of cordycepin in diabetic mice. Finally, an AMPK-dependent pathway was found to upregulate Mfn2 expression upon cordycepin treatment, indicating that cordycepin protected diabetic hearts via AMPK/Mfn2-dependent mitochondrial fusion. Collectively, our study firstly demonstrated that cordycepin could be a potential cardioprotective agent for MI/R injury, and we established a novel mechanism by which upregulated AMPK/Mfn2-dependent mitochondrial fusion contributes to the cardioprotective role of cordycepin.

Limited data regarding the effects of school-based obesity prevention programs focusing on the changes in obesity-related knowledge and behaviors in China are available. The objective of this paper was to evaluate the effects of a school-based comprehensive lifestyle intervention among Chinese kids against obesity (CLICK-Obesity) in primary schools in Nanjing. We designed a cluster randomized controlled trial in eight randomly selected urban primary schools among 4th graders between May 2011 to April 2012 in Jianye, an urban district of Nanjing. Each school was randomly assigned to either the intervention or control group (four schools in each group). Mixed regression models and generalized estimating equations (GEE) were used to adjust for individual-level covariates under cluster randomization. In this study, 1178 students (96.2%; 665 boys and 513 girls, 544 in control and 634 in intervention) participated in the baseline survey with mean age 10.2 ± 0.5 years. At the end of one-year intervention, 1125 students (91.8%; 628 boys and 497 girls, 513 in control and 612 in intervention) were reassessed. Notably, we found that the intervention group improved the knowledge and awareness of obesity-related risk factors, presented a lower increase of consumption of red/white meat (with a mean difference of −180.9 g/week, 95% CI: −350.6 to −11.2, p = 0.040), a larger increase in the time spent playing ball (with a mean difference of 24.2 min/week, 95% CI: −5.3 to 53.7, p = 0.090), and a significant reduction in screen time (with a mean difference of −71.0 min/week, 95% CI: −125.3 to −16.6, p = 0.020) compared to the control group after cluster (school) adjustment. The school-based integrated intervention was successful to modify unhealthy lifestyle behaviors and had a potential effect on childhood obesity prevention in urban China. However, the long-term effects and cost-effectiveness need to be evaluated in through further study.

Late-stage cancer metastasis remains incurable in the clinic and is the major cause death in patients. Circulating tumor cells (CTCs) are thought to be metastatic precursors shed from the primary tumor or metastatic deposits and circulate in the blood. The molecular network regulating CTC survival, extravasation, and colonization in distant metastatic sites is poorly defined, largely due to challenges in isolating rare CTCs. Recent advances in CTC isolation and ex vivo culture techniques facilitates single-cell omics and the development of related animal models to study CTC-mediated metastatic progression. With these powerful tools, CTCs can potentially be used as non-invasive biomarkers predicting therapeutic response. These studies may open a new avenue for CTC-specific drug discoveries. In this short review, we aim to summarize recent progress in the characterization of CTCs and their clinical relevance in various cancers, setting the stage for realizing personalized therapies against metastases.

BACKGROUND: The purpose of this study is to explore the relationship between the ferroptosis-related gene zinc finger protein 36 (ZFP36) and the prognosis of osteosarcoma patients after surgery. METHODS: Differential expression genes (DEGs) between osteosarcoma and normal tissues were screened using osteosarcoma chip data in GEO database. Based on the median expression quantity, ferroptosis DEGs were divided into high and low expression groups. Combined with its corresponding clinical survival data, the survival analysis of ferroptosis DEGs was carried out using the Survival package, and ferroptosis-related genes related to prognosis were identified. Next, the clinical data of 60 osteosarcoma patients treated in Jiangyin Hospital Affiliated to Nanjing University of Chinese Medicine, Zhongda Hospital and Nanjing Drum Tower Hospital from January 2011 to January 2016 were retrospectively analyzed. Immunohistochemistry and reverse transcription quantitative polymerase chain reaction (qRT-PCR) were used to detect gene expression in osteosarcoma. The Kaplan-Meier method and log rank test were used for univariate survival analysis, the Cox regression method was used for multivariate analysis, and the nomogram was constructed for internal verification on this basis. RESULTS: Immunohistochemical and reverse transcription quantitative PCR results showed that the expression of ZFP36 was mainly higher in cancer-adjacent tissues than in tumor tissues. There were significant differences in age, tumor location, Enneking stage, and tumor specific growth factor (TSGF) between the high and low expression groups of ZFP36 (P

The Chang’e-5 mission of the third phase of China’s Lunar Exploration Program is China’s first mission to sample and return from an extraterrestrial object. The objective of the mission was to land on the selected area of the lunar surface, collect lunar samples, and return these samples to earth safely through the processes of lunar lift-off, lunar orbit rendezvous and docking, sample transfer, moon-to-earth transfer, and reentry. This report describes the mission’s technical features, brief introduction, and development process, and summarizes the breakthroughs and innovation of the key technologies involved, and presents the flight results. The on-orbit results show that all functions and specifications satisfy the mission requirements, the spacecraft is in good condition in flight, and the design of the scheme is validated.

This paper defines a new visual reasoning paradigm by introducing an important factor, i.e.~transformation. The motivation comes from the fact that most existing visual reasoning tasks, such as CLEVR in VQA, are solely defined to test how well the machine understands the concepts and relations within static settings, like one image. We argue that this kind of \textbf{state driven visual reasoning} approach has limitations in reflecting whether the machine has the ability to infer the dynamics between different states, which has been shown as important as state-level reasoning for human cognition in Piaget's theory. To tackle this problem, we propose a novel \textbf{transformation driven visual reasoning} task. Given both the initial and final states, the target is to infer the corresponding single-step or multi-step transformation, represented as a triplet (object, attribute, value) or a sequence of triplets, respectively. Following this definition, a new dataset namely TRANCE is constructed on the basis of CLEVR, including three levels of settings, i.e.~Basic (single-step transformation), Event (multi-step transformation), and View (multi-step transformation with variant views). Experimental results show that the state-of-the-art visual reasoning models perform well on Basic, but are still far from human-level intelligence on Event and View. We believe the proposed new paradigm will boost the development of machine visual reasoning. More advanced methods and real data need to be investigated in this direction. The resource of TVR is available at https://hongxin2019.github.io/TVR., Comment: Accepted to CVPR 2021. Resources including the TRANCE dataset and the code can be found at our homepage https://hongxin2019.github.io/TVR

We theoretically investigate how to manipulate the wave-vector filtering effect by δ-doping for electrons in a magnetically and electrically confined semiconductor heterostructure, which can be constructed by patterning a ferromagnetic stripe and a Schottky-metal stripe in a parallel configuration on the surface of the GaAs/AlxGa1−xAs heterostructure. The δ-doping dependent transmission is calculated by exactly solving the Schrodinger equation with the help of an improved transfer matrix method. An appreciable wave-vector filtering effect is revealed. Its wave-vector filtering efficiency is found to be tunable by changing the weight or position of the δ-doping. Thus, a structurally controllable momentum filter can be obtained for nanoelectronics device applications.

Understanding the usage patterns of a trail in a university environment is crucial for assessing the functionality of the trail and evaluating its impact to health in college students. This article presents a novel approach to map the usage patterns of a university trail by employing spatial video in a geographic information system (GIS) environment. Physical activities in the southeast part of the main campus of Kent State University (Kent, Ohio), were filmed by a GPS-enabled camera unit. The observed physical activities at the time of filming were coded from the videos and visualized as maps. The study finds that activities tend to concentrate near the center of campus, the farther from the campus, the fewer number of activities. The usage patterns are different between men and women. The activity zones of men are more dispersed, while those of women are more concentrated near campus center.

Nearly one in six hedge funds conducted corporate site visits from 2012 to 2017. Using comprehensive hedge fund site visit data, this paper is one of the first to empirically examine how corporate site visits affect fund performance. We find that hedge funds with more corporate site visits have better performance. The relation is stronger when a hedge fund manager visits a neglected firm or asks more questions during the visit, suggesting that hedge funds may be able to gain information advantage through site visits. Site visits benefit hedge funds more when a hedge fund manager conducts a site visit with a mutual fund manager. Further, the margin trading of the visited company's stock increases following a hedge fund site visit.

The T-type calcium channels Cav3.2, one of the low voltage-activated (LVA) calcium channels, have been found to play important roles in the neuronal excitability. Recently, we and others have demonstrated that accumulation of Cav3.2 channels in the dorsal root ganglion (DRG) neurons and sensory nerves contributes to neuropathic pain after peripheral nerve injury. In the present study, we aimed to further investigate the regulation of Cav3.2 channels by interleukin-6 (IL-6) in DRG neurons in neuropathic pain rats after spinal nerve ligation (SNL). The results showed that Cav3.2 channel protein expression in L5 DRG neurons was upregulated and blockade of this channel decreased the hyperexcitability of DRG neurons and mechanical allodynia in SNL neuropathic pain rats. Furthermore, inhibition of IL-6 trans-signaling reduced the upregulation of Cav3.2 T-type channel induced by FIL-6 (a fusion protein of IL-6 and sIL-6R) in primary cultured DRG neurons in vitro. In vivo, inhibition of IL-6 trans-signaling reversed the upregulation of Cav3.2, reduced the hyperexcitability of L5 DRG neurons and alleviated mechanical allodynia in SNL rats. Our results suggest that IL-6 upregulates Cav3.2 T-type channels expression and function through the IL-6/sIL-6R trans-signaling pathway in DRG neurons, thus contributes to the development of neuropathic pain in SNL rats.

In a large underground powerhouse, the surrounding rock mass at the intersection of the caverns has multiple free faces. This rock mass is more susceptible to stability issues because of its peculiar structure. This paper takes the Baihetan underground powerhouse as a case study example, wherein the failure issue of multi-freeface surrounding rock mass appears prominent. Through analysis of monitoring data from multi-point extensometers, it has been concluded that the average daily deformation of the main powerhouse sidewall on downstream side in the presence of multi-freeface rock mass proves larger than that on upstream side; the maximum deformation reaches 0.48 mm/d, overshadowing that at the rock anchor beam as well. The multi-freeface surrounding rock mass is not only more subject to large deformation but also shows more sensitivity to positional change in the working face. Moreover, the sidewall and rock anchor beam witness greater spatial deformation compared with the arch area from a spatial perspective, and from the point of time the time-related deformation presents a step growth, which tends to eventually converge. The failure mechanism is also discussed, where fiercer stress redistribution and denser cracks account for the greater deformation of the multi-freeface surrounding rock mass. In general, a wide range of underground powerhouse stability issues has arisen with respect to huge-scale and adverse geological conditions since the construction of the Baihetan Hydropower Station, and settling these issues will undoubtedly have milestone significance with regard to the construction and development of hydropower engineering projects among the worldwide.

Objective The study aimed to investigate the efficacy of computed tomography (CT)-guided cryoablation debulking of unresectable pelvic recurrent colorectal cancer (CRC). Patients and methods From January 2013 to April 2016, 30 patients (18 males and 12 females; aged 57.8±10.5 years) with unresectable pelvic recurrent CRC who had previously received radiotherapy or chemotherapy were included. A total of 35 tumors ranging from 1.2 to 6.3 cm underwent cryoablation. Tumor response was evaluated 1 month after cryoablation according to the Modified Response Evaluation Criteria in Solid Tumors. Logistic regression was used to analyze the risk factors for tumor response. Degree of pain palliation was also determined using the Numerical Rating Scale. Cox proportional hazard models were used to identify predictors of outcomes. Results Cryoablation was successfully performed in all patients. Complete response (CR) was achieved for 27 tumors in 23 patients and partial response was achieved for eight tumors in seven patients 1 month after cryoablation. The rate of CR was 77.14%, and tumor size was an independent risk factor for CR. Pain relief was satisfactory in 21 symptomatic patients (P

Honokiol (HNK) is a small-molecule lignin extracted from Magnolia Officinalis, demonstrating high potency in promoting nonrapid eye movement (NREM) sleep by modulating the benzodiazepine site of the GABAA receptor. However, the clinical use of HNK in the treatment of insomnia is restricted by its extremely low oral bioavailability. In the present work, enhanced oral bioavailability of HNK was achieved by loading it into poly lactide–glycolide acid microparticles (HNK-MP). After oral administration, HNK-MP demonstrated 15-fold increase of AUC0–12 h in comparison to free HNK. The maximum blood concentration (Cmax) of HNK in HNK-MP-treated rats was 3.6 μg/mL at 2 h after oral administration, which was 6.5-fold of that in free HNK-treated rats. Oral administration of HNK-MP (20 mg/kg) efficiently increased NREM sleep by 60% by enhancing the transition from wakefulness to NREM sleep in rats. The biosafety of HNK-MP was assessed in vivo, and no damage occurred in the gastrointestinal tract. The present study pr...

The present study was designed to investigate the effect of late phase of whole body hypoxic preconditioning on endothelial-dependent vasorelaxation and cardioprotection from ischemia-reperfusion injury in spontaneously hypertensive rats (SHR). Hypoxic preconditioning was performed by subjecting rats to four episodes of alternate exposure to low O2 (8%) and normal air O2 of 10 min each. After 24 h, the mesenteric arteries and hearts were isolated to determine the vascular function and cardioprotection from ischemia-reperfusion (I/R) injury on the Langendorff apparatus. There was a significant impairment in acetylcholine-induced relaxation in norepinephrine precontracted arteries (endothelium-dependent function) and increase in I/R-induced myocardial injury in SHR in comparison to Wistar Kyoto rats (WKY). However, hypoxic preconditioning significantly restored endothelium-dependent relaxation in SHR and attenuated I/R injury in both SHR and WKY. Hypoxic preconditioning also led to an increase in the levels of endothelin-1 (not endothelin-2 or −3), vascular endothelial growth factor-A (VEGF-A) and HIF-1α levels. Pretreatment with bevacizumab (anti-VEGF-A) and bosentan (endothelin receptor blocker) significantly attenuated hypoxic preconditioning-induced restoration of endothelium-dependent relaxation and cardioprotection from I/R injury. These interventions also attenuated the levels of VEGF-A and HIF-1α without modulating the endothelin-1 levels. It may be concluded that an increase in the endothelin-1 levels with a subsequent increase in HIF-1α and VEGF expression may possibly contribute in improving endothelium-dependent vasorelaxation and protecting hearts from I/R injury in SHR during late phase of whole body hypoxic preconditioning.

Alzheimer's Disease (AD) is a chronic neurodegenerative disease. Early diagnosis will considerably decrease the risk of further deterioration. Unfortunately, current studies mainly focus on classifying the states of disease in its current stage, instead of predicting the possible development of the disease. Long short-term memory (LSTM) is a special kind of recurrent neural network, which might be able to connect previous information to the present task. Noticing that the temporal data for a patient are potentially meaningful for predicting the development of the disease, we propose a predicting model based on LSTM. Therefore an LSTM network, with fully connected layer and activation layers, is built to encode the temporal relation between features and the next stage of Alzheimer's Disease. The Experiments show that our model outperforms most of the existing models.

We conducted a systematic review and meta-analysis to compare the clinical outcomes of percutaneous endoscopic lumbar discectomy (PELD) and microendoscopic discectomy (MED) for the treatment of lumbar disc herniation (LDH), and to clarify whether PELD is more superior to MED. We performed a comprehensive search in the databases of MEDLINE, EMBASE, PubMed, Web of Science, Cochrane database, CNKI, and Wanfang Data to acquire all relevant studies up to July 2018. The searched literatures were then screened according to the strict inclusion and exclusion criteria. The critical data were extracted and analyzed utilizing Review Manager software. The pooled effects were calculated by mean difference (MD) or odds ratio (OR) with 95% confidence intervals (CI) on the basis of data attributes. A total of 18 studies (2161 patients, 1093 in the PELD group and 1068 in the MED group) were included in this systematic review and meta-analysis. At last follow-up, the results revealed that no significant difference was found between PELD group and MED group with respect to ODI (MD − 0.30; 95% CI − 1.02 to 0.42; P = 0.41), VAS-leg pain (MD − 0.18; 95% CI − 0.45 to 0.09; P = 0.19), VAS-unspecified (MD − 0.00; 95% CI − 0.05 to 0.04; P = 0.94), excellent & good rate (OR, 1.04; 95% CI 0.68 to 1.59; P = 0.86), total complication rate (OR, 0.96; 95% CI 0.65 to 1.43; P = 0.85), dural tear rate (OR, 0.39; 95% CI 0.10 to 1.55; P = 0.18), and residue or recurrence rate (OR, 2.22; 95% CI 1.02 to 4.83; P = 0.05). When compared to MED group, the PELD group showed significantly better results with regard to shorter length of incision (MD − 1.18; 95% CI − 1.39 to − 0.97; P

Stroke leads to both regional brain functional disruptions and network reorganization. However, how brain functional networks reconfigure as task demand increases in stroke patients and whether such reorganization at baseline would facilitate post-stroke motor recovery are largely unknown. To address this gap, brain functional connectivity (FC) were examined at rest and motor tasks in eighteen chronic subcortical stroke patients and eleven age-matched healthy controls. Stroke patients underwent a 2-week intervention using a motor imagery-assisted brain computer interface-based (MI-BCI) training with or without transcranial direct current stimulation (tDCS). Motor recovery was determined by calculating the changes of the upper extremity component of the Fugl–Meyer Assessment (FMA) score between pre- and post-intervention divided by the pre-intervention FMA score. The results suggested that as task demand increased (i.e., from resting to passive unaffected hand gripping and to active affected hand gripping), patients showed greater FC disruptions in cognitive networks including the default and dorsal attention networks. Compared to controls, patients had lower task-related spatial similarity in the somatomotor–subcortical, default–somatomotor, salience/ventral attention–subcortical and subcortical–subcortical connections, suggesting greater inefficiency in motor execution. Importantly, higher baseline network-specific FC strength (e.g., dorsal attention and somatomotor) and more efficient brain network reconfigurations (e.g., somatomotor and subcortical) from rest to active affected hand gripping at baseline were related to better future motor recovery. Our findings underscore the importance of studying functional network reorganization during task-free and task conditions for motor recovery prediction in stroke. Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This research was supported by the National Medical Research Council NMRC0088/2015 and the Duke-NUS Medical School Signature Research Program funded by Ministry of Health, Singapore (J.H.Z.) and National Medical Research Council NMRC/NIG/1013/2010 (E.C.). This work was also partially supported by the RIE2020 AME Programmatic Fund, Singapore (No. A20G8b0102).

As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide a link between these two diseases. The present study compared the content and function of MPs from patients with ACS with or without T2DM. MPs from healthy subjects (n=20), patients with ACS (n=24), patients with T2DM (n=20) and patients with combined ACS and T2DM (n=24) were obtained. After incubating rat thoracic tissue with MPs, the effect of MPs on endothelial‑dependent vasodilatation, expression of caveolin‑1 and endothelial nitric oxide synthase (eNOS), phosphorylation of eNOS at the S1177 and T495 sites and its association with heat shock protein 90 (Hsp90), and the generation of NO and superoxide anion (O2˙‑) were determined. MP concentrations were higher in patients with T2DM and patients with ACS with or without T2DM than in healthy subjects. Moreover, MPs from patients with T2DM or ACS led to impairment in endothelial‑dependent vasodilatation, decreased expression of NO, as well as eNOS and its phosphorylation at Ser1177 and association with Hsp90, but increased eNOS phosphorylation at T495, caveolin‑1 expression and O2˙‑ generation. These effects were strengthened by MPs from patients with ACS combined with T2DM. T2DM not only increased MP content but also resulted in greater vascular impairment effects in ACS. These results may provide novel insight into the treatment of patients with ACS and T2DM.

Background This study aims to analyze the trends of premature mortality caused from four major non-communicable diseases (NCDs), namely cardiovascular disease (CVD), cancer, chronic respiratory diseases, and diabetes in Nanjing between 2007 and 2018 and project the ability to achieve the “Healthy China 2030” reduction target. Methods Mortality data of four major NCDs for the period 2007–2018 were extracted from the Death Information Registration and Management System of Chinese Center for Disease Control and Prevention. Population data for Nanjing were provided by the Nanjing Bureau of Public Security. The premature mortality was calculated using the life table method. Joinpoint regression model was used to estimate the average annual percent changes (AAPC) in mortality trends. Results From 2007 to 2018, the premature mortality from four major NCDs combined in Nanjing decreased from 15.5 to 9.5%, with the AAPC value at − 4.3% (95% CI [− 5.2% to − 3.4%]). Overall, it can potentially achieve the target, with a relative reduction 28.6%. The premature mortality from cancer, CVD, chronic respiratory diseases and diabetes all decreased, with AAPC values at − 4.2, − 5.0%, − 5.9% and − 1.6% respectively. A relative reduction of 40.6 and 41.2% in females and in rural areas, but only 21.0 and 12.8% in males and in urban areas were projected. Conclusion An integrated approach should be taken focusing on the modifiable risk factors across different sectors and disciplines in Nanjing. The prevention and treatment of cancers, diabetes, male and rural areas NCDs should be enhanced.

Major depressive disorder (MDD) is a debilitating mental illness affecting people worldwide. Although significant progress has been made in the development of therapeutic agents to treat this condition, fewer than half of all patients respond to currently available antidepressants, highlighting the urgent need for the development of new classes of antidepressant drugs. Here, we found that paeoniflorin (PF) produced rapid and sustained antidepressant-like effects in multiple mouse models of depression, including the forced swimming test and exposure to chronic mild stress (CMS). Moreover, PF decreased the bodyweight of mice without affecting food intake and glucose homeostasis, and also reduced the plasma levels of total ghrelin and the expression of ghrelin O-acyltransferase in the stomach; however, the plasma levels of ghrelin and the ghrelin/total ghrelin ratio were unaffected. Furthermore, PF significantly increased the expression of growth hormone secretagogue receptor 1 alpha (GHSR1α, encoded by the Ghsr gene) in the intestine, whereas the levels of GHSR1α in the brain were only marginally downregulated following subchronic PF treatment. Finally, the genetic deletion of Ghsr attenuated the antidepressant-like effects of PF in mice exposed to CMS. These results suggested that increased GHSR1α expression in the intestine mediates the antidepressant-like effects of PF. Understanding peripheral ghrelin/GHSR signaling may provide new insights for the screening of antidepressant drugs that produce fast-acting and sustained effects.

Paraquat (N, N'-dimethyl-4, 4'-bipyridinium dichloride, PQ) intoxication is a common cause of lethal poisoning. This study aimed to identify the risk of using liberal oxygen therapy in patients with PQ poisoning. This was a multi-center retrospective cohort study involving four medical institutions in Taiwan. Data were extracted from the Chang Gung Research Database (CGRD) from January 2004 to December 2016. Patients confirmed to have PQ intoxication with a urine PQ concentration ≥ 5 ppm were analyzed. Patients who received oxygen therapy before marked hypoxia (SpO2 ≥ 90%) were defined as receiving liberal oxygen therapy. The association between mortality and patient demographics, blood paraquat concentration (ppm), and liberal oxygen therapy were analyzed. A total of 416 patients were enrolled. The mortality rate was higher in the liberal oxygen therapy group (87.8% vs. 73.7%, P = 0.007), especially in 28-day mortality (adjusted odds ratio [aOR]: 4.71, 95% confidence interval [CI]: 1.533–14.471) and overall mortality (aOR: 5.97, 95% CI: 1.692–21.049) groups. Mortality in patients with PQ poisoning was also associated with age (aOR: 1.04, 95% CI: 1.015–1.073), blood creatinine level (aOR: 1.49, 95% CI: 1.124–1.978), and blood paraquat concentration (ppm) (aOR, 1.51; 95% CI: 1.298–1.766). Unless the evidence of hypoxia (SpO2 < 90%) is clear, oxygen therapy should be avoided because it is associated with increased mortality.

Aim:To compare the efficacy, safety, and tolerability of abemaciclib plus endocrine therapy (ET) versus ET alone in postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer (ABC) from China, Brazil, India, and South Africa.Methods:This randomized, double-blind, phase III study was conducted between 9 December 2016 and 29 March 2019. Postmenopausal women with HR-positive, HER2-negative ABC with no prior systemic therapy in an advanced setting (cohort A) or progression on prior ET (cohort B) received abemaciclib (150 mg twice daily) or placebo plus: anastrozole (1 mg/day) or letrozole (2.5 mg/day) (cohort A) or fulvestrant (500 mg per label) (cohort B). The primary endpoint was progression-free survival (PFS) in cohort A, analyzed using the stratified log-rank test. Secondary endpoints were PFS in cohort B (key secondary endpoint), objective response rate (ORR), and safety. This interim analysis was planned after 119 PFS events in cohort A.Results:In cohort A, 207 patients were randomly assigned to the abemaciclib arm and 99 to the placebo arm. Abemaciclib significantly improved PFS versus placebo (median: not reached versus 14.7 months; hazard ratio 0.499; 95% confidence intervals (CI) 0.346–0.719; p = 0.0001). ORR was 65.9% in the abemaciclib arm and 36.1% in the placebo arm ( p Conclusion:The addition of abemaciclib to ET demonstrated significant and clinically meaningful improvement in PFS and ORR, without new safety signals observed in this population. Trial Registration: ClinicalTrials.gov identifier: NCT02763566.

Long non-coding RNAs (lncRNAs) have emerged as key regulators of Toll-like receptor (TLR) signaling to control innate immunity, and this regulatory mechanism has recently been implicated in esophageal carcinoma (ESCA). However, a comprehensive analysis of TLR-induced lncRNAs and their roles in diagnosis and prognosis in ESCA is still lacking. In this study, we first investigated the precise relationship between lncRNA perturbations and alteration of TLR signaling by constructing the lncRNA-TLRs co-expression network involved in ESCA, and identified 357 TLR-related lncRNAs. Of them, four TLR-related lncRNAs (AP000696.1, LINC00689, LINC00900, and AP000487.1) are significantly associated with the overall survival (OS) of ESCA patients, and utilizing this four-lncRNA signature is capable of stratifying patients into high-risk and low-risk groups with significantly different OS in the discovery set. Further analysis in different independent patient sets also confirmed the robustness of the prognostic value of the four-TLR-lncRNA signature in predicting the OS of ESCA patients. Moreover, the results of multivariate analysis in different patient sets indicated that the four-TLR-lncRNA signature is an independent factor after adjusted by other clinical factors. Thus, we have identified a TLR-induced four-lncRNA signature, which represents a promising prognosis biomarker for ESCA, and our study might provide new candidate targets for therapeutic intervention via targeting TLR-induced lncRNAs in ESCA patients.

Silicon-based Schottky heterojunction photodetectors are promising due to their compatibility with the semiconductor process. However, the applications of these devices are usually limited to wavelengths shorter than 1.1 µm due to the low absorption of electrode materials at infrared. In this report, silicon-based compound semiconductor heterojunction photodetectors with graphene transparent electrodes are fabricated. Due to the high absorption of InSb at infrared, as well as the good transparency and excellent electrical conductivity of the graphene, the as-prepared photodetectors show a broadband photoresponse with high performance which includes a specific detectivity of 1.9 [Formula: see text]1012 cm Hz1/2 W-1, responsivity of 132 mA W-1, on/off ratio of 1 [Formula: see text]105, rise time of 2 µs, 3 dB cut-off frequency of 172 kHz, and response wavelengths covering 635 nm, 1.55 µm and 2.7 µm. This report proves that graphene as a transparent electrode has a great effect on the performance improvement of silicon-based compound semiconductor heterojunction photodetectors.

The subjective cognitive decline (SCD) may last for decades prior to the onset of dementia and has been proposed as a risk population for development to amnestic mild cognitive impairment (aMCI) and Alzheimer disease (AD). Disruptions of functional connectivity and causal connectivity (CC) in the salience network (SN) are generally perceived as prominent hallmarks of the preclinical AD. Nevertheless, the alterations in anterior SN (aSN), and posterior SN (pSN) remain unclear. Here, we hypothesized that both the functional connectivity (FC) and CC of the SN subnetworks, comprising aSN and pSN, were distinct disruptive in the SCD and aMCI. We utilized resting-state functional magnetic resonance imaging to investigate the altered FC and CC of the SN subnetworks in 28 healthy controls, 23 SCD subjects, and 29 aMCI subjects. In terms of altered patterns of FC in SN subnetworks, aSN connected to the whole brain was significantly increased in the left orbital superior frontal gyrus, left insula lobule, right caudate lobule, and left rolandic operculum gyrus (ROG), whereas decreased FC was found in the left cerebellum superior lobule and left middle temporal gyrus when compared with the HC group. Notably, no prominent statistical differences were obtained in pSN. For altered patterns of CC in SN subnetworks, compared to the HC group, the aberrant connections in aMCI group were separately involved in the right cerebellum inferior lobule (CIL), right supplementary motor area (SMA), and left ROG, whereas the SCD group exhibited more regions of aberrant connection, comprising the right superior parietal lobule, right CIL, left inferior parietal lobule, left post-central gyrus (PG), and right angular gyrus. Especially, SCD group showed increased CC in the right CIL and left PG, whereas the aMCI group showed decreased CC in the left pre-cuneus, corpus callosum, and right SMA when compared to the SCD group. Collectively, our results suggest that analyzing the altered FC and CC observed in SN subnetworks, served as impressible neuroimaging biomarkers, may supply novel insights for designing preclinical interventions in the preclinical stages of AD. Published version