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Objective: To investigate the effects of sevoflurane combined with remifentanil on neurologic function, cognitive function and inflammatory factors in patients with intracranial aneurysms undergoing interventional therapy. Methods: 80 patients with intracranial aneurysms who underwent interventional surgery in our hospital from January 2020 to June 2022 were selected and divided into group A(sevoflurane combined with remifentanil) and group B(propofol combined with remifentanil) according to different anesthesia methods, with 40 patients in each group. Neurological function, cognitive function and inflammatory factor level were compared between the two groups. Results: The heart rate(HR) and mean arterial pressure(MAP) of group A were better than those of group B from T1 to T3(P＜0.05). The national institutes of health stroke scale(NIHSS) score of group A was significantly lower than that of group B at 24 h and 7 d after operation(P＜0.05), and the mini-mental state examination(MMSE) score was higher than that of group B(P＜0.05).Serum tumor necrosis factor-α(TNF-α), C-reactive protein(CRP), and interleukin-6(IL-6) levels at 24 h and 3 d after operation in group A were lower than those in group B(P＜0.05). The recovery time of spontaneous respiration, recovery time, extubation time and the incidence of agitation after extubation in group A were lower than those in group B(P＜0.05). The adverse effects were not different(P＞0.05).Conclusion: The application of sevoflurane combined with remifentanil maintenance anesthesia in interventional IA patients can smooth hemodynamics, improve postoperative neurological function and cognitive function, reduce inflammatory response, and improve the quality of anesthesia awakening. [ABSTRACT FROM AUTHOR]

To observe the efficacy of pelvic floor muscle rehabilitation training combined with pelvic floor reconstruction in the treatment of female pelvic floor dysfunction (PFD) diseases and its effect on inflammatory response and stress response. 200 patients with PFD who were treated in our hospital from January 2019 to January 2021 were selected, and they were randomly divided into control group (100 cases) and study group (100 cases) by random number table method. Patients in the control group received pelvic floor reconstruction, and patients in the study group received pelvic floor muscle rehabilitation training combined with pelvic floor reconstruction. The efficacy and postoperative complications of the two groups were observed, and the related scale scores, inflammatory response and stress response indexes of the two groups were compared. After treatment, the scores of pelvic floor impact questionnaire short form (PFIQ-7), pelvic floor distress inventory short form (PFDI-20) in the study group were lower than those in the control group (P<0.05). The pelvic floor class I muscle fiber voltage and pelvic floor class II muscle fiber voltage in the study group were higher than those in the control group after treatment (P<0.05). Interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and high sensitivity C-reactive protein (hs-CRP) in the study group after treatment were lower than those in the control group (P<0.05). Cortisol (COR), norepinephrine (NE) and prostaglandin E2 (PGE2) in the study group after treatment were lower than those in the control group (P<0.05). The incidence of postoperative complications in the study group was lower than that in the control group (P<0.05). Pelvic floor muscle rehabilitation training combined with pelvic floor reconstruction in the treatment of PFD can promote the recovery of pelvic floor function, reduce inflammatory reaction and stress reaction, and reduce the incidence of postoperative complications. [ABSTRACT FROM AUTHOR]