6 results on '"Ciardi, Antonio"'
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2. Quantitative investigation of desmoplasia as a prognostic indicator in colorectal cancer
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Caporale, Alessandro, AMORE BONAPASTA, Stefano, Stefano Amore Bonapasta, Scarpini, Massimo, Ciardi, Antonio, Vestri, Anna Rita, Ruperto, Mariangela, and Giuliani, Andrea
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Oncology ,Adult ,Male ,Pathology ,medicine.medical_specialty ,Colorectal cancer ,colorectal cancer ,Kaplan-Meier Estimate ,Stroma ,Fibrosis ,Internal medicine ,stroma ,medicine ,Overall survival ,Humans ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,desmoplasia ,business.industry ,quantitative method ,barrier ,prognosis ,Cancer ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Prognosis ,Desmoplasia ,Fibrous connective tissue ,Area Under Curve ,Surgery ,Female ,medicine.symptom ,business ,Colorectal Neoplasms - Abstract
The role of desmoplastic reaction (DR) in colorectal cancer invasion is still an open question. The presence of fibrous connective tissue may represent a barrier against cancer diffusion or a stroma to build up and support the tumor. Aims of the present study were to evaluate the influence of DR on long-term survival and to validate a reliable quantitative method to measure the desmoplastic tissue.This retrospective study included 86 patients who underwent radical colorectal resection for cancer, from a database of 429 patients. To achieve a quantitative histochemical measurement of DR, digital images were analyzed by a computerized image analysis program. DR was related to the overall survival and the quantitative method was related to the traditional one.By using the Kaplan-Meier analysis, DR was found to be significantly associated with overall survival. Patients with a higher value of DR survived longer than those with smaller DR and the quantitative results were in accordance with those obtained by using the traditional methods.Desmoplasia seems to be a protective factor for survival in patients with colorectal carcinoma. The quantitative technique is easily standardized and can be routinely performed, so that DR may be a useful prognostic indicator. Notwithstanding, the conflicting outcomes reported in literature about DR need further biological and molecular studies to achieve definitive conclusions.
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- 2010
3. Cytoreductive Surgery (Peritonectomy Procedures) Combined With Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Diffuse Peritoneal Carcinomatosis From Ovarian Cancer.
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Di Giorgio, Angelo, Naticchioni, Enzo, Biacchi, Daniele, Sibio, Simone, Accarpio, Fabio, Rocco, Monica, Tarquini, Sergio, Di Seri, Marisa, Ciardi, Antonio, Montruccoli, Daniele, and Sammartino, Paolo
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SURGERY ,DRUG therapy ,CANCER ,OVARIAN cancer ,PERITONEAL cancer - Abstract
The article reports on results of a study of cytoreductive surgery or peritonectony procedures combined with hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of diffuse peritoneal carcinomatosis from ovarian cancer. A description of the experimental set-up and measurement method is provided. The study concludes that peritonectomy procedures combined with HIPEC provide promising long-term survival in patients with diffuse peritoneal ovarian carcinomas.
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- 2008
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4. Prognostic Role of Mismatch Repair Status, Histotype and High-Risk Pathologic Features in Stage II Small Bowel Adenocarcinomas
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Roberto Caronna, Enrico Solcia, Giuseppe Neri, Augusto Orlandi, Michele Martino, Catherine Klersy, Carolina Ciacci, Antonietta D'Errico, Ada Maria Florena, Giovanni Monteleone, Giacomo Caio, Paolo Giuffrida, Gianluca M. Sampietro, Luca Elli, Stefano Ferrero, Maria D'Armiento, G. Solina, Fausto Sessa, Paolo Pedrazzoli, Giuseppe Amodeo, Elena Biletta, Barbara Oreggia, Fabiana Zingone, Deborah Malvi, Claudia Mescoli, Andrea Pietrabissa, Alessandro Vanoli, Camilla Guerini, Giovanni Arpa, Anna D'Odorico, Gabriella Nesi, Massimo Rugge, Fernando Rizzello, Roberto De Giorgio, Federica Grillo, Renato Cannizzaro, Umberto Volta, Livia Biancone, Gilberto Poggioli, Vincenzo Villanacci, Luca Reggiani Bonetti, Maria Cristina Macciomei, Donatella Santini, Sandro Ardizzone, Vincenzo Canzonieri, Rachele Ciccocioppo, Francesco Tonelli, Gino Roberto Corazza, Valeria Barresi, Flavio Caprioli, Roberto Fiocca, Antonio Di Sabatino, Ombretta Luinetti, Giovanni Latella, Paolo Fociani, Marco Paulli, Antonio Calabrò, Antonino Giulio Giannone, Maurizio Vecchi, Renata D'Incà, Aroldo Rizzo, Antonio Ciardi, Marco Vincenzo Lenti, Vanoli A., Grillo F., Guerini C., Neri G., Arpa G., Klersy C., Nesi G., Giuffrida P., Sampietro G., Ardizzone S., Fociani P., Fiocca R., Latella G., Sessa F., D'Errico A., Malvi D., Mescoli C., Rugge M., Ferrero S., Poggioli G., Rizzello F., Macciomei M.C., Santini D., Volta U., De Giorgio R., Caio G., Calabro A., Ciacci C., D'Armiento M., Rizzo A., Solina G., Martino M., Tonelli F., Villanacci V., Cannizzaro R., Canzonieri V., Florena A.M., Biancone L., Monteleone G., Caronna R., Ciardi A., Elli L., Caprioli F., Vecchi M., D'Inca R., Zingone F., D'Odorico A., Lenti M.V., Oreggia B., Reggiani Bonetti L., Giannone A.G., Orlandi A., Barresi V., Ciccocioppo R., Amodeo G., Biletta E., Luinetti O., Pedrazzoli P., Pietrabissa A., Corazza G.R., Solcia E., Paulli M., Di Sabatino A., Vanoli, A., Grillo, F., Guerini, C., Neri, G., Arpa, G., Klersy, C., Nesi, G., Giuffrida, P., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Ferrero, S., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Reggiani Bonetti, L., Giannone, A. G., Orlandi, A., Barresi, V., Ciccocioppo, R., Amodeo, G., Biletta, E., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Corazza, G. R., Solcia, E., Paulli, M., Di Sabatino, A., Vanoli, Alessandro, Grillo, Federica, Guerini, Camilla, Neri, Giuseppe, Arpa, Giovanni, Klersy, Catherine, Nesi, Gabriella, Giuffrida, Paolo, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D'Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Ferrero, Stefano, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C, Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D'Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada Maria, Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D'Incà, Renata, Zingone, Fabiana, D'Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Reggiani Bonetti, Luca, Giannone, Antonino Giulio, Orlandi, Augusto, Barresi, Valeria, Ciccocioppo, Rachele, Amodeo, Giuseppe, Biletta, Elena, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Corazza, Gino Roberto, Solcia, Enrico, Paulli, Marco, and Di Sabatino, Antonio
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Male ,Oncology ,Colorectal cancer ,DNA Mismatch Repair ,COLORECTAL-CANCER ,Settore MED/12 ,0302 clinical medicine ,PMS2 ,small bowel adenocarcinoma ,Mismatch Repair Endonuclease PMS2 ,0303 health sciences ,Prognosis ,MMR ,MutS Homolog 2 Protein ,CARCINOMAS ,030220 oncology & carcinogenesis ,immunohistochemistry ,Mismatch Repair Status, small bowel adenocarcinoma ,Female ,Microsatellite Instability ,DNA mismatch repair ,MutL Protein Homolog 1 ,Colorectal Neoplasms ,stage II ,medicine.medical_specialty ,high-risk pathologic features ,Humans ,Adenocarcinoma ,mismatch repair status ,NO ,03 medical and health sciences ,small bowel carcinoma ,histotype ,Internal medicine ,Translational Research ,medicine ,030304 developmental biology ,small bowel adenocarcinomas ,business.industry ,Cancer ,Microsatellite instability ,Mismatch Repair Protein ,Adenocarcinoma IBD Cancer ,medicine.disease ,digestive system diseases ,MSH6 ,CONSENSUS ,small bowel carcinoma, MMR, immunohistochemistry ,Mismatch repair, Small bowel Adenocarcinoma ,MSH2 ,Mismatch repair status ,Surgery ,business - Abstract
Background Small bowel adenocarcinoma is a relatively rare cancer, often diagnosed in an advanced stage. In localized and resectable disease, surgery alone or in combination with adjuvant chemotherapy is the mainstay of treatment. In the recently published National Comprehensive Cancer Network Clinical Practice guidelines, criteria for selecting patients with stage II small bowel adenocarcinoma to receive adjuvant chemotherapy are provided, and they are mainly extrapolated from studies on colorectal cancer. Patients and Methods In the present study, we aimed to verify whether mismatch repair deficiency phenotype, high-risk pathologic features (including T4, positive resection margins and a low number of lymph nodes harvested), as well as tumor histologic subtype, were associated with cancer-specific survival in 66 stage II non-ampullary small bowel adenocarcinoma patients, collected through the Small Bowel Cancer Italian Consortium. A central histopathology review was performed. Mismatch repair deficiency was tested by immunohistochemistry for MLH1, MSH2, MSH6 and PMS2, and confirmed by polymerase chain reaction for microsatellite instability. Results We identified mismatch repair deficiency, glandular/medullary histologic subtype, and celiac disease as significant predictors of favorable cancer-specific survival using univariable analysis with retained significance in bivariable models adjusted for pT stage. Among the high-risk features, only T4 showed a significant association with an increased risk of death; however, its prognostic value was not independent of mismatch repair status. Conclusions Mismatch repair protein expression, histologic subtype, association with celiac disease, and, in the mismatch repair proficient subset only, T stage, may help identify patients who may benefit from adjuvant chemotherapy. Graphic Abstract
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- 2021
5. PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability
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Giovanni Arpa, Gabriella Nesi, Catherine Klersy, Carolina Ciacci, Antonietta D'Errico, Anna D'Odorico, Marco Paulli, Gino Roberto Corazza, Fausto Sessa, Valeria Barresi, Vittorio Perfetti, Federica Grillo, Vincenzo Canzonieri, Renato Cannizzaro, Roberto Fiocca, Stefano Ferrero, Luca Reggiani Bonetti, Deborah Malvi, Giovanni Latella, Paolo Pedrazzoli, Antonio Calabrò, Roberto De Giorgio, Alessandra Viglio, Fernando Rizzello, Flavio Caprioli, Roberto Caronna, Daniela Furlan, Antonino Giulio Giannone, Marco Silano, Maurizio Vecchi, Michele Martino, Francesco Tonelli, Laura Cantoro, Antonio Di Sabatino, Maria D'Armiento, Enrico Solcia, Paolo Giuffrida, Gianluca M. Sampietro, Ada Maria Florena, Giovanni Monteleone, Livia Biancone, Claudia Mescoli, G. Solina, Andrea Pietrabissa, Umberto Volta, Renata D'Incà, Ombretta Luinetti, Vincenzo Villanacci, Luca Elli, Massimo Rugge, Maria Cristina Macciomei, Paolo Fociani, Marco Astegiano, Rachele Ciccocioppo, Fabiana Zingone, Claudio Papi, Giacomo Caio, G. Sandri, Barbara Oreggia, Alessandro Vanoli, Aroldo Rizzo, Elena Biletta, Augusto Orlandi, Gilberto Poggioli, Antonio Ciardi, Marco Vincenzo Lenti, Paolo Usai, Erica Quaquarini, Donatella Santini, Sandro Ardizzone, Giuffrida, Paolo, Arpa, Giovanni, Grillo, Federica, Klersy, Catherine, Sampietro, Gianluca, Ardizzone, Sandro, Fociani, Paolo, Fiocca, Roberto, Latella, Giovanni, Sessa, Fausto, D'Errico, Antonietta, Malvi, Deborah, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Ferrero, Stefano, Furlan, Daniela, Poggioli, Gilberto, Rizzello, Fernando, Macciomei, Maria C, Santini, Donatella, Volta, Umberto, De Giorgio, Roberto, Caio, Giacomo, Calabrò, Antonio, Ciacci, Carolina, D'Armiento, Maria, Rizzo, Aroldo, Solina, Gaspare, Martino, Michele, Tonelli, Francesco, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Florena, Ada M, Biancone, Livia, Monteleone, Giovanni, Caronna, Roberto, Ciardi, Antonio, Elli, Luca, Caprioli, Flavio, Vecchi, Maurizio, D'Incà, Renata, Zingone, Fabiana, D'Odorico, Anna, Lenti, Marco Vincenzo, Oreggia, Barbara, Reggiani Bonetti, Luca, Astegiano, Marco, Biletta, Elena, Cantoro, Laura, Giannone, Antonino G, Orlandi, Augusto, Papi, Claudio, Perfetti, Vittorio, Quaquarini, Erica, Sandri, Giancarlo, Silano, Marco, Usai, Paolo, Barresi, Valeria, Ciccocioppo, Rachele, Luinetti, Ombretta, Pedrazzoli, Paolo, Pietrabissa, Andrea, Viglio, Alessandra, Paulli, Marco, Corazza, Gino R, Solcia, Enrico, Vanoli, Alessandro, Di Sabatino, Antonio, Giuffrida P., Arpa G., Grillo F., Klersy C., Sampietro G., Ardizzone S., Fociani P., Fiocca R., Latella G., Sessa F., D'Errico A., Malvi D., Mescoli C., Rugge M., Nesi G., Ferrero S., Furlan D., Poggioli G., Rizzello F., Macciomei M.C., Santini D., Volta U., De Giorgio R., Caio G., Calabro A., Ciacci C., D'Armiento M., Rizzo A., Solina G., Martino M., Tonelli F., Villanacci V., Cannizzaro R., Canzonieri V., Florena A.M., Biancone L., Monteleone G., Caronna R., Ciardi A., Elli L., Caprioli F., Vecchi M., D'Inca R., Zingone F., D'Odorico A., Lenti M.V., Oreggia B., Reggiani Bonetti L., Astegiano M., Biletta E., Cantoro L., Giannone A.G., Orlandi A., Papi C., Perfetti V., Quaquarini E., Sandri G., Silano M., Usai P., Barresi V., Ciccocioppo R., Luinetti O., Pedrazzoli P., Pietrabissa A., Viglio A., Paulli M., Corazza G.R., Solcia E., Vanoli A., Di Sabatino A., Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Reggiani Bonetti, L., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., Di Sabatino, A., and Vincenzo Lenti, Marco
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0301 basic medicine ,Male ,PD-L1 - small bowel adenocarcinoma - tumor-infiltrating lymphocytes - microsatellite instability ,Pathology ,BLOCKADE ,Colorectal cancer ,Lymphocyte ,Small bowel adenocarcinoma ,Gastroenterology ,B7-H1 Antigen ,Settore MED/12 ,0302 clinical medicine ,Crohn Disease ,Intestine, Small ,small bowel adenocarcinoma ,Small bowel adenocarcinomas ,MEDULLARY CARCINOMA ,MORPHOLOGY ,EXPRESSION ,CANCER ,biology ,microsatelliteinstability ,Middle Aged ,medicine.anatomical_structure ,Medullary carcinoma ,tumor infiltrating lymphocytes ,030220 oncology & carcinogenesis ,tumor-infiltrating lymphocytes ,Adenocarcinoma ,Female ,Microsatellite Instability ,PD-L1 ,Adult ,medicine.medical_specialty ,small bowel adenocarcinoma, tumor-infiltrating lymphocytes, microsatelliteinstability ,Settore MED/08 - Anatomia Patologica ,PD-L1, small bowel adenocarcinoma ,NO ,Pathology and Forensic Medicine ,03 medical and health sciences ,Lymphocytes, Tumor-Infiltrating ,Internal medicine ,expression ,Intestinal Neoplasms ,Biomarkers, Tumor ,medicine ,Humans ,PD-L1 in small bowel adenocarcinoma, MSI-H ,Small bowel adenocarcinoma, expression, microsatellite instability, biomarkers ,Aged ,Retrospective Studies ,business.industry ,Tumor-infiltrating lymphocytes ,biomarkers ,Cancer ,Correction ,Microsatellite instability ,medicine.disease ,Celiac Disease ,030104 developmental biology ,biology.protein ,Etiology ,business - Abstract
Small bowel adenocarcinomas (SBAs) are often associated with poor prognosis and have limited therapeutic options. Programmed cell death protein-1 (PD-1)/programmed cell death ligand 1 (PD-L1) pathway blockade is an effective treatment in many microsatellite instability-high (MSI-H) solid tumors. We aimed at investigating PD-L1 and PD-1 expression in non-hereditary, non-ampullary SBAs, associated with celiac disease (CeD), Crohn’s disease (CrD), or sporadic, recruited through the Small Bowel Cancer Italian Consortium. We assessed PD-L1 and PD-1 by immunohistochemistry in a series of 121 surgically resected SBAs, including 34 CeD-SBAs, 49 CrD-SBAs, and 38 sporadic SBAs. PD-L1 and PD-1 expression was correlated with several clinico-pathological features, such as the etiology, microsatellite instability status, and tumor-infiltrating lymphocyte (TIL) density. The prevalence of PD-L1 positivity according to combined positive score (CPS) was 26% in the whole cohort of SBAs, with significantly (p = 0.001) higher percentage (35%) in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs (5%). CPS ≥ 1 SBAs were significantly (p = 0.013) more frequent in MSI-H cases (41%) than in non-MSI-H ones (18%); however, 15 CPS ≥ 1 microsatellite stable SBAs were also identified. CPS ≥ 1 SBAs showed higher TIL and PD-1+ immune cell density, more frequently medullary histotype, as well as a better outcome in comparison with CPS < 1 cases. This study demonstrates an increased proportion of PD-L1+ cases in both CeD-SBAs and CrD-SBAs in comparison with sporadic SBAs. In addition, the identification of a subset of PD-L1+ microsatellite stable SBAs supports the need to ascertain additional biomarkers of response to immune checkpoint inhibitors along with MSI-H.
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- 2020
6. Small Bowel Carcinomas in Coeliac or Crohn’s Disease: Clinico-pathological, Molecular, and Prognostic Features. A Study From the Small Bowel Cancer Italian Consortium
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Claudia Mescoli, Michele Martino, Fausto Sessa, Massimo Rugge, Ombretta Luinetti, Gabriella Nesi, Vincenzo Canzonieri, Alessandro Vanoli, Luca Reggiani Bonetti, Ada Maria Florena, Giovanni Monteleone, Daniela Furlan, Umberto Volta, Paolo Fociani, Vincenzo Villanacci, Antonino Giulio Giannone, Marco Silano, Antonio Di Sabatino, Antonio Maccioni, Paolo Usai, G. Solina, Vittorio Perfetti, Federica Grillo, Maria Cristina Macciomei, Rachele Manca, Stefano Ferrero, Renato Cannizzaro, Aroldo Rizzo, Livia Biancone, Luca Elli, Claudio Papi, Giacomo Caio, Giovanni Latella, Antonio Calabrò, Roberta Cerutti, Marianna Salemme, Paolo Giuffrida, Gianluca M. Sampietro, Gino Roberto Corazza, Paola Migliora, Donatella Santini, Sandro Ardizzone, Augusto Orlandi, Francesco Tonelli, Antonio Ciardi, Catherine Klersy, Carolina Ciacci, Davide Trapani, Renata D'Incà, Francesco Paolo D'Armiento, Marco Paulli, Marco Astegiano, Roberto Caronna, Roberto Fiocca, Luigi Michele Coppola, Paola Alberizzi, Enrico Solcia, Giuseppe Santeusanio, G. Sandri, Roberta Riboni, Vanoli, Alessandro, Sabatino, Antonio Di, Furlan, Daniela, Klersy, Catherine, Grillo, Federica, Fiocca, Roberto, Mescoli, Claudia, Rugge, Massimo, Nesi, Gabriella, Fociani, Paolo, Sampietro, Gianluca, Ardizzone, Sandro, Luinetti, Ombretta, Calabrò, Antonio, Tonelli, Francesco, Volta, Umberto, Santini, Donatella, Caio, Giacomo, Giuffrida, Paolo, Elli, Luca, Ferrero, Stefano, Latella, Giovanni, Ciardi, Antonio, Caronna, Roberto, Solina, Gaspare, Rizzo, Aroldo, Ciacci, Carolina, D'Armiento, FRANCESCO PAOLO, Salemme, Marianna, Villanacci, Vincenzo, Cannizzaro, Renato, Canzonieri, Vincenzo, Bonetti, Luca Reggiani, Biancone, Livia, Monteleone, Giovanni, Orlandi, Augusto, Santeusanio, Giuseppe, Macciomei, Maria C, D'Incà, Renata, Perfetti, Vittorio, Sandri, Giancarlo, Silano, Marco, Florena, Ada M, Giannone, Antonino G, Papi, Claudio, Coppola, Luigi, Usai, Paolo, Maccioni, Antonio, Astegiano, Marco, Migliora, Paola, Manca, Rachele, Martino, Michele, Trapani, Davide, Cerutti, Roberta, Alberizzi, Paola, Riboni, Roberta, Sessa, Fausto, Paulli, Marco, Solcia, Enrico, Corazza, Gino R., Di Sabatino, Antonio, D’Armiento, Francesco P., Reggiani Bonetti, Luca, Macciomei, Maria C., D’Incà, Renata, Florena, Ada M., Giannone, Antonino G., Vanoli A., Di Sabatino A., Furlan D., Klersy C., Grillo F., Fiocca R., Mescoli C., Rugge M., Nesi G., Fociani P., Sampietro G., Ardizzone S., Luinetti O., Calabro A., Tonelli F., Volta U., Santini D., Caio G., Giuffrida P., Elli L., Ferrero S., Latella G., Ciardi A., Caronna R., Solina G., Rizzo A., Ciacci C., D'Armiento F.P., Salemme M., Villanacci V., Cannizzaro R., Canzonieri V., Bonetti L.R., Biancone L., Monteleone G., Orlandi A., Santeusanio G., Macciomei M.C., D'Inca R., Perfetti V., Sandri G., Silano M., Florena A.M., Giannone A.G., Papi C., Coppola L., Usai P., Maccioni A., Astegiano M., Migliora P., Manca R., Martino M., Trapani D., Cerutti R., Alberizzi P., Riboni R., Sessa F., Paulli M., Solcia E., and Corazza G.R.
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Male ,0301 basic medicine ,Neuroblastoma RAS viral oncogene homolog ,Oncology ,Survival ,Receptor, ErbB-2 ,Colorectal cancer ,medicine.disease_cause ,Inflammatory bowel disease ,tumour-infiltrating lymphocyte ,ErbB-2 ,0302 clinical medicine ,Crohn Disease ,Retrospective Studie ,Risk Factors ,80 and over ,Child ,Class I Phosphatidylinositol 3-Kinase ,Aged, 80 and over ,Colonic Neoplasm ,Settore MED/12 - Gastroenterologia ,Crohn's disease ,MLH1 methylation ,Tumour-infiltrating lymphocytes ,Gastroenterology ,General Medicine ,Middle Aged ,Prognosis ,Microsatellite instability ,MLH1 promoter methylation ,030220 oncology & carcinogenesis ,Colonic Neoplasms ,Survival Analysi ,KRAS ,Human ,Receptor ,Adult ,Proto-Oncogene Proteins B-raf ,medicine.medical_specialty ,Prognosi ,Class I Phosphatidylinositol 3-Kinases ,Settore MED/08 - Anatomia Patologica ,NO ,Proto-Oncogene Proteins p21(ras) ,Young Adult ,03 medical and health sciences ,Internal medicine ,medicine ,Carcinoma ,Humans ,inflammatory bowel disease ,microsatellite instability ,survival ,tumour-infiltrating lymphocytes ,neoplasms ,Aged ,Retrospective Studies ,Celiac Disease ,Microsatellite Instability ,Survival Analysis ,Tumor Suppressor Protein p53 ,business.industry ,Tumour-infiltrating lymphocyte ,Risk Factor ,Cancer ,medicine.disease ,eye diseases ,digestive system diseases ,030104 developmental biology ,business - Abstract
Background and aims An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's disease [CrD]. We explored clinico-pathological, molecular, and prognostic features of CD-associated SBC [CD-SBC] and CrD-associated SBC [CrD-SBC] in comparison with sporadic SBC [spo-SBC]. Methods A total of 76 patients undergoing surgical resection for non-familial SBC [26 CD-SBC, 25 CrD-SBC, 25 spo-SBC] were retrospectively enrolled to investigate patients' survival and histological and molecular features including microsatellite instability [MSI] and KRAS/NRAS, BRAF, PIK3CA, TP53, HER2 gene alterations. Results CD-SBC showed a significantly better sex-, age-, and stage-adjusted overall and cancer-specific survival than CrD-SBC, whereas no significant difference was found between spo-SBC and either CD-SBC or CrD-SBC. CD-SBC exhibited a significantly higher rate of MSI and median tumour-infiltrating lymphocytes [TIL] than CrD-SBC and spo-SBC. Among the whole SBC series, both MSI─which was the result of MLH1 promoter methylation in all but one cases─and high TIL density were associated with improved survival at univariable and stage-inclusive multivariable analysis. However, only TILs retained prognostic power when clinical subgroups were added to the multivariable model. KRAS mutation and HER2 amplification were detected in 30% and 7% of cases, respectively, without prognostic implications. Conclusions In comparison with CrD-SBC, CD-SBC patients harbour MSI and high TILs more frequently and show better outcome. This seems mainly due to their higher TIL density, which at multivariable analysis showed an independent prognostic value. MSI/TIL status, KRAS mutations and HER2 amplification might help in stratifying patients for targeted anti-cancer therapy.
- Published
- 2017
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