43 results on '"Mehnert, Anja"'
Search Results
2. Depression and anxiety in long-term survivors 5 and 10 years after cancer diagnosis
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Götze, Heide, Friedrich, Michael, Taubenheim, Sabine, Dietz, Andreas, Lordick, Florian, and Mehnert, Anja
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- 2020
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3. INPART - a psycho-oncological intervention for partners of patients with haemato-oncological disease – study protocol
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Lorenz, Inga, Bodschwinna, Daniela, Hallensleben, Nina, Döhner, Hartmut, Niederwieser, Dietger, Zimmermann, Tanja, Mehnert, Anja, Gündel, Harald, Ernst, Jochen, and Hoenig, Klaus
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- 2019
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4. Ältere Patienten (70+) in der Onkologie: Psychosoziale Problemfelder und Aspekte der Versorgung
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Götze, Heide and Mehnert, Anja
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- 2018
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5. Associations between dyadic coping and supportive care needs: findings from a study with hematologic cancer patients and their partners
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Weißflog, Gregor, Hönig, Klaus, Gündel, Harald, Lang, Dirk, Niederwieser, Dietger, Döhner, Hartmut, Vogelhuber, Martin, Mehnert, Anja, and Ernst, Jochen
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- 2017
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6. Psychological distress of cancer patients with children under 18 years and their partners—a longitudinal study of family relationships using dyadic data analysis
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Götze, Heide, Friedrich, Michael, Brähler, Elmar, Romer, Georg, Mehnert, Anja, and Ernst, Jochen
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- 2017
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7. Sozialrechtliche Beratung in ambulanten Krebsberatungsstellen: Angebote und Inanspruchnahme durch Ratsuchende
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Ernst, Jochen, Mehnert, Anja, Weis, Joachim, Faust, Tanja, Giesler, Jürgen M., and Roick, Julia
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- 2016
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8. Internet-based grief therapy for bereaved individuals after loss due to Haematological cancer: study protocol of a randomized controlled trial
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Hoffmann, Rahel, Große, Julia, Nagl, Michaela, Niederwieser, Dietger, Mehnert, Anja, and Kersting, Anette
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- 2018
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9. Validation of the German version of the late adolescence and young adulthood survivorship-related quality of life measure (LAYA-SRQL)
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Richter, Diana, Mehnert, Anja, Schepper, Florian, Leuteritz, Katja, Park, Crystal, and Ernst, Jochen
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- 2018
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10. Satisfaction with information and unmet information needs in men and women with cancer
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Faller, Hermann, Koch, Uwe, Brähler, Elmar, Härter, Martin, Keller, Monika, Schulz, Holger, Wegscheider, Karl, Weis, Joachim, Boehncke, Anna, Hund, Bianca, Reuter, Katrin, Richard, Matthias, Sehner, Susanne, Szalai, Carina, Wittchen, Hans-Ulrich, and Mehnert, Anja
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- 2016
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11. Anxiety and fear of cancer recurrence and its association with supportive care needs and health-care service utilization in cancer patients
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Sarkar, Susanne, Sautier, Leon, Schilling, Georgia, Bokemeyer, Carsten, Koch, Uwe, and Mehnert, Anja
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- 2015
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12. Predictors of employment among cancer survivors after medical rehabilitation - a prospective study
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Mehnert, Anja and Koch, Uwe
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- 2013
13. Global meaning and meaning-related life attitudes: exploring their role in predicting depression, anxiety, and demoralization in cancer patients
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Vehling, Sigrun, Lehmann, Claudia, Oechsle, Karin, Bokemeyer, Carsten, Krüll, Andreas, Koch, Uwe, and Mehnert, Anja
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- 2011
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14. Efficacy of the Managing Cancer and Living Meaningfully (CALM) individual psychotherapy for patients with advanced cancer: A single‐blind randomized controlled trial.
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Mehnert, Anja, Koranyi, Susan, Philipp, Rebecca, Scheffold, Katharina, Kriston, Levente, Lehmann‐Laue, Antje, Engelmann, Dorit, Vehling, Sigrun, Eisenecker, Christina, Oechsle, Karin, Schulz‐Kindermann, Frank, Rodin, Gary, and Härter, Martin
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PSYCHOTHERAPY patients , *RANDOMIZED controlled trials , *MENTAL depression , *PSYCHO-oncology , *GROUP psychotherapy , *CANCER patients , *BIBLIOTHERAPY - Abstract
Objective: We aimed to determine whether the Managing Cancer and Living Meaningfully (CALM) therapy is superior to a non‐manualized supportive psycho‐oncological counselling intervention (SPI). Methods: Adult patients with advanced cancer and ≥9 points on the PHQ‐9 and/or ≥5 points on the DT were randomized to CALM or SPI. We hypothesized that CALM patients would report significantly less depression (primary outcome) on the BDI‐II and the PHQ‐9 6 months after baseline compared to SPI patients. Results: From 329 eligible patients, 206 participated (61.2% female; age: M = 57.9 [SD = 11.7]; 84.5% UICC IV stage). Of them, 99 were assigned to CALM and 107 to SPI. Intention‐to‐treat analyses revealed significantly less depressive symptoms at 6 months than at baseline (P <.001 for BDI‐II and PHQ‐9), but participants in the CALM and SPI group did not differ in depression severity (BDI‐II: P =.62, PHQ‐9: P =.998). Group differences on secondary outcomes were statistically not significant either. Conclusions: CALM therapy was associated with reduction in depressive symptoms over time but this improvement was not statistically significant different than that obtained within SPI group. [ABSTRACT FROM AUTHOR]
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- 2020
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15. Assessment of depression severity with the PHQ-9 in cancer patients and in the general population
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Hinz, Andreas, Mehnert, Anja, Kocalevent, Rüya-Daniela, Brähler, Elmar, Forkmann, Thomas, Singer, Susanne, Schulte, Thomas, Universität Leipzig, Universität Hamburg, Universität Mainz, and RWTH
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Adult ,Aged, 80 and over ,Male ,Psychiatric Status Rating Scales ,Psychometrics ,Adolescent ,Depression ,Depressive symptoms ,Age Factors ,Reproducibility of Results ,Middle Aged ,Depression, cancer, depressive symptoms, psychometrics ,Psychiatry and Mental health ,Young Adult ,Sex Factors ,Case-Control Studies ,Neoplasms ,Humans ,Depression, Krebs, depressive Beschwerden, Psychometrie ,Female ,ddc:610 ,Research Article ,Cancer ,Aged - Abstract
BMC psychiatry 16, 22 (2016). doi:10.1186/s12888-016-0728-6, Published by BioMed Central, London
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- 2016
16. Characterizing death acceptance among patients with cancer.
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Philipp, Rebecca, Mehnert, Anja, Lo, Chris, Müller, Volkmar, Reck, Martin, and Vehling, Sigrun
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CANCER patients , *GENERAL Health Questionnaire , *GENERALIZED anxiety disorder , *PSYCHOLOGICAL distress , *ACCEPTANCE (Psychology) , *REGRESSION analysis - Abstract
Objective: Death acceptance may indicate positive adaptation in cancer patients. Little is known about what characterizes patients with different levels of death acceptance or its impact on psychological distress. We aimed to broaden the understanding of death acceptance by exploring associated demographic, medical, and psychological characteristics.Methods: At baseline, we studied 307 mixed cancer patients attending the University Cancer Center Hamburg and a specialized lung cancer center (age M = 59.6, 69% female, 69% advanced cancer). At 1-year follow-up, 153 patients participated. We assessed death acceptance using the validated Life Attitude Profile-Revised. Patients further completed the Memorial Symptom Assessment Scale, the Demoralization Scale, the Patient Health Questionnaire, and the Generalized Anxiety Disorder Questionnaire. Statistical analyses included multinomial and hierarchical regression analyses.Results: At baseline, mean death acceptance was 4.33 (standard deviation [SD] = 1.3, range 1-7). There was no change to follow-up (P = 0.26). When all variables were entered simultaneously, patients who experienced high death acceptance were more likely to be older (odds ratio [OR] = 1.04; 95% confidence interval [CI], 1.01-1.07), male (OR = 3.59; 95% CI, 1.35-9.56), widowed (OR = 3.24; 95% CI, 1.01-10.41), and diagnosed with stage IV (OR = 2.44; 95% CI, 1.27-4.71). They were less likely to be diagnosed with lung cancer (OR = 0.20; 95% CI, 0.07-0.58), and their death acceptance was lower with every month since diagnosis (OR = 0.99; 95% CI, 0.98-0.99). High death acceptance predicted lower demoralization and anxiety at follow-up but not depression.Conclusions: High death acceptance was adaptive. It predicted lower existential distress and anxiety after 1 year. Advanced cancer did not preclude death acceptance, supporting the exploration of death-related concerns in psychosocial interventions. [ABSTRACT FROM AUTHOR]- Published
- 2019
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17. Perceived doctor-patient relationship and its association with demoralization in patients with advanced cancer.
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Quintero Garzón, Leonhard, Koranyi, Susan, Engelmann, Dorit, Philipp, Rebecca, Scheffold, Katharina, Schulz-Kindermann, Frank, Härter, Martin, and Mehnert, Anja
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PHYSICIAN-patient relations ,HOPELESSNESS theory of depression ,BECK Depression Inventory ,REGRESSION analysis ,HELPLESSNESS (Psychology) - Abstract
Background: Advanced diseases pose a great burden on patients and go hand in hand with existential concerns. Demoralization is considered as a syndrome of existential distress with a perceived inability to cope with loss of meaning in life and feelings of helplessness and hopelessness. Professional health care providers play an important role in providing support for patients and unfavorable conversational styles in their relationship can increase patient's distress. In this study, we examine the association between the patient's perceived relationship to health care providers and demoralization.Methods: We used baseline data of a randomized control trial intervention study for advanced cancer patients (UICC-Stage ≥ III; PHQ ≥ 9 and/or Distress-Thermometer ≥5). We used a subscale of the QUAL-EC-P for assessing doctor-patient relationship, Beck Depression Inventory-II for depressive symptoms, a modified version of the MSAS as physiological symptom checklist, and the Demoralization Scale to assess demoralization. A hierarchical regression analysis was calculated.Results: In our sample of 187 patients with stage III or IV cancer (62% women), demoralization was present in 53.4% (16% moderate demoralization; 37.4% high demoralization) of the patients. Relationship to health care provider was an independent predictor (β = -.33, t(186) = -6.70, P < .001) of demoralization.Conclusions: Our findings underline the importance of the physician-patient relationship in the context of coping with existential challenges in advanced cancer patients. Trainings on how to communicate and build a sustainable relationship with patients and their specific needs may increase the buffering effect of social support by the physicians on patient's existential distress. [ABSTRACT FROM AUTHOR]- Published
- 2018
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18. The Generalized Anxiety Disorder Screener (GAD-7) and the anxiety module of the Hospital and Depression Scale (HADS-A) as screening tools for generalized anxiety disorder among cancer patients.
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Esser, Peter, Hartung, Tim J., Friedrich, Michael, Johansen, Christoffer, Wittchen, Hans‐Ulrich, Faller, Hermann, Koch, Uwe, Härter, Martin, Keller, Monika, Schulz, Holger, Wegscheider, Karl, Weis, Joachim, Mehnert, Anja, and Wittchen, Hans-Ulrich
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GENERALIZED anxiety disorder ,MENTAL depression ,ANXIETY disorders ,CANCER patients ,RECEIVER operating characteristic curves ,ANXIETY diagnosis ,DIAGNOSIS of mental depression ,TUMORS & psychology ,COMPARATIVE studies ,RESEARCH methodology ,MEDICAL cooperation ,PSYCHOLOGICAL tests ,PSYCHOMETRICS ,RESEARCH ,EVALUATION research - Abstract
Objective: Anxiety in cancer patients may represent a normal psychological reaction. To detect patients with pathological levels, appropriate screeners with established cut-offs are needed. Given that previous research is sparse, we investigated the diagnostic accuracy of 2 frequently used screening tools in detecting generalized anxiety disorder (GAD).Methods: We used data of a multicenter study including 2141 cancer patients. Diagnostic accuracy was investigated for the Generalized Anxiety Disorder Screener (GAD-7) and the anxiety module of the Hospital Anxiety and Depression Scale (HADS-A). GAD, assessed with the Composite International Diagnostic Interview for Oncology, served as a reference standard. Overall accuracy was measured with the area under the receiver operating characteristics curve (AUC). The AUC of the 2 screeners were statistically compared. We also calculated accuracy measures for selected cut-offs.Results: Diagnostic accuracy could be interpreted as adequate for both screeners, with an identical AUC of .81 (95% CI: .79-.82). Consequently, the 2 screeners did not differ in their performance (P = .86). The best balance between sensitivity and specificity was found for cut-offs ≥7 (GAD-7) and ≥8 (HADS-A). The officially recommended thresholds for the GAD-7 (≥ 10) and the HADS-A (≥11) showed low sensitivities of 55% and 48%, respectively.Conclusions: The GAD-7 and HADS-A showed AUC of adequate diagnostic accuracy and hence are applicable for GAD screening in cancer patients. Nevertheless, the choice of optimal cut-offs should be carefully evaluated. [ABSTRACT FROM AUTHOR]- Published
- 2018
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19. Body image mediates the effect of cancer-related stigmatization on depression: A new target for intervention.
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Esser, Peter, Mehnert, Anja, Johansen, Christoffer, Hornemann, Beate, Dietz, Andreas, and Ernst, Jochen
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CANCER patient psychology , *BODY image , *CANCER patients , *PROSTATE cancer patients , *LUNG tumors , *MENTAL depression , *BREAST tumors , *COLON tumors , *PROSTATE tumors , *COMPARATIVE studies , *RESEARCH methodology , *MEDICAL cooperation , *QUESTIONNAIRES , *RESEARCH , *STEREOTYPES , *SOCIAL stigma , *EVALUATION research , *PSYCHOLOGY , *CANCER & psychology ,RECTUM tumors - Abstract
Objective: Because cancer-related stigmatization is prevalent but difficult to change, research on its impact on psychological burden and respective intervening variables is needed. Therefore, we investigated the effect of stigmatization on depressive symptomatology and whether body image mediates this relationship.Methods: This bicentric study assessed patients of 4 major tumor entities. We measured stigmatization (SIS-D), depressive symptomatology (PHQ-9), and body image (FKB-20). Applying multiple mediator analyses, we calculated the total effect of stigmatization on depressive symptomatology and the indirect effects exerted via the 2 body image scales rejecting body evaluation and vital body dynamics.Results: Among the 858 cancer patients recruited (breast: n = 297; prostate: n = 268; colorectal: n = 168; lung: n = 125), stigmatization showed total effects on depressive symptomatology across all stigma dimensions (all ptotal sample < .001). Except for lung cancer patients, this result was replicated for each cancer group. Body image as a whole was shown to mediate the effect across all samples (γtotal sample = .04, 95%-CI: 0.03-0.06). Among the total sample and prostate cancer patients, the mediating effect of rejecting body evaluation was significantly larger than the effect of vital body dynamics (dtotal sample = .02, 95%-CI: 0.01-0.04).Conclusions: Perceived stigmatization is an important and generalizable risk factor for depressive symptomatology among cancer patients. Apart from interventions addressing stigmatization, improving body image could additionally help to reduce the psychological burden in stigmatized patients. [ABSTRACT FROM AUTHOR]- Published
- 2018
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20. The association of demoralization with mental disorders and suicidal ideation in patients with cancer.
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Vehling, Sigrun, Kissane, David W., Lo, Christopher, Glaesmer, Heide, Hartung, Tim J., Rodin, Gary, and Mehnert, Anja
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SUICIDAL ideation ,MORALE ,CANCER patients ,MENTAL illness ,ANXIETY disorders ,AFFECTIVE disorders ,ADJUSTMENT disorders ,MENTAL depression ,PSYCHIATRIC diagnosis ,TUMOR diagnosis ,TUMORS & psychology ,COMPARATIVE studies ,CONFIDENCE intervals ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,QUESTIONNAIRES ,RESEARCH ,RISK assessment ,PSYCHOLOGICAL stress ,SURVIVAL ,TUMORS ,EVALUATION research ,DISEASE incidence ,CROSS-sectional method ,SEVERITY of illness index ,PSYCHOLOGICAL factors ,DIAGNOSIS ,PSYCHOLOGY - Abstract
Background: Demoralization refers to a state in which there is a perceived inability to cope, that is associated with a sense of disheartenment and a loss of hope and meaning. This study investigated the co-occurrence versus independence of demoralization with mental disorders and suicidal ideation to evaluate its features as a concept of distress in the context of severe illness.Methods: In a cross-sectional sample of 430 mixed cancer patients, we assessed demoralization with the Demoralization Scale (DS); the 4-week prevalence of mood, anxiety, and adjustment disorders and suicidal ideation with the standardized Composite International Diagnostic Interview-Oncology (CIDI-O); and depressive symptoms with the Patient Health Questionnaire-9 (PHQ-9). We compared the relative risk (RR) for mental disorders associated with demoralization to that associated with self-reported depression.Results: Clinically relevant levels of demoralization were present in 21% of the patients. Demoralization co-occurred with a mood/anxiety disorder in 7%; 14% were demoralized in absence of any mood/anxiety disorder. Demoralization and adjustment disorders co-occurred in 2%. The RR for any mood/anxiety disorder was 4.0 in patients with demoralization (95% confidence interval [CI], 2.5-6.2) and 3.0 in those with depression (95% CI, 1.9-4.6). Demoralization, but not depression, was associated with a significantly increased risk for suicidal ideation after controlling for mental disorders (RR, 2.0; 95% CI, 1.1-3.5).Conclusions: Clinically relevant demoralization frequently occurs independently of a mental disorder in patients with cancer and has a unique contribution to suicidal ideation. Demoralization is a useful concept to identify profiles of psychological distress symptoms amenable to interventions improving psychological well-being in this population. Cancer 2017;123:3394-401. © 2017 American Cancer Society. [ABSTRACT FROM AUTHOR]- Published
- 2017
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21. Potreba za psihosocijalnom rehabilitacijom oboljelih od raka
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Mehnert, Anja, Müller, Diana, Gärtner, Ulrich, Jacobi, Claus, Biskup, Martin, Berger, Dieter, and Koch, Uwe
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rak ,psihoonkologija ,rehabilitacija ,cancer ,psycho-oncology ,rehabilitation - Abstract
In addition to the healing and alleviation of primary somatic cancer symptoms, the comprehensive psycho oncological treatment of cancer patients is an important and fundamental component of oncological rehabilitation in Germany. Rehabilitation treatment encompasses medical, physiotherapeutic, psychological, and creative therapeutic methods, as well as psycho-educational interventions within the framework of an individualized therapy plan. Psycho-oncological interventions within rehabilitation are governed less by individual therapeutic schools of thought, and more by a supportive, patient-centered approach that integrates various psychotherapeutic methods. Adapted methods and techniques from various psychotherapeutic approaches (behavioral therapy, psychoanalytical psychotherapies, systemic family therapy, or hypnotherapy) are currently used in the treatment of cancer patients. A total of N=116 patients of the Paracelsus Clinic am See in Bad Gandersheim were able to be included in the study. In summary, this study shows that about two thirds of the patients admitted to the oncological rehabilitation clinic exhibit middle to high degrees of distress in the areas of anxiety and/or depression. Moreover, it appears to be particularly important to assess not only the mental distress of cancer patients but also their degree of information with regard to psycho-oncological treatment when performing screening for psycho-oncological treatment outside of the rehabilitation clinic setting. Here it is particularly important to accommodate for a differing need for differing forms of treatment (need for counseling, care, or treatment)., Sveobuhvatno psiho-onkološko liječenje bolesnika s rakom važan je prilog u liječenju i ublažavanju primarnih somatskih simptoma te temeljna komponenta onkološke rehabilitacije u Saveznoj Republici Njemačkoj. Ova vrsta rehabilitacije obuhvaća medicinske, fizioterapijske, psihološke te kreativno terapijske pristupe, ali i psihoedukacijske intervencije u okviru individualiziranih terapijskih programa. Psiho-onkološki rehabilitacijski postupci manje su određeni kognitivnim psihoterapijskim metodma, a više potpornim, pacijentu usmjerenim pristupima koji obuhvaćaju različite psihoterapijske tehnike. Prilagođene metode i tehnike iz različitih psihoterapijskih pristupa (bihevioralna terapija, psihoanalitička psihoterapija, sistemska obiteljska terapija ili hipnoterapija) predstavljaju suvremeni koncept u liječenju onkoloških bolesnika. Ova studija provedena je na uzorku od 116 pacijenata Paracelsus Clinic am See u Bad Gandersheimu. Rezultati studije pokazali su da dvije trećine pacijenata uključenih u onkološku rehabilitaciju pokazuje srednji do visok stupanj poremećaja u području anksioznosti i/ili depresije. Osim toga, osobito je važno da se u uvjetima definiranja psiho-onkološkog liječenja u izvankliničkim uvjetima ne procjenjuje samo vrsta i stupanj psihičkog poremećaja, već također i razina informiranosti o psiho-onkološkom liječenju. U tom smislu posebno je važno različite oblike liječenja prilagoditi različitim osobnim potrebamabolesnika (npr. potreba za savjetovanjem, njegom, liječenjem).
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- 2010
22. Cancer-and-treatment-specific distress and its impact on posttraumatic stress in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).
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Kuba, Katharina, Esser, Peter, Scherwath, Angela, Schirmer, Lena, Schulz‐Kindermann, Frank, Dinkel, Andreas, Balck, Friedrich, Koch, Uwe, Kröger, Nicolaus, Götze, Heide, Mehnert, Anja, Schulz-Kindermann, Frank, Kröger, Nicolaus, and Götze, Heide
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SYMPTOMS ,HUMAN sexuality ,POST-traumatic stress disorder ,UNCERTAINTY ,HEMATOPOIETIC stem cell transplantation ,PSYCHOLOGY ,DIAGNOSIS of post-traumatic stress disorder ,TUMOR treatment ,TUMORS & psychology ,HOMOGRAFTS ,LONGITUDINAL method - Abstract
Background: In this prospective multicenter study, we investigated cancer-and-treatment-specific distress (CTXD) and its impact on symptoms of posttraumatic stress disorder (PTSD) in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT).Methods: Patients were consulted before (T0, N = 239), 3 (T1, N = 150), and 12 months (T2, N = 102) after HSCT. Medical (eg, diagnosis and pretreatment) and demographic information, CTXD and PTSD (PCL-C) were assessed.Results: Random intercept models revealed that the sum score of CTXD was highest pre-HSCT (T0), decreased by T1 (γ = -.18, 95% CI [-.26/-.09]), and by T2 (γ = -.10, 95% CI [-.20/-.00]). Uncertainty, family strain, and health burden were rated most distressing during HSCT. Uncertainty and family strain decreased from T0 to T1 (γ = -.30, 95% CI [-.42/-.17]; γ = -.10, 95% CI [-.20/-.00]) and health burden from T1 to T2 (γ = -.21, 95% CI [-.36/.05]). Women were more likely to report uncertainty (γ = .38, 95% CI [.19/.58]), family strain (γ = .38, 95% CI [.19/.58]), and concerns regarding appearance and sexuality (γ = .31, 95% CI [.14/.47]) than men. Uncertainty (γ = .18, 95% CI [.12/.24]), appearance and sexuality (γ = .09, 95% CI [.01/.16]), and health burden (γ = .21, 95% CI [.14/.27]) emerged as predictors of PTSD symptomatology across the 3 assessment points.Conclusions: Our data provide first evidence regarding the course of 6 dimensions of CTXD during HSCT and their impact on PTSD symptomatology. Specifically, results emphasize the major burden of uncertainty pre-HSCT and the impact of uncertainty and concerns regarding appearance and sexuality on PTSD symptomatology. [ABSTRACT FROM AUTHOR]- Published
- 2017
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23. Utilization of professional psychological care in a large German sample of cancer patients.
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Faller, Hermann, Weis, Joachim, Koch, Uwe, Brähler, Elmar, Härter, Martin, Keller, Monika, Schulz, Holger, Wegscheider, Karl, Boehncke, Anna, Hund, Bianca, Reuter, Katrin, Richard, Matthias, Sehner, Susanne, Wittchen, Hans ‐ Ulrich, and Mehnert, Anja
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CANCER patients ,MENTAL illness ,PATHOLOGICAL psychology ,ANXIETY ,SOCIAL support ,THERAPEUTICS ,TUMOR treatment ,TUMORS & psychology ,ANXIETY disorders treatment ,COMPARATIVE studies ,COUNSELING ,MENTAL depression ,RESEARCH methodology ,MEDICAL cooperation ,PHYSICIAN-patient relations ,PSYCHOTHERAPY ,QUESTIONNAIRES ,RESEARCH ,TUMORS ,EVALUATION research ,CROSS-sectional method ,ANXIETY disorders ,DISEASE complications ,PSYCHOLOGY - Abstract
Objective: Although one-third of cancer patients are perceived to have a need for psychological support based on the percentage of mental disorders, little is known about the actual utilization of psychological care in cancer. We aimed to assess cancer patients' reported use of psychological care and its correlates in a large, representative sample.Methods: In a multicenter, cross-sectional study in Germany, 4020 cancer patients (mean age 58 years, 51% women) were evaluated. We obtained self-reports of use of psychotherapy and psychological counseling. We measured distress with the Distress Thermometer, symptoms of depression with the Patient Health Questionnaire, anxiety with the Generalized Anxiety Disorder Scale, and social support with the Illness-specific Social Support Scale. In a subsample of 2141, we evaluated the presence of a mental disorder using the Composite International Diagnostic Interview.Results: In total, 28.9% (95% confidence interval 27.4%-30.4%) reported having used psychotherapy or psychological counseling or both because of distress due to cancer. Independent correlates of utilization included age (odds ratio [OR] = 0.97 per year], sex (male, OR = 0.55), social support (OR = 0.96), symptoms of depression (OR = 1.04) and anxiety (OR = 1.08), the diagnosis of a mental disorder (OR = 1.68), and a positive attitude toward psychosocial support (OR = 1.27). Less than half of those currently diagnosed with a mental disorder reported having taken up psychological support offers.Conclusion: Special efforts should be made to reach populations that report low utilization of psychological care in spite of having a need for support. [ABSTRACT FROM AUTHOR]- Published
- 2017
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24. Integrating patient reported measures as predictive parameters into decisionmaking about palliative chemotherapy: a pilot study.
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Creutzfeldt, Anna, Suling, Anna, Oechsle, Karin, Mehnert, Anja, Atanackovic, Djordje, Kripp, Melanie, Arnold, Dirk, Stein, Alexander, and Quidd, Julia
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CANCER pain treatment ,CANCER chemotherapy ,HEALTH outcome assessment ,PALLIATIVE treatment ,QUALITY of life ,QUESTIONNAIRES ,GASTROINTESTINAL tumors ,LOGISTIC regression analysis ,PILOT projects ,TREATMENT effectiveness ,PRE-tests & post-tests - Abstract
Background: Systemic treatment has proven to improve physical symptoms in patients with advanced cancer. Relationship between quality of life (QoL) or symptom burden (SYB) and treatment efficacy (tumour response and survival) is poorly described. Therefore, we evaluated the predictive value of pretreatment QoL and SYB on treatment outcomes. Methods: Eligible patients had metastatic gastrointestinal cancers and were about to receive 1st/2nd line palliative chemotherapy. 47 patients were consecutively enrolled. QoL and SYB were assessed by EORTC QLQ-C30 and MSKCC MSAS questionnaires before treatment and after first response evaluation after 8-12 weeks. Logistic regression analysis of QoL and SYB for prediction of objective treatment efficacy was performed. Patients were categorized according to response rate (RR) based on RECIST1.1 and progression free survival (PFS). PFS was categorized by a ratio (individual PFS/expected PFS) in above median (ratio ≥ 1) or below median PFS (ratio < 1). QoL and SYB were analysed for RR groups (partial response, stable or progressive disease) and PFS ratio (PFSR). Results: Objective response to chemotherapy and increase in PFS were associated with better pretreatment QoL and less SYB. Patients with future objective treatment efficacy (PFSR ≥1) evidenced clinically relevant better role/emotional/ cognitive/social functioning and less fatigue and appetite loss at baseline in comparison to PFSR < 1 (>10 points difference). Lowest scores in all functioning scales at treatment start were seen in patients with future PFSR < 1. Global health status (EORTC), PSYCH subscale and global distress index (MSAS) predicted PFSR, even if adjusted for gender, age, cancer type, ECOG and line of treatment (p < 0.05). Interestingly, improved QoL and SYB (subjective benefit) were noted even in patients with worse pretreatment status and no objective tumour response. Conclusion: Future non-responders seem to show distinct QoL patterns before chemotherapy. This may facilitate early detection of patients deriving less or even no benefit from treatment regarding prolongation of survival. Even in patients with primarily progressive disease QoL and SYB may improve during treatment. Integration of QoL and SYB assessment into decision-making about palliative chemotherapy seem to be an important approach to improve patient outcome and should be further evaluated. [ABSTRACT FROM AUTHOR]
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- 2016
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25. STRESSORS, SYMPTOM PROFILE, AND PREDICTORS OF ADJUSTMENT DISORDER IN CANCER PATIENTS. RESULTS FROM AN EPIDEMIOLOGICAL STUDY WITH THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW, ADAPTATION FOR ONCOLOGY (CIDI-O).
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Hund, Bianca, Reuter, Katrin, Härter, Martin, Brähler, Elmar, Faller, Hermann, Keller, Monika, Schulz, Holger, Wegscheider, Karl, Weis, Joachim, Wittchen, Hans‐Ulrich, Koch, Uwe, Friedrich, Michael, and Mehnert, Anja
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ADJUSTMENT disorders ,CANCER patients ,SYMPTOMS ,EPIDEMIOLOGY ,DIAGNOSTIC Interview Schedule ,ONCOLOGY ,CANCER relapse ,DIAGNOSIS ,COMPARATIVE studies ,EPIDEMIOLOGICAL research ,RESEARCH methodology ,MEDICAL cooperation ,PSYCHOLOGICAL tests ,RESEARCH ,TUMORS ,EVALUATION research ,DISEASE prevalence ,CROSS-sectional method - Abstract
Background: We aimed to investigate type and frequency of stressors, predominant symptom profiles, and predictors of adjustment disorders (AD) in cancer patients across major tumor entities.Methods: In this epidemiological study, we examined 2,141 cancer patients out of 4,020 screened with the Composite International Diagnostic Interview, adaptation for oncology (CIDI-O). AD were operationalized as subthreshold disorders according to DSM-IV criteria.Results: In our sample, 265 out of 2,141 patients (12.4%) met all criteria for AD (unweighted 4-week prevalence). The disclosure of the cancer diagnosis, relapse or metastases, and cancer treatments were most frequently described as stressors associated with depressive or anxious symptoms. With regard to AD symptom profiles, patients showed high prevalence rates of affective symptoms according to the DSM-IV criteria of Major Depression: The highest prevalence rates were found for cognitive disturbances (concentration and memory problems) (88%), sleeping disturbances (86%), and depressive mood (83%). We found sex, education, and metastasis as significant predictors for AD. Higher education was the most influential predictor. Men were half as likely to report symptoms fulfilling the AD criteria as women. Patients with metastasized tumors had a more than 80% higher risk of AD than those without metastasis. However, the explained variance of our model is very small (Nagelkerke's R² = 0.08).Conclusions: Patients with AD can be identified using a standardized instrument and deserve clinical attention, as they often show severe clinical symptoms and impairments. Improving the clinical conceptualization of AD by the adding-on of potential stress-response-symptoms is necessary to identify severe psychological strain. [ABSTRACT FROM AUTHOR]- Published
- 2016
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26. Symptom burden, loss of dignity, and demoralization in patients with cancer: a mediation model.
- Author
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Vehling, Sigrun and Mehnert, Anja
- Subjects
- *
CANCER patients , *MEDIATION , *CROSS-sectional method , *MULTIPLE regression analysis , *DIGNITY - Abstract
Background Demoralization is a syndrome of existential distress that occurs in a substantial minority of cancer patients and is associated with a higher number of physical problems. Loss of dignity refers to a range of specific existential concerns. This study examines whether the association between number of physical problems and demoralization is mediated by loss of dignity. Methods This cross-sectional study examined N = 112 inpatients with mixed tumor sites at early and advanced disease stages using the following standardized self-report questionnaires: Physical problems list of the National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT), Patient Dignity Inventory (PDI), Demoralization Scale (DS), Patient Health Questionnaire-9 (PHQ-9) and Illness-Specific Social Support Scale Short Version-8 (ISSS-8). The mediation hypothesis was tested by multiple regression analyses controlling for age, gender, curative versus palliative treatment phase, and social support. Results Patients reported M = 4.7 (SD = 6.0) dignity-related problems; 20% showed moderate to severe demoralization. Loss of dignity significantly mediated 81% of the effect of the number of physical problems on demoralization (Sobel zs = 4.4, p < .001). Testing the reverse direction, we found that demoralization mediated only 53% of the association between physical problems and loss of dignity ( zs = 3.7, p < .001). Conclusions By supporting the mediation hypothesis, our results indicate that loss of dignity partially explains the association between physical problems and demoralization. Early recognition of dignity-related existential concerns and interventions to enhance the sense of dignity may prevent demoralization in patients with cancer. Results provide a conceptual link between existential concerns (loss of dignity) and existential distress (demoralization) as two approaches to existential suffering in patients with cancer. Copyright © 2013 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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27. Work satisfaction and quality of life in cancer survivors in the first year after oncological rehabilitation.
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Mehnert, Anja and Koch, Uwe
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ANALYSIS of variance ,CANCER patients ,EDUCATION ,INCOME ,JOB satisfaction ,JOB stress ,PROBABILITY theory ,QUALITY of life ,RESEARCH funding ,SCALE analysis (Psychology) ,VOCATIONAL rehabilitation ,REPEATED measures design ,DATA analysis software - Abstract
BACKGROUND: Since a growing number of patients are likely to return to work (RTW) after cancer diagnosis and treatment, there is an increasing recognition of the work situation, and the physical as well as psychosocial functioning among those survivors who returned to work. OBJECTIVE: To prospectively examine Health Related quality of Life (HRQoL) and different aspects of work satisfaction in cancer survivors. PARTICIPANTS: N=702 employed cancer patients (85% women) were recruited on average 11 months post diagnosis and assessed at the beginning (
t_1 ), the end (t_2 ) and 12 months after cancer rehabilitation program (t_3 ). METHODS: Participants completed validated measures assessing work satisfaction, working conditions, job strain and HRQoL. RESULTS: Participants showed a high work satisfaction and were most satisfied with job related activities and least satisfied with work organization and leadership. Total work satisfaction was significantly associated with older age, higher monthly income, higher school education, and HRQoL, but not with any cancer- or treatment related characteristics. No significant changes in work satisfaction over time were observed except for a significant deterioration in satisfaction with job related activities (p=0.002; η^2 =0.019), professional acknowledgement (p=0.036; η^2 =0.009), and overall work satisfaction (p < 0.001; η^2 =0.087) with small to moderate effect sizes. CONCLUSIONS: Our findings emphasize the need for comprehensive cancer rehabilitation programs and specific vocational interventions. [ABSTRACT FROM AUTHOR]- Published
- 2013
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28. Cognitive functioning in allogeneic hematopoietic stem cell transplantation recipients and its medical correlates: a prospective multicenter study.
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Scherwath, Angela, Schirmer, Lena, Kruse, Margitta, Ernst, Gundula, Eder, Matthias, Dinkel, Andreas, Kunze, Sabine, Balck, Friedrich, Bornhäuser, Martin, Ehninger, Gerhard, Dolan, Karin, Gramatzki, Martin, Kolb, Hans‐Jochem, Heußner, Pia, Wilhelm, Hans, Beelen, Dietrich W., Schulz‐Kindermann, Frank, Zander, Axel R., Koch, Uwe, and Mehnert, Anja
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HEMATOPOIETIC stem cell transplantation ,GRAFT versus host disease ,COGNITIVE ability ,NEUROPSYCHOLOGICAL tests ,NEUROTOXICOLOGY - Abstract
Background Owing to its neurotoxicity, allogeneic hematopoietic stem cell transplantation (HSCT) carries risks for cognitive impairment. In this multicenter study, we prospectively evaluated cognitive functioning and its medical and demographic correlates in patients undergoing allogeneic HSCT. Methods A total of 102 patients were consecutively assessed prior to (T
0 ), 100 ± 20 days (T1 ) after, and 12 ± 1 months (T2 ) after HSCT (61% men, 41% acute myeloid leukemia). A comprehensive neuropsychological test battery was applied to evaluate attention, memory, executive function, and fine motor function, summing up into 14 test scores. Results Before and after HSCT, patients performed below test norms in up to 50% of the test scores. Patients were mostly impaired on word fluency (24%, T0 ), fine motor function, and verbal delayed recall (19% each, T2 ). Impairment on ≥1/5 cognitive domains occurred in 47% (T0 ) and 41% (T2 ) of the patients. Performance (mean z-scores) partially improved over time (i.e., visual span forward, verbal learning, and word fluency). However, from baseline to T2 , 16% of the patients showed reliable decline on ≥3/14 test scores (reliable change index method). For the majority of neuropsychological subtests, no associations with conditioning intensity, total body irradiation, graft-versus-host disease, cyclosporine treatment, and length of hospital stay were found. Age and premorbid intelligence level were consistently associated with cognition. Conclusions Below average cognitive performance is common in this patient group. In addition, a subgroup shows reliable cognitive decline after allogeneic HSCT. Healthcare professionals should be aware of these treatment-related cognitive side effects. Copyright © 2012 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]- Published
- 2013
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29. Employment challenges for cancer survivors.
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Mehnert, Anja, de Boer, Angela, and Feuerstein, Michael
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CANCER treatment , *CANCER patients , *DRUG side effects , *JOB performance , *JOB satisfaction , *PHARMACOLOGY , *HEALTH outcome assessment - Abstract
There is a considerable body of evidence about the adverse effects of cancer and cancer treatments on employment, work ability, work performance, and work satisfaction among cancer survivors. There is also a growing consensus that cancer survivorship research needs to address the large variety of short-term and long-term work-related problems and that programs to support return to work and employment should be developed and integrated into the follow-up survivorship care of cancer patients. Cancer survivorship and employment can be considered from the perspective of the cancer survivor, the caregiver and the family, the employer and coworkers, the health care providers, and the community or society-elements that comprise many similarities but also differences between Europe and the Unites States and that may affect employment and return to work among cancer survivors in different ways. Previous research has specifically addressed the likelihood and timeliness of work return, including factors that promote and hinder return to work and work performance, and intervention studies and programs that focus on psychological, physical, pharmacologic, or multidisciplinary approaches to work. The area of work disability has emerged as an international field with research from areas throughout the globe. In this article, the authors provide an overview of the current state of scientific research in these areas and further provide a cancer survivorship and work model that integrates significant individual cancer-related, treatment-related, and work-related factors and outcomes. The report concludes with a discussion of European and American contributions and possible future directions for the enhancement of current efforts. Cancer 2013;119(11 suppl):2151-59. © 2013 American Cancer Society. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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30. Employment and work-related issues in cancer survivors
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Mehnert, Anja
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- *
CANCER patients , *CANCER patient rehabilitation , *WAGES , *WORK environment , *WORKING hours , *RETIREMENT , *EMPLOYMENT - Abstract
Abstract: Purpose of this systematic literature review was to identify current knowledge about employment in cancer survivors. Sixty-four studies met inclusion criteria that were original papers published between 01/2000 and 11/2009. Overall, 63.5% of cancer survivors (range 24–94%) returned to work. The mean duration of absence from work was 151 days. Factors significantly associated with a greater likelihood of being employed or return to work were perceived employer accommodation, flexible working arrangements, counseling, training and rehabilitation services, younger age and cancer sites of younger individuals, higher levels of education, male gender, less physical symptoms, lower length of sick leave and continuity of care. Cancer survivors had a significantly increased risk for unemployment, early retirement and were less likely to be re-employed. Between 26% and 53% of cancer survivors lost their job or quit working over a 72-month period post diagnosis. Between 23% and 75% of patients who lost their job were re-employed. A high proportion of patients experienced at least temporary changes in work schedules, work hours, wages and a decline in work ability compared to non-cancer groups. [ABSTRACT FROM AUTHOR]
- Published
- 2011
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31. Fear of cancer progression and cancer-related intrusive cognitions in breast cancer survivors.
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Mehnert, Anja, Berg, Petra, Henrich, Gerhard, and Herschbach, Peter
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CANCER patients , *BREAST cancer , *COGNITION , *POST-traumatic stress disorder , *DRUG therapy - Abstract
Objective: To assess the character and frequency of fear of progression (FoP) and to clarify its relationship with cancer-related intrusive cognitions in breast cancer survivors. Methods: A sample of 1083 patients was recruited in this cross-sectional study through a population-based Cancer Registry an average of 47 month following diagnosis (66% response rate). Participants completed self-report measures assessing fear of cancer progression (FoP-Q-SF), posttraumatic stress-disorder symptoms (PCL-C), coping strategies (DWI) and quality of life (QoL) (SF-8). Results: In total, 23.6% of women were classified as having moderate to high FoP. Being nervous prior to doctors' appointments or examinations and being afraid of relying on strangers for activities of daily living were the most frequent fears. FoP was significantly associated with younger age, having children, disease progress, chemotherapy, perceived amount of impairments, physical and mental QoL, but not with time since initial diagnosis. Intrusive cognitions were screened in 37% of the sample. We found significant correlations between FoP and intrusive thoughts (r=0.63), avoidance (r=0.57), hyperarousal (r=0.54) and posttraumatic stress disorder diagnosis (r=0.42). Factors significantly associated with moderate and high FoP included a depressive coping style as well as an active problem-oriented coping style, intrusion, avoidance and hyperarousal symptoms (Nagelkerke's R2=0.44). Conclusions: Findings of this study give information regarding the frequency and the character of anxiety in breast cancer survivors and underline the relation of FoP to the reality of living with breast cancer. Results suggest that intrusive cognitions as well as avoidance and hyperarousal symptoms seem to be closely related to future-oriented fears of cancer recurrence. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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32. Psychometric evaluation of the German version of the Life Attitude Profile–Revised (LAP-R) in prostate cancer patients.
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Mehnert, Anja and Koch, Uwe
- Abstract
Objective:There has been an increasing interest in the measurement of patients efforts to find meaning during the experience of a life-threatening illness. The aim of this study was to validate the German version of the Life Attitude Profile–Revised (LAP-R), a multidimensional measure of meaning and purpose.Methods:A total of 511 prostate cancer patients with an average age of 64 years filled in the questionnaire during outpatient follow up care (response rate 70%).Results:Five of the original six dimensions were replicated by exploratory and confirmatory factor analysis: Coherence, Existential Vacuum, Choice/Responsibleness, Death Acceptance, and Goal Seeking. The Purpose dimension was not replicated. Most LAP-R subscales showed good internal consistencies with Cronbach's α between .80 and .82, whereas the reliability for Existential Vacuum (α = .69) and Goal Seeking (α = .74) was less sufficient, but still acceptable. Results show significant concurrent associations between all LAP-R dimensions and measures of emotional distress, coping, and health-related quality of life; however, moderate correlations were found only for Existential Vacuum and depression, and inversely for depressive coping and the mental health subscale.Significance of research:The German LAP-R is a reliable and valid instrument that can be recommended for further use in research and clinical cancer care. [ABSTRACT FROM PUBLISHER]
- Published
- 2008
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33. Prevalence of acute and post-traumatic stress disorder and comorbid mental disorders in breast cancer patients during primary cancer care: a prospective study.
- Author
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Mehnert, Anja and Koch, Uwe
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MENTAL illness , *BREAST cancer patients , *POST-traumatic stress disorder , *ANXIETY , *MENTAL depression - Abstract
This study aimed at the identification of acute and post-traumatic stress responses, and comorbid mental disorders in breast cancer patients. Structured clinical interviews for DSM-IV (SCID) were conducted post-surgery with 127 patients (t1). Screening measures were used to assess post-traumatic stress responses, anxiety, and depression at t1 and at 6 months follow-up (t2). Based on the SCID, prevalence rates were 2.4% for both, cancer-related ASD and PTSD. Experiences most frequently described as traumatic were the cancer diagnosis itself and subsequent feelings of uncertainty. Patients with lifetime PTSD (8.7%) were more likely to meet the criteria for cancer-related ASD or PTSD (OR=14.1). Prevalence estimates were 7.1% for Adjustment Disorder, 4.7% for Major Depression, 3.1% for Dysthymic Disorder and 6.3% for Generalized Anxiety Disorder. Using the screening instruments, IES-R, PCL-C and HADS, we found PTSD in 18.5% at t1 and 11.2–16.3% at t2. The estimates of anxiety and depression reveal rates of 39.6% (t1) and 32.7% (t2) for anxiety, as well as 16.0% (t1) and 13.3% (t2) for depression (t1) (cut-off⩾8). The diagnosis of a life-threatening illness has been included as a potential trauma in the DSM-IV. However, it has to be critically evaluated whether subjective feelings of uncertainty like fears of treatment count among traumatic stressors, and thus, whether the diagnosis of PTSD is appropriate in this group of cancer patients. However, a large number of women with emotional distress illustrate the need for psychosocial counseling and support in this early treatment phase. Copyright © 2006 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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34. Age and gender differences in anxiety and depression in cancer patients compared with the general population.
- Author
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Hinz, Andreas, Herzberg, Philipp Yorck, Lordick, Florian, Weis, Joachim, Faller, Hermann, Brähler, Elmar, Härter, Martin, Wegscheider, Karl, Geue, Kristina, and Mehnert, Anja
- Subjects
AGE distribution ,ANALYSIS of variance ,ANXIETY ,CANCER patient psychology ,CHI-squared test ,COMPARATIVE studies ,MENTAL depression ,FACTOR analysis ,RESEARCH funding ,STATISTICAL sampling ,SEX distribution ,SOCIOECONOMIC factors ,PREDICTIVE tests ,DATA analysis software ,FUNCTIONAL assessment ,DESCRIPTIVE statistics - Abstract
Objective: The aim of this study was to compare the levels of anxiety and depression in cancer patients with those of the general population, to examine age and gender differences in anxiety and depression, to analyse the impact of several socio‐demographic and clinical parameters on anxiety and depression, and to test the age and gender measurement invariance of the Hospital Anxiety and Depression Scale (HADS). Methods: A sample of 3,785 German patients with cancer and a sample of 2,747 people of the German general population were examined using the HADS. Results: Patients with cancer were more anxious but slightly less depressed than age‐ and gender‐matched individuals of the general population. Young patients with cancer were particularly affected by anxiety. Measurement invariance across gender and age could be established. For all analysed clinical variables, including tumour site, tumour stage, metastases, setting and Eastern Cooperative Oncology Group (ECOG) performance status we found no significant interaction effects with gender that exceeded the 5% significance criterion. Conclusion: The HADS provides fair comparisons between age and gender groups. Gender differences in anxiety and depression can be generalised across the cancer sites and clinical subgroups. Young patients with cancer deserve special attention by the healthcare system. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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35. Psychological interventions targeting partners of cancer patients: A systematic review.
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Kleine, Anne-Kathrin, Hallensleben, Nina, Mehnert, Anja, Hönig, Klaus, and Ernst, Jochen
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CANCER patients , *POSTTRAUMATIC growth , *RELATIONSHIP quality , *SOCIAL support , *PSYCHOTHERAPY , *SIGNIFICANT others , *PSYCHOLOGY of caregivers , *TREATMENT effectiveness - Abstract
Cancer patients' intimate partners often experience levels of psychological burden that are comparable to or even exceed that of the patients, making it imperative that they too be provided with appropriate psychological support. This review aimed to present the content and the effects of interventions delivered to caregiving partners of cancer patients on both partners and patients. Furthermore, we provide information about the acceptability of the interventions and study quality. An initial search in Web of Science, PsycINFO, and PubMed databases was conducted. We included RCTs as well as pre-post studies that focused on enhancing partners' wellbeing or diminishing partners' distress. To be included, interventions had to have been offered to partners either only or predominantly. We included studies published until December 2017. The methodological quality of the trials was assessed with the EPHPP assessment tool. Nine studies met the inclusion criteria. Intervention topics included social support, short-term problem solving, the marital relationship quality, role expectations, emotional resilience, and coping strategies. Positive intervention effects were found with regard to social support, emotional distress, improved communication, posttraumatic growth, self-efficacy, and coping. Despite considerably low response rates, the interventions were generally well accepted. Most of the studies suffer limitations because of methodological flaws, the lack of randomization, and small sample sizes. Interventions delivered to partners of cancer patients may have positive effects on both partners and patients. We derive several implications for future research: Intervention programs should be tailored to the specific needs of caregiving partners with regard to the cancer trajectory and gender. Effort has to be made to increase sample sizes as well as to include particularly burdened individuals. Selected measurement instruments should be sensitive to specific intervention effects. Finally, information on both statistical as well as clinical relevance of research findings should be provided. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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36. Assessment of Patients' Dignity in Cancer Care: Preliminary Psychometrics of the German Version of the Patient Dignity Inventory (PDI-G).
- Author
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Sautier, Leon P., Vehling, Sigrun, and Mehnert, Anja
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- *
DIGNITY , *CANCER treatment , *PATIENT psychology , *CANCER patients , *GERMAN language , *PRINCIPAL components analysis , *CRONBACH'S alpha - Abstract
Abstract: Context: The Patient Dignity Inventory (PDI) is a valid and reliable instrument designed to measure different sources of dignity-related distress in cancer patients receiving palliative care. Objectives: We investigated item characteristics, factor structure, reliability, and concurrent validity of the German version of the PDI (PDI-G) among patients with cancer. Methods: PDI was translated into the German language following state-of-the-art criteria. In a sample of 112 inpatients with mixed tumor types, principal component analysis, reliability analysis (Cronbach's coefficient alpha), and correlation analysis were performed. Concurrent validity was evaluated by validated measures of distress, demoralization, anxiety, depression, hopelessness, quality of life, sense of meaning and purpose, and supportive care needs. Results: Cronbach's coefficient alpha for PDI-G was 0.96; factor analysis resulted in a four-factor solution, accounting for 71% of the overall variance, with factor loadings ranging from 0.49 to 0.86. Factor labels include Loss of Sense of Worth and Meaning, Anxiety and Uncertainty, Physical Symptom Distress and Body Image, and Loss of Autonomy, showing high internal consistencies ranging from Cronbach's α 0.80 to 0.95. Evidence for concurrent validity was established by significant associations between PDI-G scales and concurrent measures of distress. Conclusion: Although we were unable to replicate the five-factor structure provided by Chochinov, this study gave strong support to an alternative four-factor solution of PDI-G, capturing all 25 items. We conclude that PDI-G is a psychometrically sound instrument assessing a broad range of dignity-related distress issues in patients with cancer. [Copyright &y& Elsevier]
- Published
- 2014
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37. Psychotherapy in the Oncology Setting
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de Vries, Mirjam, Stiefel, Friedrich, Schlag, Peter-Michael, Series editor, Senn, Hans-Jörg, Series editor, Goerling, Ute, editor, and Mehnert, Anja, editor
- Published
- 2018
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38. In which context is physician empathy associated with cancer patient quality of life?
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Lelorain, Sophie, Cattan, Stéphane, Lordick, Florian, Mehnert, Anja, Mariette, Christophe, Christophe, Véronique, and Cortot, Alexis
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- *
PSYCHOLOGY of physicians , *EMPATHY , *QUALITY of life , *CANCER patients , *PSYCHOLOGICAL distress , *REGRESSION analysis , *CANCER patient psychology , *EMOTIONS , *PHYSICIAN-patient relations , *QUESTIONNAIRES , *MULTIPLE regression analysis , *CROSS-sectional method , *DIGESTIVE organs , *TUMORS ,CHEST tumors - Abstract
Objective: In cancer settings, physician empathy is not always linked to a better patient emotional quality of life quality of life (eQoL). We tested two possible moderators of the inconsistent link: type of consultation (bad news versus follow-up) and patient emotional skills (emoSkills, i.e., the way patients process emotional information).Methods: In a cross-sectional design, 296 thoracic and digestive tract cancer patients completed validated questionnaires to assess their physician empathy, their emoSkills and eQoL. Moderated multiple regressions were performed.Results: In follow-up consultations, physician empathy was associated with a better eQoL in patients with low or average emotional skills. Those with high emotional skills did not benefit from physician empathy. Their eQoL was nonetheless very good. In bad news consultations, the pattern was reversed: only patients with average or high emotional skills benefited from physician empathy. Those with low emotional skills were not sensitive to it and presented a poor eQoL.Conclusion: Medical empathy is important in all consultations. However, in bad news consultations, patients with low emoSkills are at risk of psychological distress even with an empathetic doctor.Practice Implications: Accordingly, physicians should be trained to detect patients with low emoSkills in order to refer them to supportive care. [ABSTRACT FROM AUTHOR]- Published
- 2018
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39. Attachment Insecurity in Advanced Cancer Patients: Psychometric Properties of the German Version of the Brief Experiences in Close Relationships Scale (ECR-M16-G).
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Philipp, Rebecca, Vehling, Sigrun, Scheffold, Katharina, Grünke, Britta, Härter, Martin, Mehnert, Anja, Oechsle, Karin, Schulz-Kindermann, Frank, Lo, Christopher, Rebecca, Philipp, Sigrun, Vehling, Katharina, Scheffold, Britta, Grünke, Martin, Härter, Anja, Mehnert, Frank, Schulz-Kindermann, and Christopher, Lo
- Subjects
- *
MENTAL depression , *ONCOLOGY , *CANCER treatment , *CANCER patients , *INPATIENT care , *ANXIETY diagnosis , *DIAGNOSIS of mental depression , *TUMOR diagnosis , *ADAPTABILITY (Personality) , *COMPARATIVE studies , *FACTOR analysis , *INTERPERSONAL relations , *LEARNING , *NEUROPSYCHOLOGICAL tests , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOANALYTIC interpretation , *PSYCHOMETRICS , *RESEARCH , *SPIRITUALITY , *TRANSLATIONS , *TRUST , *EVALUATION research ,TUMORS & psychology - Abstract
Context: Attachment insecurity refers to difficulty in trusting and relying on others in times of need. Its underlying factors attachment anxiety and attachment avoidance have been empirically associated with impaired coping in advanced cancer and, therefore, should be considered in individually tailored medical and psychosocial treatment.Objectives: The objective of this study was to evaluate the psychometric properties of the German translation of the Brief Experiences in Close Relationships Scale (ECR-M16-G).Methods: We recruited 182 advanced cancer patients from outpatient psycho-oncology clinics of the University Medical Center Hamburg-Eppendorf and the University Medical Center Leipzig, local and external cancer care facilities. We performed confirmatory factor analysis to replicate the higher order factor structure reported in previous research. We conducted item and reliability analysis, also correlation analysis, to examine concurrent validity.Results: One hundred fifty-eight patients completed the ECR-M16-G (women 61%, mean age 57.9, SD = 11.1). We replicated the factor structure with the subscales Attachment Anxiety and Attachment Avoidance as second-order factors and Worrying about relationships, Frustration about unavailability, Discomfort with close others, and Turning away from others as first-order factors. An adjusted model that interchanged factor loadings of items 4 and 10 showed good fit (Comparative Fit Index = 0.94, Non-Normed Fit Index = 0.93, root mean square error of approximation = 0.05). Subscales showed acceptable to good internal consistency (anxiety α = .81 and avoidance α = .78). Attachment insecurity (mean = 3.1, SD = 1.0) was positively associated with depression, anxiety, demoralization (P < 0.001), and symptom burden (P = 0.02) and negatively associated with spiritual well-being (P < 0.001).Conclusion: The ECR-M16-G is a valid and reliable measure of attachment insecurity in patients with advanced cancer and can be recommended as a tool for clinical care and further research. [ABSTRACT FROM AUTHOR]- Published
- 2017
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40. Dimensionality, Stability, and Validity of the Beck Hopelessness Scale in Cancer Patients Receiving Curative and Palliative Treatment.
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Spangenberg, Lena, Zenger, Markus, Garcia-Torres, Francisco, Mueller, Volkmar, Reck, Martin, Mehnert, Anja, and Vehling, Sigrun
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BECK Hopelessness Scale , *CANCER patients , *FOLLOW-up studies (Medicine) , *PALLIATIVE treatment , *LONGITUDINAL method , *CONFIRMATORY factor analysis , *TUMOR diagnosis , *TUMOR treatment , *COMPARATIVE studies , *FACTOR analysis , *HOPE , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOLOGICAL tests , *PSYCHOMETRICS , *QUESTIONNAIRES , *RESEARCH , *EVALUATION research ,TUMORS & psychology - Abstract
Context: Hopelessness is a clinically important construct in patients with advanced illness.Objectives: To evaluate the dimensionality, stability, and validity of the Beck Hopelessness Scale (BHS) in cancer patients receiving either curative or palliative treatment.Methods: Following a longitudinal design, we assessed a sample of cancer patients receiving either curative or palliative treatment (N = 315) at baseline and at follow-up after 12 months (N = 158). In addition to hopelessness, we measured depression (Patient Health Questionnaire-9), anxiety (General Anxiety Disorder-7), and health-related quality of life (Short-Form Health Survey-8). We analyzed dimensionality, stability, and construct validity of the BHS using confirmatory factor analysis, exploratory factor analysis and correlational analysis.Results: Independent of treatment intention, confirmatory factor analyses resulted in unsatisfactory model fits. Exploratory factor analysis yielded a two-factor solution in both groups receiving curative or palliative treatment. Factor 1 reflected pessimistic/resigned beliefs (Cronbach alpha ≥ 0.85), Factor 2 reflected positive beliefs toward the future (Cronbach alpha = 0.73). Both subscales showed significant associations with anxiety, depression, and decreased health-related quality of life. The factorial structure was partially replicated in patients being reexamined after 12 months (CMIN/DF = 2.130, Standardized Root Mean Square Residual = 0.0716, Comparative Fit Index = 0.904, Tucker-Lewis-Index = 0.883, Root Mean Square Error of Approximation = 0.085). Hopelessness scores were significantly higher in patients reporting suicidal ideation according to the Patient Health Questionnaire-9.Conclusion: Our study demonstrates psychometric limitations of the BHS in patients receiving both curative and palliative treatment, suggesting reduced utility in cancer populations. Given the clinical importance of the construct, a cancer-specific approach to capture the unique meaning of hopelessness in patients with severe medical illness is recommended. [ABSTRACT FROM AUTHOR]- Published
- 2016
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41. Perceived need for psychosocial support depending on emotional distress and mental comorbidity in men and women with cancer.
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Faller, Hermann, Weis, Joachim, Koch, Uwe, Brähler, Elmar, Härter, Martin, Keller, Monika, Schulz, Holger, Wegscheider, Karl, Boehncke, Anna, Hund, Bianca, Reuter, Katrin, Richard, Matthias, Sehner, Susanne, Szalai, Carina, Wittchen, Hans-Ulrich, and Mehnert, Anja
- Subjects
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PSYCHOSOCIAL factors , *EMOTIONAL state , *PSYCHOLOGICAL distress , *COMORBIDITY , *CANCER in women , *CANCER in men , *PSYCHIATRIC epidemiology , *COMPARATIVE studies , *MENTAL depression , *RESEARCH methodology , *MEDICAL cooperation , *SENSORY perception , *QUALITY of life , *RESEARCH , *PSYCHOLOGICAL stress , *SOCIAL support , *EVALUATION research , *CROSS-sectional method ,TUMORS & psychology - Abstract
Objective: Although elevated levels of distress are supposed to constitute a need for psychosocial support, the relation between elevated distress and need for support does not appear to be straightforward. We aimed to determine cancer patients' perceived need for psychosocial support, and examine the relation of need to both self-reported emotional distress and the interview-based diagnosis of a mental disorder.Methods: In a multicenter, cross-sectional study in Germany, 4020 cancer patients (mean age 58 years, 51% women) were evaluated. We obtained self-reports of need for psychosocial support. We measured distress with the National Comprehensive Cancer Network (NCCN) Distress Thermometer (DT) and depressive symptoms with the Patient Health Questionnaire (PHQ-9). In a subsample, we evaluated the presence of a mental disorder using the Composite International Diagnostic Interview (CIDI).Results: 32.1% (95%-CI 30.6 to 33.6) of patients perceived a need for psychosocial support. Younger age, female sex, and higher education were associated with more needs, being married and living with a partner with fewer needs, respectively. While up to 51.2% of patients with elevated distress levels reported a need for psychosocial support, up to 26.1% of those without elevated distress levels perceived such a need. Results were similar across distress assessment methods.Conclusion: Our findings emphasize that the occurrence of mental distress is one important but not an exclusive factor among different motives to report the need for psychosocial support. We should thus consider multifaceted perspectives, facilitators and barriers when planning and implementing patient-centered psychosocial care services. [ABSTRACT FROM AUTHOR]- Published
- 2016
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42. Psychosocial interventions for adolescents and young adult cancer patients: A systematic review and meta-analysis.
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Richter, Diana, Koehler, Michael, Friedrich, Michael, Hilgendorf, Inken, Mehnert, Anja, and Weißflog, Gregor
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CANCER in adolescence , *ADOLESCENT psychology , *META-analysis , *SYSTEMATIC reviews , *DEVELOPMENTAL disabilities - Abstract
Adolescent and young adult (AYA) cancer patients experience unique psychosocial needs and developmental challenges. A cancer diagnosis can stress this development and disrupt AYAs in their normal life. The aim of this systematic review and meta-analysis was to assess the impact of psychosocial interventions on mental health in AYAs. A literature research was conducted, which resulted in twelve eligible studies. The standardized mean difference between intervention and control conditions was 0.13 (95% CI: −0.16 to 0.42) for quality of life, 0.27 (95% CI: −0.22 to 0.76) for cancer-related knowledge and −0.16 (95% CI: −0.73 to 0.42) on psychological distress indicating, small and non-significant effects for interventions improving mental health. This work strengthens the need for age-appropriated interventions in psycho-oncology. Future research should develop interventions more graduated by age. Randomized intervention studies with larger samples and focusing psychosocial outcomes are needed to establish evidence-based psycho-oncological interventions for AYAs. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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43. Measuring the Psychosocial Dimensions of Quality of Life in Patients With Advanced Cancer: Psychometrics of the German Quality of Life at the End of Life-Cancer-Psychosocial Questionnaire.
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Grünke, Britta, Philipp, Rebecca, Vehling, Sigrun, Scheffold, Katharina, Härter, Martin, Oechsle, Karin, Schulz-Kindermann, Frank, Mehnert, Anja, and Lo, Christopher
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CANCER invasiveness , *PSYCHOSOCIAL factors , *QUALITY of life , *TERMINAL care , *PSYCHOMETRICS , *PSYCHOLOGICAL well-being , *PSYCHOLOGY , *CANCER patient psychology , *FACTOR analysis , *QUESTIONNAIRES , *RESEARCH , *DESCRIPTIVE statistics ,RESEARCH evaluation - Abstract
Context: Quality of life (QoL) is a central focus of care in advanced cancer. Specialized instruments, such as the Quality of Life at the End of Life-Cancer (QUAL-EC), may be useful to assess psychosocial issues associated with QoL unique to this population.Objectives: To evaluate the measurement of the psychosocial dimensions of QoL using the German translation of the QUAL-EC-Psychosocial (QUAL-EC-P) questionnaire, including factor structure and psychometrics.Methods: About 183 patients with advanced cancer from the University Medical Center Hamburg-Eppendorf and University Medical Center Leipzig completed the QUAL-EC-P questionnaire. We conducted exploratory factor analysis as well as item and reliability analysis. We examined convergent validity with correlations between the scale and relevant psychological constructs.Results: The sample was 60% female with mean age of 57.7 (SD = 11.7). We extracted three factors accounting for 44% of the variance aligning with the structure of the instrument. The QUAL-EC-P questionnaire showed good to acceptable internal consistency for the QoL-psychosocial total score (α = 0.77), the Life completion subscale (α = 0.77), and the Relationship with health care provider subscale (α = 0.81). The Preparation for end of life subscale had adequate albeit low internal consistency (α = 0.64) because concerns about family were less associated with financial worry and fear of death than expected. The psychosocial dimensions of QoL correlated negatively with depression (r = -0.27, P ≤ 0.001), anxiety (r = -0.32, P ≤ 0.001), demoralization (r = -0.63, P ≤ 0.001), and attachment insecurity (r = -0.51, P ≤ 0.001) and positively with spiritual well-being (r = 0.63, P ≤ 0.001).Conclusion: The QUAL-EC-P questionnaire may be used to assess the psychosocial aspects of QoL and promote their clinical discussion in patients with advanced cancer. [ABSTRACT FROM AUTHOR]- Published
- 2018
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