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1. Iron Chelates in Biological Systems. Its Relevance to lnduction of Pathogenesis of Tissue Damage and Carcinogenesis

Author

Shigeru Ohba, Toyoaki Fujita, Tadashi Tokii, Atsuko Goto, Shigeru Okada, Tetsuya Akamatsu, and Yuzo Nishida

Subjects
General Chemistry, medicine.disease_cause, Nephrotoxicity, Pathogenesis, chemistry.chemical_compound, chemistry, Biochemistry, Toxicity, medicine, Reactivity (chemistry), Chelation, Hydrogen peroxide, Carcinogenesis, Carcinogen
Abstract

Iron-nta(nitrilotriacetate) solution induces severe nephrotoxicity and high accidence of renal carcinoma in rats and mice, however, the effect by an iron-pac(2-aminomethylpyridine-N,N-diacetate) solution is negligible. These facts were interpreted in terms of different reactivity of the two compounds toward hydrogen peroxide.

Published
1994
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