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Background: Cats with subclinical hypertrophic cardiomyopathy (sHCM) have elevated serum insulin and serum amyloid A concentrations correlating with the degree of cardiac hypertrophy. Diet might affect these and other cardiac variables. Objective: Evaluate the effect of a complete, balanced diet with restricted starch and supplemented with eicosapentaenoic acid + docosahexaenoic acid (EPA + DHA) on echocardiographic variables and cardiac biomarkers in cats with sHCM. Animals Forty‐four client‐owned cats with sHCM. Methods: A prospective, randomized, double‐blind, multicenter study enrolled cats with end‐diastole interventricular septum thickness (IVSd) or left ventricular wall thickness (LVWd) ≥6 mm, or both. Nonsedated, fasted cats were examined at baseline and after 6 and 12 months of Test (restricted starch and EPA + DHA supplements) (n = 23) or Control (unrestricted starch without EPA + DHA supplementation) (n = 21) diet. Assessments included auscultation, body weight, body condition score, echocardiography and blood analysis. Linear and generalized mixed models analyzed diet, time and diet * time interactions (5% significance level). Results: No differences between diet groups were significant for any variable at any timepoint. There were significant decreases in the Test but not Control group in maximum IVSd (P =.03), maximum LVWd (P =.02) and insulin‐like growth factor‐1 levels (P =.04) after 12 months, and in ultrasensitive cardiac troponin I (cTnI) (P =.001) after 6 months; effect sizes (95% confidence interval) were 0.53 (0.09; 0.99), 0.63 (0.18; 1.09), 0.61 (0.16; 1.07), and 0.37 (−0.06; 0.8), respectively. Conclusions and Clinical Importance: Cats with sHCM fed Test diet had significant decreases in echocardiographic variables of sHCM and in cTnI and IGF‐1. [ABSTRACT FROM AUTHOR]

Background: Insulin, insulin‐like growth factor‐1 (IGF‐1), and inflammation possibly are involved in cats with asymptomatic hypertrophic cardiomyopathy (aHCM). Objectives: To evaluate echocardiography, morphology, cardiac and inflammatory markers, insulin and IGF‐1 in cats with aHCM. Animals: Fifty‐one client‐owned cats with aHCM. Methods: Observational descriptive study. Variables (body weight [BW], body condition score [BCS], echocardiography, and serum concentrations of N‐terminal pro‐B‐type natriuretic peptide [NT‐proBNP], ultra‐sensitive troponin‐I [c‐TnI], serum amyloid A [SAA], insulin, glucose and IGF‐1) were evaluated for significant increases above echocardiography cutoff values and laboratory reference ranges, associations and effect of left atrial (LA) remodeling and generalized hypertrophy. Results: Cats with aHCM had BCS ≥6/9 (P =.01) and insulin (P <.001), NT‐proBNP (P =.001) and cTn‐I (P <.001) above laboratory reference ranges. Associations were present between NT‐proBNP and maximum end‐diastolic interventricular septum thickness (IVSd; ρ =.32; P =.05), maximum end‐diastolic left ventricular free wall thickness;(ρ =.41; P =.01), LA/Aorta (ρ =.52; P =.001) and LA diameter (LA‐max; ρ =.32; P =.05); c‐TnI and LA/Aorta (ρ =.49; P =.003) and LA‐max (ρ =.28; P =.05); and SAA and number of IVSd regions ≥6 mm thickness (ρ =.28; P =.05). Body weight and BCS were associated with IGF‐1 (r = 0.44; P =.001), and insulin (ρ =.33; P =.02), glucose (ρ =.29; P =.04) and IGF‐1 (ρ =.32; P =.02), respectively. Concentrations of NT‐proBNP (P =.02) and c‐TnI (P =.01), and SAA (P =.02), were higher in cats with LA remodeling, and generalized hypertrophy, respectively. Conclusions and clinical importance: Results suggest potential implications of insulin, IGF‐1, and inflammation in cats with aHCM, but it remains to be confirmed whether these findings represent a physiological process or a part of the pathogenesis and development of disease. [ABSTRACT FROM AUTHOR]