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1. Studies on the Effective Use of Char

Author

Knight, A T, Sergeant, G D, and National Conference on Chemical Engineering 1979; Expanding Horizons in Chemical Engineering; Preprints of Papers

Published
1979

2. Acrylamide Synthesis on Raney Copper Catalysts

Author

Wainwright, M S, Onuoha, N I, Chaplin, R P, and National Conference on Chemical Engineering 1979; Expanding Horizons in Chemical Engineering; Preprints of Papers

Published
1979

3. Antiangiogenic activity of synthetic dihydrobenzofuran lignans

Author

Slavka Baronikova, Jutta Bürgermeister, Luc Pieters, Stefaan Van Dyck, D. H. Paper, Sandra Apers, Guy L. F. Lemiere, and A. Vlietinck

Subjects
Magnetic Resonance Spectroscopy, Stereochemistry, Pharmaceutical Science, Stereoisomerism, Angiogenesis Inhibitors, Chemical synthesis, Catalysis, Lignans, Analytical Chemistry, Ferulic acid, chemistry.chemical_compound, Caffeic Acids, Drug Discovery, Organic chemistry, Derivatization, Chromatography, High Pressure Liquid, Benzofurans, Pharmacology, Lignan, Bicyclic molecule, Molecular Structure, Organic Chemistry, Biological activity, Chorion, Chorioallantoic membrane, Complementary and alternative medicine, chemistry, Molecular Medicine, Propionates
Abstract

A series of synthetic dihydrobenzofuran lignans, obtained by biomimetic oxidative dimerization of caffeic or ferulic acid methyl ester followed by derivatization reactions, was tested for its antiangiogenic activity in the CAM (chorioallantoic membrane) assay. The dimerization product of caffeic acid methyl ester (2a) (methyl (E)-3-[2-(3,4-dihydroxyphenyl)-7-hydroxy-3-methoxycarbonyl-2,3-dihydro-1-benzofuran-5-yl]prop-2-enoate) showed a pronounced antiangiogenic activity, especially the 2R,3R-enantiomer.

Published
2002

5. Utilizing Nitroarenes and HCHO to Directly Construct Functional N-Heterocycles by Supported Cobalt/Amino Acid Relay Catalysis

Author

Jia‐Lu Sun, Chenggang Ci, Huanfeng Jiang, Pierre H. Dixneuf, Min Zhang, South China University of Technology [Guangzhou] (SCUT), Qiannan Normal College for Nationalities [Duyun] (QNCN), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and The authors are grateful to the financial support of State Key Laboratoryof Pulp and Paper Engineering (2022C03), the National Natural Science Foundation of China (21971071, 22163007), the Natural Science Foundation of Guangdong Province (2023A1515012318 and2021A1515010155), and Guizhou Province Science Foundation ([2020]1Y050).

Subjects
Nitroarenes and formaldehyde, [CHIM]Chemical Sciences, Reductive coupling, General Medicine, General Chemistry, N-heterocyclic carbene ligands, Imidazolines, Catalysis, Relay catalysis
Abstract

International audience; Due to the generation of multiple intermediates during the nitroarene reduction, precise interception of single one to develop tandem reactions involving both C-C and C-N bond formations still remains a significant challenge. Herein, the relay catalysis of a supported bifunctional cobalt catalyst with L-proline has been successfully applied to establish a bran-new reductive annulation reaction of nitroarenes and formaldehyde, which enables direct and diverse construction of both symmetrical and unsymmetrical 1,3-diaryl imidazolines. It proceeds with operational simplicity, good substrate and functionality compatibility, and excellent step and atom-efficiency. Mechanistic studies reveal that the Co-catalyst exhibits a synergistic effect on the formation of key N-hydroxy imine, and the L-proline subsequently facilitates the key C-C bond formation. The current work opens a door to develop useful transformations with nitroarenes by reduction-interrupted strategy.

Published
2023

6. Pre- and Postnatal Dietary Exposure to a Pesticide Cocktail Disrupts Ovarian Functions in 8-Week-Old Female Mice

Author

Léonie Dopavogui, Florence Cadoret, Gaspard Loison, Sara El Fouikar, François-Xavier Frenois, Frank Giton, Sandrine Ellero-Simatos, Frédéric Lasserre, Arnaud Polizzi, Clémence Rives, Nicolas Loiseau, Roger D. Léandri, Nicolas Gatimel, Laurence Gamet-Payrastre, Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Toulouse [Toulouse], Développement Embryonnaire, Fertilité et Environnement (DEFE), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), L.D. was supported by a Ph.D. grant from INRAE (Animal Health Department). This work was supported by a grant from the Ministry for Agriculture and Food and the Ministry for an Ecological and Solidary Transition, with the financial support of the French Biodiversity Agency (GepeTho), by ANR France (Syneract), and by Région Occitanie. This work also received funding from Agence de la Biomédecine (AOR 2019).This paper benefited from the Imag’IN Platform of the Institut Universitaire du Cancer from April 2019 to August 2021 https://www.imagin-labs.net/imagin_v2/index.php? lang=EN (last accessed on 5 June 2022). We thank X. Blanc from INRAe SAAJ (Jouy-en-Josas) for his technical support for pellet preparation., ANR-18-CE34-0009,SYNERACT,Activation synergique de recepteurs nucléaires(2018), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), LESUR, Hélène, and APPEL À PROJETS GÉNÉRIQUE 2018 - Activation synergique de recepteurs nucléaires - - SYNERACT2018 - ANR-18-CE34-0009 - AAPG2018 - VALID

Subjects
pesticide, folliculogenesis, ovary, endocrine disruption, progesterone, [SDV]Life Sciences [q-bio], Organic Chemistry, Pesticide Residues, General Medicine, Catalysis, Computer Science Applications, [SDV] Life Sciences [q-bio], Inorganic Chemistry, Dietary Exposure, Mice, Fruit, Animals, Female, Chlorpyrifos, Physical and Theoretical Chemistry, Pesticides, Molecular Biology, Spectroscopy
Abstract

International audience; Female infertility has a multifactorial origin, and exposure to contaminants, including pesticides, with endocrine-disrupting properties is considered to be involved in this reproductive disorder, especially when it occurs during early life. Pesticides are present in various facets of the environment, and consumers are exposed to a combination of multiple pesticide residues through food intake. The consequences of such exposure with respect to female fertility are not well known. Therefore, we aimed to assess the impact of pre- and postnatal dietary exposure to a pesticide mixture on folliculogenesis, a crucial process in female reproduction. Mice were exposed to the acceptable daily intake levels of six pesticides in a mixture (boscalid, captan, chlorpyrifos, thiacloprid, thiophanate and ziram) from foetal development until 8 weeks old. Female offspring presented with decreased body weight at weaning, which was maintained at 8 weeks old. This was accompanied by an abnormal ovarian ultrastructure, a drastic decrease in the number of corpora lutea and progesterone levels and an increase in ovary cell proliferation. In conclusion, this study shows that this pesticide mixture that can be commonly found in fruits in Europe, causing endocrine disruption in female mice with pre- and postnatal exposure by disturbing folliculogenesis, mainly in the luteinisation process.

Published
2022
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7. Translation and codon usage regulate Argonaute slicer activity to trigger small RNA biogenesis

Author

Germano Cecere, Meetali Singh, Eric Cornes, Blaise Li, Piergiuseppe Quarato, Loan Bourdon, Florent Dingli, Damarys Loew, Simone Procaccia, Mécanismes de l'Hérédité épigénétique / Mechanisms of epigenetic inheritance, Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Hub Bioinformatique et Biostatistique - Bioinformatics and Biostatistics HUB, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Collège doctoral [Sorbonne universités], Sorbonne Université (SU), Laboratoire de Spectrométrie de Masse Protéomique, Institut Curie [Paris], University of Trento [Trento], Some strains were provided by the CGC, funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). This project has received funding from the Institut Pasteur, the CNRS, and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program under grant agreement No. ERC-StG- 679243. M.S. and E.C. were supported by the Pasteur-Roux-Cantarini Postdoctoral Fellowship program. P.Q. was supported by Ligue Nationale Contre le Cancer (SFB19032). F.D. and D.L. have received funding from Région Ile-de-France and Fondation pour la Recherche Médicale grants to support this study., We would like to thank all the members of the Cecere laboratory, Manish Grover, Sudarshan Gadadhar, and Angela Anderson (Life Science Editors), for the helpful discussions on the paper. We thank Micheline Fromont for her help to set up Ribosome profiling. We thank Celine Didier for technical assistance. Sequencing was performed at the Biomics centre at the Institut Pasteur. We thank the Heng-Chi Lee lab, Miska lab, Desai lab, Strome lab, Mello lab, Updike lab, and Kennedy lab for sharing strains and reagents., European Project: 679243,H2020,ERC-2015-STG,RNAEPIGEN(2016), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Collège Doctoral

Subjects
Science, Small RNAs, chemical and pharmacologic phenomena, RNA-Dependent RNA Polymerase, RNA decay, Ribosome, Catalysis, Article, Cytosol, Oogonia, Protein Biosynthesis, RNAi, Argonaute Proteins, Mutation, Animals, RNA Interference, RNA, Messenger, RNA, Small Interfering, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Codon Usage, Ribosomes, [SDV.BDD]Life Sciences [q-bio]/Development Biology
Abstract

In the Caenorhabditis elegans germline, thousands of mRNAs are concomitantly expressed with antisense 22G-RNAs, which are loaded into the Argonaute CSR-1. Despite their essential functions for animal fertility and embryonic development, how CSR-1 22G-RNAs are produced remains unknown. Here, we show that CSR-1 slicer activity is primarily involved in triggering the synthesis of small RNAs on the coding sequences of germline mRNAs and post-transcriptionally regulates a fraction of targets. CSR-1-cleaved mRNAs prime the RNA-dependent RNA polymerase, EGO-1, to synthesize 22G-RNAs in phase with translating ribosomes, in contrast to other 22G-RNAs mostly synthesized in germ granules. Moreover, codon optimality and efficient translation antagonize CSR-1 slicing and 22G-RNAs biogenesis. We propose that codon usage differences encoded into mRNA sequences might be a conserved strategy in eukaryotes to regulate small RNA biogenesis and Argonaute targeting., 22G-RNAs are single-stranded antisense small RNAs that are expressed in C. elegans germline. Here the authors show that CSR-1 dependent 22G-RNAs are produced in the cytosol on mRNAs actively engaged in translation and that codon usage of an mRNA regulates the biogenesis of CSR-1 dependent 22G-RNAs.

Published
2021

8. The effects of catalysts on the conversion of organic matter and bio-fuel production in the microwave pyrolysis of sludge at different temperatures

Author

Xianghua Zhang, Xiaofei Huang, Rui Ma, Yang Zhou, Xuxin Zhao, Peixin Zhang, Shichang Sun, Lin Fang, Shenzhen Univerisity [Shenzhen], Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), This paper was supported by the China National Natural Science Foundation (50906058), the Natural Science Foundation of SZU (No. 827-000037), and the Shenzhen Science and Technology Planning Project (Grant Nos. JCYJ20150828113927076, JCYJ20130329113322731)., Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Environmental Engineering, Materials science, Hot Temperature, 020209 energy, Bio-fuel, Catalytic microwave pyrolysis, Bioengineering, 02 engineering and technology, Activation energy, 010501 environmental sciences, Fluid catalytic cracking, CaO catalyst, 01 natural sciences, 7. Clean energy, Ferric Compounds, Sludge, Catalysis, [CHIM.GENI]Chemical Sciences/Chemical engineering, 0202 electrical engineering, electronic engineering, information engineering, Organic matter, Microwaves, Waste Management and Disposal, 0105 earth and related environmental sciences, chemistry.chemical_classification, Waste management, Sewage, Renewable Energy, Sustainability and the Environment, [SDE.IE]Environmental Sciences/Environmental Engineering, Temperature, General Medicine, [CHIM.CATA]Chemical Sciences/Catalysis, Cracking, chemistry, Chemical engineering, 13. Climate action, Biofuel, Yield (chemistry), Biofuels, Pyrolysis, Fe(2)O(3) catalyst
Abstract

International audience; Adding catalyst could improve the yields and qualities of bio-gas and bio-oil, and realize the oriented production. Results showed that the catalytic gas-production capacities of CaO were higher than those of Fe2O3, and the bio-gas yield at 800°C reached a maximum of 35.1%. Because the polar cracking active sites of CaO reduced the activation energy of the pyrolysis reaction and resulted in high catalytic cracking efficiencies. In addition, the quality of bio-oil produced by CaO was superior to that by Fe2O3, although the bio-oil yield of CaO was relatively weak. The light bio-fuel oriented catalytic pyrolysis could be realized when adding different catalysts. At 800°C, CaO was 45% higher than Fe2O3 in aspect of H2 production while Fe2O3 was 103% higher than CaO in aspect of CH4 production. Therefore, CaO was more suitable for H2 production and Fe2O3 was more suitable for CH4 production.

Published
2017

9. Tumour heterogeneity: the key advantages of single-cell analysis

Author

Francois Lamoureux, Marta Tellez-Gabriel, Benjamin Ory, Dominique Heymann, Marie-Françoise Heymann, Laboratorio Hematologia Oncologica y de Transplantes [Barcelona, Spain], Institut Investigacions Biomèdiques (IBB) Sant Pau [Barcelona, Spain]-Hospital de la Santa Creu i Sant Pau, Equipe LIGUE Nationale Contre le Cancer 2012, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Oncology and Metabolism [Sheffield, UK], The University of Sheffield [Sheffield, U.K.], European Associated Laboratory [Sheffield, UK] (Sarcoma Research Unit), This paper was written as a part of a research project which received funding from the Seventh Framework Programme ([FP7/2007-2013]) under grant agreement n 264817—BONE-NET. This work was supported by the Bone Cancer Research Trust (UK, research project number 144681)., European Project: 264817,EC:FP7:PEOPLE,FP7-PEOPLE-2010-ITN,BONE-NET(2011), Heymann, Dominique, and European Training Network on Cancer-Induced Bone Diseases - BONE-NET - - EC:FP7:PEOPLE2011-02-01 - 2015-01-31 - 264817 - VALID

Subjects
0301 basic medicine, Tumour heterogeneity, circulating tumour cells, [SDV.CAN]Life Sciences [q-bio]/Cancer, Disease, Review, Biology, Bioinformatics, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, Genetic Heterogeneity, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, Single-cell analysis, [SDV.CAN] Life Sciences [q-bio]/Cancer, single cells, Neoplasms, Gene expression, Biopsy, medicine, Humans, Epigenetics, Physical and Theoretical Chemistry, Neoplasm Metastasis, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, [SDV.MHEP.EM] Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, medicine.diagnostic_test, Organic Chemistry, General Medicine, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Neoplastic Cells, Circulating, Phenotype, 3. Good health, Computer Science Applications, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Cancer cell, Cancer research, Single-Cell Analysis, heterogeneity
Abstract

International audience; Tumour heterogeneity refers to the fact that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. This phenomenon occurs both between tumours (inter-tumour heterogeneity) and within tumours (intra-tumour heterogeneity), and it is caused by genetic and non-genetic factors. The heterogeneity of cancer cells introduces significant challenges in using molecular prognostic markers as well as for classifying patients that might benefit from specific therapies. Thus, research efforts for characterizing heterogeneity would be useful for a better understanding of the causes and progression of disease. It has been suggested that the study of heterogeneity within Circulating Tumour Cells (CTCs) could also reflect the full spectrum of mutations of the disease more accurately than a single biopsy of a primary or metastatic tumour. In the last years many high throughput methodologies have raised for the study of heterogeneity at different levels (i.e.: RNA, DNA, protein, epigenetic events). The aim of the current review is to stress clinical implications of tumour heterogeneity, as well as current available methodologies for their study with a specific attention to those able to assess heterogeneity at the single cell level.

Published
2016