1. Role of specific microRNAs for endothelial function and angiogenesis
- Author
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Wu, Fusheng, Yang, Zeran, and Li, Guohong
- Subjects
- *
NON-coding RNA , *ENDOTHELIUM , *NEOVASCULARIZATION , *CELL proliferation , *CELL migration , *MORPHOGENESIS -- Molecular aspects , *TARGETED drug delivery , *CANCER treatment - Abstract
Abstract: Accumulating evidence indicates that various aspects of angiogenesis, such as proliferation, migration, and morphogenesis of endothelial cells, can be regulated by specific miRNAs in an endothelial-specific manner. As novel molecular targets, miRNAs have a potential value for treatment of angiogenesis-associated diseases such as cancers, inflammation, and vascular diseases. In this article, we review the latest advances in the identification and validation of angiogenesis-regulatory miRNAs and their targets, and discuss their roles and mechanisms in regulating endothelial cell function and angiogenesis. [Copyright &y& Elsevier]
- Published
- 2009
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