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Start Over Author "Raffoux, Colette" Topic cell-mediated cytotoxicity
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1. Characterization of the human peripheral effector cells mediating antibody dependent cellular cytotoxicity against allogenic cells.

Author

Donner, Mireille, Raffoux, Colette, and Streiff, F.

Subjects
*CELL-mediated cytotoxicity, *CELL proliferation, *LEUCOCYTES, *CELL membranes, *LYMPHOCYTES, *NEUTROPHILS, *ELECTROPHORESIS, *CYTOLOGY
Abstract

The effector cell populations in human peripheral blood responsible for antibody-dependent cellular cytotoxicity against allogenic cells coated with HLA polyspecific antibodies were investigated using several separation techniques including preparative electrophoresis. Electrophoresis produced a marked effector cells enrichment in a range of 2-5 fractions which exhibited an intermediary electrophoretic mobility. Monocytic cells do not contribute an effector mechanism but minor subsets of polymorphonuclear cells and nylon wool non-adherent non-phagocytic lymphocytes displayed ADCC. Both effector cell populations were found to exhibit a similar electrical charge of cell surface centered around -1.05 μm · sec-1 V-1 cm. These observations provided a precise biophysical basis for the identification of effector cells in ADCC. [ABSTRACT FROM AUTHOR]

Published
1979

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