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The reaction of the five-membered C,N-palladacycle [(L)PdCl]2, where LH= 1-methyl-5-phenyl- 1H-1,4-benzodiazepin-2(3H)-one, with 1,2-ethanebis(diphenylphosphine), dppe, leads to the formation of the bridged palladacycle. [Pd2L2(μ-dppe)Cl2] 3, which was characterised in solution by 1H and 31P NMR spectroscopy and in the solid state by X-ray crystallography. Complex 3 was tested in vitro against a number of cell lines. For example, it inhibited K562 leukaemia cells with an IC50value of 4.3 μM (1 h exposure) and displayed cathepsin B inhibitory action with an IC50 value of 3 μM. [ABSTRACT FROM AUTHOR]

The reaction of the five-membered C,N-palladacycle [(L)PdCl]2, where LH = 1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one, with 1,2-ethanebis(diphenylphosphine), dppe, leads to the formation of the bridged palladacycle. [Pd2L2(μ-dppe)Cl2] 3, which was characterised in solution by 1H and 31P NMR spectroscopy and in the solid state by X-ray crystallography. Complex 3was tested in vitroagainst a number of cell lines. For example, it inhibited K562 leukaemia cells with an IC50value of 4.3 μM (1 h exposure) and displayed cathepsin B inhibitory action with an IC50value of 3 μM. [ABSTRACT FROM AUTHOR]

The Grignard reagent ArF'MgBr (ArF' = 4-(C6F5)C6F4) reacts withMe2SiCl,Me2SiCl2 andMe3SnCl to give the 4-nonafluorobiphenyl group 14 complexes ArF'Me3Si, (ArF')2Me2Si and ArF'Me3Sn respectively. ArF'Me3Sn undergoes only methyl group exchange when treated with BBr3, yielding ArF'Me2SnBr. The solid state structures of ArF'Me3Sn and ArF'Me2SnBr have been determined and exhibit the expected distorted tetrahedral geometries at tin. The reaction between three equivalents of ArF'MgBr and BF3 was not selective, while one equivalent of ArF'MgBr and (ArF)2BF (ArF = C6F5) reacted cleanly to give (ArF)2ArF'B. Treatment of BCl3 with three equivalents of ArF'Li, prepared at low temperature from the reaction between ArF'Br and n-BuLi, yielded (ArF')3B. The molecular structures of the acetonitrile adducts of (ArF)2ArF'B and (ArF')3B closely resemble that of (ArF)3B.NCMe. During the course of the boron investigations, reaction with adventitious water led to the structural characterization of (ArF')2BOH.OH2 as a hydrogen-bonded dimer. The Grignard reagent reacts selectively with ZnCl2 in diethyl ether giving first [(ArF')Zn(m-Cl)(OEt2)]2 then (ArF')2Zn(OEt2)2, both of which have been characterised by X-ray diffraction. The corresponding reaction with HgCl2 requires the use of tetrahydrofuran as the solvent and yields (ArF')2Hg(THF)2. [ABSTRACT FROM AUTHOR]

A series of aryiboronates has befell synlhesizeil from the reaction of 2-{2-, (3-, or (4-(bramomethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-diaxabarolane 1 {1-3} respectively with a range of N-, S-, and O-nucleophiles, using microwave-medialed chemistry. For the synthesis of N- and S-substituted boronates, a supported base, PS-NMM, was With O-nucleophiles, a mixture of tetrabutylammonium bromide, potassium carbonate, and sodium hydroxide was employed. The resulting aminomethyl, mercaptomethyl, or alkoxy-phenoxymethyl-arylboronates were subjected lo microwave-mediated Suzuki Miyanra cuuphng reactions to afford a range of biaryls in moderate to good yields. The X-ray structures of five boronates were determined. [ABSTRACT FROM AUTHOR]

Changes in the optical properties of an alkynyldigold(I) complex upon reaction with Cu(I) are associated with a complicated structural change to form an unusual Au4Cu2 cluster with metallophilic interactions as well as π-alkyne coordination. [ABSTRACT FROM AUTHOR]