1. Improved visualization of virtual-assisted lung mapping by indocyanine green
- Author
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Masaaki Sato, Akihiro Aoyama, Hiroshi Date, Daisuke Nakajima, Junko Tokuno, Toyofumi F. Chen-Yoshikawa, and Hideki Motoyama
- Subjects
Pulmonary and Respiratory Medicine ,indocyanine green ,genetic structures ,ICG, indocyanine green ,Computed tomography ,Ground-glass opacity ,chemistry.chemical_compound ,Fluorescence endoscopy ,Thoracoscopy ,medicine ,NIR, near-infrared ,VAL-MAP ,Lung ,medicine.diagnostic_test ,business.industry ,Visibility (geometry) ,GGO, ground glass opacity ,eye diseases ,CT, computed tomography ,Visualization ,body regions ,medicine.anatomical_structure ,ICG-VAL-MAP, indocyanine green virtual-assisted ling mapping ,chemistry ,Thoracic: Lung: Evolving Technology ,iVATS ,Surgery ,medicine.symptom ,Nuclear medicine ,business ,Indocyanine green ,VAL-MAP, virtual-assisted lung mapping - Abstract
Objectives Virtual-assisted lung mapping (VAL-MAP) is a bronchoscopic marking method of dye application on the surface of the lungs before resecting nonpalpable nodules. However, in some cases, it can be difficult to identify the markings of VAL-MAP on computed tomography and intraoperative thoracoscopy. We developed and assessed the feasibility of indocyanine green VAL-MAP (ICG-VAL-MAP). Methods A historical control trial was conducted to investigate the effectiveness of ICG-VAL-MAP for marking visualization compared with that of VAL-MAP. In ICG-VAL-MAP, instead of indigo carmine, ICG and computed tomography contrast agents were used for dye marking, and near-infrared fluorescence endoscopy was employed to visualize the ICG markings. The other processes in VAL-MAP were carried out. The marking visibility was assessed in 3 grades of easy, faint, or not identifiable. We compared the visibility of the markings on computed tomography images and during thoracoscopic operations between VAL-MAP (567 markings in 147 cases) and ICG-VAL-MAP (142 markings in 63 cases). Results On the preoperative computed tomography images, ICG-VAL-MAP provided significantly better marking visualization than VAL-MAP (easy/faint/not identifiable = 142/0/0 vs 427/100/30; P, Graphical abstract Comparison of marking visibility between VAL-MAP and ICG-VAL-MAP. ICG-VAL-MAP showed significantly better marking visualization on preoperative CT and during thoracoscopic surgery than VAL-MAP.
- Published
- 2021