1. Planar-Chiral Secondary Ferrocenylphosphanes.
- Author
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Pandey, Souvik, Sárosi, Menyhárt B., Lönnecke, Peter, and Hey‐Hawkins, Evamarie
- Subjects
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FERROCENE derivatives , *PHOSPHINES , *CHIRALITY , *DIASTEREOISOMERS , *BORANE derivatives , *COLUMN chromatography , *NUCLEAR magnetic resonance spectroscopy - Abstract
An efficient way to obtain pure diastereomeric mixtures of C-chiral, P-chiral, planar-chiral ferrocenylphosphanes is demonstrated by ortho-lithiation of enantiomerically pure ( SC)- N, N-dimethyl-1-ferrocenylethylamine (Ugi's amine) and reaction with RPX2 [X = Cl, Br; R = tBu, 2,4,6-Me3C6H2 (Mes)]. Four secondary ferrocenylphosphanes [Fe(C5H5)(1-PHR-2-CHR′NMe2-C5H3)] [R′ = H, R = tBu ( 1); R′ = H, R = Mes ( 2); R′ = CH3, R = tBu ( 3); R′ = CH3, R = Mes ( 4)] were synthesised and characterised. Pure diastereomeric mixtures of 1 and 2, a mixture of the pure major diastereomers of 4, as well as diastereomerically pure 3 were obtained by column chromatography under a nitrogen atmosphere. The formation of amine-borane or phosphane-borane adducts was studied by 11B and 31P NMR spectroscopy. A theoretical study was performed to understand the tendency of 1- 4 toward borane adduct formation. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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