1. Genipin crosslinked quaternary ammonium chitosan hydrogels for wound dressings.
- Author
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Wang L, Ding X, Li J, Li M, Ding P, Guo W, Wu Q, Sun Y, Jiang G, Okoro OV, Mirzaei M, Shavandi A, Fan L, and Nie L
- Subjects
- Animals, Mice, NIH 3T3 Cells, Biocompatible Materials chemistry, Biocompatible Materials pharmacology, Materials Testing, Porosity, Chitosan chemistry, Iridoids chemistry, Hydrogels chemistry, Bandages, Wound Healing drug effects, Anti-Bacterial Agents chemistry, Anti-Bacterial Agents pharmacology, Staphylococcus aureus drug effects, Escherichia coli drug effects, Cross-Linking Reagents chemistry, Quaternary Ammonium Compounds chemistry
- Abstract
Bacterial infection can lead to various complications, such as inflammations on surrounding tissues, which can prolong wound healing and thus represent a significant clinical and public healthcare problem. Herein, a report on the fabrication of a novel genipin/quaternized chitosan (CS) hydrogel for wound dressing is presented. The hydrogel was prepared by mixing quaternized CS and genipin under 35 °C bath. The hydrogels showed porous structure (250-500 μm) and mechanical properties (3000-6000 Pa). In addition, the hydrogels displayed self-healing ability and adhesion performance on different substrates. Genipin crosslinked quaternized CS hydrogels showed antibacterial activities against E. coli and S. aureus . The CCK-8 and fluorescent images confirmed the cytocompatibility of hydrogels by seeding with NIH-3T3 cells. The present study showed that the prepared hydrogel has the potential to be used as wound dressing., (© 2024 IOP Publishing Ltd.)
- Published
- 2024
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