1. Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund's adjuvant.
- Author
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Rong Z, Yang L, Chen Y, Qin Y, Cheng CY, Zhao J, Li LF, Ma X, Wu YM, Liu SB, Liang YN, and Zhao MG
- Subjects
- Mice, Animals, Freund's Adjuvant toxicity, Matrines, Analgesics pharmacology, Analgesics therapeutic use, Anxiety complications, Anxiety drug therapy, Hyperalgesia complications, Hyperalgesia drug therapy, Hyperalgesia chemically induced, Chronic Pain drug therapy
- Abstract
Chronic pain, along with comorbid psychiatric disorders, is a common problem worldwide. A growing number of studies have focused on non-opioid-based medicines, and billions of funds have been put into digging new analgesic mechanisms. Peripheral inflammation is one of the critical causes of chronic pain, and drugs with anti-inflammatory effects usually alleviate pain hypersensitivity. Sophoridine (SRI), one of the most abundant alkaloids in Chinese herbs, has been proved to exert antitumor, antivirus and anti-inflammation effects. Here, we evaluated the analgesic effect of SRI in an inflammatory pain mouse model induced by complete Freund's adjuvant (CFA) injection. SRI treatment significantly decreased pro-inflammatory factors release after LPS stimuli in microglia. Three days of SRI treatment relieved CFA-induced mechanical hypersensitivity and anxiety-like behavior, and recovered abnormal neuroplasticity in the anterior cingulate cortex of mice. Therefore, SRI may be a candidate compound for the treatment of chronic inflammatory pain and may serve as a structural basis for the development of new drugs.
- Published
- 2023
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