1. Prenylated flavins: structures and mechanisms.
- Author
-
Bloor, Samuel, Michurin, Iaroslav, Titchiner, Gabriel R., and Leys, David
- Subjects
- *
FLAVINS , *AROMATIC compounds , *DIMETHYLALLYLTRANSTRANSFERASE , *CARBOXYLATION , *CARBOXYLIC acids , *COFACTORS (Biochemistry) - Abstract
The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter formed by the flavin prenyltransferase UbiX. A detailed picture of the biochemistry of flavin prenylation, oxidative maturation, and covalent catalysis underpinning reversible decarboxylation is emerging. This reveals the prFMN cofactor can undergo a wide range of transformations, complemented by considerable UbiD‐variability. These provide a blueprint for biotechnological applications aimed at producing hydrocarbons or aromatic C–H activation through carboxylation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF