1. Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen.
- Author
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Petronilho F, Michels M, Danielski LG, Goldim MP, Florentino D, Vieira A, Mendonça MG, Tournier M, Piacentini B, Giustina AD, Leffa DD, Pereira GW, Pereira VD, and Rocha JB
- Subjects
- Animals, Azoles pharmacology, Benzene Derivatives pharmacology, Catalase metabolism, Colitis chemically induced, Colitis metabolism, Colon drug effects, Colon metabolism, Disease Models, Animal, Inflammation chemically induced, Inflammation metabolism, Isoindoles, Male, Neutrophils, Organoselenium Compounds pharmacology, Rats, Rats, Wistar, Reactive Oxygen Species metabolism, Superoxide Dismutase metabolism, Azoles therapeutic use, Benzene Derivatives therapeutic use, Colitis drug therapy, Inflammation drug therapy, Organoselenium Compounds therapeutic use, Oxidative Stress drug effects
- Abstract
Objetive: The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats., Methods: The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations., Results: Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model., Conclusions: The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB., (Copyright © 2016 Elsevier GmbH. All rights reserved.)
- Published
- 2016
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