1. Thermo-responsive shell cross-linked PMMA-b-P(NIPAAm-co-NAS) micelles for drug delivery
- Author
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Chang, Cong, Wei, Hua, Wu, De-Qun, Yang, Bin, Chen, Ni, Cheng, Si-Xue, Zhang, Xian-Zheng, and Zhuo, Ren-Xi
- Subjects
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CROSSLINKED polymers , *POLYMETHYLMETHACRYLATE , *MICELLES , *DRUG delivery systems , *BLOCK copolymers , *POLYMERIZATION , *ETHYLENEDIAMINE - Abstract
Abstract: Thermo-responsive amphiphilic poly(methyl methacrylate)-b-poly(N-isopropylacrylamide-co-N-acryloxysuccinimide) (PMMA-b-P(NIPAAm-co-NAS)) block copolymer was synthesized by successive RAFT polymerizations. The uncross-linked micelles were facilely prepared by directly dissolving the block copolymer in an aqueous medium, and the shell cross-linked (SCL) micelles were further fabricated by the addition of ethylenediamine as a di-functional cross-linker into the micellar solution. Optical absorption measurements showed that the LCST of uncross-linked and cross-linked micelles was 31.0°C and 40.8°C, respectively. Transmission electron microscopy (TEM) showed that both uncross-linked and cross-linked micelles exhibited well-defined spherical shape in aqueous phase at room temperature, while the SCL micelles were able to retain the spherical shape with relatively smaller dimension even at 40°C due to the cross-linked structure. In vitro drug release study demonstrated a slower and more sustained drug release behavior from the SCL micelles at high temperature as compared with the release profile of uncross-linked micelles, indicating the great potential of SCL micelles developed herein as novel smart carriers for controlled drug release. [Copyright &y& Elsevier]
- Published
- 2011
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