1. Tankyrase-mediated ADP-ribosylation is a regulator of TNF-induced death.
- Author
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Lin Liu, Sandow, Jarrod J., Pedrioli, Deena M. Leslie, Samson, Andre L., Silke, Natasha, Kratina, Tobias, Ambrose, Rebecca L., Doerflinger, Marcel, Zhaoqing Hu, Morrish, Emma, Diep Chau, Kueh, Andrew J., Fitzibbon, Cheree, Pellegrini, Marc, Pearson, Jaclyn S., Hottiger, Michael O., Webb, Andrew I., Lalaoui, Najoua, and Silke, John
- Subjects
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CELL death , *COVID-19 , *DEATH receptors , *LIFE sciences , *ADP-ribosylation , *SARS-CoV-2 , *GREEN fluorescent protein , *PROTEOMICS - Abstract
The article presents a study which explores about the Tankyrase-mediated ADP-ribosylation as a regulator of Tumor necrosis factor (TNF)-induced death. It mentions that TNF, a key component of the innate immune response and suggests that disruption of ADP-ribosylation during an infection can prime a cell to retaliate with an inflammatory cell death.
- Published
- 2022
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