1. Thrombosis and thrombocytopenia after vaccination against and infection with SARS-CoV-2 in the United Kingdom.
- Author
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Burn E, Li X, Delmestri A, Jones N, Duarte-Salles T, Reyes C, Martinez-Hernandez E, Marti E, Verhamme KMC, Rijnbeek PR, Strauss VY, and Prieto-Alhambra D
- Subjects
- Humans, BNT162 Vaccine, SARS-CoV-2, Vaccination adverse effects, United Kingdom, COVID-19 epidemiology, COVID-19 prevention & control, COVID-19 Vaccines adverse effects, Thrombocytopenia epidemiology, Thrombocytopenia etiology, Thrombosis epidemiology, Thrombosis etiology, Venous Thromboembolism epidemiology, Venous Thromboembolism etiology
- Abstract
Population-based studies can provide important evidence on the safety of COVID-19 vaccines. Using data from the United Kingdom, here we compare observed rates of thrombosis and thrombocytopenia following vaccination against SARS-CoV-2 and infection with SARS-CoV-2 with background (expected) rates in the general population. First and second dose cohorts for ChAdOx1 or BNT162b2 between 8 December 2020 and 2 May 2021 in the United Kingdom were identified. A further cohort consisted of people with no prior COVID-19 vaccination who were infected with SARS-Cov-2 identified by a first positive PCR test between 1 September 2020 and 2 May 2021. The fourth general population cohort for background rates included those people in the database as of 1 January 2017. In total, we included 3,768,517 ChAdOx1 and 1,832,841 BNT162b2 vaccinees, 401,691 people infected with SARS-CoV-2, and 9,414,403 people from the general population. An increased risk of venous thromboembolism was seen after first dose of ChAdOx1 (standardized incidence ratio: 1.12 [95% CI: 1.05 to 1.20]), BNT162b2 (1.12 [1.03 to 1.21]), and positive PCR test (7.27 [6.86 to 7.72]). Rates of cerebral venous sinus thrombosis were higher than otherwise expected after first dose of ChAdOx1 (4.14 [2.54 to 6.76]) and a SARS-CoV-2 PCR positive test (3.74 [1.56 to 8.98]). Rates of arterial thromboembolism after vaccination were no higher than expected but were increased after a SARS-CoV-2 PCR positive test (1.39 [1.21 to 1.61]). Rates of venous thromboembolism with thrombocytopenia were higher than expected after a SARS-CoV-2 PCR positive test (5.76 [3.19 to 10.40])., (© 2022. The Author(s).)
- Published
- 2022
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