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Start Over Author "Toğay VA" Topic diabetes mellitus, experimental

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1. DNA damage in rats with streptozotocin-induced diabetes; protective effect of silibinin.

Author

Toğay VA, Sevimli TS, Sevimli M, Çelik DA, and Özçelik N

Subjects
Animals, Body Weight, Case-Control Studies, Comet Assay, Diabetes Mellitus, Experimental genetics, Male, Rats, Silybin pharmacology, DNA Damage drug effects, Diabetes Mellitus, Experimental drug therapy, Silybin administration & dosage
Abstract

Silibinin, the active component of Silybum marianum (L.), is a powerful antioxidant. Male rats with streptozotocin-induced diabetes were treated with silibinin. DNA damage was demonstrated by the comet assay in the control, diabetic, and treatment groups. DNA damage was increased in diabetic rats and decreased by silibinin treatment., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2018
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