1. Intrasession and Intersession Repeatability of Diffusion Tensor Imaging in Healthy Human Liver.
- Author
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Wong OL, Leung TWT, Lo GG, Yuan J, Li WW, and Noseworthy MD
- Subjects
- Adult, Female, Humans, Male, Observer Variation, Reference Values, Reproducibility of Results, Signal-To-Noise Ratio, Diffusion Tensor Imaging methods, Image Processing, Computer-Assisted methods, Liver anatomy & histology
- Abstract
Objective: The aim of this study was to evaluate the effect of signal to noise ratio (SNR) and number of gradient directions (NGD) on intra- and intersession repeatability of liver diffusion tensor imaging (DTI) metrics., Methods: At each of 3 liver DTI scan sessions, liver diffusion was assessed in 5 healthy volunteers using a 6-direction DTI scan performed 9 separate times (ie, number of signal averages [NSA]). In addition, 4 combinations of NSA and NGD were acquired (NSA/NGD = 1/30, 3/10, 3/12, and 5/6) to determine the combined effect to DTI metrics, which was based on intersubject variability and intrasession (Vintra) and intersession (Vinter) repeatability., Results: Intersubject variability was less than 20%, whereas Vintra and Vinter repeatability were less than 5% and less than 10%, respectfully. Vinter was not affected by the NGD used. Decreases in Vinter(FA), Vinter(λ1), Vinter(RD), and Vinter(MD) were observed with increasing NSA, and hence SNR., Conclusion: Increased SNR may improve intrasession and intersession repeatability of liver DTI metrics. Scan repeatability was not influenced by NGD.
- Published
- 2017
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