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Your search keyword '"Heparin, Low-Molecular-Weight chemical synthesis"' showing total 2 results
Start Over Descriptor "Heparin, Low-Molecular-Weight chemical synthesis" Topic disaccharides
2 results on '"Heparin, Low-Molecular-Weight chemical synthesis"'

1. A latent reactive handle for functionalising heparin-like and LMWH deca- and dodecasaccharides.

Author

Miller GJ, Broberg KR, Rudd C, Helliwell MR, Jayson GC, and Gardiner JM

Subjects
Alkylation, Anticoagulants chemical synthesis, Crystallography, X-Ray, Disaccharides chemical synthesis, Glucosamine chemical synthesis, Glycosaminoglycans chemical synthesis, Heparin chemical synthesis, Heparin, Low-Molecular-Weight chemical synthesis, Models, Molecular, Oligosaccharides chemical synthesis, Anticoagulants chemistry, Disaccharides chemistry, Glucosamine analogs & derivatives, Glycosaminoglycans chemistry, Heparin analogs & derivatives, Heparin, Low-Molecular-Weight analogs & derivatives, Oligosaccharides chemistry
Abstract

d-Glucosamine derivatives bearing latent O4 functionality provide modified H/HS-type disaccharide donors for a final stage capping approach enabling introduction of conjugation-suitable, non-reducing terminal functionality to biologically important glycosaminoglycan oligosaccharides. Application to the synthesis of the first O4-terminus modified synthetic LMWH decasaccharide and an HS-like dodecasaccharide is reported.

Published
2015
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2. Preparation and application of a 'clickable' acceptor for enzymatic synthesis of heparin oligosaccharides.

Author

Cai C, Edgar K, Liu J, and Linhardt RJ

Subjects
Carbohydrate Sequence, Chemistry Techniques, Synthetic, Disaccharides chemistry, Escherichia coli Proteins chemistry, Escherichia coli Proteins metabolism, Glycosylation, Glycosyltransferases chemistry, Glycosyltransferases metabolism, Heparin chemical synthesis, Hydrogenation, Hydroxylamine chemistry, Molecular Sequence Data, Molecular Weight, N-Acetylglucosaminyltransferases chemistry, N-Acetylglucosaminyltransferases metabolism, Pasteurella multocida enzymology, Disaccharides chemical synthesis, Heparin chemistry, Heparin, Low-Molecular-Weight chemical synthesis
Abstract

A 'clickable' disaccharide was prepared by treating the aldehyde precursor with hydroxylamine, followed by the catalytic hydrogenation and diazotransfer reaction. This disaccharide was successfully applied to the elongation of the backbone construction of ultralow molecular weight (ULMW) heparins using two bacterial glycosyl transferases, N-acetyl glucosaminyl transferase from Escherichia coli K5 (KfiA) and heparosan synthase-2 (pmHS2) from Pasteurella multocida., (Copyright © 2013 Elsevier Ltd. All rights reserved.)

Published
2013
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