1. Euphzycopins A - D, macrocyclic diterpenoids with potential anti-inflammatory activity from Euphorbia Helioscopia.
- Author
-
Qiu X, Zhang Y, Xu YJ, Liang ZD, Dai XC, Xiao WL, Zhang XJ, and Li XL
- Subjects
- Molecular Structure, Anti-Inflammatory Agents pharmacology, Euphorbia, Diterpenes pharmacology
- Abstract
Four new diterpenoids (1-4) and four known diterpenoids (5-8) were purified from the whole plant of Euphorbia helioscopia L. Compounds 1 and 2 were jathophanes diterpenoids with a 5/12 polycyclic systems, compound 3 was rhamofolane diterpenoid with a 5/10 bicyclic skeleton and compound 4 was a rare class of euphorbia diterpenes featuring an unusual 5/10 fused ring system. Anti-inflammatory activity tests were conducted on the separated compounds, indicating that compound 4 had significant inhibitory effect on NLRP3 inflammasome with an IC
50 value of 7.75 μM. Further, the inhibitory effect of 4 was determined using immunofluorescence assays., Competing Interests: Declaration of competing interest The authors declare no conflict of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)- Published
- 2024
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