1. DNA interactions of cobalt(III) mixed-polypyridyl complexes containing asymmetric ligands.
- Author
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Wang XL, Chao H, Li H, Hong XL, Liu YJ, Tan LF, and Ji LN
- Subjects
- Acenaphthenes chemical synthesis, Animals, Cattle, Ligands, Organometallic Compounds chemical synthesis, Phenanthrolines chemical synthesis, Photochemistry, Pyridines chemical synthesis, Triazines chemical synthesis, Acenaphthenes chemistry, Cobalt chemistry, DNA chemistry, Organometallic Compounds chemistry, Phenanthrolines chemistry, Plasmids chemistry, Pyridines chemistry, Triazines chemistry
- Abstract
Three novel asymmetric ligands, 3-(pyridine-2-yl)-5,6-diphenyl-as-triazine (pdtb), 3-(pyridine-2-yl)-as-triazino[5,6-f]acenaphthylene (pdta) and 3-(pyridine-2-yl)-as-triazino[5,6-f]phenanthroline (pdtp) and their cobalt(III) complexes have been synthesized and characterized. Binding of the three complexes with calf thymus DNA (CT-DNA) has been investigated by spectroscopic methods, viscosity, cyclic voltammetry, and electrophoresis measurements. The experimental results indicate that the size and shape of the intercalated ligand have a marked effect on the binding affinity of complexes to CT-DNA. Complexes 2 and 3 have also been found to promote cleavage of plasmid pBR322 DNA from the supercoiled form I to the open circular form II upon irradiation.
- Published
- 2004
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