1. A comprehensive and perspective view of oncoprotein SET in cancer
- Author
-
Hanmei Xu, Buuvee Bayarkhangai, Na Zhao, Gu Yaru, Liting Yu, Changying Guo, and Suzan Noureldin
- Subjects
0301 basic medicine ,Cancer Research ,DNA repair ,Cancer therapy ,Reviews ,Computational biology ,Review ,Biology ,Metastasis ,03 medical and health sciences ,Transcription (biology) ,medicine ,Radiology, Nuclear Medicine and imaging ,RC254-282 ,Cancer Biology ,function ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cell migration ,regulation ,SET Protein ,Cell cycle ,medicine.disease ,030104 developmental biology ,Oncology ,Apoptosis ,cancer therapy ,oncoprotein SET - Abstract
SET is a multifunctional oncoprotein which is ubiquitously expressed in all kinds of cells. The SET protein participates in many cellular processes including cell cycle, cell migration, apoptosis, transcription, and DNA repair. Accumulating evidence demonstrates that the expression and activity of SET correlate with cancer occurrence, metastasis, and prognosis. Therefore, the SET protein is regarded as a potential target for cancer therapy and several inhibitors are being developed for clinical use. Herein, we comprehensively review the physiological and pathological functions of SET as well as its structure‐function relationship. Additionally, the regulatory mechanisms of SET at both transcriptional and posttranslational levels are also discussed.
- Published
- 2018