Search

Your search keyword '"Eiji Katayama"' showing total 6 results
Start Over Author "Eiji Katayama" Topic drug discovery
6 results on '"Eiji Katayama"'

1. Reductive pinacol-type rearrangement of chiral α-mesyloxy ketones promoted by organoaluminum compounds

Author

Eiji Katayama, Takashi Matsumoto, Gen-ichi Tsuchihashi, and Keisuke Suzuki

Subjects
chemistry.chemical_compound, Sulfonate, Chemistry, Pinacol, Organic Chemistry, Drug Discovery, Chemical reduction, Organic chemistry, Primary alcohol, Aliphatic compound, Biochemistry
Abstract

Reductive pinacol-type rearrangement of chiral α-mesyloxy ketones was effected by organoaluminums (DIBAL in combination with Et 3 Al or Et 2 AlCl) leading to enantiomerically pure 2-aryl- or 2-alkenyl-1-propanols.

Published
1984

2. Highly stereoselective approach to chiral building block possessing three contiguous asymmetric centers. Preparation of four possible diastereomers of β,β′-dimethyl-bis-homoallylic alcohol derivative

Author

Katsuhiko Tomooka, Eiji Katayama, Gen ichi Tsuchihashi, Takashi Matsumoto, and Keisuke Suzuki

Subjects
chemistry.chemical_classification, Nucleophilic addition, Stereochemistry, Organic Chemistry, Acetal, Diastereomer, Biochemistry, Aldehyde, Crotyl, chemistry.chemical_compound, Nucleophile, chemistry, Drug Discovery, Stereoselectivity, Aliphatic compound
Abstract

All four diastereomere of chiral alcohol 2 with three contiguous chiral centers were stereoselectively prepared via diastereoselective addition of nucleophiles (crotyl metal or H-) to α-methyl-β,γ-unsaturated carbonyl compounds 1 .

Published
1985

3. Asymmetric pinacol-type rearrangement of α-hydroxy methanesulfonates promoted by triethylaluminum — preparation of optically pure α-aryl and α-vinyl ketones

Author

Keisuke Suzuki, Gen-ichi Tsuchihashi, and Eiji Katayama

Subjects
chemistry.chemical_compound, Stereospecificity, chemistry, Pinacol, Aryl, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry, Medicinal chemistry
Abstract

Asymmetric (stereospecific) pinacol-type rearrangement of aryl or vinyl group in α-hydroxy methanesulfonates is promoted by Et3Al in CH2Cl2 at −78°C to afford optically pure α-aryl or α-vinyl ketones.

Published
1983

4. Enantio- and diastereomerically pure threo-homoallylic alcohols via highly stereoselective reduction of α-methyl-β,γ-unsaturated ketones

Author

Keisuke Suzuki, Gen-ichi Tsuchihashi, and Eiji Katayama

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Ketone, chemistry, Organic Chemistry, Drug Discovery, Chemical reduction, Organic chemistry, Alcohol, Stereoselectivity, Aliphatic compound, Selectivity, Biochemistry
Abstract

Reduction of α-methyl-β,γ-unsaturated ketones with L-Selectride proceeded with high threo -selectivity to afford threo -β-methyl homoallylic alcohols of high enantio- and diastereomerical purities.

Published
1984

5. Asymmetric synthesis of optically pure α-methyl-β,γ-unsaturated ketones via triethylaluminum-mediated stereospecific pinacol rearrangement of alkenyl groups

Author

Keisuke Suzuki, Gen-ichi Tsuchihashi, and Eiji Katayama

Subjects
chemistry.chemical_classification, Ketone, Stereospecificity, chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Enantioselective synthesis, Aliphatic compound, Pinacol rearrangement, Biochemistry
Abstract

Optically pure α-methyl-β,γ-unsaturated ketones are synthesized by the Et3Al-mediated pinacol-type rearrangement where alkenyl groups migrate stereospecifically with complete retention of the olefin-geometry.

Published
1984

6. Stereoselective synthesis of C(1)–C(9) and C(11)–C(17)fragments of protomycinolide iv based on asymmetric pinacol-typerearrangement

Author

Keisuke Suzuki, Takashi Matsumoto, Gen ichi Tsuchihashi, Katsuhiko Tomooka, and Eiji Katayama

Subjects
chemistry.chemical_classification, Protomycinolide IV, Stereochemistry, Pinacol, Organic Chemistry, Acetal, Nuclear magnetic resonance spectroscopy, Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, Stereoselectivity, Aliphatic compound, Protecting group, Lactone
Abstract

Two chiral intermediates, C(1)–C(9) and C(11)–C(17) portionsof protomycinolide IV, were synthesized both from (S)-ethyl lactatevia asymmetric pinacol-type rearrangement followed bydiastereoselective reactions on α-methyl-β,γ-unsaturatedcarbonyl compounds.

Published
1985

Catalog

Books, media, physical & digital resources
See catalog results