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1. Benzyne-mediated trichloromethylation of chiral oxazolines.

Author

Huang, Xin, Zhao, Weizhao, Chen, De-Li, Zhan, Yaling, Zeng, Tingting, Jin, Huiquan, and Peng, Bo

Subjects
METHYLATION, ELECTROPHILES, OXAZOLINE
Abstract

A three-component reaction between benzyne, oxazolines and chloroform was developed for the synthesis of trichloromethylated chiral oxazolidines. Benzyne not only serves as an electrophile towards oxazolines but also acts as a base for the deprotonation of chloroform. The dual functions of benzyne enable the trichloromethylation of chiral oxazolines and thus construct chiral N,O-quaternary stereocenters. [ABSTRACT FROM AUTHOR]

Published
2019
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