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Purpose: This study aimed to evaluate the cumulative live birth rate (CLBR) and surplus embryo rate of polycystic ovarian syndrome (PCOS) patients during in vitro fertilization and embryo transfer (IVF-ET) treatment., Methods: In this retrospective cohort study, we analyzed 1142 PCOS patients who underwent first IVF in our institution between January 2011 and December 2014. All patients were categorized into five groups according to the number of oocytes retrieved. Main outcomes include CLBR and surplus embryo rate., Results: A strong correlation was observed between number of oocytes retrieved and CLBR as well as surplus embryo rate in PCOS patients. CLBR was elevated with the increasing number of oocytes and plateaued when oocyte number was up to ten, whereas the surplus embryo rate steadily increased in line with the increase of oocyte number. Patients transferred with frozen embryos showed higher CLBR and LBR during first ET than patients transferred with fresh embryos., Conclusions: For PCOS patients, retrieving more than ten oocytes leads to no significant benefit to CLBR but generates surplus embryos. Thus, moderate ovarian stimulation should be reconsidered during IVF treatment.

Polycystic ovary syndrome (PCOS),a common clinical endocrine disorder, is the main cause of anovulatory infertility in women of childbearing age. Due to the particular endocrine disorders in PCOS patients, it is hard to predict ovarian responses to drugs during controlled ovarian stimulation (COS). So, poor ovarian responses and ovarian hyperstimulation syndrome (OHSS) are incredibly common. The common protocols used in IVF for PCOS patients include long protocol, antagonist protocol, mild stimulation protocol, revised super-long protocol, super-long protocol and in vitro maturation (IVM). Presently, long protocol is most frequently used in most of reproductive centers. At the same time, antagonist protocol and mild stimulation protocol, as new protocols, are gradually favored by many clinicians. Super-long protocol and the revised super-long protocol, as the improved traditional protocols, have also obtained good clinic results. IVM,as a technical innovation, can simplify treatment and reduce the risk of OHSS. During IVF for patients with PCOS,it is the key point for clinicians to choose the optimal and economical treatment, to get high -quality eggs and embryos, and to avoid complications such as OHSS. [ABSTRACT FROM AUTHOR]