1. Soybean polar lipids differently impact adipose tissue inflammation and the endotoxin transporters LBP and sCD14 in flaxseed vs. palm oil-rich diets
- Author
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Manon Lecomte, Emmanuelle Loizon, Carole Vaysse, Pascale Plaisancié, Alain Géloën, Annie Durand, Marie-Caroline Michalski, Leslie Couëdelo, Florent Joffre, Emmanuelle Meugnier, Fabienne Laugerette, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut des Corps Gras (ITERG), ITERG, Université Panthéon-Sorbonne - UFR d'Économie (UP1 UFR02), Université Panthéon-Sorbonne (UP1), ITERG (ITERG), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Institut Multidisciplinaire de Biochimie des Lipides (IMBL), Covalab-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Oméga 21, and Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL)
- Subjects
Male ,0301 basic medicine ,endotoxin ,Panniculitis ,huile de palme ,[SDV]Life Sciences [q-bio] ,Endocrinology, Diabetes and Metabolism ,Clinical Biochemistry ,Lipopolysaccharide Receptors ,tissu adipeux ,Adipose tissue ,White adipose tissue ,endotoxine ,Biochemistry ,Lecithin ,chemistry.chemical_compound ,0302 clinical medicine ,Food science ,ComputingMilieux_MISCELLANEOUS ,2. Zero hunger ,chemistry.chemical_classification ,palm oil ,Membrane Glycoproteins ,Nutrition and Dietetics ,alpha-Linolenic acid ,Fatty Acids ,adipose tissue ,Liver ,lipide polaire ,medicine.symptom ,Lipopolysaccharide binding protein ,food.ingredient ,Dietary lipid ,030209 endocrinology & metabolism ,Inflammation ,Biology ,Diet, High-Fat ,03 medical and health sciences ,food ,medicine ,Animals ,soja ,Molecular Biology ,soya bean ,huile de lin ,Fatty acid ,linseed oil ,Mice, Inbred C57BL ,030104 developmental biology ,chemistry ,Dietary Supplements ,biology.protein ,Soybeans ,Carrier Proteins ,Acute-Phase Proteins - Abstract
Obesity and type 2 diabetes are nutritional pathologies, characterized by a subclinical inflammatory state. Endotoiins are now well recognized as an important factor implicated in the onset and maintain of this inflammatory state during fat digestion in high-fat diet. As a preventive strategy, lipid formulation could be optimized to limit these phenomena, notably regarding fatty acid profile and PL emulsifier content. Little is known about soybean polar lipid (SPL) consumption associated to oils rich in saturated FA vs. anti-inflammatory omega-3 FA such as alpha-linolenic acid on inflammation and metabolic endotoxemia. We then investigated in mice the effect of different synthetic diets enriched with two different oils, palm oil or flaxseed oil and containing or devoid of SPL on adipose tissue inflammation and endotoxin receptors. In both groups containing SPL, adipose tissue (WAT) increased compared with groups devoid of SPL and an induction of MCP-1 and LBP was observed in WAT. However, only the high-fat diet in which flaxseed oil was associated with SPL resulted in both higher WAT inflammation and higher circulating sCD14 in plasma. In conclusion, we have demonstrated that LPS transporters LBP and sCD14 and adipose tissue inflammation can be modulated by SPL in high fat diets differing in oil composition. Notably high-flaxseed oil diet exerts a beneficial metabolic impact, however blunted by PL addition. Our study suggests that nutritional strategies can be envisaged by optimizing dietary lipid sources in manufactured products, including fats/oils and polar lipid emulsifiers, in order to limit the inflammatory impact of palatable foods.
- Published
- 2017