8 results on '"Ishida, Tsugitaka"'
Search Results
2. A case of endoscopic submucosal dissection for neuroendocrine carcinoma of the esophagus with invasion to the muscularis mucosae
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Fukui, Hayato, Dohi, Osamu, Miyazaki, Hajime, Yasuda, Takeshi, Yoshida, Takuma, Ishida, Tsugitaka, Doi, Toshifumi, Hirose, Ryohei, Inoue, Ken, Harusato, Akihito, Yoshida, Naohisa, Uchiyama, Kazuhiko, Ishikawa, Takeshi, Takagi, Tomohisa, Konishi, Hideyuki, Morinaga, Yukiko, and Itoh, Yoshito
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- 2022
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3. Blue laser imaging identifies endoscopic findings corresponding to metachronous esophageal squamous cell carcinoma
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Azuma, Yuka, Dohi, Osamu, Naito, Yuji, Yasuda, Takeshi, Yoshida, Takuma, Ishida, Tsugitaka, Kitae, Hiroaki, Matsumura, Shinya, Doi, Toshihumi, Hirose, Ryohei, Inoue, Ken, Yoshida, Naohisa, Kamada, Kazuhiro, Uchiyama, Kazuhiko, Takagi, Tomohisa, Ishikawa, Takeshi, Konishi, Hideyuki, Nishimura, Ayako, Kishimoto, Mitsuo, and Itoh, Yoshito
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- 2022
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4. Clinical Outcomes of Vonoprazan-Treated Patients after Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Multicenter Observation Study.
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Ishida, Tsugitaka, Dohi, Osamu, Yamada, Shinya, Yasuda, Takeshi, Yamada, Nobuhisa, Tomie, Akira, Tsuji, Toshifumi, Horii, Yusuke, Majima, Atsushi, Horie, Ryusuke, Fukui, Akifumi, Zen, Keika, Tomatsuri, Naoya, Yagi, Nobuaki, Naito, Yuji, and Itoh, Yoshito
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PROPENSITY score matching , *TREATMENT effectiveness , *PROTON pump inhibitors , *TUMORS , *DISSECTION , *GASTRIC bypass - Abstract
Background: Vonoprazan (VPZ) has the potential to prevent delayed bleeding and promote ulcer healing after endoscopic submucosal dissection (ESD) similar to proton pump inhibitors (PPIs). Objective: We aimed to evaluate the outcomes of VPZ-treated patients after ESD and compared the efficacy and feasibility in preventing a delayed bleeding and in healing an artificial ulcer after ESD between the VPZ and PPI therapies. Methods: This was a prospective, observation study in 11 Japanese medical institutions. We enrolled and evaluated 223 patients who underwent gastric ESD followed by VPZ treatment (VPZ group). We selected 385 patients who underwent gastric ESD followed by PPI treatment as historical controls (PPI group) to compare the outcomes between the VPZ and PPI groups using a propensity score matching analysis. Results: Among the 223 patients treated with VPZ, 173 were men and 50 were women with a median age of 72 years and with a median tumor size of 12.0 mm. Rates of en bloc resection and complete resection were 99.1 and 94.2%, respectively. Lymphovascular invasion was found in 6 (6.3%) cases. Intraoperative perforation and delayed bleeding occurred in 3 (1.3%) and 10 patients (4.5%), respectively. Scarring of artificial post-ESD ulcer was found in 153 patients (68.6%) at 6 weeks after ESD. The 205 pairs of propensity score-matched patients were comparable between the VPZ and PPI groups. The rate of delayed bleeding in the VPZ and PPI groups was 3.9 and 4.4%, respectively (difference, 0.5 percentage points; 95% confidence interval, −3.7 to 2.8%; non-inferiority, p = 0.01). Therefore, VPZ therapy demonstrated non-inferiority against PPI therapy in reducing the rate of delayed bleeding. The scar-stage ulcer at 6 weeks in the VPZ group and 8 weeks in the PPI group was 68.3 and 74.6%, respectively (p = 0.19). Conclusions: VPZ therapy showed an efficacy and feasibility in preventing a delayed bleeding after ESD similar to the PPI therapy. VPZ for 6 weeks and PPI for 8 weeks were similarly effective for an artificial ulcer healing after ESD. [ABSTRACT FROM AUTHOR]
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- 2021
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5. Effects of Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment on Postoperative Bleeding after Endoscopic Submucosal Dissection for Early Gastric Cancer: A Propensity Score-Matching Analysis.
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Terasaki, Kei, Dohi, Osamu, Naito, Yuji, Azuma, Yuka, Ishida, Tsugitaka, Kitae, Hiroaki, Matsumura, Shinya, Ogita, Kazuyuki, Takayama, Shun, Mizuno, Naoki, Nakano, Takahiro, Iwai, Naoto, Ueda, Tomohiro, Hirose, Ryohei, Inoue, Ken, Yoshida, Naohisa, Kamada, Kazuhiro, Uchiyama, Kazuhiko, Ishikawa, Takeshi, and Takagi, Tomohisa
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INTERNATIONAL normalized ratio ,STOMACH cancer ,ENDOSCOPIC hemostasis ,PLATELET aggregation inhibitors ,ANTICOAGULANTS ,FIBRINOLYTIC agents ,PREOPERATIVE risk factors - Abstract
Background: Management of antithrombotic agents during endoscopic treatment changed after the publishing of -Japan Gastroenterological Endoscopy Society guidelines for gastroenterological endoscopy in antithrombotic drug users (GL-2012). Objectives: We aimed to evaluate the effect of implementing antithrombotic agent management guidelines (GL-2012) on postoperative bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) and on the prevention of thromboembolic events. Methods: A total of 1,264 patients who underwent ESD for EGC at Kyoto Prefectural University Hospital between June 2002 and March 2017 were enrolled and divided into 2 groups: 621 patients before the publication of GL-2012 (Pre-GL group) and 643 patients after (Post-GL group). Relationships between postoperative bleeding and various clinicopathological factors in each group were investigated through propensity score-matching analysis. Results: In the Pre-GL group, antihypertensive agent use (p < 0.01) and upper third of the stomach (p < 0.01) were significantly related to postoperative bleeding in univariate analysis. Antihypertensive agent use (OR 4.6, 95% CI 1.6–12.8) and upper third of the stomach (OR 4.9, 95% CI 1.8–13.4) were significantly related to postoperative bleeding in multivariate analysis. In the Post-GL group, antihypertensive agent use (p < 0.01), dual antiplatelet agents use (p < 0.01), anticoagulant agents use (p < 0.01), and heparin replacement therapy (p < 0.01) were significantly related to postoperative bleeding in univariate analysis. Antihypertensive agent use (OR 3.4, 95% CI 1.1–9.6), dual antiplatelet agents (OR 12.3, 95% CI 2.4–63.0), and heparin replacement therapy (OR 10.2, 95% CI 2.5–41.5) were significantly related to postoperative bleeding in multivariate analysis. Conclusions: The adherence to GL-2012 might reduce risk of thromboembolic events. On the other hand, dual antiplatelet agents therapy and heparin replacement therapy were the new independent risk factors for ESD postoperative bleeding in EGC after GL-2012. Especially as for heparin replacement therapy, uninterrupted warfarin or a temporary short interruption of direct oral anticoagulants without heparin replacement therapy might be recommended rather than heparin replacement therapy. [ABSTRACT FROM AUTHOR]
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- 2021
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6. Efficacy and safety of endoscopic submucosal dissection using a scissors‐type knife with prophylactic over‐the‐scope clip closure for superficial non‐ampullary duodenal epithelial tumors.
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Dohi, Osamu, Yoshida, Naohisa, Naito, Yuji, Yoshida, Takuma, Ishida, Tsugitaka, Azuma, Yuka, Kitae, Hiroaki, Matsumura, Shinya, Takayama, Shun, Ogita, Kazuyuki, Mizuno, Naoki, Nakano, Takahiro, Majima, Atsushi, Hirose, Ryohei, Inoue, Ken, Kamada, Kazuhiro, Uchiyama, Kazuhiko, Takagi, Tomohisa, Ishikawa, Takeshi, and Konishi, Hideyuki
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DUODENAL tumors ,EPITHELIAL tumors ,KNIVES ,DISSECTION ,HOSPITAL closures ,SURGICAL gloves - Abstract
Background and study aim: This study aimed to assess the safety and feasibility of endoscopic submucosal dissection (ESD) using a scissors‐type knife with prophylactic closure using over‐the‐scope clip (OTSC) for superficial non‐ampullary duodenal epithelial tumors (SNADETs). Patients and methods: Consecutive patients who underwent ESD for SNADETs >10 mm between January 2009 and July 2019 were retrospectively enrolled. We performed ESD using either a needle‐type knife (Flush Knife‐ESD) or a scissors‐type knife (Clutch Cutter‐ESD). Mucosal defects were prophylactically closed using three methods: conventional clip, laparoscopic closure, or OTSC. Results: A total of 84 lesions were resected using the Flush Knife‐ESD and the Clutch Cutter‐ESD (37 and 47 patients, respectively), and conventional clip, laparoscopic closure, and OTSC for mucosal defect closure after ESD were applied in 13, 13, and 56 lesions, respectively. The R0 resection rate was significantly higher in the Clutch Cutter‐ESD than that in the Flush Knife‐ESD (97.9% vs 83.8%, respectively, P = 0.040). The intraoperative perforation rate was significantly lower in the Clutch Cutter‐ESD than in the Flush Knife‐ESD (0% vs 13.5%, respectively, P = 0.014). Complete closure rates of conventional clip, laparoscopic closure, and OTSC were 76.9%, 92.3%, and 98.2%, respectively (P = 0.021); and delayed perforation rates were 15.4%, 7.7%, and 1.8%, respectively (P = 0.092). Conclusions: Endoscopic submucosal dissection using a scissors‐type knife with prophylactic OTSC closure is safe and feasible for the low‐invasive treatment of SNADETs. [ABSTRACT FROM AUTHOR]
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- 2020
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7. Efficacy of scissor‐type knives for endoscopic mucosal dissection of superficial gastrointestinal neoplasms.
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Yoshida, Naohisa, Dohi, Osamu, Inoue, Ken, Yasuda, Ritsu, Ishida, Tsugitaka, Hirose, Ryohei, Naito, Yuji, Ogiso, Kiyoshi, Murakami, Takaaki, Morinaga, Yukiko, Kishimoto, Mitsuo, Inada, Yutaka, Itoh, Yoshito, and Gotoda, Takuji
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KNIVES ,GASTROINTESTINAL tumors ,DENTAL floss ,TUMORS ,DISSECTION - Abstract
Endoscopic submucosal dissection (ESD) for superficial gastrointestinal neoplasms has become widespread. However, certain aspects of the procedure remain difficult to manage, such as intraoperative bleeding and perforation. There are two kinds of scissor‐type knife: the Clutch Cutter (Fujifilm Co., Tokyo, Japan) and the SB knife (Sumitomo Bakelite Co., Tokyo, Japan). These knives have different features from other types of ESD knives and enable the performance of all ESD procedures, including mucosal incision, submucosal dissection, and hemostasis. The standard approach with scissor‐type knives involves first grabbing the tissue and then incising or dissecting it. Theoretically, perforation as a result of unintentional movement should never happen with scissor‐type knives compared to needle‐ or blade‐type knives, which may induce perforation through unintentional movement. Moreover, the rates of severe bleeding and self‐completion of ESD with scissor‐type knives by non‐experts were reported to be significantly better than for other knives. Thus, scissor‐type knives can resolve these problems and help to further standardize ESD globally. In this review, we summarize reports on the efficacy of such scissor‐type knives for ESD of gastrointestinal tumors. We also present the pocket‐creation method and the application of traction devices, such as dental floss and S‐O clips (Zeon Medical Co., Tokyo, Japan) for improving the performance of ESD with a Clutch Cutter. [ABSTRACT FROM AUTHOR]
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- 2020
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8. Efficacy of Clutch Cutter for Standardizing Endoscopic Submucosal Dissection for Early Gastric Cancer: A Propensity Score-Matched Analysis.
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Dohi, Osamu, Yoshida, Naohisa, Terasaki, Kei, Azuma, Yuka, Ishida, Tsugitaka, Kitae, Hiroaki, Matsumura, Shinya, Ogita, Kazuyuki, Takayama, Shun, Mizuno, Naoki, Nakano, Takahiro, Hirose, Ryohei, Inoue, Ken, Kamada, Kazuhiro, Uchiyama, Kazuhiko, Ishikawa, Takeshi, Takagi, Tomohisa, Kishimoto, Mitsuo, Konishi, Hideyuki, and Naito, Yuji
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STOMACH cancer ,TREATMENT effectiveness ,FORCEPS ,RETROSPECTIVE studies ,HEMORRHAGE - Abstract
Background/Aims: The purpose of this study was to evaluate the safety and efficacy of gastric endoscopic submucosal dissection (ESD) using the Clutch Cutter (CC), a scissor-type knife, compared with those of procedures using conventional devices. Methods: This single-center retrospective study evaluated 237 patients with early gastric cancer: 83 who underwent ESD using the CC group and 154 who underwent ESD using the insulated-tip knife 2 (IT2 group). Clinicopathological features and technical outcomes were compared between the 2 groups using a propensity score-matched analysis. Results: In 61 pairs of matched patients, there was no significant difference in R0 resection, perforation, or postoperative bleeding between the CC and IT2 groups. Comparisons between the 2 groups showed similar treatment outcomes for an expert endoscopist. Nevertheless, there were significant differences between the 2 groups for nonexperts in terms of self-completion (61.7 and 24.5%, respectively, p < 0.001), mean procedure times (45 and 61 min, respectively, p = 0.002), and mean numbers of intraoperative bleeding points and bleeding points requiring hemostatic forceps (3 and 0 vs. 8 and 3, respectively, p < 0.001). Conclusion: Better self-completion rates and shorter procedure times were noted for gastric ESD using the CC by nonexperts than for that using IT2, probably due to hemostatic efficacy. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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