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Your search keyword '"Mohammad Mahdi Naghizadeh"' showing total 3 results
Start Over Author "Mohammad Mahdi Naghizadeh" Topic estradiol
3 results on '"Mohammad Mahdi Naghizadeh"'

1. Locus coeruleus lesions and PCOS: role of the central and peripheral sympathetic nervous system in the ovarian function of rat

Author

Farideh Zafari Zangeneh, Alireza Abdollahi, Fatemeh Aminee, and Mohammad Mahdi Naghizadeh

Subjects
Polycystic ovary syndrome, Locus coeruleus, Gonadotropines, Estradiol, Ovary morphology, Rat, Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder associated with ovulatory dysfunction”. “Autonomic and central nervous systems play important roles in the regulation of ovarian physiology”. The noradrenergic nucleus locus coeruleus (LC) plays a central role in the regulation of the sympathetic nervous system and synaptically connected to the preganglionic cell bodies of the ovarian sympathetic pathway and its activation is essential to trigger spontaneous or induced LH surges. This study evaluates sympathetic outflow in central and peripheral pathways in PCO rats. Objective: Our objectives in this study were (1) to estimate LC activity in rats with estradiol valerate (EV)-induced PCO; (2) to antagonized alpha2a adrenoceptor in systemic conditions with yohimbine. Materials and Methods: Forty two rats were divided into two groups: 1) LC and yohimbine and 2) control. Every group subdivided in two groups: eighteen rats were treated with estradiol valerate for induction of follicular cysts and the remainders were sesame oil groups. Results: Estradiol concentration was significantly augmented by the LC lesion in PCO rats (p

Published
2012

2. The effect of cold stress on polycystic ovary syndrome in rat: before and during modeling

Author

Farideh Zafari Zangeneh, Mohammad Mahdi Naghizadeh, Alireza Abdollahi, and Pouyan Tavassoli

Subjects
Sympathetic nervous system, medicine.medical_specialty, Time Factors, Internal medicine, medicine, Animals, Chronic stress, Rats, Wistar, Cold stress, Estradiol, business.industry, Polycystic ovary syndrome (PCOS), Ovary, Estradiol valerate, Obstetrics and Gynecology, General Medicine, Luteinizing Hormone, medicine.disease, Polycystic ovary, eye diseases, Rats, Cold Temperature, Disease Models, Animal, medicine.anatomical_structure, Endocrinology, cardiovascular system, Female, Follicle Stimulating Hormone, business, human activities, Polycystic Ovary Syndrome, circulatory and respiratory physiology, medicine.drug
Abstract

The aim of this study was the evaluation effects of a chronic intermittent cold stress regimen before and during PCO modeling in rat. Forty-eight rats were treated with estradiol valerate for 60 days in order to induction of follicular cysts (PCO modeling). Rats were divided into two groups: (1) before (cold stress 3 weeks then PCO modeling) and (2) during modeling (cold stress and PCO simultaneous). The biochemical and histological findings show that in simultaneous cold stress and estradiol injection group PCOS modeling has been done successfully and in the other group cold stress prevents induction of PCO in rats. The present study is the first survey that reports 3-week chronic stress before estradiol injection prevents the induction of PCO in rats.

Published
2010
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3. The role of opioid system and its interaction with sympathetic nervous system in the processing of polycystic ovary syndrome modeling in rat

Author

Aminee Fatemeh, Sh. Ejtemaeimehr, Farideh Zafari Zangeneh, A. Mohammadi, and Mohammad Mahdi Naghizadeh

Subjects
medicine.medical_specialty, Sympathetic nervous system, Sympathetic Nervous System, Narcotic Antagonists, Naltrexone, Clonidine, Internal medicine, medicine, Adrenergic alpha-2 Receptor Agonists, Animals, Adrenergic agonist, Rats, Wistar, Gonadal Steroid Hormones, Estradiol, business.industry, Ovary, Adrenergic alpha-2 Receptor Antagonists, Obstetrics and Gynecology, Yohimbine, General Medicine, Polycystic ovary, Rats, Disease Models, Animal, Endocrinology, medicine.anatomical_structure, Opioid, Receptors, Opioid, Female, business, medicine.drug, Polycystic Ovary Syndrome
Abstract

This study was conducted to evaluate the effect of interaction of sympathetic and opioid systems in the processing of polycystic ovary syndrome modeling in rat. Ninety adult female rats (7–8 weeks of age) were treated with EV for 60 days for induction of follicular cysts (PCO modeling). Clonidine and yohimbine were used for sympathic agonist and antagonist and nalterxone was used for opioid system inhibition. Interactions of two systems were studied. Our results indicate that both systems and interaction of two systems are effective in processing modeling of PCOS in rat. Interaction of two system drugs decreased estradiol (P

Published
2010

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