20 results on '"Yeh, Steven"'
Search Results
2. Clinical and Perioperative Management in Ophthalmology During the COVID-19 Pandemic.
- Author
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Leung EH, Flynn HW Jr, Gayer S, Yeh S, Berrocal AM, Olmos de Koo LC, Chen RWS, Albini TA, and Foroozan R
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- COVID-19, Comorbidity, Eye Diseases epidemiology, Humans, SARS-CoV-2, Betacoronavirus, Coronavirus Infections epidemiology, Disease Transmission, Infectious prevention & control, Eye Diseases surgery, Ophthalmology methods, Pandemics, Perioperative Care methods, Pneumonia, Viral epidemiology
- Published
- 2020
- Full Text
- View/download PDF
3. Emerging Drug Delivery Systems for Posterior Segment Disease.
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Levine D, Albini TA, Fine HF, and Yeh S
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- Humans, Posterior Eye Segment, Drug Delivery Systems statistics & numerical data, Eye Diseases drug therapy
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- 2020
- Full Text
- View/download PDF
4. Early clinical sequelae of Ebola virus disease in Sierra Leone: a cross-sectional study.
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Mattia JG, Vandy MJ, Chang JC, Platt DE, Dierberg K, Bausch DG, Brooks T, Conteh S, Crozier I, Fowler RA, Kamara AP, Kang C, Mahadevan S, Mansaray Y, Marcell L, McKay G, O'Dempsey T, Parris V, Pinto R, Rangel A, Salam AP, Shantha J, Wolfman V, Yeh S, Chan AK, and Mishra S
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- Adolescent, Adult, Child, Child, Preschool, Cohort Studies, Cross-Sectional Studies, Female, Hemorrhagic Fever, Ebola epidemiology, Humans, Logistic Models, Male, Odds Ratio, Risk Factors, Sierra Leone epidemiology, Viral Load, Young Adult, Arthralgia etiology, Eye Diseases etiology, Hearing Loss etiology, Hemorrhagic Fever, Ebola complications
- Abstract
Background: Limited data are available on the prevalence and predictors of clinical sequelae in survivors of Ebola virus disease (EVD). The EVD Survivor Clinic in Port Loko, Sierra Leone, has provided clinical care for 603 of 661 survivors living in the district. We did a cross-sectional study to describe the prevalence, nature, and predictors of three key EVD sequelae (ocular, auditory, and articular) in this cohort of EVD survivors., Methods: We reviewed available clinical and laboratory records of consecutive patients assessed in the clinic between March 7, 2015, and April 24, 2015. We used univariate and multiple logistic regression to examine clinical and laboratory features of acute EVD with the following outcomes in convalescence: new ocular symptoms, uveitis, auditory symptoms, and arthralgias., Findings: Among 277 survivors (59% female), median age was 29 years (IQR 20-36) and median time from discharge from an EVD treatment facility to first survivor clinic visit was 121 days (82-151). Clinical sequelae were common, including arthralgias (n=210, 76%), new ocular symptoms (n=167, 60%), uveitis (n=50, 18%), and auditory symptoms (n=67, 24%). Higher Ebola viral load at acute EVD presentation (as shown by lower cycle thresholds on real-time RT-PCR testing) was independently associated with uveitis (adjusted odds ratio [aOR] 3·33, 95% CI 1·87-5·91, for every five-point decrease in cycle threshold) and with new ocular symptoms or ocular diagnoses (aOR 3·04, 95% CI 1·87-4·94)., Interpretation: Clinical sequelae during early EVD convalescence are common and sometimes sight threatening. These findings underscore the need for early clinical follow-up of survivors of EVD and urgent provision of ocular care as part of health systems strengthening in EVD-affected west African countries., Funding: Canadian Institutes of Health Research., (Copyright © 2016 World Health Organization. Published by Elsevier Ltd/Inc/BV. All rights reserved. Published by Elsevier Ltd.. All rights reserved.)
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- 2016
- Full Text
- View/download PDF
5. Quality of life in sarcoidosis: comparing the impact of ocular and non-ocular involvement of the disease.
- Author
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Saligan LN, Levy-Clarke G, Wu T, Faia LJ, Wroblewski K, Yeh S, Nussenblatt RB, and Sen HN
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- Adult, Aged, Cost of Illness, Cross-Sectional Studies, Female, Health Status, Humans, Male, Middle Aged, Prospective Studies, Sickness Impact Profile, Social Class, Surveys and Questionnaires, Vision, Ocular physiology, Young Adult, Eye Diseases psychology, Quality of Life, Sarcoidosis psychology
- Abstract
Purpose: To compare the differences in vision and health-related quality of life (HRQOL) of individuals with ocular and non-ocular sarcoidosis; and to examine the impact of specific demographic and clinical factors on the noted differences., Methods: A cross-sectional study using non-randomized prospective cohort was conducted at the National Eye Institute (protocol number: 06-EI-0239, NCT00379275) from August 31, 2006 until November 15, 2007. Each participant completed vision and HRQOL questionnaires, the Sarcoidosis Health Questionnaire (SHQ) and the National Eye Institute Visual Function Questionnaire (NEI-VFQ), along with a demographic/environmental exposure survey. Clinical data were collected through an ophthalmic exam as part of the research protocol., Results: The study enrolled 75 biopsy-proven and 20 clinically presumed sarcoidosis participants which were divided into two cohorts, ocular (N = 60) and non-ocular groups (N = 35). The ocular group had significantly lower (P < 0.01) total NEI-VFQ scores compared to the non-ocular group. Multiple linear regression analysis showed that participants with ocular sarcoidosis who had an annual household income of < $50,000 (P < 0.01) had significantly lower total SHQ scores while participants with ocular sarcoidosis whose visual acuity was 20/100 or worse had significantly lower total NEI-VFQ scores (P = 0.03)., Conclusions: Ocular involvement impacts both overall and vision-related quality of life among sarcoidosis patients. Lower economic status appears to have a significant impact on the quality of life of sarcoidosis patients. Assessment of visual function and general health status provide pertinent information for individuals with sarcoidosis and should be included in their care to assess burden of their disease on their quality of life.
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- 2010
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6. Posterior segment ophthalmic complications of aplastic anemia.
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Agarwal M, Yeh S, Faia LJ, Bishop RJ, Lai MM, Pantin J, Scheinberg P, Chew EY, and Weichel ED
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- Antilymphocyte Serum therapeutic use, Child, Preschool, Choroid blood supply, Eye Diseases pathology, Eye Diseases physiopathology, Eye Diseases therapy, Follow-Up Studies, Fundus Oculi, Humans, Ischemia etiology, Male, Retinal Neovascularization etiology, Treatment Outcome, Visual Acuity, Vitrectomy methods, Vitreous Hemorrhage etiology, Young Adult, Anemia, Aplastic complications, Eye Diseases etiology, Posterior Eye Segment
- Abstract
Three patients with aplastic anemia were evaluated by the ophthalmology service within 2 months of the aplastic anemia diagnosis for bilateral visual loss. The mean age of diagnosis of aplastic anemia was 14.3 years (range: 5 to 19 years) and the mean follow-up was 25 months (range: 15 to 44 months). All 6 eyes demonstrated choroidal ischemia and vitreous hemorrhage. Pars plana vitrectomy was performed in four eyes of two patients for non-clearing vitreous hemorrhage; one patient was observed. Successful anatomic outcomes were achieved in 3 of 4 eyes that underwent vitrectomy. Initial visual acuity ranged from 20/80 to bare light perception and final visual acuity ranged from 20/20 to no light perception. All patients received immunosuppressive therapy including cyclosporine and anti-thymocyte globulin, and two underwent hematopoietic stem cell transplantation. All patients received perioperative platelet and blood transfusions. Pars plana vitrectomy resulted in functional and anatomic success in the majority of eyes in this series. Coordination of medical and surgical care with the hematology service is advisable to stabilize hematologic parameters prior to undertaking a vitreoretinal procedure., (Copyright 2010, SLACK Incorporated.)
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- 2010
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7. Seeing red: guiding the management of ocular hyperemia.
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Saligan LN and Yeh S
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- Anti-Bacterial Agents therapeutic use, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Causality, Diagnosis, Differential, Documentation, Early Diagnosis, Emergencies nursing, Eye Diseases etiology, Histamine H1 Antagonists therapeutic use, Humans, Hyperemia etiology, Medical History Taking, Nurse Practitioners, Nursing Assessment, Nursing Records, Physical Examination, Referral and Consultation, Therapeutic Irrigation, Eye Diseases diagnosis, Eye Diseases therapy, Hyperemia diagnosis, Hyperemia therapy
- Published
- 2008
8. AI SCREENING SYSTEM INCREASES ADHERENCE: Nebraska Medicine taps technology for use in clinics.
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Hutton, David and Yeh, Steven
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OPHTHALMOLOGY equipment , *HEALTH services accessibility , *PATIENT compliance , *ACADEMIC medical centers , *MEDICAL technology , *OPHTHALMOLOGISTS , *ARTIFICIAL intelligence , *DIABETIC retinopathy , *EYE diseases , *RURAL conditions , *DEEP learning , *ARTIFICIAL neural networks , *COMPUTER-aided diagnosis , *MEDICAL screening , *EARLY diagnosis - Abstract
The article discusses the use of an artificial intelligence (AI) screening tool by Nebraska Medicine to provide better care for its patients with diabetes. Topics discussed include benefits of using the AI screening tool to Nebraska Medicine, the work of cloud-based AI solution in tandem with fundus cameras, and comments from Dr. Stephen Mohring, medical director for patient-centered medical home and population health at Nebraska Medicine.
- Published
- 2024
9. Rhegmatogenous Retinal Detachment in Children: Clinical Factors Predictive of Successful Surgical Repair
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Smith, Jesse M., Ward, Laura T., Townsend, Justin H., Yan, Jiong, Hendrick, Andrew M., Cribbs, Blaine E., Yeh, Steven, Jain, Nieraj, and Hubbard, G. Baker
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Male ,Adolescent ,Infant, Newborn ,Retinal Detachment ,Visual Acuity ,Infant ,Vitreoretinal Surgery ,Retinal Perforations ,eye diseases ,Article ,Retina ,Scleral Buckling ,Treatment Outcome ,Child, Preschool ,Vitrectomy ,Humans ,Female ,Child ,Follow-Up Studies ,Retrospective Studies - Abstract
OBJECTIVE: To describe presenting clinical features and surgical techniques that are associated with successful surgical repair of pediatric rhegmatogenous retinal detachment (RRD). DESIGN: Retrospective interventional case series. SUBJECTS: 212 eyes of 191 patients, aged 0–18 years, undergoing surgical repair for RRD between 2001 and 2015 with a minimum follow up of 3 months. METHODS: Patients were divided into three age groups (0–6 years, 7–12 years, 13–18 years) and comparisons were made using bivariate and multivariable generalized estimating equation models. A mixed means model was used to examine visual acuity in each age group over time. MAIN OUTCOME MEASURES: Complete reattachment of the retina at final follow up. RESULTS: Of a total of 212 eyes, 166 (78%) achieved total reattachment at final follow up. Mean follow up was 36.3 months. RRD associated with Stickler syndrome was more likely to occur in the younger cohorts (odds ratio [OR] 0.45, 95 % confidence interval [CI] 0.22 – 0.91), while RRD associated with blunt trauma was more likely to occur in the oldest cohort (OR 2.3, 95% CI 1.2–4.4). Subtotal RRD was more likely to be successfully repaired than total RRD (OR 3.6, 95% CI 1.5 – 8.4, p = 0.0100), and eyes with previous vitreoretinal surgery were less likely to have successful repair (OR 0.30, 95% CI 0.12 – 0.78, p = 0.0258). There was no significant difference between age groups in the rate of surgical success (p = 0.55). There was a significantly higher success rate with primary scleral buckle (SB) (63%, OR 2.2, 95% CI 1.1–4.5) and combined scleral buckle/vitrectomy (SB/PPV) (68%, OR 2.3 95% CI 1.1–5.1) compared to vitrectomy (PPV) alone (51%). CONCLUSIONS: Most pediatric patients with RRD achieved complete reattachment with surgery. Success was more common in patients with a subtotal RRD at presentation. Previous vitreoretinal surgery was a risk factor for failure. Younger patients were more likely to present with RRD involving the macula but there was no difference between age groups in successful reattachment at final follow up. Primary PPV had a lower rate of success than SB or combined SB/PPV.
- Published
- 2018
10. Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy
- Author
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Cham, Abdourahman, Bansal, Mayank, Banda, Himanshu K, Kwon, Young, Tlucek, Paul S, Bassuk, Alexander G, Tsang, Stephen H, Sobol, Warren M, Folk, James C, Yeh, Steven, and Mahajan, Vinit B
- Subjects
genetic structures ,secondary glaucoma ,calpain-5 ,uveitis ,fluocinolone acetonide ,Clinical Ophthalmology ,sense organs ,ADNIV ,CAPN5 ,eye diseases ,Original Research - Abstract
Abdourahman Cham,1,2 Mayank Bansal,3 Himanshu K Banda,4 Young Kwon,1 Paul S Tlucek,1 Alexander G Bassuk,5 Stephen H Tsang,6,7 Warren M Sobol,8 James C Folk,1 Steven Yeh,4 Vinit B Mahajan1,2 1Department of Ophthalmology and Visual Sciences, 2Omics Laboratory, University of Iowa, Iowa City, IA, USA; 3Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India; 4Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, 5Department of Pediatrics, University of Iowa, Iowa City, IA, 6Barbara and Donald Jonas Laboratory of Stem Cells and Regenerative Medicine and Bernard and Shirlee Brown Glaucoma Laboratory, Department of Pathology and Cell Biology, Institute of Human Nutrition, College of Physicians and Surgeons, Columbia University, 7Edward S Harkness Eye Institute, New York-Presbyterian Hospital, New York, NY, 8Retina Physicians & Surgeons, Inc., Dayton, OH, USA Objective: The objective of this study was to review the treatment outcomes of patients with secondary glaucoma in cases of autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), a hereditary autoimmune uveitis due to mutations in CAPN5. Patients and methods: A retrospective, observational case series was assembled from ADNIV patients with secondary glaucoma. The main outcome measures were intraocular pressure (IOP), visual acuity, use of antiglaucoma medications, ocular surgeries, and adverse outcomes. Perimetry and optic disk optical coherence tomography (OCT) were also analyzed. Results: Nine eyes of five ADNIV patients with secondary glaucoma were reviewed. Each received a fluocinolone acetonide (FA) implant for the management of posterior uveitis. Following implantation, no eyes developed neovascular glaucoma. Five eyes (in patients 1, 2, and 5) required Ahmed glaucoma valve surgery for the management of steroid-responsive glaucoma. Patient 2 also developed angle closure with iris bombe and underwent laser peripheral iridotomy. Patient 4 had both hypotony and elevated IOP that required periodic antiglaucoma medication in the FA-implanted eye. Patient 3 did not develop steroid-response glaucoma in either eye. Optic disk examinations were obscured by fibrosis and better assessed with OCT. Conclusion: ADNIV patients show combined mechanism secondary glaucoma best assessed by OCT of the optic disk. The FA implants have reduced uveitic and neovascular glaucoma. Nevertheless, IOP management remains complex due to steroid-response glaucoma, angle closure glaucoma, and hypotony. Keywords: ADNIV, CAPN5, calpain-5, fluocinolone acetonide, secondary glaucoma, uveitis
- Published
- 2016
11. Development of a screening eye clinic for Ebola virus disease survivors: Lessons learned and rapid implementation at ELWA Hospital in Monrovia, Liberia 2015.
- Author
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Shantha, Jessica G., Hayek, Brent R., Crozier, Ian, Gargu, Catherine, Dolo, Robert, Brown, Jerry, Fankhauser, John, and Yeh, Steven
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NURSE-physician relationships ,EBOLA virus disease - Abstract
Background: In the wake of the West African Ebola virus disease (EVD) outbreak of 2014–2016, thousands of EVD survivors began to manifest a constellation of systemic and ophthalmic sequelae. Besides systemic arthralgias, myalgias, and abdominal pain, patients were developing uveitis, a spectrum of inflammatory eye disease leading to eye pain, redness, and vision loss. To investigate this emerging eye disease, resources and equipment were needed to promptly evaluate this sight-threatening condition, particularly given our identification of Ebola virus in the ocular fluid of an EVD survivor during disease convalescence. Methodology/Principal findings: A collaborative effort involving ophthalmologists, infectious disease specialists, eye care nurses, and physician leadership at Eternal Love Winning Africa (ELWA) Hospital in Liberia led to the development of a unique screening eye clinic for EVD survivors to screen, treat, and refer patients for more definitive care. Medications, resources, and equipment were procured from a variety of sources including discount websites, donations, purchasing with humanitarian discounts, and limited retail to develop a screening eye clinic and rapidly perform detailed ophthalmologic exams. Findings were documented in 96 EVD survivors to inform public health officials and eye care providers of the emerging disease process. Personal protective equipment was tailored to the environment and implications of EBOV persistence within intraocular fluid. Conclusions/Significance: A screening eye clinic was feasible and effective for the rapid screening, care, and referral of EVD survivors with uveitis and retinal disease. Patients were screened promptly for an initial assessment of the disease process, which has informed other efforts within West Africa related to immediate patient care needs and our collective understanding of EVD sequelae. Further attention is needed to understand the pathogensis and treatment of ophthalmic sequelae given recent EVD outbreaks in West Africa and ongoing outbreak within Democratic Republic of Congo. [ABSTRACT FROM AUTHOR]
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- 2019
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12. Ocular Manifestations of Systemic Lupus Erythematosus: A Review of the Literature
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Palejwala, Neal V., Walia, Harpreet S., and Yeh, Steven
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genetic structures ,Article Subject ,eye diseases - Abstract
About one-third of patients suffering from systemic lupus erythematosus have ocular manifestations. The most common manifestation is keratoconjunctivitis sicca. The most vision threatening are retinal vasculitis and optic neuritis/neuropathy. Prompt diagnosis and treatment of eye disease is paramount as they are often associated with high levels of systemic inflammation and end-organ damage. Initial management with high-dose oral or IV corticosteroids is often necessary. Multiple “steroid-sparing” treatment options exist with the most recently studied being biologic agents.
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- 2012
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13. Fundus autofluorescence features in the inflammatory maculopathies.
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Lee, Cecilia S., Lee, Aaron Y., Forooghian, Farzin, Bergstrom, Chris S., Jiong Yan, and Yeh, Steven
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EYE diseases ,BIOFLUORESCENCE ,INFLAMMATION ,MACULA lutea ,OPHTHALMOLOGY - Abstract
Purpose: To describe the fundus autofluorescence (FAF) features of the inflammatory maculopathies and develop a quantification method for FAF analysis. Methods: This is a retrospective, consecutive case series of patients with inflammatory maculopathies from two tertiary centers. The clinical findings, demographics, and FAF imaging characteristics were reviewed. Foveal autofluorescence (AF) was analyzed. Median and standard deviation (SD) of foveal AF intensity were measured. Results: Thirty eyes of 15 patients were evaluated with both qualitative and quantitative FAF analysis. In acute macular neuroretinopathy, the active phase showed foveal hypoautofluorescence, which became hypoautofluorescent with resolution. In acute posterior multifocal placoid pigment epitheliopathy, multiple lesions with hypoautofluorescent centers with hyperautofluorescent borders were observed in active disease and became hypoautofluorescent with disease convalescence. In multifocal choroiditis and punctate inner choroiditis, the active hyperautofluorescent lesions progressed to inactive, hypoautofluorescent scars. Active serpiginous choroiditis showed hyperautofluorescent borders adjacent to a helicoid-shaped, hypoautofluorescent scar. Active unilateral acute idiopathic maculopathy (UAIM) showed a complex pattern of hypo- andhyperautoflourescence in the macula. The median foveal AF was the greatest in acute macular neuroretinopathy and UAIM among the maculopathies, while the greatest SD of foveal AF intensity was observed in UAIM. Conclusion: The active phase of the majority of inflammatory maculopathies was characterized by hyperautofluorescent lesions. Increased SD of foveal AF correlated with a mixture of hypo-and hyperautoflourescence. Median and SD may be useful metrics in foveal AF and quantifiable values that may be assessed over time as a disease process evolves. Improvements in quantification methods of FAF imaging may allow us to objectively evaluate posterior uveitis. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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14. Advances in the diagnosis and immunotherapy for ocular inflammatory disease.
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Yeh, Steven, Faia, Lisa, and Nussenblatt, Robert
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UVEITIS , *IMMUNOTHERAPY , *EYE diseases , *FLUORESCENCE angiography , *OPTICAL coherence tomography , *DIAGNOSIS - Abstract
Significant advances in the diagnosis and therapy for uveitis have been made to improve the quality of care for patients with ocular inflammatory diseases. While traditional ophthalmic examination techniques, fluorescein angiography, and optical coherence tomography continue to play a major role in the evaluation of patients with uveitis, the advent of spectral domain optical coherence tomography and fundus autofluorescence into clinical practice provides additional information about disease processes. Polymerase chain reaction and cytokine diagnostics have also continued to play a greater role in the evaluation of patients with inflammatory diseases. The biologic agents, a group of medications that targets cytokines and other soluble mediators of inflammation, have demonstrated promise in targeted immunotherapy for specific uveitic entities. Their ophthalmic indications have continued to expand, improving the therapeutic armentarium of uveitis specialists. [ABSTRACT FROM AUTHOR]
- Published
- 2008
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15. Cystoid Macular Edema Without Leakage Secondary to Nab-Paclitaxel (Abraxane): Clinical Experience with Intravitreal Bevacizumab.
- Author
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Rahman, Hassan T., Yeh, Steven, and Bergstrom, Chris S.
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BEVACIZUMAB , *EDEMA , *ALBUMINS , *ANTINEOPLASTIC agents , *MONOCLONAL antibodies , *EYE diseases - Abstract
Purpose: Cystoid macular edema (CME) is a rarely reported side effect of nanoparticle albumin bound (nab)-paclitaxel therapy-an antimitotic agent used for breast cancer. We describe a patient with bilateral CME secondary to Abraxane that was minimally responsive to intravitreal bevacizumab. To our knowledge, this is the first reported case of the use of intravitreal bevacizumab for this condition. A previous report has described the ineffectiveness of concurrent intravenous bevacizumab with Abraxane. This lack of efficacy and knowledge of the mechanism of paclitaxel may provide insights into the mechanisms of CME without angiographic leakage. Methods: Retrospective, interventional case report of a patient with bilateral CME after starting Abraxane therapy for recurrent breast cancer treated with intravitreal bevacizumab (1.25 mg/0.05 mL) every 4 weeks. Records were reviewed for visual acuity and macular edema as assessed by spectral-domain optical coherence tomography (SD-OCT). Results: A 73-year-old patient with recurrent, metastatic breast cancer presented with bilateral visual loss 3 months after nab-paclitaxel was initiated. Baseline visual acuities (VA) were 20/50 in the right eye (OD) and 20/80 in the left eye (OS). Fundus exam showed marked CME in both eyes (OU). Fluorescein angiography was notable for the marked absence of petalloid late-phase leakage characteristic of vascular, ischemic, and inflammatory causes of CME. SD-OCT showed marked cystoid spaces predominantly involving the outer and inner nuclear layers with central subfield thicknesses (CST) of 398 μm OD and 441 μm OS. Serial intravitreal bevacizumab injections (OD, 2 injections; OS, 3 injections) were administered on a 4-week basis with an improvement and stabilization of VA at 20/50 OD and 20/70 OS. However, CME on SD-OCT persisted with CST of 492 μm OD and 478 μm OS. Conclusions: The pathogenesis of CME without leakage is poorly understood; however, fluid accumulation in Muller cells due to toxicity has been proposed. The persistence of CME suggests that additional nonvascular endothelial growth factor-mediated mechanisms are involved. Improved understanding of the mechanisms underlying paclitaxel-associated CME is needed, especially in patients with limited systemic options for metastatic carcinoma. [ABSTRACT FROM AUTHOR]
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- 2013
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16. Pathogenesis of Uveitis in Ebola Virus Disease Survivors: Evolving Understanding from Outbreaks to Animal Models.
- Author
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Hartley, Caleb, Bavinger, J. Clay, Kuthyar, Sanjana, Shantha, Jessica G., and Yeh, Steven
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EBOLA virus disease ,EMERGING infectious diseases ,PATHOLOGY ,UVEITIS ,EYE diseases ,EBOLA virus - Abstract
Ebola virus disease (EVD) and emerging infectious disease threats continue to threaten life, prosperity and global health security. To properly counteract EVD, an improved understanding of the long-term impact of recent EVD outbreaks in West Africa and the Democratic Republic of Congo are needed. In the wake of recent outbreaks, numerous health sequelae were identified in EVD survivors. These findings include joint pains, headaches, myalgias, and uveitis, a vision-threatening inflammatory condition of the eye. Retrospective and more recent prospective studies of EVD survivors from West Africa have demonstrated that uveitis may occur in 13–34% of patients with an increase in prevalence from baseline to 12-month follow-up. The clinical spectrum of disease ranges from mild, anterior uveitis to severe, sight-threatening panuveitis. Untreated inflammation may ultimately lead to secondary complications of cataract and posterior synechiae, with resultant vision impairment. The identification of Ebola virus persistence in immune privileged organs, such as the eye, with subsequent tissue inflammation and edema may lead to vision loss. Non-human primate models of EVD have demonstrated tissue localization to the eye including macrophage reservoirs within the vitreous matter. Moreover, in vitro models of Ebola virus have shown permissiveness in retinal pigment epithelial cells, potentially contributing to viral persistence. Broad perspectives from epidemiologic studies of the outbreak, animal modeling, and immunologic studies of EVD survivors have demonstrated the spectrum of the eye disease, tissue specificity of Ebola virus infection, and antigen-specific immunologic response. Further studies in these areas will elucidate the mechanisms of this highly prevalent disease with the potential for improved therapeutics for Ebola virus in immune-privileged sites. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
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17. Structural Modeling of a Novel CAPN5 Mutation that Causes Uveitis and Neovascular Retinal Detachment
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Bassuk, Alexander G., Yeh, Steven, Wu, Shu, Martin, Daniel F., Tsang, Stephen H., Gakhar, Lokesh, and Mahajan, Vinit B.
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Eye--Diseases--Genetic aspects ,Uveitis ,Ophthalmology ,Retinal detachment ,FOS: Biological sciences ,Genetics ,Pathology ,Medicine ,Proteins--Structure ,Three-dimensional modeling ,eye diseases ,3. Good health - Abstract
CAPN5 mutations have been linked to autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), a blinding autoimmune eye disease. Here, we link a new CAPN5 mutation to ADNIV and model the three-dimensional structure of the resulting mutant protein. In our study, a kindred with inflammatory vitreoretinopathy was evaluated by clinical eye examinations, DNA sequencing, and protein structural modeling to investigate the disease-causing mutation. Two daughters of an affected mother demonstrated symptoms of stage III ADNIV, with posterior uveitis, cystoid macular edema, intraocular fibrosis, retinal neovascularization, retinal degeneration, and cataract. The women also harbored a novel guanine to thymine (c.750G>T, p.Lys250Asn) missense mutation in exon 6 of CAPN5, a gene that encodes a calcium-activated cysteine protease, calpain-5. Modeling based on the structures of all known calpains revealed the mutation falls within a calcium-sensitive flexible gating loop that controls access to the catalytic groove. Three-dimensional modeling placed the new mutation in a region adjacent to two previously identified disease-causing mutations, all three of which likely disrupt hydrogen bonding within the gating loop, yielding a CAPN5 with altered enzymatic activity. This is the third case of a CAPN5 mutation leading to inherited uveitis and neovascular vitreoretinopathy, suggesting patients with ADNIV features should be tested for CAPN5 mutations. Structural modeling of novel variants can be used to support mechanistic consequences of the disease-causing variants.
18. Additional file 1: of Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study
- Author
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Angeles-Han, Sheila, Yeh, Steven, Purnima Patel, Duong, Duc, Jenkins, Kirsten, Rouster-Stevens, Kelly, Mekibib Altaye, Ndate Fall, Thornton, Sherry, Sampath Prahalad, and Holland, Gary
- Subjects
sense organs ,eye diseases ,3. Good health - Abstract
Cytokines and chemokines reported in pediatric uveitis biomarker studies using aqueous humor. (DOCX 13 kb)
19. Additional file 1: of Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study
- Author
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Angeles-Han, Sheila, Yeh, Steven, Purnima Patel, Duong, Duc, Jenkins, Kirsten, Rouster-Stevens, Kelly, Mekibib Altaye, Ndate Fall, Thornton, Sherry, Sampath Prahalad, and Holland, Gary
- Subjects
sense organs ,eye diseases ,3. Good health - Abstract
Cytokines and chemokines reported in pediatric uveitis biomarker studies using aqueous humor. (DOCX 13 kb)
20. Chorioretinal Folds: Associated Disorders and a Related Maculopathy.
- Author
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MUSETTI, DONATELLA, NICOLÒ, MASSIMO, BAGNIS, ALESSANDRO, TRAVERSO, CARLO ENRICO, OLSEN, TIMOTHY W., PALEJWALA, NEAL V., LEE, LYNDON B., BERGSTROM, CHRIS S., and YEH, STEVEN
- Subjects
- *
CHOROID diseases , *RETINAL diseases , *OPHTHALMOLOGY , *EYE diseases , *DISEASE prevalence , *MEDICAL research - Published
- 2014
- Full Text
- View/download PDF
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