1. Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles
- Author
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Marca, A. L., Sighinolfi, G., Giulini, S., Traglia, M., Argento, C., Sala, C., Masciullo, C., Volpe, Annibale, Toniolo, D., and LA MARCA, Antonio
- Subjects
Adult ,Anti-Mullerian Hormone ,Oral ,Aging ,endocrine system ,medicine.medical_specialty ,Adolescent ,endocrine system diseases ,Cross-sectional study ,media_common.quotation_subject ,European Continental Ancestry Group ,Reproductive Endocrinology ,Normal serum ,White People ,Reference Values ,Internal medicine ,medicine ,Humans ,Ovarian reserve ,Contraceptives ,Cross-Sectional Studies ,Female ,Menstrual Cycle ,Middle Aged ,Menstrual cycle ,media_common ,biology ,urogenital system ,business.industry ,Obstetrics and Gynecology ,Anti-Müllerian hormone ,female genital diseases and pregnancy complications ,Endocrinology ,Reproductive Medicine ,Ageing ,biology.protein ,business ,hormones, hormone substitutes, and hormone antagonists ,Contraceptives, Oral ,Developmental Biology ,Hormone - Abstract
Anti-Müllerian hormone (AMH) has become the 'molecule of the moment' in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18-50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient.
- Published
- 2010