1. Chronic and recurrent benign lymphadenopathy without constitutional symptoms associated with human herpesvirus-6B reactivation
- Author
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Giulio Rossi, Roberta Gelmini, Roberto Marasca, Daniela Vallerini, Patrizia Barozzi, Antonino Maiorana, Franco Narni, Goretta Bonacorsi, Claudio Cermelli, Valeria Coluccio, Sara Tagliazucchi, Monica Morselli, Fabio Rumpianesi, Mario Luppi, Monica Maccaferri, Leonardo Potenza, Chiara Quadrelli, Francesco Mattioli, Sara Bigliardi, Livio Presutti, Elisabetta Colaci, Ambra Paolini, Patrizia Comoli, Giovanni Riva, Fabio Forghieri, Forghieri F., Luppi M., Barozzi P., Riva G., Morselli M., Bigliardi S., Quadrelli C., Vallerini D., Maccaferri M., Coluccio V., Paolini A., Colaci E., Bonacorsi G., Maiorana A., Tagliazucchi S., Rumpianesi F., Mattioli F., Presutti L., Gelmini R., Cermelli C., Rossi G., Comoli P., Marasca R., Narni F., and Potenza L.
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Constitutional symptoms ,Herpesvirus 6, Human ,Human herpesvirus 6 ,Roseolovirus Infections ,Lymphoproliferative disorders ,Chronic/recurrent lymphadenopathy ,Reactive follicular hyperplasia ,Lymphoid hyperplasia ,03 medical and health sciences ,0302 clinical medicine ,Recurrence ,Neoplasms ,medicine ,Humans ,music ,Lymphatic Diseases ,Aged ,Retrospective Studies ,benign lymphadenopathy, chronic/recurrent lymphadenopathy, reactive follicular hyperplasia, human herpesvirus 6, immunohistochemistry ,Hyperplasia ,music.instrument ,biology ,Follicular dendritic cells ,business.industry ,Dendritic Cells ,Hematology ,Middle Aged ,medicine.disease ,biology.organism_classification ,Immunohistochemistry ,Follicular hyperplasia ,Lymphoma ,Benign lymphadenopathy ,030104 developmental biology ,030220 oncology & carcinogenesis ,Chronic Disease ,Lymph Node Excision ,Female ,Virus Activation ,Lymph Nodes ,medicine.symptom ,business - Abstract
Chronic/recurrent behaviour may be encountered in some distinct atypical or malignant lymphoproliferations, while recurrences are not generally observed in reactive/benign lymphadenopathies. We retrospectively analysed a consecutive series of 486 human immunodeficiency virus-negative adults, who underwent lymphadenectomy. Neoplastic and benign/reactive histopathological pictures were documented in 299 (61·5%) and 187 (38·5%) cases, respectively. Of note, seven of the 111 (6·3%) patients with benign lymphadenopathy without well-defined aetiology, showed chronic/recurrent behaviour, without constitutional symptoms. Enlarged lymph nodes were round in shape and hypoechoic, mimicking lymphoma. Reactive follicular hyperplasia and paracortical expansion were observed. Human herpesvirus (HHV)-6B positive staining in follicular dendritic cells (FDCs) was documented in all seven patients. Serological, molecular and immunological examinations suggested HHV-6B reactivation. Among the remaining 104 cases with reactive lymphoid hyperplasia in the absence of well-known aetiology and without recurrences, positivity for HHV-6B on FDCs was found in three cases, whereas in seven further patients, a scanty positivity was documented in rare, scattered cells in inter-follicular regions. Immunohistochemistry for HHV-6A and HHV-6B was invariably negative on 134 lymph nodes, with either benign pictures with known aetiology or malignant lymphoproliferative disorders, tested as further controls. Future studies are warranted to investigate a potential association between HHV-6B reactivation and chronic/recurrent benign lymphadenopathy.
- Published
- 2015