1. Protective effect of 6-O-methyl-scutellarein on repeated cerebral ischemia/reperfusion in rats.
- Author
-
Wu WY, Zhong Y, Lu YT, Sun Y, Li NG, Shi ZH, Dong ZX, Gu T, Xue X, Fang F, Li HM, Tang YP, and Duan JA
- Subjects
- Animals, Dose-Response Relationship, Drug, Drug Administration Schedule, Flavones administration & dosage, Male, Maze Learning, Molecular Structure, Random Allocation, Rats, Reperfusion Injury pathology, Brain Ischemia pathology, Flavones pharmacology, Reperfusion Injury prevention & control
- Abstract
Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses. More importantly, 6-O-methyl-scutellarein (3) had better protective effects than scutellarin in rat cerebral ischemia.
- Published
- 2018
- Full Text
- View/download PDF