1. A new methylene bisflavan-3-ol from the branches and leaves of Potentilla fruticosa .
- Author
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Zeng Y, Sun YX, Meng XH, Yu T, Zhu HT, and Zhang YJ
- Subjects
- Anti-Bacterial Agents pharmacology, Bacteria drug effects, Biflavonoids isolation & purification, Catechin isolation & purification, Glucose pharmacokinetics, Glycosides analysis, Glycosides isolation & purification, Phenols isolation & purification, Plant Extracts chemistry, Plant Extracts pharmacology, Plant Leaves chemistry, Proanthocyanidins isolation & purification, Anti-Bacterial Agents isolation & purification, Flavonoids isolation & purification, Potentilla chemistry, Rosaceae chemistry
- Abstract
Dasiphora fruticosa L. (Rosaceae), also known as Potentilla fruticosa L. (syn.), is a hardy deciduous shrub widely distributed in the north temperate regions of the world. Three methylene bisflavan-3-ols ( 1 - 3 ), together with a procyanidin dimer, (-)-afzelechin-(4α→8)-(-)-afzelechin ( 4 ) were isolated for the first time from the branches and leaves of the titled plant, in addition to 11 known compounds ( 5 - 15 ). Their structures were elucidated by means of extensive spectroscopic analysis and by comparison with data reported in the literatures. Methylene 6,8-bis(7- O -glucosyl) catechin ( 1 ) was determined to be a new dimeric flavan-3-ol glycoside through a methylene linkage between C-8 and C-8 of two units. At a concentration of 128 μg/mL, the known compounds 9 - 13 exhibited antibacterial activities on Escherichia coli , Staphylococcus aureus subsp. aureus , Salmonella enterica subsp. enterica , and Pseudomonas aeruginosa . Compound 12 also showed certain glucose uptake stimulating activity.
- Published
- 2020
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