1. Monoamine oxidase-A targeting probe for prostate cancer imaging and inhibition of metastasis.
- Author
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Kim WY, Won M, Salimi A, Sharma A, Lim JH, Kwon SH, Jeon JY, Lee JY, and Kim JS
- Subjects
- Antineoplastic Agents pharmacology, Cell Death drug effects, Cell Line, Tumor, Cell Proliferation drug effects, Cell Survival drug effects, Drug Screening Assays, Antitumor, Fluorescent Dyes pharmacology, Humans, Male, Models, Molecular, Molecular Structure, Monoamine Oxidase metabolism, Monoamine Oxidase Inhibitors pharmacology, Optical Imaging, Photons, Prostatic Neoplasms drug therapy, Prostatic Neoplasms metabolism, Antineoplastic Agents chemistry, Fluorescent Dyes chemistry, Monoamine Oxidase analysis, Monoamine Oxidase Inhibitors chemistry, Prostatic Neoplasms diagnostic imaging
- Abstract
Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.
- Published
- 2019
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