1. Association between Visceral Adipose Tissue Metabolism and Cerebral Glucose Metabolism in Patients with Cognitive Impairment.
- Author
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Yu MH, Lim JS, Yi HA, Won KS, and Kim HW
- Subjects
- Humans, Male, Female, Aged, Cross-Sectional Studies, Middle Aged, Prospective Studies, Alzheimer Disease metabolism, Alzheimer Disease diagnostic imaging, Neuropsychological Tests, Intra-Abdominal Fat metabolism, Intra-Abdominal Fat diagnostic imaging, Glucose metabolism, Cognitive Dysfunction metabolism, Cognitive Dysfunction diagnostic imaging, Positron Emission Tomography Computed Tomography, Fluorodeoxyglucose F18 metabolism, Brain metabolism, Brain diagnostic imaging
- Abstract
Visceral adipose tissue (VAT) dysfunction has been recently recognized as a potential contributor to the development of Alzheimer's disease (AD). This study aimed to explore the relationship between VAT metabolism and cerebral glucose metabolism in patients with cognitive impairment. This cross-sectional prospective study included 54 patients who underwent
18 F-fluorodeoxyglucose (18 F-FDG) brain and torso positron emission tomography/computed tomography (PET/CT), and neuropsychological evaluations. VAT metabolism was measured by18 F-FDG torso PET/CT, and cerebral glucose metabolism was measured using18 F-FDG brain PET/CT. A voxel-based analysis revealed that the high-VAT-metabolism group exhibited a significantly lower cerebral glucose metabolism in AD-signature regions such as the parietal and temporal cortices. In the volume-of-interest analysis, multiple linear regression analyses with adjustment for age, sex, and white matter hyperintensity volume revealed that VAT metabolism was negatively associated with cerebral glucose metabolism in AD-signature regions. In addition, higher VAT metabolism was correlated with poorer outcomes on cognitive assessments, including the Korean Boston Naming Test, Rey Complex Figure Test immediate recall, and the Controlled Oral Word Association Test. In conclusion, our study revealed significant relationships among VAT metabolism, cerebral glucose metabolism, and cognitive function. This suggests that VAT dysfunction actively contributes to the neurodegenerative processes characteristic of AD, making VAT dysfunction targeting a novel AD therapy approach.- Published
- 2024
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