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Enteropathy-associated T-cell lymphoma (EATL) is a rare gastrointestinal non-Hodgkin's lymphoma, originating from intraepithelial T-lymphocyte, which is specifically associated with celiac disease. EATL most commonly presents in the sixth and seventh decades of life. We report a unique case of type I EATL in the colon with liver metastasis, which was presented with nonspecific radiological findings and at a very young age (29 years old) compared with previously published data. We suggest that EATL should be regarded as part of differential diagnosis in any patient presenting with abdominal pain, diarrhea, weight loss, and malabsorption because delay in treatment can result in an irreversible clinical outcome.

Cyclin B2 (CCNB2), a member of the cyclin protein family, has been found to be up-regulated in human cancers. To evaluate the potential use of circulating CCNB2 in serum in cancer surveillance, we examined relative expression levels of serum circulating CCNB2 mRNA in 103 cancer patients, 19 normal controls, and 40 benign disease patients using real-time quantitative reverse transcriptase polymerase chain reaction. We found that the relative expression level of circulating CCNB2 mRNA in cancer patients was significantly higher (p

Human tissue homeostasis is precisely regulated by cellular division, differentiation and death. Normal human somatic cells progressively lose telomere restriction fragment (TRF) length with each successive cell division, eventually leading to cellular quiescence, chromosomal end-degradation and apoptosis[1]. On the contrary, stabilization of telomere lengths by expressing telomerase, a n RNA-dependent DNA polymerase, may be involved in cellular immortality and carcinogenesis[2-4]. Changes of telomerase activity and telomere lengths have been found in almost all human cancers[4-10], but the evidence of their relationship with immortalization of cancers cell remain to be directly demonstrated. Since shortened telomere was first discovered in Hela cells with antisense RNA techniques in 1995[11], anticancer agents based on inhibition of telomerase RNA have been reported[12,13]. However, the relationship between telomerase inhibition and cell apoptosis has not been fully understood. In this study, we investigated the effect of blocking telomerase activity on apoptosis of human gastric cancer cells in vitro using an antisense vector for human telomerase RNA component (hTR) into human gastric cancer cells.